IL134874A - Method to create triazolinethione derivatives - Google Patents
Method to create triazolinethione derivativesInfo
- Publication number
- IL134874A IL134874A IL13487498A IL13487498A IL134874A IL 134874 A IL134874 A IL 134874A IL 13487498 A IL13487498 A IL 13487498A IL 13487498 A IL13487498 A IL 13487498A IL 134874 A IL134874 A IL 134874A
- Authority
- IL
- Israel
- Prior art keywords
- carbon atoms
- moiety
- atoms
- alkoxy
- alkyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 224
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 56
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 54
- 125000001424 substituent group Chemical group 0.000 claims abstract description 52
- 125000005843 halogen group Chemical group 0.000 claims abstract description 45
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 35
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 35
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 31
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 25
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 25
- 150000002367 halogens Chemical class 0.000 claims abstract description 25
- 150000002429 hydrazines Chemical class 0.000 claims abstract description 25
- 125000003118 aryl group Chemical group 0.000 claims abstract description 23
- 239000003085 diluting agent Substances 0.000 claims abstract description 21
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims abstract description 18
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract description 15
- 125000004414 alkyl thio group Chemical group 0.000 claims abstract description 15
- 125000004438 haloalkoxy group Chemical group 0.000 claims abstract description 15
- 125000001188 haloalkyl group Chemical group 0.000 claims abstract description 15
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims abstract description 15
- 239000003054 catalyst Substances 0.000 claims abstract description 14
- 150000003583 thiosemicarbazides Chemical class 0.000 claims abstract description 13
- 150000003839 salts Chemical class 0.000 claims abstract description 12
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000019253 formic acid Nutrition 0.000 claims abstract description 9
- 125000005429 oxyalkyl group Chemical group 0.000 claims abstract description 8
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 claims abstract description 7
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 claims abstract description 7
- 150000007522 mineralic acids Chemical class 0.000 claims abstract description 7
- 150000007524 organic acids Chemical class 0.000 claims abstract description 7
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims abstract description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims abstract description 5
- 125000004429 atom Chemical group 0.000 claims abstract description 5
- 229910052700 potassium Inorganic materials 0.000 claims abstract description 5
- 239000011591 potassium Substances 0.000 claims abstract description 5
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 5
- 239000011734 sodium Substances 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 41
- 238000006243 chemical reaction Methods 0.000 claims description 22
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 6
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 claims description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 5
- 229910052799 carbon Inorganic materials 0.000 claims description 5
- 239000007858 starting material Substances 0.000 claims description 5
- SOIFLUNRINLCBN-UHFFFAOYSA-N ammonium thiocyanate Chemical compound [NH4+].[S-]C#N SOIFLUNRINLCBN-UHFFFAOYSA-N 0.000 claims description 3
- 238000002955 isolation Methods 0.000 claims description 3
- -1 methoxy, ethoxy, propoxy, isopropoxy Chemical group 0.000 description 107
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 30
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 30
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 30
- 229910052794 bromium Inorganic materials 0.000 description 30
- 229910052801 chlorine Inorganic materials 0.000 description 30
- 239000000460 chlorine Substances 0.000 description 30
- 229910052731 fluorine Inorganic materials 0.000 description 30
- 239000011737 fluorine Substances 0.000 description 30
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 29
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 24
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 22
- 150000003254 radicals Chemical class 0.000 description 21
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 20
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 20
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 20
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 19
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 18
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 15
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 10
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 8
- 125000003342 alkenyl group Chemical group 0.000 description 8
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 8
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000011541 reaction mixture Substances 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 6
- 239000012074 organic phase Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 5
- 239000003960 organic solvent Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 description 4
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 4
- 239000005864 Sulphur Substances 0.000 description 4
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 4
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 4
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 description 4
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 description 4
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 description 4
- 125000002541 furyl group Chemical group 0.000 description 4
- 125000002883 imidazolyl group Chemical group 0.000 description 4
- 125000001041 indolyl group Chemical group 0.000 description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 4
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 description 4
- 125000002971 oxazolyl group Chemical group 0.000 description 4
- 125000005359 phenoxyalkyl group Chemical group 0.000 description 4
- 125000003884 phenylalkyl group Chemical group 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 4
- 125000003226 pyrazolyl group Chemical group 0.000 description 4
- 125000004076 pyridyl group Chemical group 0.000 description 4
- 125000000714 pyrimidinyl group Chemical group 0.000 description 4
- 125000000168 pyrrolyl group Chemical group 0.000 description 4
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 4
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 4
- 238000001953 recrystallisation Methods 0.000 description 4
- 125000000335 thiazolyl group Chemical group 0.000 description 4
- 125000001544 thienyl group Chemical group 0.000 description 4
- 125000004306 triazinyl group Chemical group 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 3
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 3
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 3
- 150000002170 ethers Chemical class 0.000 description 3
- 239000000155 melt Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 229910052938 sodium sulfate Inorganic materials 0.000 description 3
- 235000011152 sodium sulphate Nutrition 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000010626 work up procedure Methods 0.000 description 3
- 239000008096 xylene Substances 0.000 description 3
- 125000006426 1-chlorocyclopropyl group Chemical group [H]C1([H])C([H])([H])C1(Cl)* 0.000 description 2
- 125000006420 1-fluorocyclopropyl group Chemical group [H]C1([H])C([H])([H])C1(F)* 0.000 description 2
- 125000006432 1-methyl cyclopropyl group Chemical group [H]C([H])([H])C1(*)C([H])([H])C1([H])[H] 0.000 description 2
- AVMSWPWPYJVYKY-UHFFFAOYSA-N 2-Methylpropyl formate Chemical compound CC(C)COC=O AVMSWPWPYJVYKY-UHFFFAOYSA-N 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 230000003641 microbiacidal effect Effects 0.000 description 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000001117 sulphuric acid Substances 0.000 description 2
- 235000011149 sulphuric acid Nutrition 0.000 description 2
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 description 2
- SZIFAVKTNFCBPC-UHFFFAOYSA-N 2-chloroethanol Chemical class OCCCl SZIFAVKTNFCBPC-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- XPOLVIIHTDKJRY-UHFFFAOYSA-N acetic acid;methanimidamide Chemical compound NC=N.CC(O)=O XPOLVIIHTDKJRY-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 125000004789 chlorodifluoromethoxy group Chemical group ClC(O*)(F)F 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine Substances NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 1
- BRWIZMBXBAOCCF-UHFFFAOYSA-N hydrazinecarbothioamide Chemical compound NNC(N)=S BRWIZMBXBAOCCF-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- HKOOXMFOFWEVGF-UHFFFAOYSA-N phenylhydrazine Chemical compound NNC1=CC=CC=C1 HKOOXMFOFWEVGF-UHFFFAOYSA-N 0.000 description 1
- 229940067157 phenylhydrazine Drugs 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- VGTPCRGMBIAPIM-UHFFFAOYSA-M sodium thiocyanate Chemical compound [Na+].[S-]C#N VGTPCRGMBIAPIM-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 125000005017 substituted alkenyl group Chemical group 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 150000003567 thiocyanates Chemical class 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19744400A DE19744400A1 (de) | 1997-10-08 | 1997-10-08 | Verfahren zur Herstellung von Triazolinthion-Derivaten |
| PCT/EP1998/006113 WO1999018088A1 (fr) | 1997-10-08 | 1998-09-25 | Procede de preparation de derives de thione de triazoline |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL134874A0 IL134874A0 (en) | 2001-05-20 |
| IL134874A true IL134874A (en) | 2004-03-28 |
Family
ID=7844917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13487498A IL134874A (en) | 1997-10-08 | 1998-09-25 | Method to create triazolinethione derivatives |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6262276B1 (fr) |
| EP (1) | EP1030848B1 (fr) |
| JP (1) | JP4028174B2 (fr) |
| KR (1) | KR100549805B1 (fr) |
| CN (1) | CN1178924C (fr) |
| AT (1) | ATE239001T1 (fr) |
| AU (1) | AU9746898A (fr) |
| BR (1) | BR9812856B1 (fr) |
| DE (2) | DE19744400A1 (fr) |
| DK (1) | DK1030848T3 (fr) |
| ES (1) | ES2193571T3 (fr) |
| HU (1) | HUP0004946A3 (fr) |
| IL (1) | IL134874A (fr) |
| MX (1) | MX212936B (fr) |
| WO (1) | WO1999018088A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19917617A1 (de) * | 1999-04-19 | 2000-10-26 | Bayer Ag | -(-)Enantiomeres des 2-[2-(1-Chlor-cyclopropyl)-3-(2-chlorphenyl) 2-hydroxy-propyl]-2,4-dihydro-[1,2,4]-triazol-3-thions |
| DE19961603A1 (de) | 1999-12-21 | 2001-06-28 | Bayer Ag | Verfahren zur Herstellung eines Triazolinthion-Derivates |
| DE10233171A1 (de) * | 2002-07-22 | 2004-02-12 | Bayer Cropscience Ag | Kristallmodifikation II des 2-[2-(Chlor-cyclopropyl)-3-(2-chlorphenyl)-2-hydroxy-propyl]-2,4dihydro-3H-1,2,4-triazol-3-thions |
| CN101848904B (zh) * | 2007-11-05 | 2013-05-01 | 巴斯夫欧洲公司 | 生产ε-己内酯的方法 |
| CN101945580A (zh) * | 2007-12-19 | 2011-01-12 | 巴斯夫欧洲公司 | 唑基甲基环氧乙烷、其应用和包含它们的组合物 |
| EP2235005A2 (fr) * | 2007-12-19 | 2010-10-06 | Basf Se | Azolylméthyloxiranes, leur utilisation et agents les contenant |
| US20100311581A1 (en) * | 2007-12-19 | 2010-12-09 | Basf Se | Azolylmethyloxiranes, use Thereof and Agents Containing the Same |
| WO2009077497A2 (fr) * | 2007-12-19 | 2009-06-25 | Basf Se | Azolylméthyloxiranes, utilisation de ceux-ci et agents contenant ceux-ci |
| EP2440535A1 (fr) | 2009-06-12 | 2012-04-18 | Basf Se | Dérivés antifongiques de 1,2,4-triazolyle ayant un substituant soufré en 5 |
| JP2012530109A (ja) | 2009-06-18 | 2012-11-29 | ビーエーエスエフ ソシエタス・ヨーロピア | 抗菌性１，２，４−トリアゾリル誘導体 |
| CN102803232A (zh) | 2009-06-18 | 2012-11-28 | 巴斯夫欧洲公司 | 杀真菌的具有5-硫取代基的1,2,4-三唑衍生物 |
| WO2010146112A1 (fr) | 2009-06-18 | 2010-12-23 | Basf Se | Derives triazolyle antifongiques 1, 2, 4 |
| WO2010149758A1 (fr) | 2009-06-25 | 2010-12-29 | Basf Se | Dérivés de 1,2,4-triazole antifongiques |
| BR112012015040A2 (pt) | 2009-12-18 | 2015-09-22 | Basf Se | processo para a preparação de grupos tio-triazol substituídos da fórmula geral (i) e compostos (lla) |
| CN103130731B (zh) * | 2013-03-06 | 2015-06-03 | 陕西科技大学 | 一种制备4-氨基-5-芳基-1,2,4-三唑-3-硫酮的方法 |
| CN105949137B (zh) | 2016-07-15 | 2019-01-29 | 泸州东方农化有限公司 | 一种丙硫菌唑及其光学活性体的合成方法和中间体 |
| CN108912062B (zh) * | 2018-06-21 | 2020-10-27 | 江西天宇化工有限公司 | 一种三唑硫酮衍生物的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3812967A1 (de) | 1987-06-24 | 1989-01-05 | Bayer Ag | Azolylmethyl-cyclopropyl-derivate |
| DE4030039A1 (de) * | 1990-09-22 | 1992-03-26 | Bayer Ag | Verfahren zur herstellung von 2-(1-chlor-cyclopropyl)-1- (2-chlor-phenyl)-3-(1,2,4-triazol-1-yl- propan-2-ol |
| DE4339412A1 (de) * | 1993-11-18 | 1995-05-24 | Bayer Ag | Verfahren und neue Zwischenprodukte zur Herstellung von Triazolinonen |
| DE19528046A1 (de) | 1994-11-21 | 1996-05-23 | Bayer Ag | Triazolyl-Derivate |
| DE19601189A1 (de) | 1996-01-15 | 1997-07-17 | Degussa | Verfahren zur Herstellung von 1,2,4-Triazolin-3(2H)-onen |
| EP0784053A1 (fr) | 1996-01-15 | 1997-07-16 | Degussa Aktiengesellschaft | Procédé pour la préparation des triazolinones comme herbicides |
-
1997
- 1997-10-08 DE DE19744400A patent/DE19744400A1/de not_active Withdrawn
-
1998
- 1998-09-25 CN CNB988099586A patent/CN1178924C/zh not_active Expired - Lifetime
- 1998-09-25 HU HU0004946A patent/HUP0004946A3/hu unknown
- 1998-09-25 JP JP2000514899A patent/JP4028174B2/ja not_active Expired - Lifetime
- 1998-09-25 DK DK98951467T patent/DK1030848T3/da active
- 1998-09-25 WO PCT/EP1998/006113 patent/WO1999018088A1/fr active IP Right Grant
- 1998-09-25 EP EP98951467A patent/EP1030848B1/fr not_active Expired - Lifetime
- 1998-09-25 ES ES98951467T patent/ES2193571T3/es not_active Expired - Lifetime
- 1998-09-25 US US09/509,927 patent/US6262276B1/en not_active Expired - Lifetime
- 1998-09-25 BR BRPI9812856-6A patent/BR9812856B1/pt active IP Right Grant
- 1998-09-25 DE DE59808194T patent/DE59808194D1/de not_active Expired - Lifetime
- 1998-09-25 AU AU97468/98A patent/AU9746898A/en not_active Abandoned
- 1998-09-25 IL IL13487498A patent/IL134874A/en not_active IP Right Cessation
- 1998-09-25 AT AT98951467T patent/ATE239001T1/de active
- 1998-09-25 KR KR20007003073A patent/KR100549805B1/ko not_active IP Right Cessation
-
2000
- 2000-04-07 MX MXPA00003449 patent/MX212936B/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1274347A (zh) | 2000-11-22 |
| JP2001519338A (ja) | 2001-10-23 |
| KR20010024244A (ko) | 2001-03-26 |
| JP4028174B2 (ja) | 2007-12-26 |
| BR9812856B1 (pt) | 2009-01-13 |
| EP1030848A1 (fr) | 2000-08-30 |
| ES2193571T3 (es) | 2003-11-01 |
| AU9746898A (en) | 1999-04-27 |
| MX212936B (es) | 2003-02-11 |
| DE59808194D1 (de) | 2003-06-05 |
| US6262276B1 (en) | 2001-07-17 |
| BR9812856A (pt) | 2000-08-08 |
| EP1030848B1 (fr) | 2003-05-02 |
| CN1178924C (zh) | 2004-12-08 |
| WO1999018088A1 (fr) | 1999-04-15 |
| MXPA00003449A (es) | 2000-11-01 |
| HUP0004946A3 (en) | 2002-02-28 |
| ATE239001T1 (de) | 2003-05-15 |
| HUP0004946A2 (hu) | 2001-06-28 |
| DE19744400A1 (de) | 1999-04-15 |
| KR100549805B1 (ko) | 2006-02-08 |
| DK1030848T3 (da) | 2003-08-11 |
| IL134874A0 (en) | 2001-05-20 |
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