IL132822A0 - Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid - Google Patents

Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid

Info

Publication number
IL132822A0
IL132822A0 IL13282299A IL13282299A IL132822A0 IL 132822 A0 IL132822 A0 IL 132822A0 IL 13282299 A IL13282299 A IL 13282299A IL 13282299 A IL13282299 A IL 13282299A IL 132822 A0 IL132822 A0 IL 132822A0
Authority
IL
Israel
Prior art keywords
manufacture
hydroxy acid
controlled fermentation
fermentation procedure
lovastatin hydroxy
Prior art date
Application number
IL13282299A
Other languages
English (en)
Original Assignee
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9800619A external-priority patent/HU226966B1/hu
Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar
Publication of IL132822A0 publication Critical patent/IL132822A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL13282299A 1998-03-20 1999-03-19 Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid IL132822A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9800619A HU226966B1 (en) 1998-03-20 1998-03-20 Fermentation process
PCT/HU1999/000021 WO1999049072A1 (en) 1998-03-20 1999-03-19 Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid

Publications (1)

Publication Number Publication Date
IL132822A0 true IL132822A0 (en) 2001-03-19

Family

ID=89996304

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13282299A IL132822A0 (en) 1998-03-20 1999-03-19 Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid

Country Status (8)

Country Link
US (1) US6500651B1 (cs)
JP (1) JP2001527424A (cs)
AU (1) AU753564B2 (cs)
CA (1) CA2289553C (cs)
CZ (1) CZ300153B6 (cs)
IL (1) IL132822A0 (cs)
NZ (1) NZ500870A (cs)
UA (1) UA73074C2 (cs)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080064076A1 (en) * 2006-09-11 2008-03-13 Saucedo Victor M Dissolved Oxygen Profile to Increase Fermentation Productivity and Economics
US20130005010A1 (en) 2011-06-30 2013-01-03 Peter Simpson Bell Bioreactor for syngas fermentation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925599B2 (ja) 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
US4294926A (en) 1979-06-15 1981-10-13 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4319039A (en) 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
US4294846A (en) 1979-09-21 1981-10-13 Merck & Co., Inc. Hypocholesteremic fermentation products and products of preparation
US4342767A (en) 1980-01-23 1982-08-03 Merck & Co., Inc. Hypocholesteremic fermentation products
US4420491A (en) 1980-05-28 1983-12-13 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US5316776A (en) 1984-01-31 1994-05-31 Arnott's Biscuits Limited Fermentation method
US4945048A (en) 1987-05-23 1990-07-31 Takeda Chemical Industries, Ltd. Process for producing L-sorbose by subculture of seed
NZ245713A (en) * 1992-02-10 1994-12-22 Novopharm Ltd Production of the antibiotic lovastatin from genetically engineered aspergillus strains
HU208997B (en) * 1992-06-17 1994-02-28 Gyogyszerkutato Intezet Microbiological method for producing mevinoline
SI9300047A (en) 1993-01-29 1994-09-30 Krka Microbiological method for preparation of lovostatin and/or mevinoline acid
US5494808A (en) 1994-09-15 1996-02-27 Merck & Co., Inc. Defined medium OMPC fermentation process
SI9500238A (en) 1995-07-27 1997-02-28 Krka Tovarna Zdravil Procedure for the production of lovastatin
HU226966B1 (en) * 1998-03-20 2010-03-29 Teva Gyogyszergyar Zartkoeruee Fermentation process

Also Published As

Publication number Publication date
US6500651B1 (en) 2002-12-31
AU3046699A (en) 1999-10-18
CA2289553A1 (en) 1999-09-30
CZ300153B6 (cs) 2009-02-25
CA2289553C (en) 2004-05-18
JP2001527424A (ja) 2001-12-25
NZ500870A (en) 2002-03-01
AU753564B2 (en) 2002-10-24
UA73074C2 (en) 2005-06-15
CZ412199A3 (cs) 2000-02-16

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