IL132363A - Capa agonist compounds for use in the prevention or treatment of itching and antipruritic pharmaceutical preparations containing them - Google Patents

Capa agonist compounds for use in the prevention or treatment of itching and antipruritic pharmaceutical preparations containing them

Info

Publication number
IL132363A
IL132363A IL13236398A IL13236398A IL132363A IL 132363 A IL132363 A IL 132363A IL 13236398 A IL13236398 A IL 13236398A IL 13236398 A IL13236398 A IL 13236398A IL 132363 A IL132363 A IL 132363A
Authority
IL
Israel
Prior art keywords
alkyl
group
alkoxy
hydroxy
methyl
Prior art date
Application number
IL13236398A
Other languages
English (en)
Hebrew (he)
Other versions
IL132363A0 (en
Original Assignee
Adolor Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/892,599 external-priority patent/US5760023A/en
Application filed by Adolor Corp filed Critical Adolor Corp
Publication of IL132363A0 publication Critical patent/IL132363A0/xx
Publication of IL132363A publication Critical patent/IL132363A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL13236398A 1997-07-14 1998-06-19 Capa agonist compounds for use in the prevention or treatment of itching and antipruritic pharmaceutical preparations containing them IL132363A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/892,599 US5760023A (en) 1997-07-14 1997-07-14 Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
US09/064,695 US5869521A (en) 1997-07-14 1998-04-22 Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
PCT/US1998/012789 WO1999003459A1 (en) 1997-07-14 1998-06-19 Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith

Publications (2)

Publication Number Publication Date
IL132363A0 IL132363A0 (en) 2001-03-19
IL132363A true IL132363A (en) 2004-02-19

Family

ID=26744793

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13236398A IL132363A (en) 1997-07-14 1998-06-19 Capa agonist compounds for use in the prevention or treatment of itching and antipruritic pharmaceutical preparations containing them

Country Status (10)

Country Link
US (3) US6004964A (ja)
EP (1) EP0996434A4 (ja)
JP (1) JP2003526594A (ja)
BR (1) BR9810706A (ja)
CA (1) CA2288828A1 (ja)
IL (1) IL132363A (ja)
MX (1) MXPA99011298A (ja)
NO (1) NO996353L (ja)
NZ (1) NZ500438A (ja)
WO (1) WO1999003459A1 (ja)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763445A (en) * 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
ATE291429T1 (de) * 1996-11-25 2005-04-15 Toray Industries Mittel gegen juckreiz
US6383511B1 (en) 1999-10-25 2002-05-07 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
US20060172007A1 (en) * 2001-05-01 2006-08-03 Nawaz Ahmad Compositions and methods for reducing vaginal pH
US20030017207A1 (en) * 2001-05-01 2003-01-23 Lin Shun Y. Compositions and methods for treating vulvovaginitis and vaginosis
US6844438B2 (en) 2001-08-15 2005-01-18 Mclean Hospital Corporation N-substituted derivatives of morphinan and uses thereof
US6638981B2 (en) 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain
GB0129267D0 (en) * 2001-12-06 2002-01-23 Syngenta Ltd Fungicides
US20060105008A1 (en) * 2002-03-28 2006-05-18 Nawaz Ahmad Compositions and methods for reducing vaginal pH
CN1692426B (zh) * 2002-11-20 2010-05-12 Lg电子有限公司 具有管理数据重现的数据结构的记录介质及记录和重现的方法和装置
GB0227551D0 (en) 2002-11-26 2002-12-31 Syngenta Ltd Fungicides
GB0227555D0 (en) * 2002-11-26 2002-12-31 Syngenta Ltd Fungicides
GB0227558D0 (en) * 2002-11-26 2002-12-31 Syngenta Ltd Fungicides
GB0227554D0 (en) * 2002-11-26 2002-12-31 Syngenta Ltd Fungicides
GB0227556D0 (en) * 2002-11-26 2002-12-31 Syngenta Ltd Fungicides
GB0312863D0 (en) * 2003-06-04 2003-07-09 Syngenta Ltd Fungicides
GB0312864D0 (en) * 2003-06-04 2003-07-09 Syngenta Ltd Fungicides
US7718664B2 (en) 2004-03-30 2010-05-18 Toray Industries, Inc. Anti-itching agent
US20080119820A1 (en) 2006-09-20 2008-05-22 Phan Phillip C Methods for Delivering Volatile Anesthetics for Regional Anesthesia and/or Pain Relief
KR20080067586A (ko) * 2007-01-16 2008-07-21 에스케이에너지 주식회사 분리막을 구비하고 있는 염료감응태양전지 및 그 제조방법
JP5789100B2 (ja) 2008-01-22 2015-10-07 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 抽出溶媒を含む、局部的な麻酔および／または疼痛低減のための揮発性麻酔薬組成物
US8637538B1 (en) 2012-12-14 2014-01-28 Trevi Therapeutics, Inc. Methods for treatment of pruritis
US8987289B2 (en) 2012-12-14 2015-03-24 Trevi Therapeutics, Inc. Methods for treating pruritus
US20140179727A1 (en) 2012-12-14 2014-06-26 Trevi Therapeutics, Inc. Methods for treating pruritus
CN103554021A (zh) * 2013-11-25 2014-02-05 中国药科大学 一类茚酮四氢异喹啉衍生物、其制备方法及医药用途
EP3558300B1 (en) * 2016-12-21 2021-11-24 Tioga Pharmaceuticals, Inc. Solid pharmaceutical formulations of asimadoline
EP3826635A4 (en) 2018-07-23 2022-04-27 Trevi Therapeutics, Inc. TREATMENT OF CHRONIC COUGH, DIFFICULT BREATHING AND DYSPNEA

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4145435A (en) * 1976-11-12 1979-03-20 The Upjohn Company 2-aminocycloaliphatic amide compounds
US4466977A (en) * 1981-04-09 1984-08-21 The Upjohn Company N-[2-Amino(oxy- or thia- group-substituted-cycloaliphatic)]benzeneacetamides and -benzamide analgesics
US4360531A (en) * 1981-04-09 1982-11-23 The Upjohn Company Substituted cycloalkanes
US4359476A (en) * 1981-04-09 1982-11-16 The Upjohn Company Adjacently substituted cycloalkane-amide analgesics
US4438130A (en) * 1981-11-12 1984-03-20 The Upjohn Company Analgesic 1-oxa-, aza- and thia-spirocyclic compounds
US4663343A (en) * 1985-07-19 1987-05-05 Warner-Lambert Company Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds
GB8618188D0 (en) * 1986-07-25 1986-09-03 Ici Plc Diamine compounds
ZA876778B (en) * 1986-09-10 1989-05-30 Du Pont Benzo-fused cycloalkane and oxa-and thia-,cycloalkane trans-1,2-diamine derivatives
US4876269A (en) * 1986-09-10 1989-10-24 E. I. Du Pont De Nemours And Company Benoz-fused cycloalkane trans-1,2-diamine derivatives
DE3766335D1 (de) * 1986-09-17 1991-01-03 Zambeletti Spa L N-1-acylierte-(1-(phenyl- oder benzyl-))-1,2-aethylendiamine.
GB8801304D0 (en) * 1988-01-21 1988-02-17 Ici Plc Diamine compounds
US4855316A (en) * 1988-02-18 1989-08-08 Warner-Lambert Company 1,2-diamino-4,5-dimethoxycyclohexyl amide analgesic compounds
GB8804014D0 (en) * 1988-02-23 1988-03-23 Humphreys & Glasgow Ltd Synthesis gas production
PT89780A (pt) * 1988-02-23 1989-10-04 Glaxo Group Ltd Processo para a preparacao de derivados da tetrahidroisoquinolina
EP0330467A1 (en) * 1988-02-23 1989-08-30 Glaxo Group Limited Heterocyclic compounds
DK124089A (da) * 1988-03-16 1989-09-17 Zambeletti Spa L Heterocykliske derivater
FI892468A (fi) * 1988-05-23 1989-11-24 Glaxo Group Ltd Piperazinderivat.
US5021413B1 (en) * 1988-08-24 1994-12-13 Sankyo Co Analgesic thiomorpholins, their preparation, and pharmaceutical compositions containing them
GB8824400D0 (en) * 1988-10-18 1988-11-23 Glaxo Group Ltd Chemical compounds
AU626949B2 (en) * 1988-12-06 1992-08-13 Warner-Lambert Company 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
DE4034785A1 (de) * 1990-11-02 1992-05-07 Merck Patent Gmbh 1-(2-arylethyl)-pyrrolidine
GB8830219D0 (en) * 1988-12-23 1989-02-22 Zambeletti Spa L Novel compounds
US4906655A (en) * 1989-01-24 1990-03-06 Warner-Lambert Company Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents
US4965278A (en) * 1989-04-21 1990-10-23 Warner-Lambert Company 7-(substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro[4,5]decanes as diuretics antiiflammatory, and cerebrovascular agents
PT94070A (pt) * 1989-05-18 1991-01-08 Glaxo Group Ltd Processo para a preparacao de derivados de piperazina
GB8916395D0 (en) * 1989-07-18 1989-09-06 Zambeletti Spa L Pharmaceuticals
EP0585296A1 (en) * 1991-05-21 1994-03-09 Smithkline Beecham Farmaceutici S.p.A. 2-(pyrrolidinyl-1-methyl)-piperidine derivatives and their use as kappa-recept or agonists
NZ246687A (en) * 1992-01-23 1996-12-20 Toray Industries Morphinan derivative and pharmaceutical compositions thereof
DE4215213A1 (de) * 1992-05-09 1993-11-11 Merck Patent Gmbh Arylacetamide
WO1994018165A1 (en) * 1993-02-12 1994-08-18 Pfizer Inc. Sulfonamide compounds as opioid k-receptor agonists
CA2143864C (en) * 1993-07-23 2006-01-24 Hiroshi Nagase Morphinan derivatives and pharmaceutical use thereof
WO1996006078A1 (en) * 1994-08-24 1996-02-29 Pfizer Pharmaceuticals Inc. N-(2-(pyrrolidinyl-1)-1-phenylethyl)acetamides as kappa receptor antagonists
DE19523502A1 (de) * 1995-06-28 1997-01-02 Merck Patent Gmbh Kappa-Opiatagonisten für entzündliche Darmerkrankungen
US5688955A (en) * 1996-03-08 1997-11-18 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5763445A (en) * 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5646151A (en) * 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5888494A (en) * 1996-03-12 1999-03-30 Adolor Corporation Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic and pruritic conditions therewith
ATE291429T1 (de) * 1996-11-25 2005-04-15 Toray Industries Mittel gegen juckreiz
US5849762A (en) * 1997-07-14 1998-12-15 Adolor Corporation Peripherally acting anti-pruritic opiates
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith

Also Published As

Publication number Publication date
NO996353L (no) 2000-03-13
MXPA99011298A (es) 2004-10-28
EP0996434A4 (en) 2001-10-10
JP2003526594A (ja) 2003-09-09
BR9810706A (pt) 2000-08-08
US6048860A (en) 2000-04-11
NO996353D0 (no) 1999-12-20
US6156769A (en) 2000-12-05
WO1999003459A1 (en) 1999-01-28
CA2288828A1 (en) 1999-01-28
US6004964A (en) 1999-12-21
EP0996434A1 (en) 2000-05-03
NZ500438A (en) 2001-11-30
IL132363A0 (en) 2001-03-19

Similar Documents

Publication Publication Date Title
US6004964A (en) Kappa agonist anti-pruritic pharmaceutical formulaitons and method of treating pruritus therewith
US5869521A (en) Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
US6353004B1 (en) Peripherally acting anti-pruritic opiates
US6166039A (en) Peripherally active anti-hyperalgesic opiates
US5849762A (en) Peripherally acting anti-pruritic opiates
JP7541483B2 (ja) 糖尿病性末梢神経障害のための医薬
US5798093A (en) Spray formulations of antihyperalgesic opiates and method of treating topical hyperalgesic conditions and pruritus therewith
AU758122B2 (en) Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
AU740566B2 (en) Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
AU7829701A (en) Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
AU7934701A (en) Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
AU7935001A (en) Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
MXPA99011155A (en) Peripherally acting anti-pruritic opiates
MXPA98001514A (en) Optical hyperalgesic perifericame active

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees