IL132185A0 - Asymmetric synthesis of benzoxazinones via new intermediates - Google Patents

Asymmetric synthesis of benzoxazinones via new intermediates

Info

Publication number
IL132185A0
IL132185A0 IL13218598A IL13218598A IL132185A0 IL 132185 A0 IL132185 A0 IL 132185A0 IL 13218598 A IL13218598 A IL 13218598A IL 13218598 A IL13218598 A IL 13218598A IL 132185 A0 IL132185 A0 IL 132185A0
Authority
IL
Israel
Prior art keywords
asymmetric synthesis
new intermediates
via new
benzoxazinones
benzoxazinones via
Prior art date
Application number
IL13218598A
Other languages
English (en)
Original Assignee
Pont Pharmaceuticals Company M
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pont Pharmaceuticals Company M filed Critical Pont Pharmaceuticals Company M
Publication of IL132185A0 publication Critical patent/IL132185A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL13218598A 1997-04-07 1998-04-02 Asymmetric synthesis of benzoxazinones via new intermediates IL132185A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4280397P 1997-04-07 1997-04-07
PCT/US1998/006462 WO1998045278A1 (fr) 1997-04-07 1998-04-02 Synthese asymetrique de benzoxazinones via de nouveaux intermediaires

Publications (1)

Publication Number Publication Date
IL132185A0 true IL132185A0 (en) 2001-03-19

Family

ID=21923837

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13218598A IL132185A0 (en) 1997-04-07 1998-04-02 Asymmetric synthesis of benzoxazinones via new intermediates

Country Status (19)

Country Link
US (2) US5925789A (fr)
EP (1) EP0973755A1 (fr)
JP (1) JP2001519810A (fr)
KR (1) KR20010006074A (fr)
CN (2) CN1251582A (fr)
AR (1) AR014342A1 (fr)
AU (1) AU6876898A (fr)
BR (1) BR9808486A (fr)
CA (1) CA2285000A1 (fr)
EA (1) EA199900911A1 (fr)
EE (1) EE9900446A (fr)
HR (1) HRP980192A2 (fr)
HU (1) HUP0001407A3 (fr)
IL (1) IL132185A0 (fr)
NO (1) NO994836D0 (fr)
NZ (1) NZ500727A (fr)
SK (1) SK136199A3 (fr)
WO (1) WO1998045278A1 (fr)
ZA (1) ZA982956B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU229087B1 (en) * 1997-02-05 2013-07-29 Merck Sharp & Dohme Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
US5965729A (en) 1997-02-05 1999-10-12 Merck & Co., Inc. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
US6673372B1 (en) 1998-06-11 2004-01-06 Bristol-Myers Squibb Pharma Company Crystalline Efavirenz
TWI326283B (en) * 2002-07-31 2010-06-21 Du Pont Method for preparing fused oxazinones
US7696372B2 (en) * 2007-10-01 2010-04-13 Ascenta Therapeutics, Inc. Process for preparing R-gossypol L-phenylalaninol dienamine
WO2009133538A1 (fr) * 2008-05-01 2009-11-05 Ranbaxy Laboratories Limited Procédé de préparation d’éfavirenz
WO2010085978A1 (fr) * 2009-01-30 2010-08-05 F.I.S. Fabbrica Italiana Sintetici S.P.A. Procédé de préparation d'éfavirenz
US8080655B2 (en) * 2009-07-20 2011-12-20 Apotex Pharmachem Inc. Methods of making efavirenz and intermediates thereof
CN103664816B (zh) * 2011-01-06 2016-03-02 中国科学院上海有机化学研究所 Hiv逆转录酶抑制剂依法韦伦类化合物的一锅法不对称合成工艺
CN102617367A (zh) * 2012-03-08 2012-08-01 浙江江北药业有限公司 (S)-5-氯-α-（环丙基乙炔）-2-氨基-α-（三氟甲基）苯甲醇晶型的制备
CN103833560B (zh) * 2013-03-25 2016-05-25 安徽贝克联合制药有限公司 (S)-5-氯-α-环丙炔基-2-氨基-α-三氟甲基苯甲醇的制备方法
CN105001101B (zh) * 2015-05-28 2017-11-28 乐平市瑞盛制药有限公司 一种4‑氯‑2‑三氟乙酰基苯胺水合物盐酸盐的合成方法
CN105010124B (zh) * 2015-06-16 2017-06-16 湖南省作物研究所 可专用作绿肥的甘蓝型油菜的选育方法
CN105010129B (zh) * 2015-08-05 2017-06-23 江苏省农业科学院 早熟陆地棉新种质选育方法
CN105801442A (zh) * 2015-10-16 2016-07-27 浙江沙星医药化工有限公司 4-氯-2-(三氟乙酰基)苯胺盐酸盐水合物的制备方法
NL2018412B1 (en) * 2017-02-23 2018-09-17 Univ Nelson Mandela Metropolitan Method for the manufacture of efavirenz
CN108997152A (zh) * 2018-08-31 2018-12-14 江苏沙星化工有限公司 制备4-氯-2-（三氟乙酰基）苯胺盐酸盐的改进工艺
CN108997150B (zh) * 2018-08-31 2021-01-12 江苏沙星化工有限公司 一种依法韦仑中间体的制备方法
CN110204450B (zh) * 2019-05-24 2022-05-03 浙江江北药业有限公司 一种4-氯-2-三氟乙酰基苯胺盐酸盐水合物的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5316731B2 (fr) * 1974-07-08 1978-06-03
US5665720A (en) * 1992-08-07 1997-09-09 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
IL106507A (en) * 1992-08-07 1997-11-20 Merck & Co Inc Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type
WO1995020389A1 (fr) * 1994-01-28 1995-08-03 Merck & Co., Inc. Benzoxazinones en tant qu'inhibiteurs de transcriptase inverse du vih
US5663467A (en) * 1995-01-23 1997-09-02 Merck & Co., Inc. Synthesis of cyclopropylacetylene
US5633405A (en) * 1995-05-25 1997-05-27 Merck & Co., Inc. Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxanzin-2-one

Also Published As

Publication number Publication date
JP2001519810A (ja) 2001-10-23
CN1327976A (zh) 2001-12-26
HUP0001407A1 (hu) 2001-04-28
EE9900446A (et) 2000-04-17
HUP0001407A3 (en) 2001-06-28
ZA982956B (en) 1999-10-07
CN1251582A (zh) 2000-04-26
US6040480A (en) 2000-03-21
BR9808486A (pt) 2000-05-23
AR014342A1 (es) 2001-02-28
CA2285000A1 (fr) 1998-10-15
EP0973755A1 (fr) 2000-01-26
NO994836L (no) 1999-10-04
HRP980192A2 (en) 1999-02-28
SK136199A3 (en) 2000-06-12
AU6876898A (en) 1998-10-30
NO994836D0 (no) 1999-10-04
WO1998045278A1 (fr) 1998-10-15
EA199900911A1 (ru) 2000-04-24
NZ500727A (en) 2001-06-29
KR20010006074A (ko) 2001-01-15
US5925789A (en) 1999-07-20

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