IL130913A0 - Methods and compositions for detectin or quantification of nucleic acid species - Google Patents

Methods and compositions for detectin or quantification of nucleic acid species

Info

Publication number
IL130913A0
IL130913A0 IL13091398A IL13091398A IL130913A0 IL 130913 A0 IL130913 A0 IL 130913A0 IL 13091398 A IL13091398 A IL 13091398A IL 13091398 A IL13091398 A IL 13091398A IL 130913 A0 IL130913 A0 IL 130913A0
Authority
IL
Israel
Prior art keywords
detectin
quantification
compositions
methods
nucleic acid
Prior art date
Application number
IL13091398A
Other languages
English (en)
Original Assignee
Hyseq Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/784,747 external-priority patent/US6309824B1/en
Priority claimed from US08/812,951 external-priority patent/US6297006B1/en
Application filed by Hyseq Inc filed Critical Hyseq Inc
Publication of IL130913A0 publication Critical patent/IL130913A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
IL13091398A 1997-01-16 1998-01-14 Methods and compositions for detectin or quantification of nucleic acid species IL130913A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/784,747 US6309824B1 (en) 1997-01-16 1997-01-16 Methods for analyzing a target nucleic acid using immobilized heterogeneous mixtures of oligonucleotide probes
US08/812,951 US6297006B1 (en) 1997-01-16 1997-03-04 Methods for sequencing repetitive sequences and for determining the order of sequence subfragments
US08/892,503 US20020042048A1 (en) 1997-01-16 1997-07-14 Methods and compositions for detection or quantification of nucleic acid species
PCT/US1998/000704 WO1998031836A1 (en) 1997-01-16 1998-01-14 Methods and compositions for detection or quantification of nucleic acid species

Publications (1)

Publication Number Publication Date
IL130913A0 true IL130913A0 (en) 2001-01-28

Family

ID=27419818

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13091398A IL130913A0 (en) 1997-01-16 1998-01-14 Methods and compositions for detectin or quantification of nucleic acid species

Country Status (11)

Country Link
US (2) US20020042048A1 (ja)
EP (1) EP0968305A1 (ja)
JP (1) JP2001509027A (ja)
KR (1) KR20000070230A (ja)
CN (1) CN1250485A (ja)
AU (1) AU745201B2 (ja)
BR (1) BR9806914A (ja)
CA (1) CA2278011A1 (ja)
IL (1) IL130913A0 (ja)
NZ (1) NZ513913A (ja)
WO (1) WO1998031836A1 (ja)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6090555A (en) * 1997-12-11 2000-07-18 Affymetrix, Inc. Scanned image alignment systems and methods
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US6741344B1 (en) * 1994-02-10 2004-05-25 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US6406848B1 (en) 1997-05-23 2002-06-18 Lynx Therapeutics, Inc. Planar arrays of microparticle-bound polynucleotides
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
DE69830395T2 (de) 1997-03-20 2006-01-26 Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara Iterative resequenzierung
GB9718921D0 (en) * 1997-09-05 1997-11-12 Brax Genomics Ltd Catalytically generated mass labels
US20030036084A1 (en) * 1997-10-09 2003-02-20 Brian Hauser Nucleic acid detection method employing oligonucleotide probes affixed to particles and related compositions
US20020081583A1 (en) * 1998-01-08 2002-06-27 Satoshi Abe Probes for detecting of target nucleic acid, method of detecting target nucleic acid, and solid phase for detecting target acid and process for producing the same
US6268210B1 (en) 1998-05-27 2001-07-31 Hyseq, Inc. Sandwich arrays of biological compounds
US7060431B2 (en) 1998-06-24 2006-06-13 Illumina, Inc. Method of making and decoding of array sensors with microspheres
US7399844B2 (en) 1998-07-09 2008-07-15 Agilent Technologies, Inc. Method and reagents for analyzing the nucleotide sequence of nucleic acids
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1001037A3 (en) * 1998-09-28 2003-10-01 Whitehead Institute For Biomedical Research Pre-selection and isolation of single nucleotide polymorphisms
US6245518B1 (en) 1998-12-11 2001-06-12 Hyseq, Inc. Polynucleotide arrays and methods of making and using the same
WO2000040758A2 (en) * 1999-01-06 2000-07-13 Hyseq Inc. Enhanced sequencing by hybridization using pools of probes
US7595189B2 (en) 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
CA2358566A1 (en) 1999-01-08 2000-07-13 Charles S. Vann Fiber array for contacting chemical species and methods for using and making same
US6537755B1 (en) 1999-03-25 2003-03-25 Radoje T. Drmanac Solution-based methods and materials for sequence analysis by hybridization
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
CA2374390A1 (en) 1999-05-20 2000-12-14 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
WO2000079007A1 (en) * 1999-06-19 2000-12-28 Hyseq Inc. Improved methods of sequence assembly in sequencing by hybridization
CA2382157C (en) 1999-08-18 2012-04-03 Illumina, Inc. Compositions and methods for preparing oligonucleotide solutions
US6291180B1 (en) * 1999-09-29 2001-09-18 American Registry Of Pathology Ultrasound-mediated high-speed biological reaction and tissue processing
JP3668075B2 (ja) 1999-10-12 2005-07-06 光夫 板倉 遺伝物質シーケンス決定用懸濁系、その懸濁系を用いた遺伝物質シーケンス決定方法およびその懸濁系を用いたＳＮＰｓ高速スコアリング方法
US6512580B1 (en) * 1999-10-27 2003-01-28 Verification Technologies, Inc. Method and apparatus for portable product authentication
US6812005B2 (en) 2000-02-07 2004-11-02 The Regents Of The University Of California Nucleic acid detection methods using universal priming
CA2399733C (en) 2000-02-07 2011-09-20 Illumina, Inc. Nucleic acid detection methods using universal priming
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
EP2261240B1 (en) 2000-02-11 2015-09-02 The Texas A & M University System Biosensor compositions and methods of use
DE60136335D1 (de) 2000-02-16 2008-12-11 Illumina Inc Parallele genotypisierung mehrerer patientenproben
US6591196B1 (en) * 2000-06-06 2003-07-08 Agilent Technologies Inc. Method and system for extracting data from surface array deposited features
US20020182609A1 (en) * 2000-08-16 2002-12-05 Luminex Corporation Microsphere based oligonucleotide ligation assays, kits, and methods of use, including high-throughput genotyping
US20030190612A1 (en) * 2000-08-31 2003-10-09 Nobuko Yamamoto Detecting method and detection substrate for use therein
ATE483161T1 (de) * 2001-04-03 2010-10-15 Thermo Finnigan Llc Zur vereinfachung komplexer peptidgemische geeignete verfahren und kits
EP1390526A4 (en) * 2001-04-18 2005-02-02 Perlegen Sciences Inc METHOD FOR IDENTIFYING THE EVOLUTIONARY PRESERVED SEQUENCES
US20030119015A1 (en) * 2001-05-10 2003-06-26 Perlegen Sciences, Inc. Methods for nucleic acid analysis
US20030036073A1 (en) * 2001-06-07 2003-02-20 Saba James Anthony Matrix Sequencing: a novel method of polynucleotide analysis utilizing probes containing universal nucleotides
US7297553B2 (en) * 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
AU2002322458A1 (en) * 2001-07-13 2003-01-29 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
DE10140499B4 (de) * 2001-08-17 2005-02-03 Bruker Daltonik Gmbh Probenträgerplatten für Massenspektrometrie mit Ionisierung durch matrixunterstützte Laserdesorption
RU2004120771A (ru) * 2001-12-08 2006-01-10 Сиджин, Инк. (Kr) Праймер, регулирующий отжиг, и его применения
WO2004065000A1 (en) 2003-01-21 2004-08-05 Illumina Inc. Chemical reaction monitor
CA2897376A1 (en) 2003-02-26 2004-09-10 Radoje T. Drmanac Modular system and probes for dna analysis
US7276338B2 (en) * 2003-11-17 2007-10-02 Jacobson Joseph M Nucleotide sequencing via repetitive single molecule hybridization
JPWO2005056834A1 (ja) * 2003-12-10 2007-07-05 オリンパス株式会社 核酸配列解析方法
EP1807146A4 (en) * 2004-09-29 2013-07-03 Tel Hashomer Medical Res Infrastructure & Services Ltd COMPOSITION FOR IMPROVING THE EFFICACY OF DRUG DELIVERY
EP2233583A1 (en) * 2005-02-01 2010-09-29 AB Advanced Genetic Analysis Corporation Nucleic acid sequencing by performing successive cycles of duplex extension
EP2272983A1 (en) * 2005-02-01 2011-01-12 AB Advanced Genetic Analysis Corporation Reagents, methods and libraries for bead-based sequencing
CA2611671C (en) 2005-06-15 2013-10-08 Callida Genomics, Inc. Single molecule arrays for genetic and chemical analysis
US8055098B2 (en) 2006-01-27 2011-11-08 Affymetrix, Inc. System, method, and product for imaging probe arrays with small feature sizes
US9445025B2 (en) 2006-01-27 2016-09-13 Affymetrix, Inc. System, method, and product for imaging probe arrays with small feature sizes
KR100812259B1 (ko) * 2006-06-12 2008-03-10 주식회사 씨젠 기지의 서열에 인접한 미지의 ｄｎａ 서열을 증폭하는 방법
EP2456887B1 (en) 2009-07-21 2015-11-25 Gen-Probe Incorporated Methods and compositions for quantitative detection of nucleic acid sequences over an extended dynamic range
WO2011103467A2 (en) 2010-02-19 2011-08-25 Life Technologies Corporation Methods and systems for nucleic acid sequencing validation, calibration and normalization
US20130065790A1 (en) 2010-05-05 2013-03-14 Check-Points Holding B.V. Assays, compositions and methods for detecting drug resistant micro-organisms
WO2015166768A1 (ja) * 2014-05-02 2015-11-05 国立大学法人金沢大学 単一細胞由来核酸の解析方法
US20180327822A1 (en) * 2014-09-23 2018-11-15 Ait Austrian Institute Of Technology Gmbh Fast and highly specific dna-based multiplex detection
WO2017222453A1 (en) * 2016-06-21 2017-12-28 Hauling Thomas Nucleic acid sequencing

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4562159A (en) 1981-03-31 1985-12-31 Albert Einstein College Of Medicine, A Division Of Yeshiva Univ. Diagnostic test for hepatitis B virus
US4677054A (en) 1983-08-08 1987-06-30 Sloan-Kettering Institute For Cancer Research Method for simple analysis of relative nucleic acid levels in multiple small samples by cytoplasmic dot hybridization
AU575586B2 (en) 1983-09-02 1988-08-04 Syngene, Inc. Oligonucleotide synthesis employing primer with oxidzable substituents in system
US4613566A (en) 1984-01-23 1986-09-23 President And Fellows Of Harvard College Hybridization assay and kit therefor
FI71768C (fi) 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
US4766062A (en) 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
GB8432118D0 (en) 1984-12-19 1985-01-30 Malcolm A D B Sandwich hybridisation technique
DE3506703C1 (de) 1985-02-26 1986-04-30 Sagax Instrument AB, Sundbyberg Verfahren zur Sequenzanalyse von Nucleinsaeuren,insbesondere der Desoxyribonucleinsaeure (DNA) und der Ribonucleinsaeure (RNA),sowie Traeger zur Durchfuehrung des Verfahrens und Verfahren zur Herstellung des Traegers
GB8509880D0 (en) 1985-04-17 1985-05-22 Ici Plc Testing device
EP0228075B1 (en) 1986-01-03 1991-04-03 Molecular Diagnostics, Inc. Eucaryotic genomic dna dot-blot hybridization method
NO870613L (no) 1986-03-05 1987-09-07 Molecular Diagnostics Inc Deteksjon av mikroorganismer i en prŸve inneholdende nukleinsyre.
US5348855A (en) 1986-03-05 1994-09-20 Miles Inc. Assay for nucleic acid sequences in an unpurified sample
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5310893A (en) 1986-03-31 1994-05-10 Hoffmann-La Roche Inc. Method for HLA DP typing
US4981783A (en) 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
CA1308372C (en) 1986-08-11 1992-10-06 Geneva Ruth Davis Nucleic acid probe sandwich assay methods and compositions
AU601021B2 (en) 1987-03-11 1990-08-30 Molecular Diagnostics, Inc. Assay for necleic acid sequences in a sample
US6270961B1 (en) 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US4849334A (en) 1987-06-09 1989-07-18 Life Technologies, Inc. Human papillomavirus 43 nucleic acid hybridization probes and methods for employing the same
WO1988010313A1 (en) 1987-06-26 1988-12-29 E.I. Du Pont De Nemours And Company Affinity removal of contaminating sequences from recombinant cloned na using capture beads
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5002867A (en) 1988-04-25 1991-03-26 Macevicz Stephen C Nucleic acid sequence determination by multiple mixed oligonucleotide probes
AU632494B2 (en) 1988-05-20 1993-01-07 F. Hoffmann-La Roche Ag Immobilized sequence-specific probes
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
EP0392546A3 (en) 1989-04-14 1991-09-11 Ro Institut Za Molekularnu Genetiku I Geneticko Inzenjerstvo Process for determination of a complete or a partial contents of very short sequences in the samples of nucleic acids connected to the discrete particles of microscopic size by hybridization with oligonucleotide probes
WO1992010588A1 (en) 1990-12-06 1992-06-25 Affymax Technologies N.V. Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides
EP0514927A1 (en) 1991-05-24 1992-11-25 Walter Gilbert Method and apparatus for rapid nucleic acid sequencing
WO1993004204A1 (en) 1991-08-23 1993-03-04 Isis Pharmaceuticals, Inc. Synthetic unrandomization of oligomer fragments
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US5503980A (en) * 1992-11-06 1996-04-02 Trustees Of Boston University Positional sequencing by hybridization
ATE257861T1 (de) * 1993-09-27 2004-01-15 Arch Dev Corp Methoden und zusammensetzungen zur effizienten nukleinsaeuresequenzierung
US6974666B1 (en) * 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
WO1997029212A1 (en) 1996-02-08 1997-08-14 Affymetrix, Inc. Chip-based speciation and phenotypic characterization of microorganisms
US5804384A (en) * 1996-12-06 1998-09-08 Vysis, Inc. Devices and methods for detecting multiple analytes in samples
US6037186A (en) * 1997-07-16 2000-03-14 Stimpson; Don Parallel production of high density arrays

Also Published As

Publication number Publication date
AU745201B2 (en) 2002-03-14
WO1998031836A1 (en) 1998-07-23
CN1250485A (zh) 2000-04-12
AU6131798A (en) 1998-08-07
KR20000070230A (ko) 2000-11-25
CA2278011A1 (en) 1998-07-23
EP0968305A1 (en) 2000-01-05
US6383742B1 (en) 2002-05-07
NZ513913A (en) 2001-09-28
JP2001509027A (ja) 2001-07-10
BR9806914A (pt) 2001-09-18
US20020042048A1 (en) 2002-04-11

Similar Documents

Publication Publication Date Title
IL130913A0 (en) Methods and compositions for detectin or quantification of nucleic acid species
HUP9901321A3 (en) Methods and compositions for determining the sequence of nucleic acid molecules
AU6544598A (en) Compositions and methods for analysis of nucleic acids
PL347125A1 (en) Methods of nucleic acid amplification and sequencing
EP1027145A4 (en) APPARATUS AND METHODS FOR ISOLATING NUCLEIC ACID
IL132704A0 (en) Methods and compositions for the selective modification of nucleic acids
EP1062360A4 (en) COMPOUNDS AND METHODS FOR VERTÄARKERRN NUCLEIC ACID MOLECULAR SYNTHASE
AU4065397A (en) Stable compositions for nucleic acid amplification and sequencing
EP1019083A4 (en) METHOD AND COMPOSITIONS FOR SELECTIVE MODIFICATION OF NUCLEIC ACIDS
AU7980298A (en) Methods and compositions for multiplex amplification of nucleic acids
HUP9901856A3 (en) Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
EP1027450A4 (en) METHOD FOR DNA SHUFFLING
AU8909998A (en) Methods and compositions for cloning nucleic acid molecules
EP1141234A4 (en) METHOD AND COMPOSITIONS FOR INSULATING NUCLEIC ACID MOLECULES
AU1450699A (en) Methods of nucleic acid detection
PL330750A1 (en) Method of obtaining phenylheterocyclic compounds being useful as inhibitors of cox-2
PL322652A1 (en) Compounds of pyrolydinylohydroxamic acid and method of obtaining them
EP1131078A4 (en) COMPOSITIONS AND METHODS FOR RECOMBINATORY CLONING OF NUCLEIC ACID MOLECULES
IL129177A0 (en) Methods and compositions for lipidization of hydrophilic molecules
GB9410345D0 (en) Method of genetic testing
AU1824500A (en) Methods and compositions for detection of nucleic acid sequences and signal amplification
GB9717932D0 (en) Estimation of nucleic acid
PL341205A1 (en) Method of obtaining l-dihydroorotic acid and application thereof
AU2003200470A1 (en) Methods and compositions for detection or quantification of nucleic acid species
AU4894696A (en) Detection of nucleic acid sequences