IL130502A - Remineralizing material for organomineral tissues - Google Patents
Remineralizing material for organomineral tissuesInfo
- Publication number
- IL130502A IL130502A IL13050297A IL13050297A IL130502A IL 130502 A IL130502 A IL 130502A IL 13050297 A IL13050297 A IL 13050297A IL 13050297 A IL13050297 A IL 13050297A IL 130502 A IL130502 A IL 130502A
- Authority
- IL
- Israel
- Prior art keywords
- resins
- ions
- mixture
- organomineral
- functionalized
- Prior art date
Links
- 239000000463 material Substances 0.000 title claims abstract description 42
- 230000000395 remineralizing effect Effects 0.000 title claims abstract description 10
- 239000011347 resin Substances 0.000 claims abstract description 56
- 229920005989 resin Polymers 0.000 claims abstract description 56
- 239000000203 mixture Substances 0.000 claims abstract description 31
- 150000002500 ions Chemical class 0.000 claims abstract description 26
- 210000001519 tissue Anatomy 0.000 claims abstract description 24
- 125000000129 anionic group Chemical group 0.000 claims abstract description 12
- 125000002091 cationic group Chemical group 0.000 claims abstract description 10
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 239000003456 ion exchange resin Substances 0.000 claims abstract description 9
- 229920003303 ion-exchange polymer Polymers 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 6
- 150000001450 anions Chemical class 0.000 claims abstract description 5
- 150000001768 cations Chemical class 0.000 claims abstract description 5
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000000120 Artificial Saliva Substances 0.000 claims abstract description 3
- 210000002966 serum Anatomy 0.000 claims abstract description 3
- 210000004268 dentin Anatomy 0.000 claims description 25
- 238000011282 treatment Methods 0.000 claims description 24
- 208000002925 dental caries Diseases 0.000 claims description 23
- 239000002253 acid Substances 0.000 claims description 14
- -1 Zn2+ ion Chemical class 0.000 claims description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 9
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 6
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Inorganic materials [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 6
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 5
- 239000001110 calcium chloride Substances 0.000 claims description 5
- 235000011148 calcium chloride Nutrition 0.000 claims description 5
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- 239000004793 Polystyrene Substances 0.000 claims description 4
- 229920002223 polystyrene Polymers 0.000 claims description 4
- 229910000406 trisodium phosphate Inorganic materials 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 3
- 239000000551 dentifrice Substances 0.000 claims description 3
- 239000003792 electrolyte Substances 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 125000001302 tertiary amino group Chemical group 0.000 claims description 3
- 230000037123 dental health Effects 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical group OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 claims description 2
- 239000011575 calcium Substances 0.000 description 21
- 239000000945 filler Substances 0.000 description 9
- 241000282693 Cercopithecidae Species 0.000 description 7
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 4
- 239000000920 calcium hydroxide Substances 0.000 description 4
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 208000034189 Sclerosis Diseases 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 239000006072 paste Substances 0.000 description 3
- 230000008929 regeneration Effects 0.000 description 3
- 238000011069 regeneration method Methods 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- GFIKIVSYJDVOOZ-UHFFFAOYSA-L calcium;fluoro-dioxido-oxo-$l^{5}-phosphane Chemical compound [Ca+2].[O-]P([O-])(F)=O GFIKIVSYJDVOOZ-UHFFFAOYSA-L 0.000 description 2
- 239000004568 cement Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 230000001373 regressive effect Effects 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical group N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000867607 Chlorocebus sabaeus Species 0.000 description 1
- 229910005260 GaCl2 Inorganic materials 0.000 description 1
- 201000004328 Pulpitis Diseases 0.000 description 1
- 206010037464 Pulpitis dental Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000001949 anaesthesia Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000010425 asbestos Substances 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033558 biomineral tissue development Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
- 229910001634 calcium fluoride Inorganic materials 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005115 demineralization Methods 0.000 description 1
- 230000002328 demineralizing effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000001941 electron spectroscopy Methods 0.000 description 1
- 229910052587 fluorapatite Inorganic materials 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000004452 microanalysis Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 244000005706 microflora Species 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000012254 powdered material Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229910052895 riebeckite Inorganic materials 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001720 vestibular Effects 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/70—Preparations for dentistry comprising inorganic additives
- A61K6/71—Fillers
- A61K6/74—Fillers comprising phosphorus-containing compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/838—Phosphorus compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8117—Homopolymers or copolymers of aromatic olefines, e.g. polystyrene; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/54—Polymers characterized by specific structures/properties
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dental Preparations (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009700016A ES2129344B1 (es) | 1997-01-07 | 1997-01-07 | Material remineralizante de tejidos organominerales. |
| PCT/ES1997/000316 WO1998030191A1 (es) | 1997-01-07 | 1997-12-30 | Material remineralizante de tejidos organominerales |
| US09/347,966 US6413498B1 (en) | 1997-01-07 | 1999-07-06 | Remineralizing material for organomineral tissues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL130502A0 IL130502A0 (en) | 2000-06-01 |
| IL130502A true IL130502A (en) | 2002-07-25 |
Family
ID=26155024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13050297A IL130502A (en) | 1997-01-07 | 1997-12-30 | Remineralizing material for organomineral tissues |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6413498B1 (no) |
| EP (1) | EP0968700B1 (no) |
| JP (1) | JP3652377B2 (no) |
| CN (1) | CN1104229C (no) |
| AT (1) | ATE241333T1 (no) |
| AU (1) | AU741537B2 (no) |
| BG (1) | BG103544A (no) |
| BR (1) | BR9714521A (no) |
| CA (1) | CA2277020C (no) |
| CZ (1) | CZ291311B6 (no) |
| DE (1) | DE69722458T2 (no) |
| ES (2) | ES2129344B1 (no) |
| HU (1) | HUP0000617A3 (no) |
| IL (1) | IL130502A (no) |
| NO (1) | NO993343D0 (no) |
| NZ (1) | NZ336675A (no) |
| PL (1) | PL334367A1 (no) |
| PT (1) | PT968700E (no) |
| SK (1) | SK91799A3 (no) |
| TR (1) | TR199901489T2 (no) |
| WO (1) | WO1998030191A1 (no) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2129344B1 (es) * | 1997-01-07 | 2000-03-01 | Univ Barcelona Autonoma | Material remineralizante de tejidos organominerales. |
| ES2178953B1 (es) * | 2000-12-20 | 2003-09-16 | Sl Para El Desarrollo Cientifi | Producto dentifrico. |
| ES2178952B1 (es) * | 2000-12-20 | 2003-09-16 | Sl Para El Desarrollo Cientifi | Goma de mascar. |
| JP4489761B2 (ja) | 2003-03-14 | 2010-06-23 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | マイクロ流体無膜交換装置を有する血液ベースの治療のためのシステム及び方法 |
| US20060076295A1 (en) | 2004-03-15 | 2006-04-13 | The Trustees Of Columbia University In The City Of New York | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
| EP1641426A1 (en) * | 2003-07-02 | 2006-04-05 | Ada Foundation | Remineralizing dental cements |
| US7309232B2 (en) * | 2003-10-10 | 2007-12-18 | Dentigenix Inc. | Methods for treating dental conditions using tissue scaffolds |
| WO2007137245A2 (en) | 2006-05-22 | 2007-11-29 | Columbia University | Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams |
| WO2008102214A2 (en) * | 2007-02-22 | 2008-08-28 | Ghassemian Pour Bavandi, Madjid | Endodontic filling material |
| AU2009212396A1 (en) | 2008-02-04 | 2009-08-13 | The Trustees Of Columbia University In The City Of New York | Fluid separation devices, systems and methods |
| US8932055B2 (en) * | 2009-06-11 | 2015-01-13 | Roberto Armanino | Method employing electric fields to selectively kill microbes in a root canal preparation |
| US8741268B2 (en) * | 2009-09-10 | 2014-06-03 | Preventive Technologies, Inc. | Dental prophylactic paste |
| RU2452462C1 (ru) * | 2011-04-06 | 2012-06-10 | Сергей Владимирович Сирак | Комбинированная лекарственная паста для лечения глубокого кариеса зубов |
| US10813849B2 (en) * | 2015-02-05 | 2020-10-27 | University Of Maryland, Baltimore | Rechargeable calcium phosphate-containing dental materials |
| DE102016205950A1 (de) * | 2016-04-08 | 2017-10-12 | Dietrich Seidel | Mittel zur Verwendung bei entzündlichen Zuständen der Schleimhäute |
| AU2019384940A1 (en) * | 2018-11-19 | 2021-06-03 | 3M Innovative Properties Company | Dental appliance with ion exchange coating |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3425790A (en) * | 1967-01-31 | 1969-02-04 | Walter John Sloan | Process for obtaining equilibrium controlled amounts of halogen and/or interhalogen in a fluid medium |
| DE1807299A1 (de) * | 1968-11-06 | 1970-06-04 | Bayer Ag | Austauscherharze enthaltende Zahnputzmittel,zahnaerztliche Behelfe,Zahnfuellmassen,Zahnlacke und andere mit dem lebenden Zahn in Beruehrung kommende Produkte |
| CH585668A5 (no) * | 1972-09-29 | 1977-03-15 | Alusuisse | |
| US4135935A (en) * | 1973-09-17 | 1979-01-23 | Ernst Leitz Wetzlar Gmbh | Sintered composite material, a process of making same, and a method of using same |
| GB1477899A (en) * | 1973-09-17 | 1977-06-29 | Leitz Ernst Gmbh | Manufacture of therapeutically useful composite materials |
| US4080440A (en) * | 1974-12-13 | 1978-03-21 | The Procter & Gamble Company | Method for remineralizing tooth enamel |
| US4198295A (en) * | 1975-04-01 | 1980-04-15 | Sandor Vajna | Process for increasing the exchange yield in ion exchange processes |
| US4083955A (en) * | 1975-04-02 | 1978-04-11 | The Procter & Gamble Company | Processes and compositions for remineralization of dental enamel |
| US4138477A (en) * | 1976-05-28 | 1979-02-06 | Colgate Palmolive Company | Composition to control mouth odor |
| SU825074A1 (ru) * | 1978-11-03 | 1981-04-30 | Urusov Kazim Kh | Состав дл лечени пародонтоза |
| US4643735A (en) * | 1985-02-27 | 1987-02-17 | Hayes Separation, Inc. | Repair material for use with bones |
| EP0265186A3 (en) * | 1986-10-21 | 1989-05-31 | The Procter & Gamble Company | Anticalculus compositions |
| US5092883A (en) * | 1988-12-28 | 1992-03-03 | Eppley Barry L | Method for promoting soft connective tissue growth and repair in mammals |
| US4988358A (en) * | 1988-12-28 | 1991-01-29 | Eppley Barry L | Method for promoting hard tissue growth and repair in mammals |
| RU1826976C (ru) * | 1991-06-24 | 1993-07-07 | Д.Н. Муравьев. Л.В. Звонникова и Л.А. Дмитриева | Полимерна композици |
| FR2719996A1 (fr) * | 1994-05-18 | 1995-11-24 | Balis Jean Francois | Poudre dentifrice antitartre. |
| AUPM807094A0 (en) * | 1994-09-09 | 1994-10-06 | Commonwealth Scientific And Industrial Research Organisation | Polymer beads and method for preparation thereof |
| DE69613872T2 (de) * | 1995-03-02 | 2002-04-04 | Praxair Technology Inc | Herstellung eines Mischkationsorbentmittels in einem Einzeldurchlaufionenaustauschverfahren |
| US5571502A (en) * | 1995-08-08 | 1996-11-05 | Enamelon Research | Stable single-part compositions and the use thereof for remineralization of lesions in teeth |
| ES2129344B1 (es) * | 1997-01-07 | 2000-03-01 | Univ Barcelona Autonoma | Material remineralizante de tejidos organominerales. |
-
1997
- 1997-01-07 ES ES009700016A patent/ES2129344B1/es not_active Expired - Fee Related
- 1997-12-30 JP JP53056998A patent/JP3652377B2/ja not_active Expired - Fee Related
- 1997-12-30 ES ES97948914T patent/ES2200202T3/es not_active Expired - Lifetime
- 1997-12-30 PT PT97948914T patent/PT968700E/pt unknown
- 1997-12-30 CZ CZ19992391A patent/CZ291311B6/cs not_active IP Right Cessation
- 1997-12-30 TR TR1999/01489T patent/TR199901489T2/xx unknown
- 1997-12-30 HU HU0000617A patent/HUP0000617A3/hu unknown
- 1997-12-30 AT AT97948914T patent/ATE241333T1/de not_active IP Right Cessation
- 1997-12-30 EP EP97948914A patent/EP0968700B1/en not_active Expired - Lifetime
- 1997-12-30 PL PL97334367A patent/PL334367A1/xx unknown
- 1997-12-30 IL IL13050297A patent/IL130502A/en not_active IP Right Cessation
- 1997-12-30 SK SK917-99A patent/SK91799A3/sk unknown
- 1997-12-30 CN CN97181280A patent/CN1104229C/zh not_active Expired - Fee Related
- 1997-12-30 CA CA002277020A patent/CA2277020C/en not_active Expired - Fee Related
- 1997-12-30 DE DE69722458T patent/DE69722458T2/de not_active Expired - Lifetime
- 1997-12-30 BR BR9714521-1A patent/BR9714521A/pt not_active IP Right Cessation
- 1997-12-30 NZ NZ336675A patent/NZ336675A/xx unknown
- 1997-12-30 AU AU79943/98A patent/AU741537B2/en not_active Expired
- 1997-12-30 WO PCT/ES1997/000316 patent/WO1998030191A1/es active IP Right Grant
-
1999
- 1999-07-01 BG BG103544A patent/BG103544A/xx unknown
- 1999-07-06 NO NO993343A patent/NO993343D0/no not_active Application Discontinuation
- 1999-07-06 US US09/347,966 patent/US6413498B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69722458T2 (de) | 2004-04-01 |
| JP2001508433A (ja) | 2001-06-26 |
| ES2200202T3 (es) | 2004-03-01 |
| ES2129344A1 (es) | 1999-06-01 |
| AU741537B2 (en) | 2001-12-06 |
| ATE241333T1 (de) | 2003-06-15 |
| CN1244112A (zh) | 2000-02-09 |
| DE69722458D1 (de) | 2003-07-03 |
| HUP0000617A2 (hu) | 2000-08-28 |
| PL334367A1 (en) | 2000-02-28 |
| BR9714521A (pt) | 2000-05-09 |
| CZ239199A3 (cs) | 2000-01-12 |
| US6413498B1 (en) | 2002-07-02 |
| WO1998030191A1 (es) | 1998-07-16 |
| AU7994398A (en) | 1998-08-03 |
| NO993343L (no) | 1999-07-06 |
| NZ336675A (en) | 2000-12-22 |
| NO993343D0 (no) | 1999-07-06 |
| CZ291311B6 (cs) | 2003-01-15 |
| PT968700E (pt) | 2003-10-31 |
| CN1104229C (zh) | 2003-04-02 |
| JP3652377B2 (ja) | 2005-05-25 |
| EP0968700B1 (en) | 2003-05-28 |
| CA2277020A1 (en) | 1998-07-16 |
| SK91799A3 (en) | 2000-02-14 |
| ES2129344B1 (es) | 2000-03-01 |
| CA2277020C (en) | 2003-05-27 |
| IL130502A0 (en) | 2000-06-01 |
| EP0968700A1 (en) | 2000-01-05 |
| HUP0000617A3 (en) | 2001-06-28 |
| BG103544A (en) | 2000-02-29 |
| TR199901489T2 (xx) | 1999-10-21 |
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| RH1 | Patent not in force |