IL129035A0 - 3-Mercaptoacetylamino-1,5-substituted-2-oxo- azepan derivatives useful as inhibitors of matrix metalloproteinase - Google Patents
3-Mercaptoacetylamino-1,5-substituted-2-oxo- azepan derivatives useful as inhibitors of matrix metalloproteinaseInfo
- Publication number
- IL129035A0 IL129035A0 IL12903597A IL12903597A IL129035A0 IL 129035 A0 IL129035 A0 IL 129035A0 IL 12903597 A IL12903597 A IL 12903597A IL 12903597 A IL12903597 A IL 12903597A IL 129035 A0 IL129035 A0 IL 129035A0
- Authority
- IL
- Israel
- Prior art keywords
- mercaptoacetylamino
- oxo
- inhibitors
- substituted
- matrix metalloproteinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71929196A | 1996-09-19 | 1996-09-19 | |
| PCT/US1997/013738 WO1998012211A1 (en) | 1996-09-19 | 1997-08-04 | 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL129035A0 true IL129035A0 (en) | 2000-02-17 |
Family
ID=24889504
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12903597A IL129035A0 (en) | 1996-09-19 | 1997-08-04 | 3-Mercaptoacetylamino-1,5-substituted-2-oxo- azepan derivatives useful as inhibitors of matrix metalloproteinase |
| IL129035A IL129035A (en) | 1996-09-19 | 1999-03-17 | History of 3 Mercaptoacetylamino 5, 1 - Transformed - 2 Oxo Azpan as Matroprotein Matrix Inhibitors, Pharmaceutical Preparations Containing Them and Their Use |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL129035A IL129035A (en) | 1996-09-19 | 1999-03-17 | History of 3 Mercaptoacetylamino 5, 1 - Transformed - 2 Oxo Azpan as Matroprotein Matrix Inhibitors, Pharmaceutical Preparations Containing Them and Their Use |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0928291B1 (zh) |
| JP (1) | JP3962091B2 (zh) |
| KR (1) | KR100545460B1 (zh) |
| CN (1) | CN1150205C (zh) |
| AR (1) | AR009363A1 (zh) |
| AT (1) | ATE229034T1 (zh) |
| AU (1) | AU718055B2 (zh) |
| BR (1) | BR9713207A (zh) |
| CA (1) | CA2266759C (zh) |
| DE (1) | DE69717647T2 (zh) |
| DK (1) | DK0928291T3 (zh) |
| ES (1) | ES2184126T3 (zh) |
| HK (1) | HK1020741A1 (zh) |
| HU (1) | HUP9904165A3 (zh) |
| IL (2) | IL129035A0 (zh) |
| NO (1) | NO991316L (zh) |
| NZ (1) | NZ334490A (zh) |
| PT (1) | PT928291E (zh) |
| TW (1) | TW445262B (zh) |
| WO (1) | WO1998012211A1 (zh) |
| ZA (1) | ZA978307B (zh) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2356969A1 (en) * | 1998-12-31 | 2000-07-13 | Aventis Pharmaceuticals Inc. | 3-substituted pyrrolidines useful as inhibitors of matrix metallo-proteinases |
| US6486193B2 (en) | 1998-12-31 | 2002-11-26 | Aventis Pharmaceuticals Inc. | 3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases |
| US6770640B1 (en) | 1998-12-31 | 2004-08-03 | Aventis Pharmaceuticals Inc. | 1-Carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of MMP-12 |
| WO2000040577A1 (en) * | 1998-12-31 | 2000-07-13 | Aventis Pharmaceuticals Inc. | 1-carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of mmp-12 |
| US6297233B1 (en) | 1999-02-09 | 2001-10-02 | Bristol-Myers Squibb Company | Lactam inhibitors of FXa and method |
| US6344450B1 (en) | 1999-02-09 | 2002-02-05 | Bristol-Myers Squibb Company | Lactam compounds and their use as inhibitors of serine proteases and method |
| WO2001034600A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
| WO2001034599A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
| US6534498B1 (en) | 1999-11-10 | 2003-03-18 | Smithkline Beecham Corporation | Protease inhibitors |
| US7141607B1 (en) | 2000-03-10 | 2006-11-28 | Insite Vision Incorporated | Methods and compositions for treating and inhibiting retinal neovascularization |
| AU2001243441B2 (en) | 2000-03-21 | 2004-11-25 | Smithkline Beecham Corporation | Protease inhibitors |
| US6511973B2 (en) | 2000-08-02 | 2003-01-28 | Bristol-Myers Squibb Co. | Lactam inhibitors of FXa and method |
| US20080255234A1 (en) * | 2007-04-11 | 2008-10-16 | Zinpro Corporation | Rumen protected lysine |
| US7704521B2 (en) | 2007-04-11 | 2010-04-27 | Zinpro Corporation | Rumen protected essential amino acids |
| CN110770340B (zh) | 2017-05-31 | 2023-09-19 | Brain生物科技股份公司 | 在宿主细胞中丝氨酸蛋白酶的表达的优化 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988006890A1 (en) * | 1987-03-17 | 1988-09-22 | Research Corporation Technologies, Inc. | Synthetic inhibitors of mammalian collagenase |
| JPH07304746A (ja) * | 1994-05-11 | 1995-11-21 | Kanebo Ltd | 新規ベンゾアゼピンカルボン酸誘導体 |
| JP3787605B2 (ja) * | 1994-10-05 | 2006-06-21 | ダーウィン・ディスカバリー・リミテッド | ペプチジル化合物および金属プロテアーゼのインヒビターとしてのその治療的使用 |
| US5672598A (en) * | 1995-03-21 | 1997-09-30 | The Procter & Gamble Company | Lactam-containing hydroxamic acids |
-
1997
- 1997-08-04 BR BR9713207-1A patent/BR9713207A/pt not_active IP Right Cessation
- 1997-08-04 NZ NZ334490A patent/NZ334490A/xx not_active IP Right Cessation
- 1997-08-04 AT AT97935308T patent/ATE229034T1/de active
- 1997-08-04 DE DE69717647T patent/DE69717647T2/de not_active Expired - Lifetime
- 1997-08-04 WO PCT/US1997/013738 patent/WO1998012211A1/en active IP Right Grant
- 1997-08-04 IL IL12903597A patent/IL129035A0/xx active IP Right Grant
- 1997-08-04 AU AU38278/97A patent/AU718055B2/en not_active Ceased
- 1997-08-04 EP EP97935308A patent/EP0928291B1/en not_active Expired - Lifetime
- 1997-08-04 JP JP51465898A patent/JP3962091B2/ja not_active Expired - Fee Related
- 1997-08-04 ES ES97935308T patent/ES2184126T3/es not_active Expired - Lifetime
- 1997-08-04 KR KR1019997002336A patent/KR100545460B1/ko not_active IP Right Cessation
- 1997-08-04 CN CNB971990247A patent/CN1150205C/zh not_active Expired - Fee Related
- 1997-08-04 PT PT97935308T patent/PT928291E/pt unknown
- 1997-08-04 DK DK97935308T patent/DK0928291T3/da active
- 1997-08-04 CA CA002266759A patent/CA2266759C/en not_active Expired - Fee Related
- 1997-08-04 HU HU9904165A patent/HUP9904165A3/hu unknown
- 1997-09-13 TW TW086113339A patent/TW445262B/zh not_active IP Right Cessation
- 1997-09-15 ZA ZA9708307A patent/ZA978307B/xx unknown
- 1997-09-17 AR ARP970104242A patent/AR009363A1/es active IP Right Grant
-
1999
- 1999-03-17 IL IL129035A patent/IL129035A/en not_active IP Right Cessation
- 1999-03-18 NO NO991316A patent/NO991316L/no not_active Application Discontinuation
- 1999-12-21 HK HK99105993A patent/HK1020741A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001501926A (ja) | 2001-02-13 |
| NO991316L (no) | 1999-05-18 |
| IL129035A (en) | 2006-12-10 |
| ZA978307B (en) | 1998-03-19 |
| ATE229034T1 (de) | 2002-12-15 |
| DK0928291T3 (da) | 2003-03-17 |
| KR20000036246A (ko) | 2000-06-26 |
| ES2184126T3 (es) | 2003-04-01 |
| AU718055B2 (en) | 2000-04-06 |
| NO991316D0 (no) | 1999-03-18 |
| CN1234039A (zh) | 1999-11-03 |
| PT928291E (pt) | 2003-03-31 |
| HUP9904165A2 (hu) | 2000-03-28 |
| JP3962091B2 (ja) | 2007-08-22 |
| CN1150205C (zh) | 2004-05-19 |
| EP0928291B1 (en) | 2002-12-04 |
| EP0928291A1 (en) | 1999-07-14 |
| CA2266759A1 (en) | 1998-03-26 |
| DE69717647T2 (de) | 2003-09-25 |
| HK1020741A1 (en) | 2000-05-19 |
| WO1998012211A1 (en) | 1998-03-26 |
| NZ334490A (en) | 2000-08-25 |
| BR9713207A (pt) | 2000-04-04 |
| HUP9904165A3 (en) | 2002-01-28 |
| TW445262B (en) | 2001-07-11 |
| KR100545460B1 (ko) | 2006-01-24 |
| DE69717647D1 (de) | 2003-01-16 |
| AR009363A1 (es) | 2000-04-12 |
| CA2266759C (en) | 2004-10-26 |
| AU3827897A (en) | 1998-04-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| FF | Patent granted | ||
| KB | Patent renewed |