IL128345A - Enhanced contrast agent for ultrasound imaging of the liver - Google Patents
Enhanced contrast agent for ultrasound imaging of the liverInfo
- Publication number
- IL128345A IL128345A IL12834597A IL12834597A IL128345A IL 128345 A IL128345 A IL 128345A IL 12834597 A IL12834597 A IL 12834597A IL 12834597 A IL12834597 A IL 12834597A IL 128345 A IL128345 A IL 128345A
- Authority
- IL
- Israel
- Prior art keywords
- liver
- contrast agent
- ultrasound imaging
- enhanced contrast
- phospholipid
- Prior art date
Links
- 210000004185 liver Anatomy 0.000 title abstract 2
- 239000002872 contrast media Substances 0.000 title 1
- 238000012285 ultrasound imaging Methods 0.000 title 1
- 150000003904 phospholipids Chemical class 0.000 abstract 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 abstract 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 239000002961 echo contrast media Substances 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- -1 sulphur halide Chemical class 0.000 abstract 1
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9616301.9A GB9616301D0 (en) | 1996-08-02 | 1996-08-02 | Improvements in or relating to contrast agents |
| GBGB9705918.2A GB9705918D0 (en) | 1997-03-21 | 1997-03-21 | Improvements in or relating to contrast agents |
| PCT/GB1997/002119 WO1998005364A2 (en) | 1996-08-02 | 1997-08-04 | Improvements in or relating to contrast agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL128345A true IL128345A (en) | 2003-06-24 |
Family
ID=26309806
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12834597A IL128345A (en) | 1996-08-02 | 1997-08-04 | Enhanced contrast agent for ultrasound imaging of the liver |
| IL12934597A IL128345A0 (en) | 1996-08-02 | 1997-08-04 | Improvements in or relating to contrast agents |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12934597A IL128345A0 (en) | 1996-08-02 | 1997-08-04 | Improvements in or relating to contrast agents |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7892522B2 (de) |
| EP (1) | EP0918546B1 (de) |
| JP (2) | JP3634869B2 (de) |
| KR (1) | KR100593873B1 (de) |
| CN (1) | CN1104911C (de) |
| AT (1) | ATE411055T1 (de) |
| AU (1) | AU3780497A (de) |
| CA (1) | CA2262908A1 (de) |
| CZ (1) | CZ28999A3 (de) |
| DE (1) | DE69739047D1 (de) |
| ES (1) | ES2316157T3 (de) |
| IL (2) | IL128345A (de) |
| MX (1) | MXPA99001053A (de) |
| NO (1) | NO990276D0 (de) |
| NZ (1) | NZ334365A (de) |
| WO (1) | WO1998005364A2 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9708246D0 (en) * | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Improvements in or relating to ultrasound imaging |
| GB9717589D0 (en) * | 1997-08-19 | 1997-10-22 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| GB9809084D0 (en) * | 1998-04-28 | 1998-06-24 | Nycomed Imaging As | Improvements in or relating to diagnostic/therapeutic agents |
| US6548048B1 (en) | 1998-04-28 | 2003-04-15 | Amersham Health As | Lipopeptide stabilized microbubbles as diagnostic/therapeutic agents |
| US6984373B2 (en) | 2000-12-23 | 2006-01-10 | Dyax Corp. | Fibrin binding moieties useful as imaging agents |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| WO2004065621A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| WO2003074005A2 (en) | 2002-03-01 | 2003-09-12 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| NO20024755D0 (no) | 2002-10-03 | 2002-10-03 | Amersham Health As | Metode |
| DK1590006T3 (da) * | 2003-02-04 | 2010-12-20 | Bracco Suisse Sa | Ultralydskontrastmidler og fremgangsmåde til frembringelse deraf |
| SI2949658T1 (sl) | 2003-03-03 | 2018-10-30 | Dyax Corp. | Peptidi, ki specifično vežejo HGF receptor (cMet) in njihove uporabe |
| JP5513708B2 (ja) | 2003-12-22 | 2014-06-04 | ブラッコ・シュイス・ソシエテ・アノニム | 造影イメージング用の気体封入マイクロベシクル・アセンブリー |
| US8357351B2 (en) | 2004-04-21 | 2013-01-22 | Ananth Annapragada | Nano-scale contrast agents and methods of use |
| US7713517B2 (en) * | 2004-04-21 | 2010-05-11 | Marval Biosciences, Inc. | Compositions and methods for enhancing contrast in imaging |
| CN103120799A (zh) | 2004-08-18 | 2013-05-29 | 博莱科瑞士股份有限公司 | 用于反差成像的充气微泡组合物 |
| WO2006076826A1 (fr) * | 2005-01-18 | 2006-07-27 | Institute Of Pharmacology Toxicology, Academy Of Military Medical Sciences | Composition de contraste pour ultrasons utilisant un phospholipide filmogene et procede de preparation de celle-ci |
| JP2006335745A (ja) * | 2005-06-06 | 2006-12-14 | Fujifilm Holdings Corp | リポソームを含むｍｒｉ造影剤 |
| CN100453050C (zh) * | 2005-09-21 | 2009-01-21 | 北京市肿瘤防治研究所 | 提高超声造影图像分辨力的方法和超声造影成像仪 |
| BRPI0619522B8 (pt) | 2005-12-09 | 2021-07-27 | Bracco Suisse Sa | conjugados de objetivação de vetor-fosfolipídio, composição compreendendo os referidos conjugados, composição de agente de contraste para ultra-som e método para preparo de microvesícula cheia de gás compreendendo um fosfolipídio e de fabricação de conjugado de peptídeo-fosfolipídio tendo baixos níveis de tfa |
| WO2007070827A2 (en) * | 2005-12-15 | 2007-06-21 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardium perfusion imaging |
| CN104274840A (zh) | 2007-12-05 | 2015-01-14 | 马维尔生物科学公司 | 纳米级对比剂和使用方法 |
| WO2009152445A1 (en) * | 2008-06-13 | 2009-12-17 | Marval Biosciences, Inc. | Imaging of atherosclerotic plaques using liposomal imaging agents |
| GB0811856D0 (en) * | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
| WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
| WO2013164269A1 (en) | 2012-04-30 | 2013-11-07 | Ge Healthcare As | Method for filling a container with a foamable composition |
| WO2014142927A1 (en) * | 2013-03-14 | 2014-09-18 | Empire Technology Development Llc | Identification of surgical smoke |
| AU2016353345B2 (en) | 2015-11-12 | 2021-12-23 | University Of Virginia Patent Foundation | Compositions and methods for vas-occlusive contraception and reversal thereof |
| CN107233583B (zh) * | 2016-03-29 | 2020-04-24 | 北京飞锐达医疗科技有限公司 | 一种具有超长持续时间的超声造影剂及其制备方法 |
| EP3565484B1 (de) | 2017-01-05 | 2024-04-03 | Contraline, Inc. | Zusammensetzungen zur implantation und umkehrung von auf stimuli reagierenden implantaten |
| US11253391B2 (en) | 2018-11-13 | 2022-02-22 | Contraline, Inc. | Systems and methods for delivering biomaterials |
| GB201821049D0 (en) * | 2018-12-21 | 2019-02-06 | Ge Healthcare As | Ultrasound contrast agent and methods for use therof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2129685B (en) * | 1982-11-11 | 1985-11-13 | Nat Biolog Standards Board | Anti-haemophilic compositions |
| US5773024A (en) * | 1989-12-22 | 1998-06-30 | Imarx Pharmaceutical Corp. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
| US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| DE4100470A1 (de) * | 1991-01-09 | 1992-07-16 | Byk Gulden Lomberg Chem Fab | Echokontrastmittel |
| WO1995026205A1 (en) * | 1994-03-28 | 1995-10-05 | Nycomed Imaging A/S | Liposomes |
| US5540909A (en) * | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
| HU229090B1 (en) * | 1996-02-19 | 2013-07-29 | Ge Healthcare As | Improvements in or relating to contrast agents |
| ATE237362T1 (de) * | 1996-02-19 | 2003-05-15 | Amersham Health As | Thermostabilisiertes kontrastmittel |
| US5837221A (en) * | 1996-07-29 | 1998-11-17 | Acusphere, Inc. | Polymer-lipid microencapsulated gases for use as imaging agents |
| US6054118A (en) * | 1997-01-22 | 2000-04-25 | Nycomed Imaging As | Contrast agents comprising two types of gas-containing microparticles |
-
1997
- 1997-08-04 MX MXPA99001053A patent/MXPA99001053A/es unknown
- 1997-08-04 DE DE69739047T patent/DE69739047D1/de not_active Expired - Lifetime
- 1997-08-04 CN CN97197006A patent/CN1104911C/zh not_active Expired - Lifetime
- 1997-08-04 AT AT97934662T patent/ATE411055T1/de not_active IP Right Cessation
- 1997-08-04 AU AU37804/97A patent/AU3780497A/en not_active Abandoned
- 1997-08-04 EP EP97934662A patent/EP0918546B1/de not_active Expired - Lifetime
- 1997-08-04 KR KR1019997000899A patent/KR100593873B1/ko not_active IP Right Cessation
- 1997-08-04 CA CA002262908A patent/CA2262908A1/en not_active Abandoned
- 1997-08-04 IL IL12834597A patent/IL128345A/xx not_active IP Right Cessation
- 1997-08-04 WO PCT/GB1997/002119 patent/WO1998005364A2/en active IP Right Grant
- 1997-08-04 CZ CZ99289A patent/CZ28999A3/cs unknown
- 1997-08-04 JP JP50773798A patent/JP3634869B2/ja not_active Expired - Lifetime
- 1997-08-04 IL IL12934597A patent/IL128345A0/xx unknown
- 1997-08-04 ES ES97934662T patent/ES2316157T3/es not_active Expired - Lifetime
- 1997-08-04 NZ NZ334365A patent/NZ334365A/en unknown
-
1999
- 1999-01-22 NO NO990276A patent/NO990276D0/no not_active Application Discontinuation
-
2001
- 2001-09-13 US US09/950,985 patent/US7892522B2/en not_active Expired - Lifetime
-
2003
- 2003-08-20 JP JP2003208062A patent/JP2004002453A/ja not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO990276L (no) | 1999-01-22 |
| ATE411055T1 (de) | 2008-10-15 |
| EP0918546B1 (de) | 2008-10-15 |
| IL128345A0 (en) | 2000-01-31 |
| KR20000029780A (ko) | 2000-05-25 |
| WO1998005364A2 (en) | 1998-02-12 |
| US20020106328A1 (en) | 2002-08-08 |
| JP3634869B2 (ja) | 2005-03-30 |
| NO990276D0 (no) | 1999-01-22 |
| CN1104911C (zh) | 2003-04-09 |
| MXPA99001053A (es) | 2002-03-11 |
| CA2262908A1 (en) | 1998-02-12 |
| NZ334365A (en) | 1999-10-28 |
| CN1227502A (zh) | 1999-09-01 |
| AU3780497A (en) | 1998-02-25 |
| ES2316157T3 (es) | 2009-04-01 |
| JP2004002453A (ja) | 2004-01-08 |
| JP2000517296A (ja) | 2000-12-26 |
| CZ28999A3 (cs) | 1999-07-14 |
| DE69739047D1 (de) | 2008-11-27 |
| WO1998005364A3 (en) | 1998-06-18 |
| US7892522B2 (en) | 2011-02-22 |
| EP0918546A2 (de) | 1999-06-02 |
| KR100593873B1 (ko) | 2006-07-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees | ||
| HC | Change of name of proprietor(s) |
Owner name: GE HEALTHCARE AS Free format text: FORMER NAME:AMERSHAM HEALTH AS |