IL125809A - Process and intermediates for production of donepezil and related compounds - Google Patents
Process and intermediates for production of donepezil and related compoundsInfo
- Publication number
- IL125809A IL125809A IL12580998A IL12580998A IL125809A IL 125809 A IL125809 A IL 125809A IL 12580998 A IL12580998 A IL 12580998A IL 12580998 A IL12580998 A IL 12580998A IL 125809 A IL125809 A IL 125809A
- Authority
- IL
- Israel
- Prior art keywords
- donepezil
- intermediates
- production
- related compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12580998A IL125809A (en) | 1998-08-17 | 1998-08-17 | Process and intermediates for production of donepezil and related compounds |
| US09/763,245 US6492522B1 (en) | 1998-08-17 | 1999-08-11 | Process and intermediates for production of donepezil and related compounds |
| EP99936948A EP1129073A2 (fr) | 1998-08-17 | 1999-08-11 | Nouveau procede et intermediaires pour la production de donepezil et de ses composes apparentes |
| HU0103253A HUP0103253A3 (en) | 1998-08-17 | 1999-08-11 | Novel process and intermediates for production of donepezil and related compounds |
| PCT/IL1999/000436 WO2000009483A2 (fr) | 1998-08-17 | 1999-08-11 | Nouveau procede et intermediaires pour la production de donepezil et de ses composes apparentes |
| JP2000564937A JP2002525264A (ja) | 1998-08-17 | 1999-08-11 | ドネペジルおよび関連化合物の製造のための新規方法および中間体 |
| AU51910/99A AU5191099A (en) | 1998-08-17 | 1999-08-11 | Novel process and intermediates for production of donepezil and related compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12580998A IL125809A (en) | 1998-08-17 | 1998-08-17 | Process and intermediates for production of donepezil and related compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL125809A0 IL125809A0 (en) | 1999-04-11 |
| IL125809A true IL125809A (en) | 2005-08-31 |
Family
ID=11071859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12580998A IL125809A (en) | 1998-08-17 | 1998-08-17 | Process and intermediates for production of donepezil and related compounds |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6492522B1 (fr) |
| EP (1) | EP1129073A2 (fr) |
| JP (1) | JP2002525264A (fr) |
| AU (1) | AU5191099A (fr) |
| HU (1) | HUP0103253A3 (fr) |
| IL (1) | IL125809A (fr) |
| WO (1) | WO2000009483A2 (fr) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL150982A (en) * | 2002-07-30 | 2007-02-11 | Ori Lerman | Process for making Donafzil |
| US20040192919A1 (en) * | 2002-08-14 | 2004-09-30 | Finetech Laboratories, Ltd. | Process for production of highly pure donepezil hydrochloride |
| IL151253A0 (en) * | 2002-08-14 | 2003-04-10 | Finetech Lab Ltd | Process for production of highly pure donepezil hydrochloride |
| ATE487492T1 (de) * | 2003-02-27 | 2010-11-15 | Eisai R&D Man Co Ltd | Pharmazeutische zusammensetzung zur behandlung von drogenabhängigkeit |
| AU2003247158A1 (en) * | 2003-07-01 | 2005-01-21 | Hetero Drugs Limited | Preparation of intermediates for acetyl cholinesterase inhibitors |
| JP2007519733A (ja) * | 2004-01-26 | 2007-07-19 | コーテックス ファーマシューティカルズ インコーポレーティッド | アンパカインにより誘導されるシナプス応答促通のコリンエステラーゼ阻害剤による増強方法 |
| US20060122226A1 (en) * | 2004-12-08 | 2006-06-08 | Itai Adin | Crystalline forms of Donepezil base |
| CN100436416C (zh) * | 2005-07-29 | 2008-11-26 | 西南合成制药股份有限公司 | 盐酸多奈哌齐合成工艺 |
| GB0515803D0 (en) | 2005-07-30 | 2005-09-07 | Pliva Hrvatska D O O | Intermediate compounds |
| HU227474B1 (en) * | 2005-12-20 | 2011-07-28 | Richter Gedeon Nyrt | Process for industrial scale production of high purity donepezil hydrochloride polymorph i. |
| EP1973878B1 (fr) | 2006-01-04 | 2010-11-24 | Cipla Limited | Procede et intermediaire pour la preparation de donepezil |
| US20100113793A1 (en) * | 2006-03-20 | 2010-05-06 | Ind-Swift Laboratories Limited | Process for the Preparation of Highly Pure Donepezil |
| EP2089383B1 (fr) | 2006-11-09 | 2015-09-16 | Probiodrug AG | Dérivés 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one utiles en tant qu' inhibiteurs de la glutaminyl-cyclase dans le traitement des ulcères, du cancer et d'autres maladies |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| CN101626688A (zh) | 2006-12-11 | 2010-01-13 | 雷维瓦药品公司 | 茚满酮基胆碱酯酶抑制剂的组合物、合成和使用方法 |
| MX2009009234A (es) | 2007-03-01 | 2009-12-01 | Probiodrug Ag | Uso nuevo de inhibidores de ciclasa de glutaminilo. |
| WO2008128985A1 (fr) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Dérivés de thio-urée utilisés comme inhibiteurs de la glutaminyl cyclase |
| EA037187B1 (ru) | 2010-02-09 | 2021-02-17 | Дзе Джонс Хопкинс Юниверсити | Способ и композиция для лечения когнитивного расстройства |
| US9181233B2 (en) | 2010-03-03 | 2015-11-10 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| CA2789440C (fr) | 2010-03-10 | 2020-03-24 | Probiodrug Ag | Inhibiteurs heterocycliques de la glutaminyl cyclase (qc, ec 2.3.2.5) |
| JP5945532B2 (ja) | 2010-04-21 | 2016-07-05 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
| WO2011151359A1 (fr) | 2010-06-02 | 2011-12-08 | Noscira, S.A. | Traitement combiné comprenant un inhibiteur de la cholinestérase et un dérivé de thiadiazolidinedione |
| ES2570167T3 (es) | 2011-03-16 | 2016-05-17 | Probiodrug Ag | Derivados de benzimidazol como inhibidores de glutaminil ciclasa |
| CN103524515B (zh) | 2012-07-03 | 2016-07-06 | 浙江海正药业股份有限公司 | 具有乙酰胆碱酯酶抑制活性的苯并间二氧杂环戊烯衍生物及其制备方法和用途 |
| US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| WO2014144801A1 (fr) | 2013-03-15 | 2014-09-18 | Agenebio Inc. | Procédés et compositions pour améliorer la fonction cognitive |
| WO2014144663A1 (fr) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Procédés et compositions pour améliorer la fonction cognitive |
| US10925834B2 (en) | 2015-05-22 | 2021-02-23 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3476759A (en) * | 1967-05-02 | 1969-11-04 | Mcneilab Inc | 2- and 3-(4-piperidyl) indanes and indanols |
| FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| JP2893893B2 (ja) * | 1990-02-02 | 1999-05-24 | 三菱化学株式会社 | 環状ケトン類の製造方法 |
| NZ318843A (en) | 1995-12-15 | 2000-01-28 | Pfizer | Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine |
-
1998
- 1998-08-17 IL IL12580998A patent/IL125809A/xx not_active IP Right Cessation
-
1999
- 1999-08-11 EP EP99936948A patent/EP1129073A2/fr not_active Withdrawn
- 1999-08-11 US US09/763,245 patent/US6492522B1/en not_active Expired - Fee Related
- 1999-08-11 JP JP2000564937A patent/JP2002525264A/ja active Pending
- 1999-08-11 WO PCT/IL1999/000436 patent/WO2000009483A2/fr not_active Application Discontinuation
- 1999-08-11 AU AU51910/99A patent/AU5191099A/en not_active Abandoned
- 1999-08-11 HU HU0103253A patent/HUP0103253A3/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1129073A2 (fr) | 2001-09-05 |
| JP2002525264A (ja) | 2002-08-13 |
| US6492522B1 (en) | 2002-12-10 |
| AU5191099A (en) | 2000-03-06 |
| WO2000009483A2 (fr) | 2000-02-24 |
| IL125809A0 (en) | 1999-04-11 |
| WO2000009483A3 (fr) | 2001-06-21 |
| HUP0103253A3 (en) | 2002-02-28 |
| HUP0103253A2 (hu) | 2002-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |