IL125150A - Magnetic resonance contrast media - Google Patents

Magnetic resonance contrast media

Info

Publication number
IL125150A
IL125150A IL12515097A IL12515097A IL125150A IL 125150 A IL125150 A IL 125150A IL 12515097 A IL12515097 A IL 12515097A IL 12515097 A IL12515097 A IL 12515097A IL 125150 A IL125150 A IL 125150A
Authority
IL
Israel
Prior art keywords
contrast media
magnetic resonance
resonance contrast
coating
serves
Prior art date
Application number
IL12515097A
Other languages
English (en)
Other versions
IL125150A0 (en
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9600427.0A external-priority patent/GB9600427D0/en
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of IL125150A0 publication Critical patent/IL125150A0/xx
Publication of IL125150A publication Critical patent/IL125150A/xx

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A61K49/0485—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A61K49/049—Surface-modified nanoparticles, e.g. immune-nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
    • A61K49/1842—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule the small organic molecule being a phosphate or a phosphonate, not being a phospholipid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A61K49/1857—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA
    • A61K49/186—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA the organic macromolecular compound being polyethyleneglycol [PEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A61K49/1863—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being a polysaccharide or derivative thereof, e.g. chitosan, chitin, cellulose, pectin, starch

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Compounds Of Iron (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Soft Magnetic Materials (AREA)
  • Light Receiving Elements (AREA)
  • Glass Compositions (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Steroid Compounds (AREA)
  • Liquid Crystal (AREA)
  • Devices For Indicating Variable Information By Combining Individual Elements (AREA)
IL12515097A 1996-01-10 1997-01-09 Magnetic resonance contrast media IL125150A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9600427.0A GB9600427D0 (en) 1996-01-10 1996-01-10 Contrast media
US08/729,836 US6123920A (en) 1996-01-10 1996-10-15 Superparamagnetic contrast media coated with starch and polyalkylene oxides
PCT/GB1997/000067 WO1997025073A2 (en) 1996-01-10 1997-01-09 Contrast media

Publications (2)

Publication Number Publication Date
IL125150A0 IL125150A0 (en) 1999-01-26
IL125150A true IL125150A (en) 2001-03-19

Family

ID=26308448

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12515097A IL125150A (en) 1996-01-10 1997-01-09 Magnetic resonance contrast media

Country Status (18)

Country Link
US (1) US6423296B1 (hu)
EP (1) EP0877630B1 (hu)
JP (1) JP4280304B2 (hu)
CN (1) CN1212629A (hu)
AT (1) ATE291439T1 (hu)
AU (1) AU716667B2 (hu)
CA (1) CA2242647A1 (hu)
CZ (1) CZ219498A3 (hu)
DE (1) DE69732831T2 (hu)
EA (1) EA001336B1 (hu)
ES (1) ES2239349T3 (hu)
HU (1) HUP9901192A3 (hu)
IL (1) IL125150A (hu)
MX (1) MX9805508A (hu)
NO (1) NO983060L (hu)
NZ (1) NZ325403A (hu)
PL (1) PL327679A1 (hu)
WO (1) WO1997025073A2 (hu)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5855868A (en) * 1996-04-01 1999-01-05 Nycomed Imaging As Method of T1 -weighted resonance imaging of RES organs
GB9716365D0 (en) 1997-08-01 1997-10-08 Nycomed Imaging As Improvements in or relating to magnetic resonance imaging
EP1118009A1 (en) 1998-09-28 2001-07-25 Nycomed Imaging As Method of magnetic resonance imaging
JP2003500136A (ja) * 1999-05-21 2003-01-07 アマシャム・ヘルス・エーエス 磁気共鳴イメージング方法
AU5086000A (en) * 1999-05-21 2000-12-12 Nycomed Imaging As Method of magnetic resonance imaging
GB9921579D0 (hu) * 1999-09-13 1999-11-17 Nycomed Imaging As
US7082326B2 (en) 2000-03-31 2006-07-25 Amersham Health As Method of magnetic resonance imaging
PT1272507E (pt) 2000-04-12 2005-11-30 Amersham Health As Derivados de peptidos para ligacao a integrina
NO20004795D0 (no) 2000-09-26 2000-09-26 Nycomed Imaging As Peptidbaserte forbindelser
US6549798B2 (en) 2001-02-07 2003-04-15 Epix Medical, Inc. Magnetic resonance angiography data
JP4510444B2 (ja) 2001-07-10 2010-07-21 ジーイー・ヘルスケア・アクスイェ・セルスカプ ペプチドベースの化合物
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
US6693426B1 (en) * 2002-02-09 2004-02-17 Intematix Corporation Spatially resolved spin resonance detection
AU2003202872A1 (en) * 2002-01-04 2003-07-24 Nuccon Technologies Inc. Preparation of nano-sized crystals
DE10222481A1 (de) * 2002-05-22 2003-12-04 Eucro Europe Contract Res Gmbh Kontrastmittel für die Verwendung in bildgebenden Verfahren
US7381317B2 (en) * 2002-08-12 2008-06-03 Beckman Coulter, Inc. Methods and compositions for capillary electrophoresis (CE)
US7792568B2 (en) * 2003-03-17 2010-09-07 Boston Scientific Scimed, Inc. MRI-visible medical devices
JP2005060221A (ja) * 2003-07-31 2005-03-10 Rikogaku Shinkokai 有機物質とフェライトとの複合材料とその製造方法
WO2005063617A1 (en) * 2003-12-18 2005-07-14 Massachusets Institute Of Technology Bioprocesse enhanced by magnetic nanoparticles
WO2005070471A2 (en) * 2004-01-20 2005-08-04 Alnis Biosciences, Inc. Articles comprising magnetic material and bioactive agents
US8620406B2 (en) * 2004-01-23 2013-12-31 Boston Scientific Scimed, Inc. Medical devices visible by magnetic resonance imaging
US7761138B2 (en) * 2004-03-12 2010-07-20 Boston Scientific Scimed, Inc. MRI and X-ray visualization
DE102004052533A1 (de) † 2004-10-15 2006-05-04 Mykhaylyk, Olga, Dr. Magnetische Partikel zur Verwendung in Therapie und Diagnostik
US7778684B2 (en) * 2005-08-08 2010-08-17 Boston Scientific Scimed, Inc. MRI resonator system with stent implant
US20090098057A1 (en) * 2007-10-16 2009-04-16 Shiying Zheng Silica-cored carrier particle
US20070098641A1 (en) * 2005-11-02 2007-05-03 General Electric Company Nanoparticle-based imaging agents for X-ray/computed tomography
ITFI20060006A1 (it) * 2006-01-04 2007-07-05 Colorobbia Italiana Spa Nanoparticelle funzionalizzate, loro produzione ed uso
TW200738752A (en) 2006-01-31 2007-10-16 Bayer Schering Pharma Ag Modulation of MDL-1 activity for treatment of inflammatory disease
WO2007105047A2 (en) * 2006-03-10 2007-09-20 Mcgill University Ultrasound molecular sensors and uses thereof
US20070239256A1 (en) * 2006-03-22 2007-10-11 Jan Weber Medical devices having electrical circuits with multilayer regions
US20070258907A1 (en) * 2006-04-24 2007-11-08 Davis Mark E Polymer-coated paramagnetic particles
FR2918868A1 (fr) * 2006-06-06 2009-01-23 Guerbet Sa Methode d'imagerie de diagnostic utilisant en combinaison avec l'imagerie de diffusion de l'eau, des agents de contraste
US7892520B2 (en) * 2006-07-31 2011-02-22 The Hong Kong University Of Science And Technology Solid-state synthesis of iron oxide nanoparticles
CN1970575B (zh) * 2006-11-30 2010-05-12 华南理工大学 一种超顺磁性淀粉的制备方法
AU2007336297B2 (en) * 2006-12-18 2013-09-05 Colorobbia Italia S.P.A. Magnetic nanoparticles for the application in hyperthermia, preparation thereof and use in constructs having a pharmacological application
KR20090038337A (ko) * 2007-10-15 2009-04-20 재단법인서울대학교산학협력재단 무기계 나노입자를 수계 매질에 분산시키는 생체적합성분산 안정화제
US20100283570A1 (en) * 2007-11-14 2010-11-11 Lavoie Adrien R Nano-encapsulated magnetic particle composite layers for integrated silicon voltage regulators
EP2277181B1 (en) * 2008-04-16 2017-08-30 StemCell Technologies Inc. Magnetic particles
GB2464956A (en) * 2008-10-31 2010-05-05 Apaclara Ltd Water purification method using a field separable osmotic agent
GB2472446A (en) * 2009-08-07 2011-02-09 Ct Fuer Angewandte Nanotechnologie Metal oxide particles coated with polyethylene glycol and their synthesis
EP2289553A1 (en) * 2009-09-01 2011-03-02 ETH Zurich Dispersant stabilization of inorganic non-metallic particles
US9555136B2 (en) 2010-06-21 2017-01-31 University Of Washington Through Its Center For Commercialization Coated magnetic nanoparticles
EP2582400A4 (en) 2010-06-21 2016-05-25 Univ Washington Ct Commerciali MODULABLE MULTIFUNCTIONAL MAGNETIC NANOPARTICLES FOR BIOMEDICINE
US8895068B2 (en) 2010-12-15 2014-11-25 General Electric Company Nanoparticle composition and associated methods thereof
US8889103B2 (en) 2010-12-15 2014-11-18 General Electric Company Diagnostic agent composition and associated methods thereof
US20120283503A1 (en) * 2011-04-29 2012-11-08 The Johns Hopkins University Nanoparticle loaded stem cells and their use in mri guided hyperthermia
US9474810B2 (en) 2012-03-02 2016-10-25 General Electric Company Superparamagnetic nanoparticles with PEG substituted α-hydroxy phosphonate shells
JP6195339B2 (ja) * 2012-07-10 2017-09-13 キヤノン株式会社 粒子及び前記粒子を有する光音響用造影剤
SG11201507287SA (en) 2013-03-15 2015-10-29 Univ California Peptides having reduced toxicity that stimulate cholesterol efflux
EP3125949B1 (en) * 2014-04-01 2023-11-08 Centre National De La Recherche Scientifique Dendronized metallic oxide nanoparticles, a process for preparing the same and their uses
CN107112105A (zh) 2014-10-23 2017-08-29 康宁股份有限公司 聚合物包封的磁性纳米颗粒
RU2683020C2 (ru) * 2014-11-11 2019-03-26 Петр Иванович Никитин Субстанция и способ для модуляции активности агента в организме
DE102015215736A1 (de) * 2015-08-18 2017-02-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung von stabil dispergierbaren magnetischen Eisenoxid-Einkern-Nanopartikeln, stabil dispergierbare magnetische Eisenoxid-Einkern-Nanopartikel und Verwendungen hiervon
US20220047727A1 (en) 2018-09-10 2022-02-17 Saving Patients' Lives Medical B.V. Ultra-small superparamagnetic iron oxide nanoparticles

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935187A (en) * 1973-10-19 1976-01-27 Standard Brands Incorporated Process for depolymerizing amylaceous polymers
JPS5913521B2 (ja) 1975-06-19 1984-03-30 メイトウサンギヨウ カブシキガイシヤ 磁性酸化鉄・デキストラン複合体の製造法
US4357259A (en) 1977-08-01 1982-11-02 Northwestern University Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres
US4335094A (en) 1979-01-26 1982-06-15 Mosbach Klaus H Magnetic polymer particles
US4647447A (en) 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4501726A (en) 1981-11-12 1985-02-26 Schroeder Ulf Intravascularly administrable, magnetically responsive nanosphere or nanoparticle, a process for the production thereof, and the use thereof
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4731239A (en) 1983-01-10 1988-03-15 Gordon Robert T Method for enhancing NMR imaging; and diagnostic use
US4735796A (en) 1983-12-08 1988-04-05 Gordon Robert T Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease
SE463651B (sv) 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
GB8408127D0 (en) 1984-03-29 1984-05-10 Nyegaard & Co As Contrast agents
CA1268208A (en) 1984-08-10 1990-04-24 Truman Brown Magnetic micro-particles as contrast agents in nuclear magnetic resonance imaging
PT81498B (pt) 1984-11-23 1987-12-30 Schering Ag Processo para a preparacao de composicoes para diagnostico contendo particulas magneticas
US4675173A (en) 1985-05-08 1987-06-23 Molecular Biosystems, Inc. Method of magnetic resonance imaging of the liver and spleen
US5512332A (en) 1985-10-04 1996-04-30 Immunivest Corporation Process of making resuspendable coated magnetic particles
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US5597531A (en) 1985-10-04 1997-01-28 Immunivest Corporation Resuspendable coated magnetic particles and stable magnetic particle suspensions
GB8601100D0 (en) 1986-01-17 1986-02-19 Cosmas Damian Ltd Drug delivery system
US4871716A (en) 1986-02-04 1989-10-03 University Of Florida Magnetically responsive, hydrophilic microspheres for incorporation of therapeutic substances and methods of preparation thereof
US5102652A (en) 1986-07-03 1992-04-07 Advanced Magnetics Inc. Low molecular weight carbohydrates as additives to stabilize metal oxide compositions
US4827945A (en) 1986-07-03 1989-05-09 Advanced Magnetics, Incorporated Biologically degradable superparamagnetic materials for use in clinical applications
US4951675A (en) 1986-07-03 1990-08-28 Advanced Magnetics, Incorporated Biodegradable superparamagnetic metal oxides as contrast agents for MR imaging
US5055288A (en) 1987-06-26 1991-10-08 Advanced Magnetics, Inc. Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides
US5248492A (en) 1986-07-03 1993-09-28 Advanced Magnetics, Inc. Low molecular weight carbohydrates as additives to stabilize metal oxide compositions
US5069216A (en) 1986-07-03 1991-12-03 Advanced Magnetics Inc. Silanized biodegradable super paramagnetic metal oxides as contrast agents for imaging the gastrointestinal tract
US5314679A (en) 1986-07-03 1994-05-24 Advanced Magnetics Inc. Vascular magnetic resonance imaging agent comprising nanoparticles
US5219554A (en) 1986-07-03 1993-06-15 Advanced Magnetics, Inc. Hydrated biodegradable superparamagnetic metal oxides
US5342607A (en) 1986-07-03 1994-08-30 Advanced Magnetics, Inc. Receptor mediated endocytosis type magnetic resonance imaging contrast agents
US5262176A (en) 1986-07-03 1993-11-16 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids
US4770183A (en) 1986-07-03 1988-09-13 Advanced Magnetics Incorporated Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents
US5352432A (en) 1986-07-03 1994-10-04 Advanced Magnetics, Inc. Hepatocyte specific composition and their use as diagnostic imaging agents
US5284646A (en) 1986-07-03 1994-02-08 Advanced Magnetics Inc. Hepatocyte specific receptor mediated endocytosis type magnetic resonance imaging contrast agents
DE3709851A1 (de) * 1987-03-24 1988-10-06 Silica Gel Gmbh Adsorptions Te Nmr-diagnostische fluessigkeitszusammensetzungen
GB8717863D0 (en) 1987-07-28 1987-09-03 Acade Diagnostic Systems Sa Nv Determination of antibodies
SE8704157L (sv) 1987-10-26 1989-04-27 Carbomatrix Ab C O Ulf Schroed Superparamagnetiska partiklar och foerfarande foer framstaellning daerav samt anvaendning
CA2000048A1 (en) 1988-10-03 1990-04-03 Edward F. Plow Peptides and antibodies that inhibit integrin-ligand bindin g
US4879210A (en) 1989-03-03 1989-11-07 Harley Hamilton Method and apparatus for teaching signing
US5114703A (en) 1989-05-30 1992-05-19 Alliance Pharmaceutical Corp. Percutaneous lymphography using particulate fluorocarbon emulsions
DE69118367T2 (de) 1990-02-15 1996-08-08 Advanced Magnetics Inc FILTERSTERILISATION ZUR HERSTELLUNG VON KOLLOIDALEN SUPERPARAMAGNETISCHEN MR-KONTRASTMITTELN und ihre Verwendung
US5358702A (en) 1990-04-10 1994-10-25 Unger Evan C Methoxylated gel particle contrast media for improved diagnostic imaging
US5368840A (en) 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
CA2097589C (en) 1990-12-19 1998-05-05 Lee Josephson Targeting of therapeutic agents using polysaccharides
ATE179894T1 (de) 1991-01-19 1999-05-15 Meito Sangyo Kk Ultrafeine magnetische metalloxideteilchen enthaltende zusammensetzung
DE4117782C2 (de) 1991-05-28 1997-07-17 Diagnostikforschung Inst Nanokristalline magnetische Eisenoxid-Partikel, Verfahren zu ihrer Herstellung sowie diagnostische und/oder therapeutische Mittel
JP2939336B2 (ja) 1991-06-11 1999-08-25 名糖産業株式会社 水溶性カルボキシ多糖−磁性酸化鉄酸化複合体
US5225282A (en) 1991-12-13 1993-07-06 Molecular Bioquest, Inc. Biodegradable magnetic microcluster comprising non-magnetic metal or metal oxide particles coated with a functionalized polymer
DE69207589T2 (de) 1992-06-01 1996-05-23 Basf Ag Anwendung von Dispersionen von magneto-ionischen Partikeln in MRI-Kontrast-Mitteln
EP0654973A4 (en) 1992-07-21 1995-08-09 Gen Hospital Corp LYPHATIC TISSUE DRUG ADMINISTRATION SYSTEM.
ES2130406T5 (es) 1992-08-05 2003-12-16 Meito Sangyo Kk Material compuesto de pequeño diametro compuesto de carboxipolisacarido soluble en agua y oxido de hierro magnetico.
US5464696A (en) 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
US5349957A (en) 1992-12-02 1994-09-27 Sterling Winthrop Inc. Preparation and magnetic properties of very small magnetite-dextran particles
JPH08508721A (ja) 1993-03-17 1996-09-17 シリカゲル ゲス．エム．ビー．エイチ 超常磁性粒子、その製法及びその用途
US5411730A (en) 1993-07-20 1995-05-02 Research Corporation Technologies, Inc. Magnetic microparticles
JP3388013B2 (ja) * 1994-03-15 2003-03-17 戸田工業株式会社 粒状ゲータイト微粒子粉末の製造法及び該微粒子粉末を用いた粒状酸化鉄微粒子粉末の製造法
AU2419695A (en) 1994-05-12 1995-12-05 Otsuka Pharmaceutical Co., Ltd. Contrast medium for magnetic resonance imaging
DK0783325T3 (da) 1994-09-27 2000-05-01 Nycomed Imaging As Kontrastmiddel
GB9600427D0 (en) * 1996-01-10 1996-03-13 Nycomed Imaging As Contrast media

Also Published As

Publication number Publication date
US6423296B1 (en) 2002-07-23
CN1212629A (zh) 1999-03-31
WO1997025073A2 (en) 1997-07-17
HUP9901192A3 (en) 2000-02-28
EA001336B1 (ru) 2001-02-26
CZ219498A3 (cs) 1998-12-16
DE69732831T2 (de) 2006-04-13
ES2239349T3 (es) 2005-09-16
NO983060D0 (no) 1998-07-01
JP2000504300A (ja) 2000-04-11
IL125150A0 (en) 1999-01-26
PL327679A1 (en) 1998-12-21
NO983060L (no) 1998-09-07
DE69732831D1 (de) 2005-04-28
JP4280304B2 (ja) 2009-06-17
AU1390497A (en) 1997-08-01
EA199800630A1 (ru) 1999-02-25
CA2242647A1 (en) 1997-07-17
EP0877630B1 (en) 2005-03-23
ATE291439T1 (de) 2005-04-15
MX9805508A (es) 1998-11-30
WO1997025073A3 (en) 1997-10-09
NZ325403A (en) 2000-02-28
AU716667B2 (en) 2000-03-02
EP0877630A2 (en) 1998-11-18
HUP9901192A1 (hu) 1999-08-30

Similar Documents

Publication Publication Date Title
IL125150A (en) Magnetic resonance contrast media
GB2396740B (en) Anti-ferromagnetically coupled perpendicular magnetic recording media
IL114713A0 (en) Iron-containing nanoparticles methods for the production thereof and use thereof as contrast media
EP0637700A3 (en) Helical spring in synthetic material reinforced with carbon fibers and its manufacturing process.
EP0863517A4 (en) COMPOSITE MAGNETIC TUBE, MANUFACTURING METHOD THEREOF, AND ELECTROMAGNETIC INTERFERENCE SUPPRESSION TUBE
GB2324154B (en) Electromagnetic detector for measuring magnetic or conductive properties
EP0675486A3 (en) Magnetoresistive transducer with integrated yoke and magnetic shunt.
AU6828500A (en) Method for detecting binding reactions through measurement of the relaxation of birefringence of magnetic nanoparticles
GB9921725D0 (en) Low resonance texturing of magnetic media
EP0709696A3 (en) Permanent magnet device provided with a magnetoresistive element for the detection / authentication of magnetic documents
DK1288098T3 (da) Hjulsensor og anordning
MXPA01013029A (es) Caste de cinta magnetica, especialmente de casete de bobina para procesar datos, con un sistema de frenado en varias partes.
EP1001508A3 (en) Electromagnetic brake with two independent front disks
AU2419695A (en) Contrast medium for magnetic resonance imaging
AU6352201A (en) Apparatus for generating electric and/or magnetic fields and detecting and usingsuch fields
EP0587142A3 (en) A rotary transformer
DE59706368D1 (de) Magnetisches Eisenoxid, Verfahren zur Herstellung und dessen Verwendung
EP1022132A4 (en) POLYAMIDE FILM LAMINATE, METHOD FOR THE PRODUCTION THEREOF AND MAGNETIC RECORDING MATERIAL
EP0681115A3 (en) Circuit for a magnetic bearing.
GB2379021B (en) Gradient coil system and magnetic resonance apparatus having the gradient coil system
EP1071104A3 (en) Rotary inductive coupling
ATE270398T1 (de) Sinterwerkstoff für eine magnetische schienenbremse
ATE270988T1 (de) Schienenkontakt für eine achszähleinrichtung
TW200701271A (en) Choke choil
GB2357183B (en) Low resonance texturing of magnetic media

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
HC Change of name of proprietor(s)
KB Patent renewed
HC Change of name of proprietor(s)

Owner name: GE HEALTHCARE AS

Free format text: FORMER NAME:AMERSHAM HEALTH AS

MM9K Patent not in force due to non-payment of renewal fees