IL125049A - Method for selective protection of baccatin derivatives and its application to taxane synthesis - Google Patents
Method for selective protection of baccatin derivatives and its application to taxane synthesisInfo
- Publication number
- IL125049A IL125049A IL12504996A IL12504996A IL125049A IL 125049 A IL125049 A IL 125049A IL 12504996 A IL12504996 A IL 12504996A IL 12504996 A IL12504996 A IL 12504996A IL 125049 A IL125049 A IL 125049A
- Authority
- IL
- Israel
- Prior art keywords
- application
- selective protection
- baccatin derivatives
- taxane synthesis
- derivatives
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229930190007 Baccatin Natural products 0.000 title 1
- 229940123237 Taxane Drugs 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 2
- -1 2,2,2-trichloroethoxycarbonyl Chemical group 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 238000007068 beta-elimination reaction Methods 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL13876896A IL138768A (en) | 1995-12-27 | 1996-12-27 | Taxane derivatives and processes for their preparation |
| IL13876996A IL138769A0 (en) | 1995-12-27 | 1996-12-27 | Taxane derivatives and processes for their preparation |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9515557A FR2743074B1 (fr) | 1995-12-27 | 1995-12-27 | Procede de protection selective des derives de la baccatine et son utilisation dans la synthese des taxanes |
| PCT/FR1996/002097 WO1997024345A1 (fr) | 1995-12-27 | 1996-12-27 | Procede de protection selective des derives de la baccatine et son utilisation dans la synthese des taxanes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL125049A0 IL125049A0 (en) | 1999-01-26 |
| IL125049A true IL125049A (en) | 2003-10-31 |
Family
ID=9486008
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12504996A IL125049A (en) | 1995-12-27 | 1996-12-27 | Method for selective protection of baccatin derivatives and its application to taxane synthesis |
| IL138769A IL138769A (en) | 1995-12-27 | 2000-09-28 | Texan derivatives and processes for their preparation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL138769A IL138769A (en) | 1995-12-27 | 2000-09-28 | Texan derivatives and processes for their preparation |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6180802B1 (es) |
| EP (1) | EP0889885B1 (es) |
| JP (1) | JP4068663B2 (es) |
| KR (1) | KR100510017B1 (es) |
| CN (3) | CN1090625C (es) |
| AT (1) | ATE218133T1 (es) |
| AU (1) | AU716876B2 (es) |
| BR (1) | BR9612242A (es) |
| CA (1) | CA2238889C (es) |
| CZ (1) | CZ20191998A3 (es) |
| DE (1) | DE69621463T2 (es) |
| DK (1) | DK0889885T3 (es) |
| ES (1) | ES2177825T3 (es) |
| FR (1) | FR2743074B1 (es) |
| HK (2) | HK1044765B (es) |
| HU (1) | HUP0000508A3 (es) |
| IL (2) | IL125049A (es) |
| NO (1) | NO982719D0 (es) |
| NZ (1) | NZ325323A (es) |
| PL (1) | PL327581A1 (es) |
| PT (1) | PT889885E (es) |
| RU (1) | RU2162844C2 (es) |
| SK (1) | SK88498A3 (es) |
| TR (1) | TR199801232T2 (es) |
| WO (1) | WO1997024345A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0875508B1 (en) * | 1997-05-02 | 2003-10-22 | Pharmachemie B.V. | Method for the preparation of baccatin III and derivatives thereof from 10-deacetylbaccatin III |
| US7288665B1 (en) * | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| JP5498168B2 (ja) | 2006-12-01 | 2014-05-21 | ブリストル−マイヤーズ スクイブ カンパニー | アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体 |
| EP2183234A4 (en) * | 2007-08-22 | 2012-02-29 | Canada Inc 6570763 | PROCESS FOR CONVERTING 9-DIHYDRO-13-ACETYLBACCATIN III IN DOCETAXEL OR PACLITAXEL |
| PL388144A1 (pl) | 2009-05-29 | 2010-12-06 | Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością | Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie |
| CN115260130A (zh) * | 2022-07-07 | 2022-11-01 | 上海卓鼎生物技术有限公司 | 一种10-脱乙酰基紫杉醇的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2601676B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Procede de preparation du taxol et du desacetyl-10 taxol |
| IL127599A (en) * | 1994-01-28 | 2004-06-01 | Upjohn Co | Process for preparing isotaxol analogs |
-
1995
- 1995-12-27 FR FR9515557A patent/FR2743074B1/fr not_active Expired - Fee Related
-
1996
- 1996-12-27 TR TR1998/01232T patent/TR199801232T2/xx unknown
- 1996-12-27 JP JP52408197A patent/JP4068663B2/ja not_active Expired - Fee Related
- 1996-12-27 CZ CZ982019A patent/CZ20191998A3/cs unknown
- 1996-12-27 DE DE69621463T patent/DE69621463T2/de not_active Expired - Lifetime
- 1996-12-27 SK SK884-98A patent/SK88498A3/sk unknown
- 1996-12-27 PT PT96944097T patent/PT889885E/pt unknown
- 1996-12-27 DK DK96944097T patent/DK0889885T3/da active
- 1996-12-27 AU AU13815/97A patent/AU716876B2/en not_active Ceased
- 1996-12-27 CN CN96199356A patent/CN1090625C/zh not_active Expired - Fee Related
- 1996-12-27 BR BR9612242A patent/BR9612242A/pt not_active Application Discontinuation
- 1996-12-27 US US09/077,099 patent/US6180802B1/en not_active Expired - Fee Related
- 1996-12-27 EP EP96944097A patent/EP0889885B1/fr not_active Expired - Lifetime
- 1996-12-27 PL PL96327581A patent/PL327581A1/xx unknown
- 1996-12-27 RU RU98113957/04A patent/RU2162844C2/ru not_active IP Right Cessation
- 1996-12-27 CN CNB011409983A patent/CN1243745C/zh not_active Expired - Fee Related
- 1996-12-27 KR KR10-1998-0704853A patent/KR100510017B1/ko not_active IP Right Cessation
- 1996-12-27 CN CNB011409991A patent/CN1244567C/zh not_active Expired - Fee Related
- 1996-12-27 IL IL12504996A patent/IL125049A/xx not_active IP Right Cessation
- 1996-12-27 CA CA002238889A patent/CA2238889C/fr not_active Expired - Fee Related
- 1996-12-27 HU HU0000508A patent/HUP0000508A3/hu not_active Application Discontinuation
- 1996-12-27 ES ES96944097T patent/ES2177825T3/es not_active Expired - Lifetime
- 1996-12-27 AT AT96944097T patent/ATE218133T1/de not_active IP Right Cessation
- 1996-12-27 WO PCT/FR1996/002097 patent/WO1997024345A1/fr active IP Right Grant
- 1996-12-27 NZ NZ325323A patent/NZ325323A/xx unknown
-
1998
- 1998-06-12 NO NO982719A patent/NO982719D0/no unknown
-
2000
- 2000-09-28 IL IL138769A patent/IL138769A/en not_active IP Right Cessation
-
2002
- 2002-08-20 HK HK02106058.4A patent/HK1044765B/zh not_active IP Right Cessation
- 2002-11-29 HK HK02108638.9A patent/HK1047099B/zh not_active IP Right Cessation
Also Published As
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| FR2696463B1 (fr) | Procédé d'obtention de la désacétyl-10 baccatine III. | |
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| IL125049A0 (en) | Method for selective protection of baccatin derivatives and its application to taxane synthesis | |
| IL147851A0 (en) | Process for the preparation of a c-4 methylcarbonate analog of paclitaxel | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |