IL122377A - Anti-viral 5-benzoyl-1h-benzimidazoles, process for their preparation and pharmaceutical compositions containing them - Google Patents

Anti-viral 5-benzoyl-1h-benzimidazoles, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL122377A
IL122377A IL12237796AA IL12237796A IL122377A IL 122377 A IL122377 A IL 122377A IL 12237796A A IL12237796A A IL 12237796AA IL 12237796 A IL12237796 A IL 12237796A IL 122377 A IL122377 A IL 122377A
Authority
IL
Israel
Prior art keywords
benzimidazoles
benzoyl
viral
preparation
pharmaceutical compositions
Prior art date
Application number
IL12237796AA
Other languages
English (en)
Other versions
IL122377A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL122377A0 publication Critical patent/IL122377A0/xx
Publication of IL122377A publication Critical patent/IL122377A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL12237796AA 1995-06-07 1996-06-05 Anti-viral 5-benzoyl-1h-benzimidazoles, process for their preparation and pharmaceutical compositions containing them IL122377A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/482,041 US5545653A (en) 1995-06-07 1995-06-07 Anti-viral compounds
PCT/US1996/008830 WO1996040124A1 (en) 1995-06-07 1996-06-05 Anti-viral compounds

Publications (2)

Publication Number Publication Date
IL122377A0 IL122377A0 (en) 1998-06-15
IL122377A true IL122377A (en) 2001-01-11

Family

ID=23914403

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12237796AA IL122377A (en) 1995-06-07 1996-06-05 Anti-viral 5-benzoyl-1h-benzimidazoles, process for their preparation and pharmaceutical compositions containing them

Country Status (10)

Country Link
US (1) US5545653A (de)
EP (1) EP0862430A4 (de)
JP (1) JPH11506772A (de)
KR (1) KR19990022363A (de)
AU (1) AU5982496A (de)
BR (1) BR9608571A (de)
CA (1) CA2223299A1 (de)
HU (1) HUP9900865A3 (de)
IL (1) IL122377A (de)
WO (1) WO1996040124A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891874A (en) * 1996-06-05 1999-04-06 Eli Lilly And Company Anti-viral compound
US5821242A (en) * 1996-06-06 1998-10-13 Eli Lilly And Company Anti-viral compounds
IL118657A0 (en) * 1996-06-14 1996-10-16 Arad Dorit Inhibitors for picornavirus proteases
AU6031898A (en) * 1997-01-22 1998-08-07 Eli Lilly And Company Anti-viral compounds
AU741772B2 (en) 1997-02-25 2001-12-06 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Substituted benzimidazoles as non-nucleoside inhibitors of reverse transcriptase
EP1001767A4 (de) * 1997-06-04 2001-07-04 Lilly Co Eli Antivirale verbindungen
IL122591A0 (en) 1997-12-14 1998-06-15 Arad Dorit Pharmaceutical compositions comprising cystein protease inhibitors
US6699705B2 (en) 1999-02-01 2004-03-02 National Research Council Of Canada Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics
US7030150B2 (en) * 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
AU2003294249A1 (en) * 2002-11-08 2004-06-03 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
AR046971A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Aminobenzoimidazoles y benzoimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
EP1711496A4 (de) * 2004-01-28 2009-02-11 Smithkline Beecham Corp Thiazolverbindungen
WO2009143571A1 (en) * 2008-05-27 2009-12-03 Biota Scientific Management Pty Ltd Antiviral salts
CN104394835B (zh) 2012-07-13 2018-09-07 莱雅公司 化妆品组合物
BR112020002674A2 (pt) * 2017-08-07 2020-07-28 Joint Stock Company Biocad compostos heterocíclicos inovadores como inibidores de cdk8/19

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR61627B (en) * 1975-08-28 1978-12-04 Lilly Co Eli Preparation process of carbonyl-substituted 1-sulfonylbenzimidazoles
US4174454A (en) * 1975-08-28 1979-11-13 Eli Lilly And Company Alkylidenylmethyl-substituted 1-sulfonylbenzimidazoles
US4434288A (en) * 1982-04-08 1984-02-28 Eli Lilly And Company Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminobenzimidazoles
US4420479A (en) * 1982-04-08 1983-12-13 Eli Lilly And Company Olefinic benzimidazoles, formulations, and antiviral methods
US4492708A (en) * 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles

Also Published As

Publication number Publication date
HUP9900865A3 (en) 2000-02-28
BR9608571A (pt) 1998-12-29
HUP9900865A2 (hu) 1999-07-28
US5545653A (en) 1996-08-13
WO1996040124A1 (en) 1996-12-19
EP0862430A1 (de) 1998-09-09
IL122377A0 (en) 1998-06-15
CA2223299A1 (en) 1996-12-19
JPH11506772A (ja) 1999-06-15
EP0862430A4 (de) 1999-03-24
AU5982496A (en) 1996-12-30
KR19990022363A (ko) 1999-03-25

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees