IL120862A0 - Use of nonpeptide bradykinin antagonists for the treatment and prevention of chronic fibrogenetic liver disorders acute liver disorders and the complications associated therewith - Google Patents
Use of nonpeptide bradykinin antagonists for the treatment and prevention of chronic fibrogenetic liver disorders acute liver disorders and the complications associated therewithInfo
- Publication number
- IL120862A0 IL120862A0 IL12086297A IL12086297A IL120862A0 IL 120862 A0 IL120862 A0 IL 120862A0 IL 12086297 A IL12086297 A IL 12086297A IL 12086297 A IL12086297 A IL 12086297A IL 120862 A0 IL120862 A0 IL 120862A0
- Authority
- IL
- Israel
- Prior art keywords
- liver disorders
- prevention
- treatment
- associated therewith
- complications associated
- Prior art date
Links
- 208000019423 liver disease Diseases 0.000 title abstract 4
- 239000003152 bradykinin antagonist Substances 0.000 title abstract 3
- 230000001154 acute effect Effects 0.000 title abstract 2
- 230000001684 chronic effect Effects 0.000 title abstract 2
- 230000001842 fibrogenetic effect Effects 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- UYRCOTSOPWOSJK-JXTBTVDRSA-N bradykinin antagonist Chemical compound C1C2=CC=CC=C2CC1[C@@H](NC(=O)C(CO)NC(=O)C(NC(=O)CNC(=O)[C@H]1N(C[C@H](O)C1)C(=O)C1N(CCC1)C(=O)C(CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=N)CCCCCCC(=N)N[C@H](CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)N1C(CCC1)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)NCC(=O)NC(C1CC2=CC=CC=C2C1)C(=O)NC(CO)C(=O)N[C@H](C1CC2=CC=CC=C2C1)C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(N)=N)C(O)=O)C1CC2=CC=CC=C2C1)C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(=N)N)C(O)=O UYRCOTSOPWOSJK-JXTBTVDRSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Quinoline Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1996120509 DE19620509A1 (de) | 1996-05-22 | 1996-05-22 | Verwendung nicht-peptidischer Bradykinin-Antagonisten zur Behandlung und Prävention von chronisch-fibrogenetischen Lebererkrankungen, akuten Lebererkrankungen und den damit verbundenen Komplikationen |
| DE19632042A DE19632042A1 (de) | 1996-08-08 | 1996-08-08 | Verwendung nicht-peptidischer Bradykinin-Antagonisten zur Behandlung und Prävention von chronisch-fibrogenetischen Lebererkrankungen, akuten Lebererkrankungen und den damit verbundenen Komplikationen |
| DE19639303A DE19639303A1 (de) | 1996-09-25 | 1996-09-25 | Verwendung nicht-peptidischer Bradykinin-Antagonisten zur Behandlung und Prävention von chronisch-fibrogenetischen Lebererkrankungen, akuten Lebererkrankungen und den damit verbundenen Komplikationen |
| US08/858,550 US5786365A (en) | 1996-05-22 | 1997-05-19 | Use of nonpeptide bradykinin antagonists for the treatment and prevention of chronic fibrogenetic liver disorders, acute liver disorders and the complications associated therewith |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL120862A0 true IL120862A0 (en) | 1997-09-30 |
Family
ID=27438369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12086297A IL120862A0 (en) | 1996-05-22 | 1997-05-20 | Use of nonpeptide bradykinin antagonists for the treatment and prevention of chronic fibrogenetic liver disorders acute liver disorders and the complications associated therewith |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5786365A (cs) |
| EP (2) | EP0808627A2 (cs) |
| JP (1) | JP4034849B2 (cs) |
| CN (1) | CN1176102A (cs) |
| AT (1) | ATE189389T1 (cs) |
| AU (1) | AU2351197A (cs) |
| BR (1) | BR9703367A (cs) |
| CA (1) | CA2205780A1 (cs) |
| CZ (1) | CZ154697A3 (cs) |
| DE (1) | DE59701078D1 (cs) |
| DK (1) | DK0808628T3 (cs) |
| ES (1) | ES2144291T3 (cs) |
| GR (1) | GR3033048T3 (cs) |
| HR (1) | HRP970278A2 (cs) |
| HU (1) | HUP9700913A1 (cs) |
| ID (1) | ID18447A (cs) |
| IL (1) | IL120862A0 (cs) |
| NO (1) | NO972311L (cs) |
| PL (1) | PL320134A1 (cs) |
| PT (1) | PT808628E (cs) |
| SI (1) | SI0808628T1 (cs) |
| SK (1) | SK63097A3 (cs) |
| TR (1) | TR199700392A2 (cs) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5935581A (en) * | 1996-07-24 | 1999-08-10 | Kapadia; Govind J. | Inhibitory effects of synthetic and natural colorants on carcinogenesis |
| DE19653969A1 (de) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
| DE19712960A1 (de) * | 1997-03-27 | 1998-10-01 | Hoechst Ag | Benzyloxy-substituierte, anellierte N-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Bradykininrezeptorantagonisten |
| DE69931140T2 (de) | 1998-11-10 | 2007-02-01 | Temple University Of The Commonwealth System Of Higher Education | Hemmung der angiogenese durch peptidanaloge der kininogen domäne 5mit hohem molekulargewicht |
| US6767889B1 (en) | 1998-11-10 | 2004-07-27 | Temple University Of The Commonwealth System Of Higher Education | Inhibition of angiogenesis by high molecular weight kininogen and peptide analogs thereof |
| JP2002529474A (ja) * | 1998-11-10 | 2002-09-10 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 高分子量キニノゲン及びそのペプチド類似体による血管形成の抑制 |
| US6869931B1 (en) | 1998-12-16 | 2005-03-22 | Temple University - Of The Commonwealth System Of Higher Education | Inhibition of angiogenesis by high molecular weight kininogen domain 3 peptide analogs |
| US6994852B1 (en) | 1999-11-12 | 2006-02-07 | Temple University-Of The Commonwealth System Of Higher Education | Inhibition of angiogenesis by antibodies against high molecular weight kininogen domain 5 |
| US6445588B1 (en) | 2001-01-02 | 2002-09-03 | Motorola, Inc. | Apparatus and method for securing a printed circuit board to a base plate |
| RU2006124843A (ru) | 2003-12-12 | 2008-01-20 | Уайт (Us) | Хинолины, пригодные для лечения сердечно-сосудистого заболевания |
| CA2603589A1 (en) * | 2005-04-01 | 2006-10-05 | Methylgene Inc. | Inhibitors of histone deacetylase |
| MX2012014948A (es) * | 2010-06-29 | 2013-05-17 | Jennifer Digrazia | Sistema y metodo para proteccion de apositos y herbicidas. |
| US12427067B2 (en) | 2010-06-29 | 2025-09-30 | Jennifer DiGrazia | Wound and bandage protection system and method |
| US10517765B2 (en) | 2010-06-29 | 2019-12-31 | Jennifer DiGrazia | Wound and bandage protection system and method |
| RU2514345C1 (ru) * | 2012-10-09 | 2014-04-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежская государственная медицинская академия им. Н.Н. Бурденко" Министерства здравоохранения и социального развития Российской Федерации | Способ прогнозирования степени риска геморрагических осложнений при миниинвазивных хирургических вмешательствах на печени |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5212182A (en) * | 1990-10-03 | 1993-05-18 | American Home Products Corpooration | Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics |
| US5216165A (en) * | 1990-10-03 | 1993-06-01 | American Home Products Corporation | N-substituted aminoquinolines as analgesic agents |
| US5438064A (en) * | 1991-12-23 | 1995-08-01 | American Home Products Corporation | Derivatives of 4-anilinoquinoline-3-carboxamide as analgesic agents |
| AU686115B2 (en) * | 1992-11-02 | 1998-02-05 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation |
| AU680870B2 (en) * | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
| JP3049648B2 (ja) * | 1993-12-13 | 2000-06-05 | 日立金属株式会社 | 加圧成形方法および加圧成形機 |
| WO1996004251A1 (en) * | 1994-08-03 | 1996-02-15 | Fujisawa Pharmaceutical Co., Ltd. | Heterocyclic compound |
-
1997
- 1997-05-09 EP EP97107624A patent/EP0808627A2/de not_active Withdrawn
- 1997-05-19 US US08/858,550 patent/US5786365A/en not_active Expired - Lifetime
- 1997-05-20 PT PT97108096T patent/PT808628E/pt unknown
- 1997-05-20 HU HU9700913A patent/HUP9700913A1/hu unknown
- 1997-05-20 TR TR97/00392A patent/TR199700392A2/xx unknown
- 1997-05-20 DE DE59701078T patent/DE59701078D1/de not_active Expired - Lifetime
- 1997-05-20 EP EP97108096A patent/EP0808628B1/de not_active Expired - Lifetime
- 1997-05-20 SI SI9730031T patent/SI0808628T1/xx unknown
- 1997-05-20 IL IL12086297A patent/IL120862A0/xx unknown
- 1997-05-20 CZ CZ971546A patent/CZ154697A3/cs unknown
- 1997-05-20 ES ES97108096T patent/ES2144291T3/es not_active Expired - Lifetime
- 1997-05-20 AU AU23511/97A patent/AU2351197A/en not_active Abandoned
- 1997-05-20 DK DK97108096T patent/DK0808628T3/da active
- 1997-05-20 AT AT97108096T patent/ATE189389T1/de active
- 1997-05-20 SK SK630-97A patent/SK63097A3/sk unknown
- 1997-05-21 ID IDP971698A patent/ID18447A/id unknown
- 1997-05-21 CN CN97113108A patent/CN1176102A/zh active Pending
- 1997-05-21 HR HR19639303.5A patent/HRP970278A2/xx not_active Application Discontinuation
- 1997-05-21 JP JP13116097A patent/JP4034849B2/ja not_active Expired - Fee Related
- 1997-05-21 NO NO972311A patent/NO972311L/no unknown
- 1997-05-22 CA CA002205780A patent/CA2205780A1/en not_active Abandoned
- 1997-05-22 PL PL97320134A patent/PL320134A1/xx unknown
- 1997-05-22 BR BR9703367A patent/BR9703367A/pt not_active Application Discontinuation
-
2000
- 2000-03-24 GR GR20000400735T patent/GR3033048T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI0808628T1 (en) | 2000-04-30 |
| CA2205780A1 (en) | 1997-11-22 |
| EP0808627A2 (de) | 1997-11-26 |
| HUP9700913A1 (hu) | 1999-09-28 |
| AU2351197A (en) | 1997-11-27 |
| GR3033048T3 (en) | 2000-08-31 |
| CZ154697A3 (en) | 1997-12-17 |
| ATE189389T1 (de) | 2000-02-15 |
| PT808628E (pt) | 2000-05-31 |
| NO972311D0 (no) | 1997-05-21 |
| JPH1045624A (ja) | 1998-02-17 |
| JP4034849B2 (ja) | 2008-01-16 |
| PL320134A1 (en) | 1997-11-24 |
| TR199700392A2 (xx) | 1997-12-21 |
| CN1176102A (zh) | 1998-03-18 |
| DE59701078D1 (de) | 2000-03-09 |
| SK63097A3 (en) | 1997-12-10 |
| NO972311L (no) | 1997-11-24 |
| ID18447A (id) | 1998-04-09 |
| EP0808628A3 (de) | 1998-01-14 |
| EP0808628B1 (de) | 2000-02-02 |
| ES2144291T3 (es) | 2000-06-01 |
| BR9703367A (pt) | 1998-09-15 |
| MX9703725A (es) | 1997-11-29 |
| HU9700913D0 (en) | 1997-07-28 |
| US5786365A (en) | 1998-07-28 |
| EP0808628A2 (de) | 1997-11-26 |
| DK0808628T3 (da) | 2000-06-26 |
| HRP970278A2 (en) | 1998-04-30 |
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