IL118581A - Optically crosslinked communication system - Google Patents

Optically crosslinked communication system

Info

Publication number
IL118581A
IL118581A IL11858196A IL11858196A IL118581A IL 118581 A IL118581 A IL 118581A IL 11858196 A IL11858196 A IL 11858196A IL 11858196 A IL11858196 A IL 11858196A IL 118581 A IL118581 A IL 118581A
Authority
IL
Israel
Prior art keywords
hif
communication system
hypoxia
purified
optically crosslinked
Prior art date
Application number
IL11858196A
Other languages
English (en)
Other versions
IL118581A0 (en
Original Assignee
Glynn Thomas William
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glynn Thomas William filed Critical Glynn Thomas William
Publication of IL118581A0 publication Critical patent/IL118581A0/xx
Publication of IL118581A publication Critical patent/IL118581A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Optical Communication System (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Electrophonic Musical Instruments (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11858196A 1995-06-06 1996-06-05 Optically crosslinked communication system IL118581A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/480,473 US5882914A (en) 1995-06-06 1995-06-06 Nucleic acids encoding the hypoxia inducible factor-1

Publications (2)

Publication Number Publication Date
IL118581A0 IL118581A0 (en) 1996-10-16
IL118581A true IL118581A (en) 2000-01-31

Family

ID=23908114

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11858196A IL118581A (en) 1995-06-06 1996-06-05 Optically crosslinked communication system

Country Status (9)

Country Link
US (3) US5882914A (de)
EP (2) EP0833840B1 (de)
JP (2) JPH11507541A (de)
AT (1) ATE355299T1 (de)
AU (1) AU704384B2 (de)
CA (1) CA2222279C (de)
DE (1) DE69636936T2 (de)
IL (1) IL118581A (de)
WO (1) WO1996039426A1 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882914A (en) * 1995-06-06 1999-03-16 The Johns Hopkins University School Of Medicine Nucleic acids encoding the hypoxia inducible factor-1
EP0990042A1 (de) * 1997-06-10 2000-04-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Regulatorische sequenzen beteiligt an der hypoxia-regulierten genexpression und deren anwendungen
US7074895B2 (en) 1997-08-21 2006-07-11 Quark Biotech, Inc. Sequences characteristic of hypoxia-regulated gene transcription
EP1015471A1 (de) * 1997-08-21 2000-07-05 Quark Biotech, Inc. Hypoxieregulierte gene
US7973156B2 (en) 1997-08-21 2011-07-05 Quark Pharmaceuticals Inc. Hypoxia-regulated genes
AU757930B2 (en) 1997-12-01 2003-03-13 Roche Diagnostics Gmbh Optimization of cells for endogenous gene activation
NZ504847A (en) * 1997-12-04 2003-02-28 Genzyme Corp Chimeric protein comprising a hypoxia inducible factor protein and a transcriptional activation domain and pharmaceutical use
JP2002507405A (ja) * 1998-03-27 2002-03-12 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 低酸素誘導ヒト遺伝子、タンパク質およびそれらの使用
US6124131A (en) * 1998-08-25 2000-09-26 The Johns Hopkins University School Of Medicine Mutant hypoxia inducible factor-1 HIF-1
JP2002525081A (ja) * 1998-08-27 2002-08-13 クォーク・バイオテク・インコーポレーテッド 低酸素により調節される遺伝子転写に特徴的な配列
SE9803891D0 (sv) * 1998-11-13 1998-11-13 Pharmacia & Upjohn Ab Protein Variants
US6436654B1 (en) * 1998-11-13 2002-08-20 Pharmacia & Upjohn Ab Methods for identifying compounds that modulate HIF-1α
EP1189611B1 (de) * 1999-06-14 2006-05-03 Cancer Research Technology Limited Krebstherapie
WO2001023426A2 (en) * 1999-09-30 2001-04-05 Varian Associates, Inc. Hypoxia-related human genes, proteins, and uses thereof
FR2801319A1 (fr) * 1999-11-18 2001-05-25 Inst Nat Sante Rech Med Construction d'acide nucleique porteuse d'un systeme regulant l'expression d'un gene
US6893867B1 (en) 1999-12-23 2005-05-17 Keith A. Webster Molecular switch for regulating mammalian gene expression
AU2001233937A1 (en) * 2000-02-22 2001-09-03 Oxford Biomedica (Uk) Limited Differential expression screening method
WO2002012326A2 (en) * 2000-08-07 2002-02-14 Angiogenetics Sweden Ab Mechanism of conditional regulation of the hypoxia-inducible factor-1 by the von hippel-lindau tumor suppressor protein
US7285414B2 (en) * 2000-09-26 2007-10-23 Emory University Viruses targeted to hypoxic cells and tissues
US20040101825A1 (en) * 2001-09-26 2004-05-27 Van Meir Erwin G. Viruses targeted to hypoxic cells and tissues
WO2002034291A2 (en) * 2000-10-26 2002-05-02 The Brigham And Women's Hospital, Inc. Compositions and methods for treating hematologic malignancies and multiple drug resistance
US6855510B2 (en) 2001-03-20 2005-02-15 Dana Farber Cancer Institute, Inc. Pharmaceuticals and methods for treating hypoxia and screening methods therefor
US7919274B2 (en) 2001-03-20 2011-04-05 Dana-Farber Cancer Institute, Inc. Light-emitting fusion proteins and diagnostic and therapeutic methods therefor
US6849718B2 (en) * 2001-03-20 2005-02-01 Dana Farber Cancer Institute, Inc. Muteins of hypoxia inducible factor alpha and methods of use thereof
US7176345B2 (en) * 2001-03-20 2007-02-13 Dana-Farber Cancer Institute, Inc. Transgenic animals expressing light-emitting fusion proteins and diagnostic and therapeutic methods therefor
US6660737B2 (en) 2001-05-04 2003-12-09 The Procter & Gamble Company Medicinal uses of hydrazones
US6878729B2 (en) 2001-05-04 2005-04-12 The Procter & Gamble Company Medicinal uses of dihydropyrazoles
CA2447958A1 (en) * 2001-05-23 2002-11-28 Angiogene Inc. Hypoxia inducible factors and uses thereof for inducing angiogenesis and improving muscular functions
AU2002304163C1 (en) * 2001-06-05 2009-01-08 Oriental Yeast Co., Ltd. Polypeptide unstabilizing protein in cells under aerobic conditions and DNA encoding the same
US6838430B2 (en) 2001-09-28 2005-01-04 The Regents Of The University Of California Use of HIF-1a variants to accelerate wound healing
FR2832154B1 (fr) 2001-11-09 2007-03-16 Centre Nat Rech Scient Oligonucleotides inhibiteurs et leur utilisation pour reprimer specifiquement un gene
AU2003208684A1 (en) * 2002-03-05 2003-09-16 Angiogenetics Sweden Ab Critical hypoxia-inducible factor-1alpha residues, products and methods related thereto
EP2264172B1 (de) * 2002-04-05 2017-09-27 Roche Innovation Center Copenhagen A/S Oligomere zur modulation von hif-1 alpha expression
ES2397060T3 (es) * 2002-04-18 2013-03-04 Opko Pharmaceuticals, Llc Medios y métodos para la modulación específica de genes diana en el ojo
NZ520321A (en) * 2002-07-19 2005-03-24 Auckland Uniservices Ltd Use of an agent adapted to inhibit HIF in use together with an antiangiogenic agent for treating tumours in a non- human animal
US7148342B2 (en) * 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
KR20120038546A (ko) * 2002-11-01 2012-04-23 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 ＨＩＦ-1 알파의 ｓｉＲＮＡ 억제를 위한 조성물 및 방법
US7144999B2 (en) * 2002-11-23 2006-12-05 Isis Pharmaceuticals, Inc. Modulation of hypoxia-inducible factor 1 alpha expression
US20050014264A1 (en) * 2002-12-11 2005-01-20 University Of Massachusetts Method of introducing siRNA into adipocytes
WO2004066949A2 (en) 2003-01-28 2004-08-12 Rexahn Corporation Antisense oligonucleotides that inhibit expression of hif-1
EP1601325B1 (de) * 2003-01-31 2009-09-02 Rexahn Corporation Antisense oligonukleotide, die die ausprägungsstufe von hif-1 hemmen
AU2004294950A1 (en) * 2003-11-26 2005-06-16 Entelos, Inc. Treatment of rheumatoid arthritis with Hypoxia-Inducible Factor 1alpha antagonists
EP1709175A2 (de) * 2003-12-03 2006-10-11 Corgentech, Inc. Hif-oligonukleotid-ködermoleküle
US20060003961A1 (en) * 2004-06-18 2006-01-05 The John Hopkins University Negative regulation of hypoxia inducible factor 1 by OS-9
EP1833840B9 (de) 2004-11-09 2010-11-10 Santaris Pharma A/S Wirksame lna-oligonukleotide zur inhibierung von hif-1a
US9447138B2 (en) 2004-11-09 2016-09-20 Roche Innovation Center Copenhagen A/S Potent LNA oligonucleotides for the inhibition of HIF-1a expression
KR100859506B1 (ko) * 2005-07-22 2008-09-22 한국과학기술연구원 프롤린 수산화반응에 의한 ｈｉｆ―1 펩타이드와 ｖｂｃ단백질과의 상호작용을 형광편광도를 이용하여 정량적으로분석하는 방법
CN100418574C (zh) * 2005-10-26 2008-09-17 王成球 一类封闭人类HIF-1α基因和调控网络中下游相关基因的染色质肽
US20070122448A1 (en) * 2005-11-28 2007-05-31 Alireza Rezania Compositions and methods to create a vascularized environment for cellular transplantation
LT2489733T (lt) 2006-06-07 2019-05-27 Genzyme Corporation Šoninės amiotrofinės sklerozės ir kitų nugaros smegenų sutrikimų genų terapija
US20080152654A1 (en) * 2006-06-12 2008-06-26 Exegenics, Inc., D/B/A Opko Health, Inc. COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS
US20080119433A1 (en) * 2006-07-06 2008-05-22 Aaron Thomas Tabor Compositions and Methods for Genetic Modification of Cells Having Cosmetic Function to Enhance Cosmetic Appearance
US7872118B2 (en) * 2006-09-08 2011-01-18 Opko Ophthalmics, Llc siRNA and methods of manufacture
LT3146982T (lt) 2006-10-03 2019-11-11 Genzyme Corp Amiotrofinės lateralinės sklerozės ir kitų nugaros smegenų sutrikimų genų terapija
WO2009102222A1 (en) * 2008-02-14 2009-08-20 Lincoln University Methods and compositions comprising trichoderma atroviride for the biological control of soil borne plant pathogens and promoting plant growth
US8470792B2 (en) 2008-12-04 2013-06-25 Opko Pharmaceuticals, Llc. Compositions and methods for selective inhibition of VEGF
CA2759801C (en) 2009-05-02 2019-04-02 Marco A. Passini Gene therapy for neurodegenerative disorders
BR112012000865A2 (pt) 2009-07-17 2019-09-24 T Tabor Aaron "composição e método para a modificação genética cosmética de células substancialmente intactas"
WO2011109427A2 (en) 2010-03-01 2011-09-09 Alnylam Pharmaceuticals, Inc. Improving the biological activity of sirna through modulation of its thermodynamic profile
US9446031B2 (en) 2012-01-18 2016-09-20 National University Of Singapore Compositions and methods for neovascularization
AU2014209218B2 (en) * 2013-01-25 2018-06-07 Xcell Biosciences, Inc. Methods, compositions, kits, and systems for selective enrichment of target cells
EP3122375B1 (de) 2014-03-28 2021-03-03 University of Washington through its Center for Commercialization Impfungen gegen brust- und eierstockkrebs
GB201601527D0 (en) 2016-01-27 2016-03-09 Univ Southampton Hif-1 and Hif-2 inhibitors
US20230212296A1 (en) * 2020-06-02 2023-07-06 Arizona Board Of Regents On Behalf Of The University Of Arizona Systems and methods for treating cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0479948B1 (de) * 1989-06-23 1998-08-26 Genentech, Inc. Zusammensetzungen und methoden zur synthese des b-rezeptors für das natriuretische protein und verwendungsmethoden
US5882914A (en) * 1995-06-06 1999-03-16 The Johns Hopkins University School Of Medicine Nucleic acids encoding the hypoxia inducible factor-1

Also Published As

Publication number Publication date
EP0833840A4 (de) 2001-12-19
ATE355299T1 (de) 2006-03-15
DE69636936D1 (de) 2007-04-12
JP2009077729A (ja) 2009-04-16
CA2222279A1 (en) 1996-12-12
CA2222279C (en) 2011-02-01
AU6332696A (en) 1996-12-24
EP1806357A1 (de) 2007-07-11
DE69636936T2 (de) 2007-10-31
US6222018B1 (en) 2001-04-24
IL118581A0 (en) 1996-10-16
WO1996039426A1 (en) 1996-12-12
US5882914A (en) 1999-03-16
JPH11507541A (ja) 1999-07-06
EP0833840A1 (de) 1998-04-08
AU704384B2 (en) 1999-04-22
EP0833840B1 (de) 2007-02-28
US6020462A (en) 2000-02-01

Similar Documents

Publication Publication Date Title
IL118581A0 (en) Optically crosslinked communication system
EP0335901A4 (en) Methods and compositions for the treatment of non-ige-mediated diseases
GR3007092T3 (de)
CA2009578A1 (en) Excitatory amino acid receptor antagonists
EP0945135A3 (de) Behandlung der Alzheimerkrankheit und Immunomodulation mit delta 5 Androstenen
ATE552891T1 (de) Kombination von sauren-proteaseenzymen und sauren pufferlösungen sowie deren verwendung
DE69534468D1 (de) Wachstums-differenzierungsfaktor-11
EP0169016A3 (en) Polypeptide cartilage-inducing factors found in bone
CA2156024A1 (en) Synthetic excitatory amino acids
AU3009089A (en) Tetrazole excitatory amino acid receptor antagonists
EP0920501B8 (de) Neuritin, ein neurogen
AU579593B2 (en) Novel peptides which are active on the central nervous system and have an action on the cholinergic system
FI880324A0 (fi) Foerfarande foer framstaellning av 4-tiazolidinkarboxylsyraderivat.
AU566133B2 (en) New polypeptide from thymus glands
ATE88349T1 (de) Hyperimmunizierte milch gegen bluthochdruck.
CA2006087A1 (en) Polypeptides isolated from the venom of the spider hololena curta
AU634003B2 (en) 4-benzyl-5-phenyl-2,4-dihydro-3h-1,2,4-triazol-3-ones and their use as anticonvulsants
HK1005877A1 (en) Cyclopentanperhydrophenanth ren-17beta-(3-furyl)-3- derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders
GR3017358T3 (en) 5-Aryl-3H-1,2,4-triazol-3-ones and their use as anticonvulsants.
EP0372503A3 (de) Antikoagulierende Peptide
AU569193B2 (en) Thymic humoral active peptides
EP0241136A3 (de) Humaner, Klasse 1 Heparin bindender, Wachstumsfaktor
EP0490383A3 (en) Peptides of the hiv-gag protein, their preparation and use
EP0235904A3 (de) Behandlung von Allergie mit Thymopentin
AU3230393A (en) Purified coriolus versicolor polypeptide complex

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees