IL118527A - Process for the preparation of D4T polymorphic form I of stavudine - Google Patents
Process for the preparation of D4T polymorphic form I of stavudineInfo
- Publication number
- IL118527A IL118527A IL11852796A IL11852796A IL118527A IL 118527 A IL118527 A IL 118527A IL 11852796 A IL11852796 A IL 11852796A IL 11852796 A IL11852796 A IL 11852796A IL 118527 A IL118527 A IL 118527A
- Authority
- IL
- Israel
- Prior art keywords
- polymorphic form
- stavudine
- preparation
- polymorphic
- approved
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- XNKLLVCARDGLGL-JGVFFNPUSA-N Stavudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1C=C[C@@H](CO)O1 XNKLLVCARDGLGL-JGVFFNPUSA-N 0.000 title 2
- 229960001203 stavudine Drugs 0.000 title 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/465,208 US5608048A (en) | 1995-06-05 | 1995-06-05 | d4 T polymorphic Form 1 process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL118527A0 IL118527A0 (en) | 1996-10-16 |
| IL118527A true IL118527A (en) | 2000-07-16 |
Family
ID=23846880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11852796A IL118527A (en) | 1995-06-05 | 1996-06-02 | Process for the preparation of D4T polymorphic form I of stavudine |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5608048A (de) |
| EP (1) | EP0749969B1 (de) |
| JP (1) | JP4208976B2 (de) |
| KR (1) | KR100375957B1 (de) |
| CN (1) | CN1058723C (de) |
| AT (1) | ATE205203T1 (de) |
| AU (1) | AU694653B2 (de) |
| CA (1) | CA2176181C (de) |
| DE (1) | DE69614936T2 (de) |
| DK (1) | DK0749969T3 (de) |
| ES (1) | ES2160768T3 (de) |
| GR (1) | GR3036768T3 (de) |
| HU (1) | HU222285B1 (de) |
| IL (1) | IL118527A (de) |
| MX (1) | MX9601957A (de) |
| PT (1) | PT749969E (de) |
| SG (1) | SG43372A1 (de) |
| TW (1) | TW336937B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001285197A1 (en) * | 2000-09-06 | 2002-03-22 | Bristol-Myers Squibb Company | Stavudine polymorphic form 1 process |
| US7825106B2 (en) * | 2003-09-03 | 2010-11-02 | Agi Therapeutics Ltd. | Modified release formulations and methods of treating inflammatory bowel disease |
| US7737133B2 (en) * | 2003-09-03 | 2010-06-15 | Agi Therapeutics Ltd. | Formulations and methods of treating inflammatory bowel disease |
| US20050131224A1 (en) * | 2003-12-15 | 2005-06-16 | Cti Pet Systems, Inc. | Method for preparing radiolabeled thymidine |
| US7160537B2 (en) * | 2003-12-15 | 2007-01-09 | Siemens Medical Solutions Usa, Inc. | Method for preparing radiolabeled thymidine having low chromophoric byproducts |
| WO2007099389A1 (en) * | 2005-07-11 | 2007-09-07 | Aurobindo Pharma Limited | A new improved process for the preparation of stavudine form i |
| ITMI20060360A1 (it) * | 2006-02-28 | 2007-09-01 | Clariant Lsm Italia Spa | Novel method for the preparation of stavudine polymorphic form 1 and form ii |
| EP2674517B1 (de) * | 2011-02-08 | 2018-10-03 | Japan Agency for Marine-Earth Science and Technology | Verfahren zur herstellung eines calcit-einkristalls |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4476248A (en) * | 1983-02-28 | 1984-10-09 | The Upjohn Company | Crystallization of ibuprofen |
| US4978655A (en) * | 1986-12-17 | 1990-12-18 | Yale University | Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses |
| US4904770A (en) * | 1988-03-24 | 1990-02-27 | Bristol-Myers Company | Production of 2',3'-dideoxy-2',3'-didehydronucleosides |
| US5539099A (en) * | 1993-11-15 | 1996-07-23 | Bristol-Myers Squibb Company | Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides |
| US5672698A (en) * | 1993-11-15 | 1997-09-30 | Bristol-Myers Squibb Co. | Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine |
| US5608049A (en) * | 1995-03-10 | 1997-03-04 | Bristol-Myers Squibb Company | Preparation of d4T from 5-methyluridine |
-
1995
- 1995-06-05 US US08/465,208 patent/US5608048A/en not_active Expired - Lifetime
-
1996
- 1996-05-03 TW TW085105338A patent/TW336937B/zh not_active IP Right Cessation
- 1996-05-09 CA CA002176181A patent/CA2176181C/en not_active Expired - Fee Related
- 1996-05-23 MX MX9601957A patent/MX9601957A/es unknown
- 1996-06-02 IL IL11852796A patent/IL118527A/xx not_active IP Right Cessation
- 1996-06-04 AU AU54692/96A patent/AU694653B2/en not_active Ceased
- 1996-06-04 PT PT96304030T patent/PT749969E/pt unknown
- 1996-06-04 HU HU9601517A patent/HU222285B1/hu not_active IP Right Cessation
- 1996-06-04 ES ES96304030T patent/ES2160768T3/es not_active Expired - Lifetime
- 1996-06-04 EP EP96304030A patent/EP0749969B1/de not_active Expired - Lifetime
- 1996-06-04 DE DE69614936T patent/DE69614936T2/de not_active Expired - Lifetime
- 1996-06-04 AT AT96304030T patent/ATE205203T1/de not_active IP Right Cessation
- 1996-06-04 DK DK96304030T patent/DK0749969T3/da active
- 1996-06-05 CN CN96110463A patent/CN1058723C/zh not_active Expired - Fee Related
- 1996-06-05 KR KR1019960020025A patent/KR100375957B1/ko not_active Expired - Fee Related
- 1996-06-05 JP JP14245796A patent/JP4208976B2/ja not_active Expired - Fee Related
- 1996-06-05 SG SG1996009966A patent/SG43372A1/en unknown
-
2001
- 2001-10-01 GR GR20010401625T patent/GR3036768T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4208976B2 (ja) | 2009-01-14 |
| JPH08333364A (ja) | 1996-12-17 |
| KR970001369A (ko) | 1997-01-24 |
| ATE205203T1 (de) | 2001-09-15 |
| PT749969E (pt) | 2001-12-28 |
| EP0749969A3 (de) | 1997-03-19 |
| DK0749969T3 (da) | 2001-11-26 |
| IL118527A0 (en) | 1996-10-16 |
| EP0749969B1 (de) | 2001-09-05 |
| HU9601517D0 (en) | 1996-07-29 |
| DE69614936D1 (de) | 2001-10-11 |
| AU5469296A (en) | 1996-12-19 |
| MX9601957A (es) | 1997-08-30 |
| US5608048A (en) | 1997-03-04 |
| TW336937B (en) | 1998-07-21 |
| EP0749969A2 (de) | 1996-12-27 |
| HU222285B1 (hu) | 2003-05-28 |
| KR100375957B1 (ko) | 2003-12-31 |
| CN1058723C (zh) | 2000-11-22 |
| CN1145903A (zh) | 1997-03-26 |
| AU694653B2 (en) | 1998-07-23 |
| HUP9601517A2 (en) | 1997-05-28 |
| GR3036768T3 (en) | 2002-01-31 |
| ES2160768T3 (es) | 2001-11-16 |
| HK1003435A1 (en) | 1998-10-30 |
| SG43372A1 (en) | 1997-10-17 |
| CA2176181C (en) | 2007-03-13 |
| DE69614936T2 (de) | 2002-04-25 |
| HUP9601517A3 (en) | 2000-03-28 |
| CA2176181A1 (en) | 1996-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |