IL118038A - 7-((2-carboalkoxy-1-methylethenyl) amino)-3-hydroxymethyl-3-cephem-4-carboxylic acids and process for their preparation - Google Patents

7-((2-carboalkoxy-1-methylethenyl) amino)-3-hydroxymethyl-3-cephem-4-carboxylic acids and process for their preparation

Info

Publication number
IL118038A
IL118038A IL11803896A IL11803896A IL118038A IL 118038 A IL118038 A IL 118038A IL 11803896 A IL11803896 A IL 11803896A IL 11803896 A IL11803896 A IL 11803896A IL 118038 A IL118038 A IL 118038A
Authority
IL
Israel
Prior art keywords
cephem
formula
methylethenyl
carboalkoxy
hydroxymethyl
Prior art date
Application number
IL11803896A
Other languages
English (en)
Other versions
IL118038A0 (en
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL118038A0 publication Critical patent/IL118038A0/xx
Publication of IL118038A publication Critical patent/IL118038A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL11803896A 1995-05-10 1996-04-26 7-((2-carboalkoxy-1-methylethenyl) amino)-3-hydroxymethyl-3-cephem-4-carboxylic acids and process for their preparation IL118038A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/438,322 US5552542A (en) 1995-05-10 1995-05-10 Preparation and use of 7-[(2-carboalkoxy-1-methylethenyl)amino]-3-hydroxymethyl-3-cephem-4-carboxylic acids

Publications (2)

Publication Number Publication Date
IL118038A0 IL118038A0 (en) 1996-08-04
IL118038A true IL118038A (en) 2000-01-31

Family

ID=23740199

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11803896A IL118038A (en) 1995-05-10 1996-04-26 7-((2-carboalkoxy-1-methylethenyl) amino)-3-hydroxymethyl-3-cephem-4-carboxylic acids and process for their preparation

Country Status (12)

Country Link
US (2) US5552542A (de)
EP (1) EP0742219B1 (de)
JP (1) JPH08301874A (de)
KR (1) KR960041184A (de)
CN (1) CN1055692C (de)
AT (1) ATE203540T1 (de)
AU (1) AU697524B2 (de)
CA (1) CA2173829A1 (de)
DE (1) DE69614030T2 (de)
ES (1) ES2158971T3 (de)
HU (1) HUP9601246A3 (de)
IL (1) IL118038A (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010031620A (ko) * 1997-10-30 2001-04-16 스티븐 비. 데이비스 데스아세틸-세팔로스포린의 화학적 아세틸화
BR112016007635A2 (pt) 2013-10-11 2017-09-12 Genentech Inc inibidores de nsp4 e métodos de uso

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK159154C (da) * 1975-02-24 1991-02-11 Takeda Chemical Industries Ltd Fremgangsmaade til fremstilling af cephalosporinderivater eller salte deraf
JPS5325589A (en) * 1976-08-03 1978-03-09 Toyama Chem Co Ltd Novel process for preparation of penicillins and cephalosporins
JPS5687584A (en) * 1979-12-20 1981-07-16 Nikken Kagaku Kk Preparation of 7-methoxycephem compound
JPS5690089A (en) * 1979-12-25 1981-07-21 Nikken Kagaku Kk Synthesis of 7-methoxycephem compound
JPS56150095A (en) * 1980-04-24 1981-11-20 Nikken Kagaku Kk Preparation of 7-methoxy-7-acylaminocephem compound
JPS5758690A (en) * 1980-09-25 1982-04-08 Nikken Kagaku Kk Preparation of 7-amino-7alpha-methoxycephem compound
JPS57188595A (en) * 1981-05-14 1982-11-19 Meiji Seika Kaisha Ltd 7alpha-methoxycephem compound and its preparation
US4584371A (en) * 1984-03-01 1986-04-22 The Upjohn Company Catalytic process for preparing 3-ester-methyl cephalosporins from desacetyl-7-aminocephalosporanic acid
US4908444A (en) * 1986-01-23 1990-03-13 Takeda Chemical Industries, Ltd. Method of producing cephem compounds
US5221739A (en) * 1992-01-09 1993-06-22 Eli Lilly And Company Acetylation of 3-hydroxymethyl cephalosporins

Also Published As

Publication number Publication date
AU5217596A (en) 1996-11-21
ATE203540T1 (de) 2001-08-15
CN1148044A (zh) 1997-04-23
CA2173829A1 (en) 1996-11-11
EP0742219A1 (de) 1996-11-13
CN1055692C (zh) 2000-08-23
DE69614030T2 (de) 2002-05-29
US5637694A (en) 1997-06-10
DE69614030D1 (de) 2001-08-30
HUP9601246A2 (en) 1997-02-28
IL118038A0 (en) 1996-08-04
HU9601246D0 (en) 1996-07-29
JPH08301874A (ja) 1996-11-19
KR960041184A (ko) 1996-12-19
ES2158971T3 (es) 2001-09-16
AU697524B2 (en) 1998-10-08
US5552542A (en) 1996-09-03
HUP9601246A3 (en) 2001-04-28
EP0742219B1 (de) 2001-07-25

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees