IL117626A - Process of atom or group transfer radical polymerization - Google Patents
Process of atom or group transfer radical polymerizationInfo
- Publication number
- IL117626A IL117626A IL117626A IL11762696A IL117626A IL 117626 A IL117626 A IL 117626A IL 117626 A IL117626 A IL 117626A IL 11762696 A IL11762696 A IL 11762696A IL 117626 A IL117626 A IL 117626A
- Authority
- IL
- Israel
- Prior art keywords
- group
- alkyl
- initiator
- transition metal
- polymerization
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 125
- 230000008569 process Effects 0.000 title claims abstract description 81
- 238000010526 radical polymerization reaction Methods 0.000 title claims abstract description 58
- 238000012546 transfer Methods 0.000 title claims abstract description 51
- 239000003999 initiator Substances 0.000 claims abstract description 139
- 229920000642 polymer Polymers 0.000 claims abstract description 138
- 150000003254 radicals Chemical class 0.000 claims abstract description 132
- 239000000178 monomer Substances 0.000 claims abstract description 119
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 93
- 229910052723 transition metal Inorganic materials 0.000 claims abstract description 54
- 150000003624 transition metals Chemical class 0.000 claims abstract description 54
- 229920001577 copolymer Polymers 0.000 claims abstract description 53
- 125000005843 halogen group Chemical group 0.000 claims abstract description 23
- -1 Cu(I)/Cu(II) Chemical class 0.000 claims abstract description 20
- 239000003054 catalyst Substances 0.000 claims abstract description 19
- 150000004820 halides Chemical class 0.000 claims abstract description 19
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 12
- 238000006243 chemical reaction Methods 0.000 claims description 64
- 239000003446 ligand Substances 0.000 claims description 59
- 125000000217 alkyl group Chemical group 0.000 claims description 55
- 125000004432 carbon atom Chemical group C* 0.000 claims description 49
- 239000000460 chlorine Substances 0.000 claims description 42
- 229910052736 halogen Inorganic materials 0.000 claims description 37
- 125000000623 heterocyclic group Chemical group 0.000 claims description 36
- 125000004429 atom Chemical group 0.000 claims description 35
- 125000003118 aryl group Chemical group 0.000 claims description 33
- 150000002367 halogens Chemical class 0.000 claims description 32
- 230000000977 initiatory effect Effects 0.000 claims description 31
- 150000003623 transition metal compounds Chemical class 0.000 claims description 30
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 22
- 239000002904 solvent Substances 0.000 claims description 22
- 229910052801 chlorine Inorganic materials 0.000 claims description 20
- 125000001424 substituent group Chemical group 0.000 claims description 20
- 230000002441 reversible effect Effects 0.000 claims description 17
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 15
- 230000000379 polymerizing effect Effects 0.000 claims description 15
- 125000003545 alkoxy group Chemical group 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 11
- 229910052794 bromium Inorganic materials 0.000 claims description 11
- 229910052799 carbon Inorganic materials 0.000 claims description 11
- 125000003342 alkenyl group Chemical group 0.000 claims description 8
- 239000010949 copper Substances 0.000 claims description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
- 229910052740 iodine Inorganic materials 0.000 claims description 8
- 125000000304 alkynyl group Chemical group 0.000 claims description 7
- 125000000058 cyclopentadienyl group Chemical group C1(=CC=CC1)* 0.000 claims description 7
- ZSWFCLXCOIISFI-UHFFFAOYSA-N endo-cyclopentadiene Natural products C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 claims description 7
- 125000002947 alkylene group Chemical group 0.000 claims description 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 5
- 125000004104 aryloxy group Chemical group 0.000 claims description 5
- 229910052751 metal Inorganic materials 0.000 claims description 5
- 239000002184 metal Substances 0.000 claims description 5
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 4
- 239000005977 Ethylene Substances 0.000 claims description 4
- 150000004945 aromatic hydrocarbons Chemical class 0.000 claims description 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 4
- 125000003055 glycidyl group Chemical group C(C1CO1)* 0.000 claims description 4
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims description 4
- 150000004032 porphyrins Chemical class 0.000 claims description 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 3
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 239000007789 gas Substances 0.000 claims description 3
- 229910052760 oxygen Inorganic materials 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims description 3
- 241001120493 Arene Species 0.000 claims description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 2
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims description 2
- 229910052783 alkali metal Inorganic materials 0.000 claims description 2
- 150000001340 alkali metals Chemical class 0.000 claims description 2
- 125000004450 alkenylene group Chemical group 0.000 claims description 2
- 125000005228 aryl sulfonate group Chemical group 0.000 claims description 2
- 229910052802 copper Inorganic materials 0.000 claims description 2
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 claims description 2
- 229910052742 iron Inorganic materials 0.000 claims description 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 2
- 229910052707 ruthenium Inorganic materials 0.000 claims description 2
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims 1
- 238000010560 atom transfer radical polymerization reaction Methods 0.000 abstract description 146
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 abstract description 58
- VMQMZMRVKUZKQL-UHFFFAOYSA-N Cu+ Chemical compound [Cu+] VMQMZMRVKUZKQL-UHFFFAOYSA-N 0.000 abstract description 31
- 238000009826 distribution Methods 0.000 abstract description 24
- 239000000543 intermediate Substances 0.000 abstract description 11
- 238000006479 redox reaction Methods 0.000 abstract description 9
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 abstract description 7
- 150000001252 acrylic acid derivatives Chemical class 0.000 abstract description 6
- 229920002725 thermoplastic elastomer Polymers 0.000 abstract description 4
- 101710141544 Allatotropin-related peptide Proteins 0.000 abstract description 3
- 238000004458 analytical method Methods 0.000 abstract description 3
- 229920001971 elastomer Polymers 0.000 abstract description 3
- 239000000806 elastomer Substances 0.000 abstract description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 abstract description 2
- 239000000853 adhesive Substances 0.000 abstract description 2
- 230000001070 adhesive effect Effects 0.000 abstract description 2
- 229920003023 plastic Polymers 0.000 abstract description 2
- 239000004033 plastic Substances 0.000 abstract description 2
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 82
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical compound N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 description 79
- 229910021591 Copper(I) chloride Inorganic materials 0.000 description 36
- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 description 36
- 238000001542 size-exclusion chromatography Methods 0.000 description 32
- 241000894007 species Species 0.000 description 29
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 24
- 229920001400 block copolymer Polymers 0.000 description 23
- 125000001309 chloro group Chemical group Cl* 0.000 description 22
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 20
- 150000001336 alkenes Chemical class 0.000 description 19
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 19
- 239000004926 polymethyl methacrylate Substances 0.000 description 19
- 239000000203 mixture Substances 0.000 description 18
- 239000000047 product Substances 0.000 description 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 230000015572 biosynthetic process Effects 0.000 description 15
- 230000000694 effects Effects 0.000 description 14
- 230000007246 mechanism Effects 0.000 description 14
- 239000004793 Polystyrene Substances 0.000 description 13
- 238000003786 synthesis reaction Methods 0.000 description 13
- 229920002319 Poly(methyl acrylate) Polymers 0.000 description 12
- 229920002223 polystyrene Polymers 0.000 description 12
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 12
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 11
- 238000007259 addition reaction Methods 0.000 description 11
- 229920002521 macromolecule Polymers 0.000 description 11
- 238000007342 radical addition reaction Methods 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 9
- 230000009849 deactivation Effects 0.000 description 9
- 230000009257 reactivity Effects 0.000 description 9
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 9
- 229920002554 vinyl polymer Polymers 0.000 description 9
- OZAIFHULBGXAKX-VAWYXSNFSA-N AIBN Substances N#CC(C)(C)\N=N\C(C)(C)C#N OZAIFHULBGXAKX-VAWYXSNFSA-N 0.000 description 8
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 8
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 7
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 6
- 239000004342 Benzoyl peroxide Substances 0.000 description 6
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- 229910021589 Copper(I) bromide Inorganic materials 0.000 description 6
- 229910021592 Copper(II) chloride Inorganic materials 0.000 description 6
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 6
- 101100030361 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pph-3 gene Proteins 0.000 description 6
- 238000007792 addition Methods 0.000 description 6
- 238000013459 approach Methods 0.000 description 6
- 235000019400 benzoyl peroxide Nutrition 0.000 description 6
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 6
- 230000000875 corresponding effect Effects 0.000 description 6
- 229910052731 fluorine Inorganic materials 0.000 description 6
- 239000011737 fluorine Substances 0.000 description 6
- 230000003647 oxidation Effects 0.000 description 6
- 238000007254 oxidation reaction Methods 0.000 description 6
- 229920005604 random copolymer Polymers 0.000 description 6
- GTLWADFFABIGAE-UHFFFAOYSA-N 1-chloroethylbenzene Chemical compound CC(Cl)C1=CC=CC=C1 GTLWADFFABIGAE-UHFFFAOYSA-N 0.000 description 5
- JNAYPRPPXRWGQO-UHFFFAOYSA-N 2-chloropropanenitrile Chemical compound CC(Cl)C#N JNAYPRPPXRWGQO-UHFFFAOYSA-N 0.000 description 5
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 5
- 238000005481 NMR spectroscopy Methods 0.000 description 5
- 230000004913 activation Effects 0.000 description 5
- 125000001246 bromo group Chemical group Br* 0.000 description 5
- 150000001721 carbon Chemical group 0.000 description 5
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 238000006276 transfer reaction Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 101150039033 Eci2 gene Proteins 0.000 description 4
- 102100021823 Enoyl-CoA delta isomerase 2 Human genes 0.000 description 4
- 239000012190 activator Substances 0.000 description 4
- 150000001350 alkyl halides Chemical class 0.000 description 4
- 230000002902 bimodal effect Effects 0.000 description 4
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 4
- 230000003197 catalytic effect Effects 0.000 description 4
- 230000003412 degenerative effect Effects 0.000 description 4
- 238000010494 dissociation reaction Methods 0.000 description 4
- 230000005593 dissociations Effects 0.000 description 4
- 235000019439 ethyl acetate Nutrition 0.000 description 4
- HOXINJBQVZWYGZ-UHFFFAOYSA-N fenbutatin oxide Chemical compound C=1C=CC=CC=1C(C)(C)C[Sn](O[Sn](CC(C)(C)C=1C=CC=CC=1)(CC(C)(C)C=1C=CC=CC=1)CC(C)(C)C=1C=CC=CC=1)(CC(C)(C)C=1C=CC=CC=1)CC(C)(C)C1=CC=CC=C1 HOXINJBQVZWYGZ-UHFFFAOYSA-N 0.000 description 4
- 125000001624 naphthyl group Chemical group 0.000 description 4
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 4
- 230000001376 precipitating effect Effects 0.000 description 4
- 238000006894 reductive elimination reaction Methods 0.000 description 4
- 230000027756 respiratory electron transport chain Effects 0.000 description 4
- 230000000087 stabilizing effect Effects 0.000 description 4
- KGIGUEBEKRSTEW-UHFFFAOYSA-N 2-vinylpyridine Chemical compound C=CC1=CC=CC=N1 KGIGUEBEKRSTEW-UHFFFAOYSA-N 0.000 description 3
- 101100433757 Arabidopsis thaliana ABCG32 gene Proteins 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 150000001351 alkyl iodides Chemical class 0.000 description 3
- 125000003710 aryl alkyl group Chemical group 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- AOJDZKCUAATBGE-UHFFFAOYSA-N bromomethane Chemical compound Br[CH2] AOJDZKCUAATBGE-UHFFFAOYSA-N 0.000 description 3
- 238000012662 bulk polymerization Methods 0.000 description 3
- 238000006555 catalytic reaction Methods 0.000 description 3
- 238000010538 cationic polymerization reaction Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- YACLQRRMGMJLJV-UHFFFAOYSA-N chloroprene Chemical compound ClC(=C)C=C YACLQRRMGMJLJV-UHFFFAOYSA-N 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- XYNZKHQSHVOGHB-UHFFFAOYSA-N copper(3+) Chemical compound [Cu+3] XYNZKHQSHVOGHB-UHFFFAOYSA-N 0.000 description 3
- WIWBLJMBLGWSIN-UHFFFAOYSA-L dichlorotris(triphenylphosphine)ruthenium(ii) Chemical compound [Cl-].[Cl-].[Ru+2].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 WIWBLJMBLGWSIN-UHFFFAOYSA-L 0.000 description 3
- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 3
- IOLQWGVDEFWYNP-UHFFFAOYSA-N ethyl 2-bromo-2-methylpropanoate Chemical compound CCOC(=O)C(C)(C)Br IOLQWGVDEFWYNP-UHFFFAOYSA-N 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 125000000524 functional group Chemical group 0.000 description 3
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- 150000008282 halocarbons Chemical class 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 229920001519 homopolymer Polymers 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 238000012690 ionic polymerization Methods 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 125000002524 organometallic group Chemical group 0.000 description 3
- 230000037361 pathway Effects 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 229920000058 polyacrylate Polymers 0.000 description 3
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- 125000004076 pyridyl group Chemical group 0.000 description 3
- 239000012966 redox initiator Substances 0.000 description 3
- 238000007086 side reaction Methods 0.000 description 3
- 229920000428 triblock copolymer Polymers 0.000 description 3
- BDZBKCUKTQZUTL-UHFFFAOYSA-N triethyl phosphite Chemical compound CCOP(OCC)OCC BDZBKCUKTQZUTL-UHFFFAOYSA-N 0.000 description 3
- KGKAYWMGPDWLQZ-UHFFFAOYSA-N 1,2-bis(bromomethyl)benzene Chemical group BrCC1=CC=CC=C1CBr KGKAYWMGPDWLQZ-UHFFFAOYSA-N 0.000 description 2
- OYSVBCSOQFXYHK-UHFFFAOYSA-N 1,3-dibromo-2,2-bis(bromomethyl)propane Chemical compound BrCC(CBr)(CBr)CBr OYSVBCSOQFXYHK-UHFFFAOYSA-N 0.000 description 2
- KPZGRMZPZLOPBS-UHFFFAOYSA-N 1,3-dichloro-2,2-bis(chloromethyl)propane Chemical compound ClCC(CCl)(CCl)CCl KPZGRMZPZLOPBS-UHFFFAOYSA-N 0.000 description 2
- NHTOCAPMPOWVNP-UHFFFAOYSA-L 2,4-ditert-butylphenolate;methylaluminum(2+) Chemical compound [Al+2]C.CC(C)(C)C1=CC=C([O-])C(C(C)(C)C)=C1.CC(C)(C)C1=CC=C([O-])C(C(C)(C)C)=C1 NHTOCAPMPOWVNP-UHFFFAOYSA-L 0.000 description 2
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 2
- XXSPGBOGLXKMDU-UHFFFAOYSA-N 2-bromo-2-methylpropanoic acid Chemical compound CC(C)(Br)C(O)=O XXSPGBOGLXKMDU-UHFFFAOYSA-N 0.000 description 2
- PGMMQIGGQSIEGH-UHFFFAOYSA-N 2-ethenyl-1,3-oxazole Chemical compound C=CC1=NC=CO1 PGMMQIGGQSIEGH-UHFFFAOYSA-N 0.000 description 2
- JDCUKFVNOWJNBU-UHFFFAOYSA-N 2-ethenyl-1,3-thiazole Chemical compound C=CC1=NC=CS1 JDCUKFVNOWJNBU-UHFFFAOYSA-N 0.000 description 2
- MLMGJTAJUDSUKA-UHFFFAOYSA-N 2-ethenyl-1h-imidazole Chemical compound C=CC1=NC=CN1 MLMGJTAJUDSUKA-UHFFFAOYSA-N 0.000 description 2
- MZNSQRLUUXWLSB-UHFFFAOYSA-N 2-ethenyl-1h-pyrrole Chemical compound C=CC1=CC=CN1 MZNSQRLUUXWLSB-UHFFFAOYSA-N 0.000 description 2
- KANZWHBYRHQMKZ-UHFFFAOYSA-N 2-ethenylpyrazine Chemical compound C=CC1=CN=CC=N1 KANZWHBYRHQMKZ-UHFFFAOYSA-N 0.000 description 2
- ZDHWTWWXCXEGIC-UHFFFAOYSA-N 2-ethenylpyrimidine Chemical compound C=CC1=NC=CC=N1 ZDHWTWWXCXEGIC-UHFFFAOYSA-N 0.000 description 2
- DTYXUWCJYMNDQD-UHFFFAOYSA-N 3-ethenylpyridazine Chemical compound C=CC1=CC=CN=N1 DTYXUWCJYMNDQD-UHFFFAOYSA-N 0.000 description 2
- UMKWZZPKADNTRP-UHFFFAOYSA-N 4-ethenylpyrimidine Chemical compound C=CC1=CC=NC=N1 UMKWZZPKADNTRP-UHFFFAOYSA-N 0.000 description 2
- YPIINMAYDTYYSQ-UHFFFAOYSA-N 5-ethenyl-1h-pyrazole Chemical compound C=CC=1C=CNN=1 YPIINMAYDTYYSQ-UHFFFAOYSA-N 0.000 description 2
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- 125000005956 isoquinolyl group Chemical group 0.000 description 1
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- 125000000842 isoxazolyl group Chemical group 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
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- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical group C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- ACEONLNNWKIPTM-UHFFFAOYSA-N methyl 2-bromopropanoate Chemical compound COC(=O)C(C)Br ACEONLNNWKIPTM-UHFFFAOYSA-N 0.000 description 1
- JLEJCNOTNLZCHQ-UHFFFAOYSA-N methyl 2-chloropropanoate Chemical compound COC(=O)C(C)Cl JLEJCNOTNLZCHQ-UHFFFAOYSA-N 0.000 description 1
- NRQNMMBQPIGPTB-UHFFFAOYSA-N methylaluminum Chemical compound [CH3].[Al] NRQNMMBQPIGPTB-UHFFFAOYSA-N 0.000 description 1
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- 239000011707 mineral Substances 0.000 description 1
- 239000012778 molding material Substances 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052758 niobium Inorganic materials 0.000 description 1
- 239000010955 niobium Substances 0.000 description 1
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 description 1
- 238000006396 nitration reaction Methods 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 238000005580 one pot reaction Methods 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
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- 150000002978 peroxides Chemical class 0.000 description 1
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- XCRBXWCUXJNEFX-UHFFFAOYSA-N peroxybenzoic acid Chemical compound OOC(=O)C1=CC=CC=C1 XCRBXWCUXJNEFX-UHFFFAOYSA-N 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
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- 125000005561 phenanthryl group Chemical group 0.000 description 1
- 125000001791 phenazinyl group Chemical group C1(=CC=CC2=NC3=CC=CC=C3N=C12)* 0.000 description 1
- 125000001484 phenothiazinyl group Chemical group C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 description 1
- 125000005954 phenoxathiinyl group Chemical group 0.000 description 1
- 125000001644 phenoxazinyl group Chemical group C1(=CC=CC=2OC3=CC=CC=C3NC12)* 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 description 1
- 125000001388 picenyl group Chemical group C1(=CC=CC2=CC=C3C4=CC=C5C=CC=CC5=C4C=CC3=C21)* 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 229920001195 polyisoprene Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920005553 polystyrene-acrylate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000012673 precipitation polymerization Methods 0.000 description 1
- 150000003138 primary alcohols Chemical group 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- AOHJOMMDDJHIJH-UHFFFAOYSA-N propylenediamine Chemical compound CC(N)CN AOHJOMMDDJHIJH-UHFFFAOYSA-N 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 125000001042 pteridinyl group Chemical group N1=C(N=CC2=NC=CN=C12)* 0.000 description 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
- 125000001725 pyrenyl group Chemical group 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- 125000005493 quinolyl group Chemical group 0.000 description 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
- 238000007154 radical cyclization reaction Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 235000015096 spirit Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000011115 styrene butadiene Substances 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000010557 suspension polymerization reaction Methods 0.000 description 1
- 125000001935 tetracenyl group Chemical group C1(=CC=CC2=CC3=CC4=CC=CC=C4C=C3C=C12)* 0.000 description 1
- ZUHZGEOKBKGPSW-UHFFFAOYSA-N tetraglyme Chemical compound COCCOCCOCCOCCOC ZUHZGEOKBKGPSW-UHFFFAOYSA-N 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- DBGVGMSCBYYSLD-UHFFFAOYSA-N tributylstannane Chemical compound CCCC[SnH](CCCC)CCCC DBGVGMSCBYYSLD-UHFFFAOYSA-N 0.000 description 1
- YFNKIDBQEZZDLK-UHFFFAOYSA-N triglyme Chemical compound COCCOCCOCCOC YFNKIDBQEZZDLK-UHFFFAOYSA-N 0.000 description 1
- 125000003960 triphenylenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C3=CC=CC=C3C12)* 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
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- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
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- C08F136/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds
- C08F136/02—Homopolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds the radical having only two carbon-to-carbon double bonds
- C08F136/04—Homopolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds the radical having only two carbon-to-carbon double bonds conjugated
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- C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
- C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
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Abstract
A new polymerization process (atom transfer radical polymerization, or ATRP) based on a redox reaction between a transition metal (e.g., Cu(I)/Cu(II), provides "living" or controlled radical polymerization of styrene, (meth)acrylates, and other radically polymerizable monomers. Using various simple organic halides as model halogen atom transfer precursors (initiators) and transition metal complexes as a model halogen atom transfer promoters (catalysts), a "living" radical polymerization affords (co)polymers having the predetermined number average molecular weight by [M]/[I] 0 (up to M n > 10 5 ) and a surprisingly narrow molecular weight distribution (M w /M n ), as low as 1.15. The participation of free radical intermediates in ATRP is supported by end-group analysis and stereochemistry of the polymerization. In addition, polymers with various topologies (e.g., block, random, star, end-functional and in-chain functional copolymers [for example, of styrene and methyl (meth)acrylate]) have been synthesized using the present process. The polymeric products encompassed by the present invention can be widely used as plastics, elastomers, adhesives, emulsifiers, thermoplastic elastomers, etc.
Description
1 17,626/3 A PROCESS OF ATOM OR GROUP TRANSFER RADICAL POLYMERIZATION 1 17,626/4 .1 FIELD OF THE INVENTION The present invention concerns a novel radical polymerization process based on transition metal-mediated atom or group transfer polymerization.
For example, EP 341012 ("Kaszas") describes a cationic living polymerization process. The cationic polymerizations of Kaszas utilize a Lewis acid to heterolytically extract a halogen (or other X group) from the initiator to form a carbocation, which initiates the polymerization. Olefinic monomers (limited to compounds containing only hydrogen and carbon atoms) add to the formed carbocation to begin the polymerization.
Cationic polymerizations, such as described Kazsas, require the addition of an electron donor species to minimize the termination reactions and therefore better control the polymerization reaction. The radical polymerization process described herein does not require an electron donor compound. In the described cationic polymerization, the Lewis acid participates in heterolytic cleavage of the initiator molecule into ionic species. However, in ATRP, the transition metal must be able to participate in a redox cycle involving transfer of an atom or group to and from the initiator or dormant polymer chain end. This involves a hemolytic scission of the initiator molecule at the bond between the initiator residue and the radically transferable atom or group to form a free radical.
It is to be noted that only subject matter embraced in the scope of the claims appended hereto, whether in the manner defined in the claims or in a manner similar thereto and involving the main features as defined in the claims, is intended to be included in the scope of the present invention, while subject matter described and exemplified to provide background and better understanding of the invention, is not intended for inclusions as part of the present invention. 117,626/1 1a DISCUSSION OF THE BACKGROUND Living polymerization renders unique possibilities of preparing a multitude of polymers which are well-defined in terms of molecular dimension, polydispersity, topology, composition, functionalization and microstructure. Many living systems based on anionic, cationic and several other types of initiators have been developed over the past 40 years (see O.W. Webster, Science, 251 , 887 (1991 ).
However, in comparison to other living systems, living radical polymerization represented a poorly answered challenge prior to the present invention. It was difficult to control the molecular weight and the polydispersity to achieve a highly uniform product of desired structure by prior radical polymerization processes.
On the other hand, radical polymerization offers the advantages of being applicable to polymerization of a wide variety of commercially important monomers, many of which cannot be polymerized by other polymerization processes.
Moreover, it is easier to make random copolymers · by radical polymerization than by other (e.g. , ionic) polymerization processes. Certain block copolymers cannot be made by other polymerization processes. Further, radical polymerization processes can be conducted in bulk, in solution, in suspension or in an emulsion, in contrast to other polymerization processes .
Thus, a need is strongly felt for a radical polymerization process which provides (co) polymers having a predetermined molecular weight, a narrow molecular weight distribution (low "polydispersity" ) , various topologies and controlled, uniform structures.
Three approaches to preparation of controlled polymers in a "living" radical process have been described (Greszta et al. Macromolecules , 27, 638 (1994)). The first approach involves the situation where growing radicals react reversibly with scavenging radicals to form covalent species. The second approach involves the situation where growing radicals react reversibly with covalent species to produce persistent radicals. The third approach involves the situation where growing radicals participate in a degenerative transfer reaction which regenerates the same type of radicals.
There are some patents and articles on living/controlled radical polymerization. Some of the best-controlled polymers obtained by "living" radical polymerization are prepared with preformed alkoxyamines or are those prepared in situ (U.S.
Patent 4,581,429; Georges et al, Macromolecules , 26, 2987 (1993)). A Co-containing complex has been used to prepare "living" polyacrylates (Wayland, B. B., Pszmik, G. , Mukerjee, S. L. , Fryd, M. J. Am. Chem. Soc . , 116, 7943 (1994)). A "living" poly (vinyl acetate) can be prepared using an Al(i-Bu)3: Bpy: EMPO initiating system (Mardare et al, Macromolecules , 27, 645 (1994)). An initiating system based on benzoyl peroxide and chromium acetate has been used to conduct the controlled radical polymerization of methyl methacrylate and vinyl acetate (Lee et al, J. Chem. Soc.
Trans. Faraday Soc. I, 74, 1726 (1978); Mardare et al. Polym. Prep. (ACS), 36(1) (1995)).
However, none of these "living" polymerization systems include an atom transfer process based on a redox reaction with a transition metal compound.
One paper describes a redox iniferter system based on Ni(0) and benzyl halides. However, a very broad and bimodal molecular weight distribution was obtained, and the initiator efficiency based on benzyl halides used was < 1% (T. Otsu, T. Tashinori, M. Yoshioka, Chem. Express 1990, 5(10), 801).
Another paper describes the polymerization of methyl methacrylate, initiated by CC1„ in the presence of RuCl2(PPh3)3 However, the reaction does not occur without methylaluminum bis (2 , 6-di-tert-butylphenoxide) , added as an activator (see M. Kato, M. Kamigaito, M. Sawamoto, T. Higashimura, Macromolecules , 28, 1721 (1995)). This system is similar to the redox initiators developed early (Bamford, in Comprehensive Polymer Science (First Supplement) , Allen, G. , Aggarwal, S. L. , Russo, S., eds., Pergamon: Oxford, 1991, vol. 3, p. 123), in which the small amount of initiating radicals were generated by redox reaction between (1) RCHX2 or RCX3 (where X = Br, Cl) and (2) Ni(0) and other transition metals. The reversible deactivation of initiating radicals by oxidized Ni is very slow in comparison with propagation, resulting in very low initiator efficiency and a very broad and bimodal molecular weight distribution.
Atom transfer radical addition, ATRA, is a well-known method for carbon-carbon bond formation in organic synthesis. (For reviews of atom transfer methods in organic synthesis, see (a) Curran, D. P. Synthesis, 1988, 489; (b) Curran, D. P. in Free Radicals in Synthesis and Biology, Minisci, F. , ed., Kluwer: Dordrecht, 1989, p. 37; and (c) Curran, D. P. in Comprehensive Organic Synthesis, Trost, B. M. , Fleming, I., eds., Pergamon: Oxford, 1991, Vol. 4, p. 715.) In a very broad class of ATRA, two types of atom transfer methods have been largely developed. One of them is known as atom abstraction or ho olytic substitution (see (a) Curran et al, J. Org. Chem., 1989, 54, 3140; and (b) Curran et al, J . Am.
Chem. Soc, 1994 , 116, 4279), in which a univalent atom (typically a halogen) or a group (such as SPh or SePh) is transferred from a neutral molecule to a radical to form a new a-bond and a new radical in accordance with Scheme 1 below: Scheme 1 : + Rj-X — Rj ' + Ri- X = I, SePh, SPh, ...
In this respect, iodine atom and the SePh group were found to work very well, due to the presence of very weak C-I and C-SePh bonds towards the reactive radicals (Curran et al.
J. Org. Chem. and J. Am. Chem. Soc, supra). In earlier work, the present inventors have discovered that alkyl iodides may induce the degenerative transfer process in radical polymerization, leading to a controlled radical polymerization of several alkenes. This is consistent with the fact that alkyl iodides are outstanding iodine atom donors that can undergo a fast and reversible transfer in an initiation step and degenerative transfer in a propagation step (see Gavnor et al, Polym. Prep. (Am. Chem. Soc, Polym. Chem. Div.), 1995 , 36(1), 467; Wang et al. Polym. Prep. (Am. Chem. Soc, Polym. Chem. Div.), 1995 , 36(1), 465).
Another atom transfer method is promoted by a transition metal species (see (a) Bellus, D. Pure & Appl . Chem. 1985 , 57, 1827; (b) Nagashima, H. ; Ozaki, N. ; Ishii, M. ; Seki, K. ; , Washiyama, M. ; Itoh, X. J. Org-. Che . 1*93, 58, 464; (c) Udding, J. H. ; Tuijp, X. J. M. ; van Zanden, M. A. ; Hiemstra, H. ; Speckamp, W. N. J. Org. Chem. 1S94, 59, 19S3; (c) Seiias et al, tetrahedron , 1392, 48(9), 1537; (d) Nagashima , K. ; Wakaaatsu, H. ; Ozaki, N.; Ishii, T. ; Watanabe, M. ; Tajima,' T.; Itoh, . J. Org. Chem. 1992, 57, 16S2; (e) Hayes, T. K. ; Villani, R. ; Weinreb, S. M. J. Am. Chem. Soc . 1988, 110, 5533; (f) Hirao et al. Syn . Lett., 1990, 217; and (g) Hirao et al , J. Synth. Org. Chem. (Japan), 1994, 52(3), 197; (h) Igbal, J; Bhatia, B. ; Nayyar, N. K. Chem. Rev., 94, 519 (1994) ) . In these reactions, a catalytic amount of transition metal compound acts as a carrier of the halogen atom in a redox process, in accordance with Figure 1.
Initially, the transition metal species, cn, abstracts halogen atom X from the organic halide, R-X, to form the oxidized species, ^"^Χ, and the carbon-centered radical R*.
"Mtn represents the transition metal species wherein the transition metal has an oxidation number of n. Examples of transition metal species in the lower oxidation state are Cu(l)CI, Fe(ll)CI2, Ni(0), RuCI2, CuBr, etc." "Mtn+ X is the original transition metal species in the lower oxidation state after undergoing a redox reaction with the initiator or dormant chain to accept the halogen, X. This results in the transition metal of a higher oxidation state, n+1 ." In the subsequent step, the radical, R*, reacts with alkene, M, with the formation of the intermediate radical species, R-M*.
The reaction between Mcn*1X and R-M' results in the target product, R-M-X, and regenerates the reduced transition metal species, Mcn, which further reacts with R-"X and promotes a new redox process.
The high efficiency of transition metal-catalyzed atom transfer reactions in producing the target product, R-M-X, in good to excellent yields (often > 90%) may suggest that the presence of an Μεη/Μεη*1 cycle-based redox process can effectively compete with the bimolecular termination reactions between radicals (see Curran , Synthesis , in Free Radicals in Synthesis and Biology, and in Comprehensive Organic Synthesis , supra) .
It is difficult to control the molecular weight and the polydispersity (molecular weight distribution) of polymers produced by radical polymerization. Thus, it is often difficult to achieve a highly uniform and well-defined product.. It is also often difficult to control radical polymerization processes with the degree of certainty necessary in specialized applications, such as in the preparation of end functional polymers, block copolymers, star (co) polymers , etc. Further, although several initiating systems have been reported for "living"/controlled polymerization, no general pathway or process for "living"/ controlled polymerization has been discovered.
Thus, a need is strongly felt for a radical polymerization process which provides (co) polymers having a predictable molecular weight and a narrow molecular weight distribution (low "polydispersity") . A further need is strongly felt for a radical polymerization process which is sufficiently flexible to provide a wide variety of products, but which can be controlled to the degree necessary to provide highly uniform products with a controlled structure (i.e., controllable topology, composition, stereoregularity, etc.), many of which are suitable for highly specialized uses (such -8- 117,626/2 as thermoplastic elastomers, end-functional polymers for chain-extended polyurethanes, polyesters and polyamides, dispersants for polymer blends, etc.).
SUMMARY OF THE INVENTION Accordingly, one object of the present invention is to provide a novel method for radical polymerization of alkenes based on atom transfer radical polymerization (ATRP) , which provides a high degree of control over the polymerization process .
A further object of the present invention is to provide a novel method for radical polymerization of alkenes based on atom transfer radical polymerization (ATRP) , which leads to more uniform and more highly controllable products (which are now obtainable only by living ionic polymerization methods) .
A further object of the present invention is to provide a broad variety of novel (co) polymers having more uniform properties than those obtained by conventional radical polymeriz tion.
These and other objects of the present invention, which will be readily understood in the context of the following detailed description of the preferred embodiments, have been provided in part by a - S - 117,626/3 controlled free radical polymerization process, of atom or group transfer radical polymerization, comprising the steps of: radically polymerizing one or more radically (co)poiymerizable monomers in the presence of an initiator having a radically transferable atom or group, and a catalyst system comprising a transition metal compound which participates in a reversible redox cycle with said initiator or a dormant polymer chain end, and a ligand to form a (co)polymer, and the ligand being any N- 0-, P- or S- containing compound which can coordinate in a σ-bond to the transition metal or any carbon-containing compound which can coordinate in a π-bond to the transition metal, such that direct bonds between the transition metal and growing polymer radicals are not formed, wherein said transition metal compound and said ligand are matched with one another in order to provide reaction with said initiator to reversibly generate a radical. .
BRIEF DESCRIPTION OF THE FIGURES Figure 1 shows an atom transfer method in which a catalytic amount of transition metal catalyst acts as a carrier of the halogen atom in a redox process; Figure 2 shows a scheme for " living" /controlled radical polymerization based on a succession of -atom transfer radical additions ; Figure 3 is a graph of the kinetics of methyl acrylate ("MA") bulk polymerization at 130°C, initiated with 1-phenylethyl chloride in the presence of Cu(I)Cl (1 equiv.) and bipyridine (Bpy; 3 equiv.); Figure 4 is a graph showing that the experimental molecular weight, M-,^, increases with monomer conversion; Figure 5 is a graph showing that the experimental molecular weight, Mn>SEC, matches the theoretical molecular weight, M„ ch, and plotting the polydispersity , Μ,,/Μ.,, as a function of monomer conversion; Figure 6 shows the correlation of the experimental molecular weights, Mn SEC, with the theoretical molecular weights, Mn ch , for a series of bulk ATRP's of MA carried out at 130°C using various monomer/ initiator molar ratios and a constant, ligand/catalyst/ initiator molar ratio of 3/1/1; Figures 7A and 7B show the lH NMR spectra of PSt prepared at 130°C using 2-chloropropionitrile as an initiator, in the presence of 1 molar equiv. of CuCl and 3 molar equiv. of Bpy; Figures 8A and 8B compare the 13C NMR spectra of the C=0 group and the quaternary carbon atom of PMMA prepared at 100 °C using methyl 2-bromoisobutyrate ("2-MiBBr") , CuBr and Bpy in a 1/1/3 molar ratio (Fig. 8A) , and of PMMA prepared using a classic radical initiator, AIBN (Fig. 8B) ; Figure 9 shows the kinetic plots of the ATRP of three typical monomers (styrene, "St", methyl aerylate, "MA", and methyl methacrylate, "MMA") using the 1/1/3 1-PECl/CuCl/Bpy initiator system, under the same experimental conditions (in bulk, at 130°C) ; Figures 10 and 11 are graphs comparing the experimental molecular weight, Mn SEC, with the theoretical molecular weight, Mn ch, and plotting the polydispersity, Mw/Mn , as a function of -11- monomer conversion when X = X' = CI ("CI ATRP" ; Fig. 10) and when X = X' = Br ("Br ATRP"; Fig. 11); Figures 12A-C show plots of ln(kpapp) vs. In ( [ l-PECl] 0) , ln(kpapp) vs. ln([CuCl]0), and ln(kpapp) vs ln([Bpy]0 for St ATRP in bulk at 130°C; Figures 13A-C are graphs showing the effects of [CuCl]0 on the initiator efficiency and the molecular weight distribution for St ATRP in bulk at 130 °C; Figures 14A-B are graphs demonstrating similar results for MA ATRP; Figure 15 is a scheme showing an overall two-electron change in which Cu(I)Cl cleaves a carbon-halogen bond to generate a Cu(III) species, followed by insertion of the alkene into the carbon-copper (III) σ-bond and halogen ligand transfer (reductive elimination) ; Figure 16 shows a putative insertion process; Figure 17 shows a putative process involving metal ' coordinated radicals; and Figures 18A and 18B show two different mechanisms for the generation of free radicals by reacting an organic halide with a transition metal compound, involving either halogen atom transfer (Figure 18A) or outer-sphere electron transfer (Figure 18B) .
DESCRIPTION OF THE PREFERRED EMBODIMENTS The present Inventors conceptualized that if (1) the organic halide R-Mj-X resulting from an ATRA reaction is sufficiently reactive towards the transition metal Mc" and (2) the alkene monomer is in excess, a number or sequence of atom transfer radical additions (i.e., a possible "living"/ controlled radical polymerization) may occur, as is shown in Fig. 2.
By analogy to ATRA, the present Inventors have termed this new class of radical polymerization "atom (or group) transfer radical polymerization" (or "ATRP") , which describes the involvement of (1) the atom or group transfer pathway and (2) a radical intermediate.
Living/controlled polymerization (i.e., when chain breaking reactions such as transfer and termination are substantially absent) enables control of various parameters of macromolecular structure such as molecular weight, molecular weight distribution and terminal functionalities. It also allows the preparation of various copolymers, including block and star copolymers. Living/controlled radical polymerization requires a low stationary concentration of radicals, in equilibrium with various dormant species.
The present invention describes use of novel initiating systems leading to living/controlled radical polymerization. The initiation system is based on the reversible formation of growing radicals in a redox reaction between various -13- transition metal compounds and an initiator, exemplified by (but not limited to) alkyl halides, aralkyl halides or haloalkyl esters. Using 1-phenylethyl chloride (l-PECl) as a model initiator, CuCl as a model catalyst and bipyridine (Bpy) as a model ligand, a "living" radical bulk polymerization of styrene at 130 °C affords the predicted molecular weight up to M„ ~ 10s with a narrow molecular weight distribution (e.g., < 1.5) .
A key factor in the present invention is to achieve rapid exchange between growing radicals present at low stationary concentrations (in the range of from 10"9 mol/L to 10"s mol/L, preferably 10"a mol/L to 10"6 mol/L) and dormant chains present at higher concentrations (typically in the range 10"4 mol/L to 1 mol/L, preferably 10'2 mol/L to 10"1 mol/L) . It may be desirable to "match" the initiator/catalyst/ ligand system and monomer (s) such that these concentration ranges are achieved.
Although these concentration ranges are not essential to conducting polymerization, certain disadvantageous effects may result if the concentration ranges are exceeded. For example, if the concentration of growing radicals exceeds 10"s mol/L, there may be too many active species in the reaction, which may lead to an undesirable increase in the rate of side reactions (e.g., radical-radical quenching, radical abstraction from species other than the catalyst system, etc.). If the concentration of growing radicals is less than 10"9 mol/L, the rate may be undesirably slow.
Similarly, if the concentration of dormant chains is less than 10"4 mol/L, the molecular weight of the product polymer may increase dramatically, thus leading to a potential loss of control of the polydispersity of the product. On the other hand, if the concentration of dormant species is greater than 1 mol/L, the molecular weight of the product may become too small, and the properties of the product may more closely resemble the properties of oligomers. For example, in bulk, a concentration of dormant chains of about 10'2 mol/L provides product having a molecular weight of about 100,000 g/mol.
However, a concentration of dormant chains exceeding 1 M leads to formation of (roughly) decameric products.
The various initiating systems of the present invention work for any radically polymerizable alkene, including (meth) acrylates , styrenes and dienes. It also provides various controlled copolymers, including block, random, gradient, star, graft or "comb," hyperbranched and dendritic (co) olymers . (In the present application, " (co) polymer" refers to a homopolymer, copolymer, or mixture thereof.) Similar systems have been used previously in organic synthesis, but have not been used for the preparation of well- defined macromolecular compounds.
In the present invention, any radically polymerizable alkene can serve as a monomer for polymerization. However, monomers suitable for polymerization in the present method include those of the formula: R1 R3 \ / C=C / \ R2 R4 wherein Rl and R2 are independently selected from, the group consisting of H, halogen, CN, CF3, straight or branched alkyl of from 1 to 20 carbon atoms (preferably from 1 to 6 carbon atoms, more preferably from 1 to 4 carbon atoms) , α,β-unsaturated straight or branched alkenyl or alkynyl of 2 to 10 carbon atoms (preferably from 2 to 6 carbon atoms, more preferably from 2 to 4 carbon atoms), a , /3-unsaturated straight or branched alkenyl of 2 to 6 carbon atoms (preferably vinyl) substituted (preferably at the -position) with a halogen (preferably chlorine), C3-C8 cycloalkyl, hetercyclyl, C(=Y)R5, C(=Y)NR6R7 and YC(=Y)R3, where Y may be NRa or O (preferably O) , R5 is alkyl of from 1 to 20 carbon atoms, alkoxy of from 1 to 20 carbon atoms, aryloxy or heterocyclyloxy , R6 and R7 are independently H or alkyl of from 1 to 20 carbon atoms, or Rs and R7 may be joined together to form an alkylene group of from 2 to 5 carbon atoms, thus forming a 3- to 6-membered ring, and Ra is H, straight or branched alkyl or aryl; and R3 and R4 are independently selected from the group consisting of H, halogen (preferably fluorine or chlorine) , - Cs (preferably CJ alkyl and COOR9 (where R9 is H, an alkali metal, or a C^-C^ alkyl group) ; or R1 and R3 may be joined to form a group of the formula (CH2)n. (which may be substituted with from l to 2n' halogen -16- atoms or C^-c, alkyl groups) or C (=0) -Y-C (=0) , where n' is from 2 to 6 (preferably 3 or 4) and Y is as defined above; and at least two of R1, R2, R3 and R" are H or halogen.
In the context of the, present application, the terms "alkyl", "alkenyl" and "alkynyl" refer to straight-chain or branched groups (except for C1 and C2 groups) .
Furthermore, in the present application, "aryl" refers to phenyl, naphthyl, phenanthryl, phenalenyl, anthracenyl, triphenylenyl , fluoranthenyl , pyrenyl, pentacenyl, chrysenyl, naphthacenyl , hexaphenyl, picenyl and perylenyl (preferably phenyl and naphthyl) , in which each hydrogen atom may be replaced with alkyl of from 1 to 20 carbon atoms (preferably from 1 to 6 carbon atoms and more preferably methyl) , alkyl of from 1 to 20 carbon atoms (preferably from l to 6 carbon atoms and more preferably methyl) in which each of the hydrogen atoms is independently replaced by a halide (preferably a fluoride or a chloride), alkenyl of from 2 to 20 carbon atoms, alkynyl of from 1 to 20 carbon atoms, alkoxy of from 1 to 6 carbon atoms, alkylthio of from 1 to 6 carbon atoms, C3-C3 cycloalkyl, phenyl, halogen, NH2, dialkylamino, and phenyl which may be substituted with from l to 5 halogen atoms and/or C^-C, alkyl groups. (This definition of "aryl" also applies to the aryl groups in "aryloxy" and "aralkyl." ) Thus, phenyl may be substituted from 1 to 5 times and naphthyl may be substituted from 1 to 7 times (preferably, any aryl group, if substituted, is substituted from 1 to 3 -17- times) with one of the above substituents . More preferably, "aryl" refers to phenyl, naphthyl, phenyl substituted from 1 to 5 times with fluorine or chlorine, and phenyl substituted from 1 to 3 times with a substituent selected from the group consisting of alkyl of from 1 to 6 carbon atoms, alkoxy of from 1 to 4 carbon atoms and phenyl. Most preferably, "aryl" refers to phenyl, tolyl and methoxyphenyl .
In the context of the present invention, "heterocyclyl" refers to pyridyl, furyl, pyrrolyl, thienyl, imidazolyl, pyrazolyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyranyl, indolyl, isoindolyl, indazolyl, benzofuryl, isobenzofuryl , benzothienyl , isobenzothienyl , chromenyl, xanthenyl, purinyl, pteridinyl, quinolyl, isoquinolyl, phthalazinyl , quinazolinyl , quinoxalinyl , naphthyridinyl, phenoxathiinyl, carbazolyl, cinnolinyl, phenanthridinyl , acridinyl, 1 , 10-phenanthrolinyl , phenazinyl, phenoxazinyl , phenothiazinyl , oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, and hydrogenated forms thereof 'known to those in the art. Preferred heterocyclyl groups include pyridyl, furyl, pyrrolyl, thienyl, imidazolyl, pyrazolyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyranyl and indolyl, the most preferred heterocyclyl group being pyridyl. Accordingly, suitable vinyl heterocycles to be used as a monomer in the present invention include 2-vinyl pyridine, 6-vinyl pyridine, 2-vinyl pyrrole, 5-vinyl pyrrole, 2-vinyl oxazole, 5-vinyl oxazole, 2-vinyl thiazole, 5-vinyl thiazole, 2-vinyl imidazole, 5-vinyl imidazole, 3-vinyl pyrazole, 5-vinyl pyrazole, 3-vinyl pyridazine, 6-vinyl pyridazine, 3-vinyl isoxazole, 3-vinyl isothiazoles , 2-vinyl pyrimidine, 4-vinyl pyrimidine, 6-vinyl pyrimidine, and any vinyl pyrazine, the most preferred being 2-vinyl pyridine. The vinyl heterocycles mentioned above may bear one or more (preferably l or 2) CL-c6 alkyl or alkoxy groups, cyano groups, ester groups or halogen atoms, either on the vinyl group or the heterocyclyl group, but preferably on the heterocyclyl group. Further, those vinyl heterocycles which, when unsubstituted, contain an N-H group may be protected at that position with a conventional blocking or protecting group, such as a C^-Cj alkyl group, a tris-C,-C3 alkylsilyl group, an acyl group of the formula R1QCO (where Ri0 is alkyl of from 1 to 20 carbon atoms, in which each of the hydrogen atoms may be independently replaced by halide [preferably fluoride or chloride]), alkenyl of from 2 to 20 carbon atoms (preferably vinyl) , alkynyl of from 2 to 10 carbon atoms (preferably acetylenyl) , phenyl which may be' substituted with from 1 to 5 halogen atoms or alkyl groups of from l to 4 carbon atoms, or aralkyl (aryl-substituted alkyl, in which the aryl group is phenyl or substituted phenyl and the alkyl group is from 1 to 6 carbon atoms), etc. (This definition of "heterocyclyl" also applies to the heterocyclyl groups in "heterocyclyloxy" and "heterocyclic ring.") More specifically, preferred monomers include (meth) acrylate esters of C^-C20 alcohols, acrylonitrile , cyanoacrylate esters of C,-C-„ alcohols, didehydromalonate -19- diesters of alkylpyrroles, vinyl oxazoles, vinyl thiazoles, vinyl pyrimidines and vinyl imidazoles, vinyl ketones in which the a-carbon atom of the alkyl group does not bear a hydrogen atom (e.g., vinyl ^-Cs-alkyl ketones in which both a-hydrogens are replaced with C^-C, alkyl, halogen, etc., or a vinyl phenyl ketone in which the phenyl may be substituted with from 1 to 5 groups and/or halogen atoms) , and styrenes which may bear a group on the vinyl moiety (preferably at the a-carbon atom) and from 1 to 5 (preferably from 1 to 3) substituents on the phenyl ring selected from the group consisting of (preferably vinyl) , C,-C3-alkynyl (preferably acetylenyl) , C^-C8-alkoxy , halogen, nitro, carboxy, , hydroxy protected with a C^-C^ acyl, cyano and phenyl. The most preferred monomers are methyl acrylate (MA) , methyl methacrylate (MMA) , butyl acrylate (BA) , 2-ethylhexyl acrylate (EHA) , acrylonitrile (AN) and styrene.
Suitable initiators include those of the formula: RUR12R13C_X where: X is selected from the group consisting of CI, Br, I, OR10 (as defined above), SRU, SeR14, 0C(=0)R14, OP(=0)R14, OP (=0) (OR11) 2 , 0P(=0)0R14, 0-N(R14)2 and S-C (=S ) N (R1 ) 2 , where R14 -20- is aryl or a straight or branched C^-C^ (preferably C^-C^) alkyl group, or where an N(R14)2 group is present, the two Ru groups may be joined to form a 5-, 6- or 7-membered heterocyclic ring (in accordance with the definition of "heterocyclyl" above) ; and R11, R12 and R13 are each independently selected from the group consisting of H, halogen,. C^C^ alkyl (preferably -C^ alkyl and more preferably Cx-C6 alkyl) , C3-C8 cycloalkyl, C(=Y)R5, C(=Y)NR6R7 (where R5-R7 are as defined above) , C0C1, OH (preferably only one of R11, R12 and Ru is OH), CN, C2-C20 alkenyl or alkynyl (preferably C2-C6 alkenyl or alkynyl, and more preferably vinyl) , glycidyl, aryl, heterocyclyl, aralkyl, aralkenyl (aryl-substituted alkenyl, where aryl is as defined above, and alkenyl is vinyl which may be substituted with one or two alkyl groups and/or halogen atoms [preferably chlorine]), Cx-C6 alkyl in which from 1 to all of the hydrogen atoms (preferably 1) are replaced with halogen (preferably fluorine or chlorine where 1 or more hydrogen atoms are replaced, and preferably fluorine, chlorine or bromine where 1 hydrogen atom is replaced) and C^C^ alkyl substituted with from l to 3 substituents (preferably l) selected from the group consisting of C^C^ alkoxy, aryl, heterocyclyl, C(=Y)RS (where Rs is as defined above), C (=Y) NR°R7 (where R6 and R7 are as defined above), and glycidyl; such that no more than two of R11, R12 and R13 are H (preferably no more than one of R11, R12 and R13 is H) .
In the present initiator, X is preferably CI or Br. Cl-containing initiators generally provide (1) a slower reaction rate and (2) higher product polydispersity than the corresponding Br-containing initiators. Thus, a Br-containing initiator is most preferred.
When an alkyl, cycloalkyl, or alkyl-substituted aryl group is selected for one of 11, R12 and R , the alkyl group may be further substituted with an X group as defined above. Thus, it is possible for the initiator to serve as a starting molecule for branch or star (co) polymers . One example of such an initiator is a 2 , 2-bis (halomethyl) -1, 3-dihalopropane (e.g., 2 , 2-bis (chloromethyl) -1, 3-dichloropropane, 2 , 2-bis (bromomethyl) -1, 3-dibromopropane) , and a preferred example is where one of R11, R12 and R13 is phenyl substituted with from one to five C,-C6 alkyl substituents , each of which may independently be further substituted with a X group (e.g., , a' -dibromoxylene, hexakis (ot-chloro- or ot-bromomethyl) - benzene) .
Preferred initiators include l-phenylethyl chloride and l-phenylethyl bromide (e.g., where R11 = Ph, R12 = CH3, R = H and X = CI or Br) , chloroform, carbon tetrachloride, 2- chloropropionitrile, esters of a 2-halo- i-C,;- carboxylic acid (such as 2-chloropro ionic acid, 2- bromopropionic acid, 2-chloroisobutyric acid, 2- bromoisobutyric acid, etc.) and compounds of the formula C6HX(CH2Y' )y, where Y ' is CI or Br, x + y = 6 and y > 1. More -22- preferred initiators include l-phenylethyl chloride, l-phenylethyl bromide, methyl 2-chloropropionate, ethyl 2-chloropropionate, methyl 2-bromopropionate, ethyl 2-bromoisobutyrate, , '-dichloroxylene, α,α'-dibromoxylene and hexakis (a-bromomethyl) benzene.
Any transition metal compound which can participate in a redox cycle with the initiator and dormant polymer chain, but which does not form a direct carbon-metal bond with the polymer chain, is suitable for use in the present invention. Preferred transition metal compounds are those of the formula rVX',,, where: Mtn* may be selected from the group consisting of Cu1*, Cu2*, Fe2*, Fe3*, Ru2*, Ru3*, Cr2*, Cr3*, o°, Mo', Mo2*, Mo3*, W2*, W3*, Rh3*, Rh4*, Co*, Co2*, Re2', Re3*, Ni°, Ni*, Mn3*, Mn4*, V2', V3', Zn*, Zn2*, Au*, Au2*, Ag* and Ag2*; X' is selected from the group consisting of halogen, C^ C6-alkoxy, (S04)1/2, (P0<)1/3, (HP04)1/2, (H-POJ , triflate, hexafluorophosphate, methanesulfonate, arylsulfonate (preferably benzenesulfonate or toluenesulfonate) , SeR14 , CN and RISC02, where R14 is as defined above and R1S is H or a straight or branched Cx-C3 alkyl group (preferably methyl) which may be substituted from l to 5 times with a halogen (preferably 1 to 3 times with fluorine or chlorine) ; and n is the formal charge on the metal (e.g., 0 < n < 7) .
Suitable ligands for use in the present invention include ligands having one or more nitrogen, oxygen, phosphorus and/ or -23- sulfur atoms which can coordinate to the transition metal through a σ-bond, ligands containing two or more carbon atoms which can coordinate to the transition metal through a 7r-bond, and ligands which can coordinate to the transition metal through a μ-bond or a 17-bond. However, preferred N-, 0-, P-and S- containing ligands may have one of the following formulas: R16-Z-R17 Rl6-Z-(R18-Z)m-R17 where : R16 and R17 are independently selected from the group consisting of H, C^C^ alkyl, aryl, heterocyclyl, and Ct-C3 alkyl substituted with C,-C6 alkoxy, Cx-C, dialkylamino, C(=Y)R5, C(=Y)R6R7 and YC(=Y)R8, where Y, R5 , R6 , R7 and Ra are as defined above; or R1S and R17 can be joined to form a saturated, unsaturated or heterocyclic ring as described above for the "heterocyclyl" grou ; Z is 0, S, NR15 or PR19, where R19 is selected from the same group as R16 and R17 , each R18 is independently a divalent group selected from the group consisting of C2-C4 alkylene (alkanediyl) and C2-C4 alkenylene where the covalent bonds to each Z are at vicinal positions (e.g., in a 1 , 2-arrangement) or at 3-positions (e.g., in a 1 , 3 -arrangement) , and from C3-CB cycloalkanediyl , C3-C3 cycloalkenediyl, arenediyl and heterocyclylene where the covalent bonds to each Z are at vicinal positions; and m is from 1 to 6.
In addition to the above ligands, each of R16-Z and R17-Z can form a ring with the R18 group to which the Z is bound to form a linked or fused heterocyclic ring system (such as is described above for "heterocyclyl") . Alternatively, when Ri≤ and/or R17 are heterocyclyl, Z can be a covalent bond (which may be single or double) , CH2 or a 4- to 7-membered ring fused to Rx€ and/ or R17, in addition to the definitions given above for Z. Exemplary ring systems for the present ligand include bipyridine, bipyrrole, l, 10-phenanthroline, a cryptand, a crown ether, etc.
Where Z is PR19, R19 can also be c^-C^-alkoxy .
Also included as suitable ligands in the present invention are CO (carbon monoxide) , porphyrins and porphycenes, the latter two of which may be substituted with from 1 to 6 (preferably from 1 to 4) halogen atoms, alkyl groups, groups, °Cl-C3 alkoxycarbonyl , aryl groups, heterocyclyl groups, and Cl-C6 alkyl groups further substituted with from 1 to 3 halogens.
Further ligands suitable for use in the present invention include compounds of the formula R20R21C(C(=Y)R5)2, where Y and R5 are as defined above, and each of R20 and R21 is independently selected from the group consisting of H, halogen, C^-C^ alkyl, aryl and heterocyclyl, and R20 and R21 may be joined to form a C3-C9 cycloalkyl ring or a hydrogenated (i.e., reduced, non-aromatic or partially or fully saturated) aromatic or heterocyclic ring (consistent with the definitions of "aryl" and "heterocyclyl" above) , any of which (except for H and halogen) may be further substituted with 1 to 5 and preferably 1 to 3 Cj-C6 alkyl groups, C^-Cg alkoxy groups, halogen atoms and/or aryl groups. Preferably, one of R20 and R2 is H or a negative charge.
Additional suitable ligands include, for example, ethylenediamine and propylenediamine, both of which may be substituted from one to four times on the amino nitrogen atom with a C^-C, alkyl group or a carboxymethyl group; aminoethanol and aminopropanol, both of which may be substituted from one to three times on the oxygen and/or nitrogen atom with a C.-C4 alkyl group; ethylene glycol and propylene glycol, both of which may be substituted one or two times on the oxygen atoms with a C^-C^ alkyl group; diglyme, triglyme, tetraglyme, etc.
Suitable carbon-based ligands include arenes (as described above for the "aryl" group) and the cyclopentadienyl ligand. Preferred carbon-based ligands include benzene (which may be substituted with from one to six C^C,, alkyl groups [e.g., methyl]) and cyclopentadienyl (which may be substituted with from one to five methyl groups, or which may be linked through an ethylene or propylene chain to a second cyclopentadienyl ligand) . Where the cyclopentadienyl ligand is used, it may not be necessary to include a counteranion (Χ') in the transition metal compound.
Preferred ligands include unsubstituted and substituted pyridines and bipyridines (where the substituted pyridines and bipyridines are as described above for "heterocyclyl" ) , acetonitrile, (R10O)3P, PR103, 1, 10-phenanthroline, porphyrin, cryptands such as K222 and crown ethers such as. 18-crown-6.
The most preferred ligands are bipyridine and (R10O)3P.
In the present polymerization, the amounts and relative proportions of initiator, transition metal compound and ligand are those effective to conduct ATRP. Initiator efficiencies with the present initiator/transition metal compound/ ligand system are generally very good (at least 50%, preferably > 80%, more preferably > 90%). Accordingly, the amount of initiator can be selected such that the initiator concentration is from 10"* M to 1 M, preferably lO'^-lO"1 M.
Alternatively, the initiator can be present in a molar ratio of from 10-4:1 to 10'1:1, preferably from 10'3:1 to 5 x 10- :i, relative to monomer. An initiator concentration of 0.1-1 M is particularly useful for preparing end-f nctional polymers.
The molar proportion of transition metal compound relative to initiator is generally that which is effective to polymerize the selected monomer(s), but may be from 0.0001:1 to 10:1, preferably from 0.1:1 to 5:1, more preferably from 0.3:1 to 2:1, and most preferably from 0.9:1 to 1.1:1.
Conducting the polymerization in a homogeneous system may permit reducing the concentration of transition metal and ligand such that the molar proportion of transition metal compound to initiator is as low as 0.001:1.
Similarly, the molar proportion of ligand relative to transition metal compound is generally that which is effective to polymerize the selected monomer (s), but can depend upon the number of coordination sites on the transition metal compound which the selected ligand will occupy. (One of ordinary skill understands the number of coordination sites on a given transition metal compound which a selected ligand will occupy.) The amount of ligand may be selected such that the ratio of (a) coordination sites on the transition metal compound to (b) coordination sites which the ligand will occupy is from 0.1:1 to 100:1, preferably from 0.2:1 to 10:1, more preferably from 0.5:1 to 3:1, and most preferably from 0.8:1 to 2:1. However, as is also known in the art, it. is possible for a solvent or for a monomer to act as a ligand. For the purposes of this application, a monomer is treated as being (a) distinct from and (b) not included within the scope of the ligand.
The present polymerization may be conducted in the absence of solvent ("bulk" polymerization) . However, when a solvent is used, suitable solvents include ethers, cyclic ethers, C3-Cl0 alkanes, C3-Ca cycloalkanes which may be substituted with from 1 to 3 Cj-C, alkyl groups, aromatic hydrocarbon solvents, halogenated hydrocarbon solvents, -28- acetonitrile, dimethylformamide, mixtures of such solvents, and supercritical solvents (such as C02/ C^-c, alkanes in which any H may be replaced with F, etc.)- The present polymerization may also be conducted in accordance with known suspension, emulsion and precipitation polymerization processes.
Suitable ethers include compounds of the formula R22OR23, in which each of R22 and R23 is independently an alkyl group of from 1 to 6 carbon atoms which may be further substituted with a ^-^-alkoxy group. Preferably, when one of R22 and R23 is methyl, the other of R22 and R23 is alkyl of from 4 to 6 carbon atoms or C^-C^-alkoxyethyl. Examples include diethyl ether, ethyl propyl ether, dipropyl ether, methyl t-butyl ether, di-t-butyl ether, glyme (dimethoxyethane) , diglyme (diethylene glycol dimethyl ether) , etc.
Suitable cyclic ethers include THF and dioxane. Suitable aromatic hydrocarbon solvents include benzene, toluene, d- xylene, m-xylene, p-xylene and any isdmer or mixture of isomers of cumene. Suitable halogenated hydrocarbon solvents include CH2C12, 1 , 2-dichloroethane and benzene substituted from 1 to 6 times with fluorine and/or chlorine, although one should ensure that the selected halogenated hydrocarbon solvent (s) does not act as an initiator under the reaction conditions.
Keys to controlling the polymerization reaction may include (1) matching the reactivity of the groups in the initiator (Ru, R12 and R13) with the group (s) on the monomer (Rl-R4) , and (2) matching the energetics of bond breaking and bond forming in dormant species (e.g., dormant polymer chains) and transition metal species (as discussed elsewhere in the specification) . Matching the reactivities of the initiator with the monomer depends to some degree on the radical stabilizing effects of the substituents . Thus, where the monomer is a simple alkene or halogenated alkene (e.g., ethylene, propylene, vinyl chloride, etc.), one may select an alkyl halide initiator (e.g., where two or three of R11, R12 and R13 are C^-Cj alkyl) . On the other hand, if one wishes to polymerize an arene- or ester-stabilized monomer (e.g., a (meth) aerylate, acrylonitrile or styrene) , one may select an initiator which is stabilized by a similar group (wherein one of R11, R12 and R13 is aryl, heterocyclyl , alkoxycarbonyl , CN, carboxyamido [C (=0) NR6R7] , etc.). Such "matching" of substituents on the initiator and monomer provides a beneficial balance of the relative reactivities of the initiator and monomer.
Preferably, the monomer, initiator, transition metal compound and ligand are selected such that the rate of initiation is not less than 1,000 times (preferably not less than 100 times) slower than the rate of propagation and/or transfer of the X group to the polymer radical. (In the present application, "propagation" refers to the reaction of a polymer radical with a monomer to form a polymer-monomer adduct radical.) The present polymerization may be conducted in bulk, in the gas phase (e.g., by passing the monomer in the gas phase over a bed of the catalyst which has been previously contacted with the initiator and ligand) , in a sealed vessel or in an autoclave. Polymerizing may be conducted at a temperature of from -78° to 200°, preferably from 0° to 160° and most preferably from 80° to 140°. The reaction should be conducted for a length of time sufficient to convert at least 10% (preferably at least 50%, more preferably at least 75% and most preferably at least 90%) of the monomer to polymer.
Typically, the reaction time will be from several minutes to 5 days, preferably from 30 minutes to 3 days, and most preferably from 1 to 24 hours. Polymerizing may be conducted at a pressure of from 0.1 to 100 atmospheres, preferably from 1 to 50 atmospheres and most preferably from 1 to 10 atmospheres (although the pressure may not be measurable directly if conducted in a sealed vessel) .
One may also conduct a "reverse" AT P, in which the transition metal compound is in its oxidized state, and the polymerization is initiated by, for example, a radical initiator such as azobis ( isobutyronitrile) ("AIBN"), a peroxide such as benzoyl peroxide (BPO) or a peroxy acid such as peroxyacetic acid or peroxybenzoic acid. The radical initiator is believed to initiate "reverse" ATRP in the following fashion: I-I 2 I" n-l I' + M > I-M" I-M" + Mtn*lX„ ™ I-M-X + McnX, I-M" + n M > I-M„ where "I" is the initiator, McnXn-1 is the transition metal compound, M is the monomer, and I-M-X and M^X^ participate in "conventional" or "forward" ATRP in the manner described above, and n, in n M, is the number of monomers, M, which react with compound, I-M', to extend the chain to l-M*n+i, After the polymerizing step is complete, the formed polymer is isolated. The isolating step of the present process is conducted by known procedures, and may comprise precipitating in a suitable solvent, filtering the precipitated polymer, washing the polymer and drying the polymer.
Precipitation can be typically conducted using a suitable C5-C9-alkane or C5-C8-cycloalkane solvent, such as pentane, hexane, heptane, cyclohexane or mineral spirits, or using a Cj.-C6-alcohol, such as methanol, ethanol or isopropanol, or any mixture of suitable solvents. Preferably, the solvent for precipitating is hexane, mixtures of hexanes, or methanol.
The precipitated (co) polymer can be filtered by gravity or by vacuum filtration, in accordance with known methods (e.g., using a BUchner funnel and an aspirator). The polymer can then be washed with the solvent used to precipitate the polymer, if desired. The steps of precipitating, filtering and washing may be repeated, as desired.
Once isolated, the (co) polymer may be dried by drawing air through the (co)polymer, by vacuum, etc., in accordance with known methods (preferably by vacuum) . The present (co) olymer may be analyzed and/or characterized by size exclusion chromatography, in accordance with known procedures.
Polymers produced by the present process may be useful in general as molding materials (e.g., polystyrene containers) and as barrier or surface materials (e.g., poly(methyl methacrylate) , or PMMA, is well-known in this regard as PLEXIGLAS7") . However, the polymers produced by the present process, which typically will have more uniform properties than polymers produced by conventional radical polymerization, will be most suitable for use in specialized applications.
For example, block copolymers of polystyrene and polyacrylate (e.g., PSt-PA-PSt triblock copolymers) are useful thermoplastic elastomers. Poly (methyl methacrylate) - polyacrylate triblock copolymers (e.g., PMMA-PA-PMMA) are useful, fully acrylic thermoplastic elastomers. Homo- and copolymers of styrene, (meth) aerylates and/or aerylonitrile are useful plastics, elastomers and adhesives. Either block or random copolymers of styrene and a (meth) acrylate or acrylonitrile may be useful thermoplastic elastomers having high solvent resistance.
Furthermore, block copolymers in which the blocks alternate between polar monomers and non-polar monomers produced by the present invention are useful amphiphilic surfactants or dispersants for making highly uniform polymer blends. Star polymers produced by the present process are useful high-impact (co) polymers . (For example, STYROLUX"*, and anionically-polymerized styrene-butadiene star block copolymer, is a known, useful high-impact copolymer.) The (co) polymers of the present invention may have a number average molecular weight of from 1,000 to 500,000 g/mol, preferably of from 2,000 to 250,000 g/mol, and more preferably of from 3,000 to 200,000 g/mol. When produced in bulk, the number average molecular weight may be up to 1,000,000 (with the same minimum weights as mentioned above). The number average molecular weight may be determined by size exclusion chromatography (SEC) or, when the initiator has a group which can be easily distinguished from the monomer (s) by NMR spectroscopy (e.g. , when 1-phenylethyl chloride is the initiator and methyl methacrylate is the monomer) .
Thus, the present invention also encompasses novel block, multi-block, star, gradient,, random hyperbranched and dendritic copolymers, as well as graft or "comb" copolymers.
Each of the these different types of copolymers will be described hereunder.
Because ATRP is a "living" polymerization, it can be started and stopped, practically at will. Further, the polymer product retains the functional group "X" necessary to initiate a further polymerization. Thus, in one embodiment, once the first monomer is consumed in the initial polymerizing step, a second monomer can then be added to form a second block on .the growing polymer chain in a second polymerizing step. Additional polymerizations with the same or different monomer (s) can be performed to prepare multi-block copolymers.
Furthermore, since ATRP is radical polymerization, blocks can be prepared in essentially any order. One is not necessarily limited to preparing block copolymers where the sequential polymerizing steps must flow from the least stabilized polymer intermediate to the most stabilized polymer intermediate, such as is necessary in ionic polymerization. (However, as is described throughout the application, certain advantageous reaction design choices will become apparent. However, one is not limited to those advantageous reaction design choices in the present invention.) Thus, one can prepare a multi-block copolymer in which a polyacrylonitrile or a poly (meth) acrylate block is prepared first, then a styrene or butadiene block is attached thereto, etc.
Furthermore, a linking group is not necessary to join the different blocks of the present block copolymer. One can simply add successive monomers to form successive blocks.
Further, it is also possible (and in some cases advantageous) to first isolate a (co) polymer produced by the present ATRP process, then react the polymer with an additional monomer using a different initiator/catalyst system (to "match" the reactivity of the growing polymer chain with the new monomer) . In such a case, the product polymer acts as the new initiator for the further polymerization of the additional monomer.
Thus, the present invention also encompasses block copolymers of the formula: RllR"R"C-(Ml)p-(M2)q-X R11R13R13C-(Ml)p-(Ma)q-(M1) r-X R11R12Rl3C-(Ml)p-(M2)q-(M3).-...-(Mu)s-X wherein R11, R12, R13 and X are as defined above; M1, M2, M3 , ... up to are each a radically polymerizable monomer (as defined above) selected such that the monomers in adjacent blocks are not identical (although monomers in non-adjacent blocks may be identical) and p, q, r, ... up to s are independently selected such that the number average molecular weight of each block is from 1,000 to 250,000 g/mol. After an appropriate end group conversion reaction (conducted in accordance with known methods), X may also be, for example, H, OH, N3, NH2, COOH or CONHj . 1 17,626/3 Where the R11 R12R13C group of the initiator contains a second "x" group, the block copolymers may have one of the following formulas: "([X-(M1)p ]-R11)R12R130- (M1)p-X, ([X-(M2)p-(M1)p] -R1 1)R12R130- (M )p-(M2)p-X, ([X-(M3)p-(M2)p-(M1)p] -R11 )R12R130- (M1 )p-(M2)p-(M3)p-X, or ([X-(M - ..-(M3)p-(M2)p-(M1 )p]-R1 1 )R12R130- (M1 )p-(M2)p-(M3)p-...-(Μι)ρ-Χ" wherein R11 , R12, R13, X, M1 , M2, M3,... up to Ml, t, and p are as defined above, with the provisio that the polymer chain enclosed in square brackets is substituted for an X group on the R11 as defined above.
The present invention is also useful for making essentially random copolymers. By "essentially random" copolymers, the copolymers are as close to statistically random, as is possible under radical polymerization conditions. The present ATRP process is particularly useful for producing random copolymers where one of the monomers has, one or two bulky substituents (e.g., 1 , 1-diarylethylene, didehydromalonate C1-C20 diesters, C1-C20 diesters of maleic or fumaric acid, maleic anhydride and/or maleic diimides [where Y is NR8 as defined above], etc.), from which homopolymers may be difficult to prepare, due to steric considerations. Thus, the present invention also concerns a random copolymer of the formula: R11R12R 3C-(M1-M2)p-(M2-M )q-(M1-M2)r-... -(Mv-My)s-X or 1 17,626/4 (R11 'R12'R13')(C)- (M1 -M2)P-(M2 -M1 )Q-(M1 -M2)r -... (MV-MY)S -X, where R1 , R12, R13, and X, are as defined for the block copolymer above, and where R11', R12 , and R13' are the same as R11 , R12, and R13 with the provisio that R1 ', R12', and R13' combined have from 1 to 5 polymer chains of the formula (M1-M2)p-(M2 -M1 )q-(M1-M2)r -... -(Mv-My)s -X at locations where R1 1 , R 2, and R13 are defined as having an X group; and C has only one of the polymer chains enclosed in square brackets attached thereto, M1 and M2 are different radically-polymerizable monomers (as defined above), and Mv is one of M1 and M2 and My is the other of M1 and M2, wherein z is from 2 to 6. However, p, q, r, ... up to s are independently selected such that the number average molecular weight of the copolymer is from 1 ,000 to 1 ,000,000 g/mol, preferably from 2,000 to 250,000, and more preferably from 3,000 to 50,000 g/mol. The ratio of (1 ) the total number of "blocks" of statistically random units to (2) the total number of monomer units is preferably at least 1 :5, more preferably at least 1 :8, and most preferably at least 1 :10. The present random copolymer can also serve as a block in any of the present block copolymers.
Preferably, at least one of 1 and M2 has the formula: R1 R3 ■ \ / C=C / \ R2 R4 wherein at least one of R1 and R2 is CN, CF3, straight or branched alkyl of from 4 to 20 carbon atoms (preferably from 4 to 10 carbon atoms, more preferably from 4 to 8 carbon atoms), C3-C8 cycloalkyl, aryl, heterocyclyl, C(=Y)R5, C(=Y)NR6R7 and YC(=Y)R8, where aryl, heterocyclyl, Y, R5, R6, R7 and R8 are as defined above; and 1 17,626/3 R3 and R4 are defined above; or R1 and R3 are joined to form a group of the formula C(=0) - Y-C (=0), where Y is as defined above.
More preferred monomers for the present include styrene, acrylonitrile, Ci-C8 esters of (meth)acrylic acid and 1 , 1 -diphenylethylene.
The present invention is also useful for forming so-called "star" polymers and copolymers. Thus, where the initiator has three or more "X" groups, each of the "X" groups can serve as a polymerization initiation site. Thus, the present invention also encompasses star (co)polymers of the formula: (R1 1 ,R12'R 3'C)-[(M1 )p-X], (R11 'R12'R13'C)-[(M1 )p-(M2)p-X], (R1 1 'R12'R13'C)-[(M1 )p-(M2)p-(M3)p-X], or (R1 1 ,R12'R13'C)-[(M1 )p-(M2)p-(M3)p-...-(Mt)p-X] where R1 1 , R12, R13, and X, are as defined for the block copolymer above, and where R1 ', R12', and R13' are the same as R11 , R12, and R13 with the provisio that R11 ', R12', and R13' combined have from 1 to 5 polymer chains of the same formula of the polymer chain in square brackets at locations where R11 , R12, and R13 are defined as having an X group, and C has only one of the polymer chains enclosed in square brackets attached thereto; X is as defined for the block copolymer above; M1 , M2, M3,... MU are as defined above for the present block copolymers; and z is from 3 to 6.
Initiator suitable for use in preparing the present star (co) polymers are those in which the R1 R 2R13C group possesses at least two substituents which can be "X" (as defined above).
Preferably, these substituents are identical to "X". Examples of such initiators include chloroform, carbon tetrachloride, [insert examples from above]. Preferred initiators of this type include 2 , 2-bis (chloromethyl) -1, 3-dichloropropane, 2,2-bis (bromomethyl) -1 , 3-dibromopropane) , a, ' , a"-trichloro- and α,α' ,a"-tribromocumene, and hexakis (a-chloro- and a-bromomethyl) benzene) , the most preferred being hexakis (a-bromomethyl) benzene.
In the present copolymers, each of the blocks may have a number average molecular weight in accordance with the homopolymers described above. Thus, the present copolymers may have a molecular weight which corresponds to the number of blocks (or in the case of star polymers, the number of branches times the number of blocks) times the number average molecular weight range for each block.
The present invention also encompasses graft or "comb" copolymers, prepared by sequential ATRP's. Thus, a (co) polymer is produced by a first ATRP, in which at least one of the monomers has a R1-R4 substituent which is encompassed by the description of the "X" group above. Preferably this substituent is Cl or Br. Examples of preferred monomers would thus include vinyl chloride, 1- or 2- chloropropene, vinyl bromide, 1,1- or 1, 2-dichloro- or dibromoethene, trichloro- or tribromoethylene , tetrachloro- or tetrabromoethylene, chloroprene, 1-chlorobutadiene, 1- or 2-bromodutadiene, etc. More preferred monomers include vinyl chloride, vinyl bromide -40- and chloroprene. It may be necessary to hydrogenate (by known methods) a (co) polymer produced in the first ATRP of chloroprene prior to the second ATRP, using the polymer produced by the first ATRP as the initiator.
Gradient or tapered copolymers can be produced using ATRP by controlling the proportion of two or more monomers being added. For example, one can prepare a first block (or a oligomer) of a first monomer, then a mixture of the first monomer and a second, distinct monomer can be added in proportions of from, for example, 1:1 to 9:1 of first monomer to second monomer. After conversion of all monomer (s) is complete, sequential additions of first monomer-second monomers mixtures can provide subsequent "blocks" in which the proportions of first monomer to second monomer vary. Thus, the present invention also encompasses a copolymer of the formula: RuRi2Ruc_ (MiaM2b) - (M1^) - (M\M2£) - ... - (MlgM2n) - (M\M2: ) -X where R11, R12, Ru and X are as defined for the block copolymer above, M1 and M2 are different radically-poly erizable monomers (as defined above), and a, b, c, d, e, f,... up to g and h are non-negative numbers independently selected such that a + b = c + d = 100, and any or all of (e + f ) , (g + h) and (i + j) = 100 or 0, wherein the a:b ratio is from 100:0 to 0:100, the c:d ratio is from 95:5 to 5:95 (preferably from 90:10 to :90), such that c < a and d > b, and where applicable, the erf ratio is from 90:10 to 10:90 (preferably from 80:20 to 20:80), such that e < c and f > d, and depending on the number of blocks, the endpoints of the molar ratio ranges of first monomer to second monomer in successive blocks may progressively decrease or increase by 5 (preferably by 10) such that the e:f ratio is from 5:95 to 95:5 (.preferably from 10:90 to 90:10), such that e ≠ c and f ≠ d, and the i:j ratio is from 0:100 to 100:0, such that i ≠ e and j ≠ f.
Preferably, the proportions of first and second monomers in subsequent "blocks" vary by at least 10% (e.g., c = a + 10 and b = d + 10), preferably by at least 20%, up to 50%, from the preceding block. In a further embodiment, the relative proportions of first monomer to second monomer can be controlled in a continuous manner, using for example a programmable syringe or feedstock supply pump.
When either the initiator or monomer contains a substituent bearing a remote (i.e., unconjugated) ethylene or acetylene moiety, ATRP can be used to prepare cross-linked polymers and copolymers.
Polymers and copolymers produced by the present process have surprisingly low polydispersity for (co) polymers produced by radical polymerization. Typically, the ratio of the weight average molecular weight to number average molecular weight ("Μ,,/Μη") is < 1.5, preferably < 1.4, and can be as low as 1.10 or less.
Because the "living" (co) polymer chains retain an initiator fragment including X or X' as an end group, or in one embodiment, as a substituent in a monomeric unit of the polymer chain, they may be considered end-functional or in-chain functional (co) polymers. Such (co) polymers may be used directly or be converted to other functional groups for further reactions, including crosslinking, chain extension, reactive injection molding (RIM) , and preparation of other types of polymers (such as polyurethanes, polyimides, etc.).
The present invention provides the following advantages: A larger number and wider variety of monomers can be polymerized by radical polymerization, relative to ionic and other chain polymerizations; Polymers and copolymers produced by the present process exhibit a low polydispersity (e.g., M^M,, < 1.5, preferably < 1.4, more preferably < 1.25, and most preferably, < 1.10), thus ensuring a greater degree of uniformity in the (co) polymer properties; One can select an initiator which provides an end group having the same structure as the repeating polymer units ( l-phenylethyl chloride as initiator and styrene as monomer) ; The present process provides high conversion of monomer and high initiator efficiency; The present process exhibits excellent "living" character, thus facilitating the preparation of -43- block copolymers which cannot be prepared by ionic processes ; Polymers produced by the present process are well- defined and highly uniform, comparable to polymers produced by living ionic polymerization; End-functional initiators (e.g., containing COOH, OH, N02, etc., groups) can be used to provide an end- functional polymer in one pot; — . The end functionality of the (co) polymers produced by the present process (e.g., CI, Br, I, CN, C02R) can be easily converted to other functional groups (e.g., CI, Br and I can be converted to OH or NH2 by known processes, and CN or C02R can be hydrolyzed to form a carboxylic acid by known processes) , thus facilitating their use in chain extension processes (e.g., to form long-chain polyamides, polyurethanes and/or polyesters) ; and In some cases (e.g., where "X" is CI, Br and I), the end functionality of the polymers produced by the present process can be reduced by known methods to provide end groups having the same structure as the repeating polymer units.
Hereinbelow, studies conducted by the present Inventors on ATRP to investigate the various parameters which affect ATRP will be described. Exemplary experimental protocols will follow.
A number of commercially available alkyl halides, R-X, combined with Cu(I)X'/Bpy, where X = X' = CI or Br, can be used as efficient model initiator systems for the atom transfer radical polymerization (ATRP) of styrene, (meth) acrylates and other radically polymerizable monomers. The effects of various parameters in ATRP will be discussed hereinbelow to provide guidance as to the efficient control of radical polymerization.
Atom Transfer Radical Polymerization of Styrene and (Meth) acrylates Initiated with an Alkyl Halide, R-X, and in the Presence of CuX', Complexed by 2,2 ' -Bipyridine. Using l-phenylethyl chloride (hereinafter "l-PECl") as an initiator, one molar equivalent of Cu(I)Cl as a catalyst, and three molar equivalents of 2 , 2 ' -bipyridine (hereinafter "Bpy") as a ligand (both equivalents of catalyst and ligand being relative to 1- PEC1) in a model system, the so-called atom transfer radical polymerization (ATRP) of styrene (hereinafter "St") proceeds in a "living" fashion at 130°C. Similarly, using various 1:1:3 R-X: CuX': Bpy initiator systems, the atom transfer radical polymerization of styrene and various (meth) acrylates at different temperatures also affords the product polymers with the predicted molecular weight (up to M„ > 10s) , having excellent low polydispersity (as low as 1.15; see Table 1 below) .
TABLE 1 Characterization Data for ATRP of Styrene and Various (M Initiated with RX/CuX'/Bpya amolar ratio of RX/CuX'/Bpy = 1/1/3; l-PECl: 1-phenylethyl chloride, 1 bromide, 2-EPNCl: ethyl 2-chloropropionate , 2-EPNBr: ethyl 2-bromoprop bromopropionate, 2-EiBBr: ethyl 2-bromoisobutyrate; Calculated accordi acetate solution, 50% by volume.
As an illustrative example of the controlled character of the ATRP of (meth) acrylic esters, Figure 3 presents the kinetics of methyl aerylate ("MA") bulk polymerization at 130°C, initiated with 1-PECl in the presence of Cu(I)Cl (l equiv.) and Bpy (3 equiv.). The straight semilogarithmic kinetic plot of In ( [M]0/ [M] ) vs. time ("t", in minutes) indicates that the concentration of growing radicals is constant, and that termination reactions are minimal.
Moreover, the experimental molecular weight, M,, SEC, increases with monomer conversion (Figure 4) and matches the theoretical molecular weight, M„ Furthermore, a series of bulk ATRP's of MA was carried out at 130°C, using various monomer/ initiator molar ratios, [MA]„/[1-PEC1]0, and a constant ligand/catalyst/ initiator molar ratio of 3/1/1. Figure 6 shows the correlation of the experimental molecular weights, Mn SEC, with the theoretical molecular weights, M„ ch , calculated by eq. (1). A linear plot is obtained in the molecular weight range of from 1.5 x 103 to 1.35 x 10s. The slope of the straight line is 0.95, thus indicating a high initiator efficiency. These results again support a "living" process of MA polymerization initiated with 1:1:3 l-PECl:CuCl:Bpy.
End Group Analysis of Polymers Obtained by Atom Transfer Radical Polymerization. The nature of the chain ends of low molecular weight polystyrene synthesized by the ATRP technique was analyzed by means of LH NMR spectroscopy. Figure 7 presents the lH NMR spectra of PSt which was prepared at 130 °C using 2-chloropropionitrile as an initiator, in the presence of one molar equiv. of CuCl and 3 molar equiv. of Bpy. Two broad signals at 4.2-4.4 ppm are assigned to two different stereoisomers (m and r) of end group a in the anticipated structure 1. Moreover, two additional broad bands at 0.85 and 0.96 ppm in Figure 7 represent two stereoisomers (m and r) of the end group d.
Comparison of the integration values for the two end group resonances in the LH NMR spectrum (Figure 7) shows a 3:i molar ratio of a and d. This may suggest that the St polymerization was initiated with 2-propionitrile radicals and -48- was efficiently deactivated with an equimolar amount of chlorine atoms (relative to the 1-propionitrile group) .
Moreover, comparison of the integration of the end groups with phenyl groups, e, at 6.5 ppm to 7.3 ppm, and to other groups, b and c, in the backbone of the polystyrene chain at 1.2 ppm to 2.5 ppm gave a molecular weight similar to the one obtained from the SEC measurement (Μ-,ιΝΜΚ - 2000 vs. MniSEC_ - 2100) , indicating a quantitative initiation by 2-chloropropionitrile. This result shows a high initiator efficiency in ATRP.
Stereochemistry of Atom Transfer Radical Polymerization.
To better understand the mechanism of ATRP, the stereochemistry of MMA polymerization was investigated.
The tacticity of poly (methyl methacrylate) , PMMA, was calculated from the 13C MR of the C=0 group and the quaternary carbon atom, and from the XH NMR of the a-methyl group. The nC NMR resonances of the C=0 group and the quaternary carbon atom are recorded in the regions 175-179 ppm and 44-46.5 ppm, respectively, with respect to the reference peak of CDC13 at 77.2 ppm. The assignment of the. UC signals was performed to Peat and Reynolds (see Bamford, Reactivity, Mechanism and Structure in Polymer Chemistry, Jenkins, A. D. and Ledwith, A., eds, John Wiley & Sons, London (1974), p. 52; and Peat et al, Tetrahedron Lett., 1972, 14, 1359).
Figure 8A displays the I3C NMR spectra of the C=0 group and the quaternary carbon atom of PMMA prepared at 100°C using methyl 2-bromoisobutyrate ("2-MiBBr") , CuBr and Bpy in a 1/1/3 molar ratio, and Figure 8B displays the 13C NMR spectra of the C=0 group and the quaternary carbon atom of PMMA prepared using a classic radical initiator, AIBN. Both spectra are almost identical. Indeed, up to a pentad sequence, PMMAs prepared using a classic radical initiator such as AIBN or BPO and various ATRP initiator systems have the same compositions, within the limits of experimental error (see Table 2 below) . Moreover, the stereochemistry for PMMA prepared by ATRP appears to be consistent with a Bernoullian process, as indicated by a p value of - l. These results indicate the presence of the same type of active species in the present Cu (I) X' -catalyzed polymerization and in conventional free radical polymerization. The similarities in stereochemistry and regiochemistry observed in the present results are consistent with the results observed in Bu3SnH-mediated radical cyclizations and in C (I) -catalyzed chlorine transfer cyclizations reported by others (see (a) Bellus, D. Pure Effect of the structure of the Initiator on Atom Transfer Radical Polymerization. Table 3 reports the data for the ATRP -50- of styrene at 130°C using various commercially available chlorides, Cu(l)Cl (1 molar equiv.) and Bpy (3 molar eau Table 2 Comparison of Fractions of Pentads, Triads, and Diads in Poly (methyl Prepared Using Classic Initiators and Various ATRP Initiat ' The persistence ratio: p = 2 0.9] and narrow molecular weight distribution [e.g., ί^/Μ,, - 1.25-1.5]).
In contrast, simple alkyl chlorides as butyl chloride, C4H9C1, and dichloromethane, CH2C12, do not work well with St, giving uncontrolled polymers with unexpectedly high molecular weights and broad molecular weight distribution. These results are very similar to those obtained under similar conditions in the absence of initiator (see Table 3 below) . These results indicate very poor efficiency of C4H9C1 and CH2C12 as initiators for the ATRP of St.
The results shown in Table 3 may be tentatively correlated with the carbon-halide bond strength or bond dissociation energy (BDE) . For initiators having a high BDE, such as C,H,C1 and CH2C12 (see Wang et al. Macromolecules , 1993, 26, 5984; and Baumgarten et al, Macromolecules, 1991, 24, 353), the chloride atom transfer from the initiator to cu(I)Cl appears to be very difficult because of the strong carbon- chlorine bonds. Introduction of an inductive or resonance- stabilizing substituent into the initiator reduces the BDE of the C-Cl bond (Wang et al and Baumqarten et al, supra) , and the generation of initiating radicals by chlorine atom transfer becomes facile and efficient, resulting in a high initiator efficiency and narrow MWD in the ATRP of St.
TABLE 3 Styrene ATRP, Using Various Initiators in the Presence of CuCl (1 molar equiv.) and Bpy (3 molar equiv.)3 a Conversion of the polymerization: 90%-100% b calculated based on eq. 1 In*: Initiator It must be pointed out here that the same conclusions are observed for ATRP of other monomers, such as MA and MMA.
Effect of the Polymer. Structure, M„, and the Polymeric Halide, Μ,^Χ', on Atom Transfer Radical Polymerization. Figure 9 illustrates the kinetic plots of the ATRP of three typical monomers, St, MA, and MMA, using the same initiator system 1-PECl/CuCl/Bpy (1/1/3), under the same experimental conditions, in bulk and at 130°C.
The slopes of the straight kinetic plots in Figure 9 allow the calculation of the apparent propagation rate constants (kpapp) in the ATRP of St, MA and MMA. Furthermore, knowing the corresponding thermodynamic parameters, Ap and EP, one can estimate the absolute propagation rate constants at various temperatures, kp", and the stationary concentrations of growing radicals, [P"]st, according to equations (5) and (6) , respectively: = -d[M]/dt = kp- x [M] x [Ρ·] SC (2) For each system described herein, [P"]3C can be considered constant. Therefore: -d[M]/dt = kp- x [M] x [P"]st = kpapp x [M] (3) and ln([M]0/[M]) (4) ln(kp-) = ln(Ap) - (Ep/RT) (5) [P"]« = PP kp ' (6) Table 4 shows the kinetic data and estimated concentrations of growing radicals in bulk ATRP of St, MMA, and MA initiated with 1-PECl/CuCl/Bpy (1/1/3) at 130°C. The concentration of growing radicals decreases in the order [Ρ .ΜΜΑ] > [Pi'.sJ ¾ [ΡΙ',ΜΑ]· TABLE 4 Kinetic Data and Estimated Concentration of Growing Radicals [Ρ'], for Bulk ATRP of St, MA, and MMA Initiated with 1-PECl/CuCl/Bpy (1/1/3) at 130°C a: In kpiMA = 18.42 - (3574/T) , see Odlan, G. Principles of Polymerization , Wiley-Interscience, New York, 1991; : In kp = 14.685 - (2669/T) , see Hutchinson et al, Macromolecuies, 1993, 26, 6410; c: In kp St = 16.786 - (3204/T) , see Hutchinson et al. supra.
Effect of the Transfer Atom (Leaving Group), X' , on Atom Transfer Radical Polymerization. Since the atom transfer process reflects the strength of the bond breaking and bond forming in M^X', it is expected that the leaving group, X', will strongly affect control of the atom transfer reaction.
From Table 5, it can be noted that ATRP is essentially faster when X is bromine as compared to when X is chlorine. This can be explained by the presence of more growing radicals in the polymerization process when X is bromine as compared to when X is chlorine.
The effect of the leaving group, X, on the living character of the polymerization is also significant. For instance, in MA polymerizations at 100 °C using the same molar ratio of initiator/CuX' /Bpy and the same initiating radical, ethyl propionate, at high monomer conversions (e.g. , > 50%) the experimental molecular weight, MnSEC, and is very close to the theoretical molecular weight, M„>ch, when X = X' = either Br or CI. However, at relatively low conversions (e.g., < 50%), the discrepancy between M„>SEC, and Mn ch is much larger when X = X' = CI ("CI ATRP") as compared to when X = X' = Br ("Br ATRP") (see Figures 10 and 11) .
Moreover, the polydispersity of resulting polymers obtained by CI ATRP is usually larger than the polydispersity obtained by Br ATRP (e.g., an M^/M,, of 1.15-1.35 vs. 1.30-1.50; see Figures 10 and 11) .
Table 5 The Effect of the Leaving Group, X, on Kinetics of ATRP at Different Temperatures* Monomer TYC ATRP kp*PP [Ρ·] *5 f1 i o3mol/i 10-9 mol/l MMA 80 CI ATRP - 1.71 1 .24 13.8 Br ATRP - 3.52 1.24 28.4 MA 80 CI ATRP b 4.01 • Br ATRP - 1.28 4.01 3.19 1 00 CI ATRP 1.45 6.89 2.10 Br ATRP 3.47 6.89 5.02 St 80 CI ATRP b 2.23 • Br ATRP - 1.45 2.23 6.50 8 1 · PECI and 1 · PEBr ware used as Initiators for CI and Br ATRP, respectively, [1 - PEX]0 = 0.1 M, and (1 - PEX]0 / [CuX]0 / [Bpyfe = 1 / 1 /3; * no polymer can be detected In 40 hrs.
Effect of the Concentrations of the Components in Initiator System, R-X/CuX/Bpy, on Atom Transfer Radical Polymerization. In order to gain a better understanding of the ATRP mechanism, the effects of the components in the initiator system compositions on the kinetics and the living character of polymerization were investigated.
As discussed in the previous sections, the slope of the kinetic semilogarithmic anamorphoses allows the calculation of apparent rate constant kpapp, and thus the external orders in initiator, catalyst, and ligand, can be determined: kpap = d(In[M])/dt = k[RX]0* x [CuX]0* x [Bpy]0z (7) and ln(kpapp) = ln(k) + xln([RX]0) + yln([CuX]Q) + zln([Bpy]0) (8) The plots of ln(kpapp) vs. In ( [ 1-PECl ] 0) , ln(kpapp) vs. ln([CuCl]0), and ln(kpapp) vs ln([Bpy]0 for St ATRP in bulk at 130°C are given in Figures 12A-C. The fraction orders observed in these graphs are approximately 1, 0.4, and 0.6 for [1-PEC1]0, [CuCl]0, and [Bpy]Q respectively. The first order of kpapp in initiator, [1-PEC1]0, is expected. However, since the systems studied were heterogenous, it is difficult to give precise physical meanings for 0.4 and 0.6 orders in [CuCl]0 and [BpyJo/ respectively.
The effects of the compositions of the components in initiator system on the living character of the above-described ATRP of St reveal several important features. As seen from Figure 13, there appear to be no significant effects of [CuCl]0 on the initiator efficiency and the molecular weight distribution. Indeed, even in the presence of 0.3 molar equiv. of CuCl relative to 1-PECl, the experimental molecular weight, I , SEC, still linearly increases with monomer conversion and is close to the theoretical molecular weight obtained by means of eq. 1 (Figure 13A) . The similar results are also found for MA (Figures 5 and 14) . These findings suggest that in ATRP, the CuX acts as a catalyst and the addition of catalytic amount of CuX complexed by Bpy is sufficient to promote a controlled ATRP, even in these heterogeneous systems.
Transition Metal Catalyzed-Atom Transfer Radical Addition and Transition Metal Catalyzed-Atom Transfer Radical Polymerization. As described above, atom transfer radical polymerization, ATRP, can be considered as a succession of consecutive atom transfer radical additions, ATRA's. The prerequisite for a successful transformation of transition metal catalyzed-ATRA to transition metal catalyzed-ATRP is that a number of polymeric halides, Mn-X, can be effectively activated by M.n (Fig. 2). Present work demonstrates that a Cu (I) /Cu (II) -based redox process in the presence of Bpy can achieve that goal.
Indeed, to prevent possible polymerization and to obtain the monomeric adduct, R-M-X, in good to excellent yields in the ATRA process, organic chemists often use either (1) activated organic halogens as radical sources, (2) terminal alkenes without resonance-stabilizing substituents or (3) both activated organic halogens as radical sources and terminal alkenes without resonance-stabilizing substituents (see (a) Bellus, D. Pure & Appl . Chem. 1985, 57, 1827; (b) Nagashima, H.; Ozaki, N. ; Ishii, M. ; Seki, K. ; Washiyama, M. ; Itoh, K. J. Org. Chem. 1993, 58, 464; (c) Udding, J. H.; Tuijp, K. J. M. ; van Zanden, M. N. A.; Hiemstra, H.; Speckamp, W. N. J. Org. Chem. ^99 , 59, 1993; (c) Seiias et al. Tetrahedron, 1992, 48(9), 1637; (d) Nagashima, H. ; Wakamatsu, H. ; Ozaki, N.; Ishii, T.; Watanabe, M. ; Tajima, T.; Itoh, K. J. Org. Chem. 1992, 57, 1682; (e) Hayes, T. K. ; Villani, R. ; Weinreb, s. M. J. Am. Chem. Soc. 1988, 110, 5533; (f) Hirao et al. Syn.
Lett., 1990, 217; and (g) Hirao et al. J. Synth. Org. Chem. (Japan), 1994, 52(3), 197; (h) Iqbal, J; Bhatia, B. ; Nayyar, N. K. Chem. Rev., 94, 519 (1994)). Under such conditions, the further generation of free radicals, R-M", is kinetically less favorable, since R-M-X is much less reactive than R-Y towards the transition metal species, M." (Fig. 1).
From the results described herein, the following parameters appear to be important to promote the successful -61- transformation of ATRA to ATRP. First, the use of suitable ligands (e.g., Bpy, P(OEt)3) increases the solubility of the transition metal compound (e.g., CuX) by coordination, can facilitate the abstraction, of a halogen atom from the initiator, and more importantly, can facilitate abstraction of the transfer atom or group from the dormant polymeric halide, R-Mn-X, with the formation of initiating and growing radicals (Fig. 2). Secondly, as demonstrated in Table 3, the presence of either inductive or resonance stabilizing substituents in the initiator are beneficial for generating initiating radicals, R", in growing PSt and PMMA chains. Finally, in practice, the use of a high polymerization temperature is beneficial, particularly for CI ATRP (Table 5) . In fact, many ATRA processes also appear to use rather high temperatures.
Prior to the present invention, RuCl2(PPh3)3 was known to promote only the monomeric addition of CC14 to alkenes. Very recently, it was reported that RuCl2(PPh3)3 induced the controlled radical polymerization of MMA at 60°C in the presence of methylaluminum bis (2 , 4-di-tert-butylphenoxide) (Sawamoto et al, Macromolecules , 1995, 28, 1721) . However, the present inventors observed that at high polymerization temperatures (e.g., 130°C, a number of radically polymerizable monomers undergo ATRP in the absence of methylaluminum bis (2 , -di-tert-butylphenoxide) or other such activators. As a result, one may increase polymerization temperature (rather than include methylaluminum bis (2 , 4-di-tert-butylphenoxide) or other activator) as a means to enhance the reactivity of less reactive monomeric or polymeric halides towards transition metal species with the formation of propagation radicals.
Indeed, it is possible that an activator may lead to a change in the polymerization mechanism.
Radical Addition vs Coordination Insertion. Regarding the mechanism of ATRP , the important question to be answered is whether the ATRP really involves radical intermediates during polymerization.
The generation of radical intermediates by reacting some transition metal species, including salts and/or complexes of copper, ruthenium, iron, vanadium, niobium, and others, with alkyl halides, R-X, is well documented (see (a) Bellus, D.
Pure & Appl . Chem. 1985, 57, 1827; (b) Nagashima, H. ; Ozaki, N. ; Ishii, M. ; Seki, K.; Washiyama, M. ; Itoh, K. J. Org. Chem. 1993, 58, 464; (c) Udding, J. H. ; Tuijp, K. J. . ; van Zanden, M. N. A.; Hiemstra, H. ; Speckamp, W. N. J. Org. Chem. 1994, 59, 1993; (c) Seiias et al. Tetrahedron, 1992, 48(9), 1637; (d) Nagashima, H. ; Wakamatsu, H. ; Ozaki, N. ; Ishii, T.; Watanabe, M. ; Tajima, T.; Itoh, K. J. Org. Chem. 1992, 57, 1682; (e) Hayes, T. K. ; Villani, R. ; Weinreb, S. M'. J. Am. Chem. Soc. 1988, 110, 5533; (f) Hirao et al, Syn. Lett., 1990, 217; and (g) Hirao et al, J. Synth. Org. Chem. (Japan), 1994, 52(3), 197; (h) Iqbal, J; Bhatia, B. ; Nayyar, N. K. Chem.
Rev., 94, 519 (1994); and ochi, J. . , Organometallic Mechanisms and Catalysis , Academic Press, New York, 1978, and references cited therein) . Moreover, it is also known that R-X/transition metal species-based redox initiators, such as Mo(CO)6/CHCl3, Cr (CO)e/CCl4 , Co4 (CO) 12/CC14 , and Ni[P (OPh) 3]4/CCl4 , promote radical polymerization (see Bamford, Comprehensive Polymer Science, Allen, G., Aggarwal, S. L. , Russo, S., eds., Pergamon: Oxford, 1991, vol. 3, p. 123). The participation of free radicals in these redox initiator-promoted polymerizations was supported by end-group analysis and direct observation of radicals by ESR spectroscopy (see Bamford, Proc. Roy. SOC, 1972, A, 326, 431).
However, different transition metal species may act in a different manner. They may induce an atom transfer reaction or provide a source of metal-complexed radicals or even initiate a catalytic cycle that does not involve radical intermediates (Curran et al, J. Org. Chem. and J. Am. Chem. Soc. , supra) .
In fact, several examples using additives such as CuX, a catalyst suitable for the present invention, reported previously showed that the reactions between some polyhaloalkanes , e.g., CC14, and alkenes exceptionally lead to exclusive 1:1 adducts in many cases (Bellus , supra). The authors argued that, if radical addition were the case, a considerable amount of telomer formation would be expected even at high organic polyhalide/alkene ratios. Thus, they questioned whether Cu(I)Cl cleaves the carbon-halogen bond by an atom transfer process to generate a carbon radical and a Cu(II) species (Fig. 2) or by an overall two-electron change to generate a Cu(III) species 2 (Fig. 15), followed by insertion of the alkene into the carbon-copper ( III) σ-bond and halogen ligand transfer (reductive elimination) with a new Cu(III) species 3. formed.
In sharp contrast to previous observations, the present invention shows that the polymerization of alkenes occurs when halide initiators, including CC1,, are used with CuX complexed by Bpy as a catalyst. The uncomplexed CuX species may not be powerful enough to abstract the halogen atom from the 1:1 monomeric adduct to promote atom transfer radical polymerization. As described below, the polymerization of st initiated with 1-PECl/CuCl without ligand is an ill- controlled, thermally self-initiated polymerization.
Moreover, the similarities in stereochemistry of the polymerizations of MMA initiated with classic radical initiators and various initiator/CuX/Bpy systems (Table 2) suggests that a putative insertion process (Fig. 16) can be rejected. Although metal coordinated radicals (Fig. 17) may be involved in the polymerizations of alkenes initiated with the R-X/CuX/Bpy system, a simple radical process is most probable (Fig. 2) . The participation of the free radical intermediates is also supported by the observation that addition of 1.5 molar equiv. of galvinoxyl (relative to l- PEC1) effectively inhibits polymerization, and no styrene polymerization was initiated with 1-PECl/CuCl/Bpy (1/1/3) within 18 hours. Further evidence for the presence of radical intermediated in ATRP is the fact that the monomer reactivity ratios for ATRP random copolymerization resembles the monomer reactivity ratios for classical radical polymerization , processes (i.e., r^ = 0.46/rSc = 0.48 for ATRP at 100°C initiated with 2-EiBBr/CuBr/Bpy , and r^ = 0.46/rsc = 0.52 for radical polymerization initiated with BPO at 60°C) .
Atom Transfer Radical Polymerization vs. Redox Radical Telomerization. It is well known that radical telomerization can be initiated by a transition metal species-based redox catalyst. The mechanism is generally described as shown below: Scheme 2 Initiation: RCC13 + Mtn > M^'Cl + RCC1,' RCClj' + M -> RCCljM' Propagation: RCCIJ + M —> RCCljM,,.
Chain Transfer: RCCl- + RCC13 —> Reeled + RCCl , Termination: RCCljM-," + Mcn*lCl > RCCl^Cl + Men Mtn+1 CI represents the transition metal species Mtn in a higher oxidation state after a redox reaction adding a CI.
The fundamental differences between ATRP and redox radical telomerization are as follows. In ATRP, the polymeric halides, R-M„-X, behave as dormant species (Fig. 2) . They can be repeatedly activated by transition metal species, M,n, to form the growing radicals, R-M,,", and oxidized transition metal species, M,."*1 , which can further react with R-M to regenerate R-M-X and M.n, i.e., a reversible transfer process.
Contrary to ATRP, redox radical telomerization represents a degradative transfer process, in which the resulting polymeric halides, R-M„-X, are dead chains (see Scheme 2 above) . Consequently, the molecular weight obtained in redox radical telomerization does not increase with the monomer conversion, whereas the molecular weight increases linearly with increasing monomer conversion in ATRP.
Factors Affecting Atom Transfer Radical Polymerization, (a) "Living"/Controlled Radical Polymerization. To better describe controlled ATRP, a .discussion of some general properties for "living"/controlled radical polymerization is in order.
Free radicals, which are the growing species in radical polymerization, are highly reactive species. Unlike anions or cations, they recombine and/or disproportionate at rates -67- approaching the diffusion controlled limit (i.e., k. of about 10a-io M'l sec-1), which is much higher than the corresponding propagating rate constant (i.e., kp - 102~* M'l-sec l) .
Moreover, initiation is incomplete due to slow decomposition of classic radical initiator (i.e., kd - 10'4"6 sec"1) . These are the kinetic reasons why classic radical polymerization yields ill-defined polymers with unpredictable molecular weight, broad molecular weight distribution, and uncontrolled structures.
Moreover, due to the same kinetic reasons, it is impossible to entirely suppress the termination reactions and to obtain a living radical polymerization, in which chain breaking (termination) reactions are absent (Szwarc, Nature, 1956, 176, 1168). Thus, for the sake of the accuracy, we propose the term controlled or "living" radical polymerization to describe the processes in which the side reactions are not significant. Consequently, structural parameters, such as molecular dimension, molecular weight distribution, composition, topology, functionality, etc., can be controlled to some extent.
The preparation of controlled polymers in a "living" radical process requires a low stationary concentration of growing radicals, M„', which are in a fast dynamic equilibrium with the dormant species, M„-D: Mn" + 0 —' t^-D Termination is second order and propagation is first order in respect to growing radicals (eqs. (12) and (13) : Rp = d(ln[M])/dt = kp[M] x [Ρ·] (12) Rt = -d[P-]/dt = kc x [P"]2 (13) At low concentration of free radicals, the proportion of termination versus propagation is reduced. If the reversible exchange . between growing radicals, M.,", and dormant species, Mn-D, is fast, the polymerization degree can be predetermined by the ratio of the concentration of the consumed monomer to that of the dormant chains (eq. 14), and the molecular weight distribution may remain narrow.
DPn = A[M]/[M„-D] = Δ[Μ]/[Ι]0 (14) Recent progress in controlled radical polymerization can be indeed related to the approach illustrated in the Mn-D reaction above, in which growing radicals, Mn", react reversibly with species D, which may be carbon-, sulfur-, and oxygen-centered radicals (Otsu et al. Makromol . Chem, Rapid Commun., 1982, 127; Otsu et al. Macromolecules, 1992, 25, 5554; Bledzki et al. Makromol . Chem,. 1983, 184, 745; Druliner . Macromo1ecu1es , 1991, 24, 6079; U.S. Patent No. 4,581,429; and Georges et al. Macromolecules , 1993, 26, 2987) , alkylaluminum complexes (Mardare et al. Macromolecules, 1994, 27, 645) , and organocobalt porphyrin complexes ( ayland, B. B. , Pszmik, G. , Mukerjee, S. L. , Fryd, M. J. Am. Chem. Soc . , 1994, 116, 7943), in a reversible deactivated process. Another approach (discovered by the present, inventors) is based on using alkyl iodides in a degenerative transfer.
The Significance of the Presence of the Low Concentration of Growing Radicals in Maintaining "Living" ATRP. Since ATRP promoted by the Cu(I)/Cu(II) redox process resembles classic radical polymerization, termination reactions can not completely eliminated, which are second order in respect to growing radicals (eq. 13) . As already discussed in the preceding section, if the concentration of growing radicals is kept low enough, and a fast and reversible equilibrium between growing radicals and dormant species is established (see Scheme 2 above) , the proportion of termination in comparison to propagation can be minimized, resulting in a predictable molecular weight and a narrow molecular weight distribution. Indeed, this is the case for "living" ATRP.
Table 6 lists the estimated polymerization time for 90% monomer conversion, t0 9, concentration of the dead polymer chains due to the spontaneous termination reactions at that time, [P]d.o. 9 , concentration of the polymer chains due to self- initiation, [P]M_.._■.»» and percentage of uncontrolled polymer chains generated by side reactions, "UC", in bulk ATRP of St, MMA, and MA initiated with 1-PECl/CuCl/Bpy at 130°C: -70- in ([M]0/(M]) = In (10) = > x t0.9 (i5) -Plself.0.9 = Rl.self X .9 (17) " = ( [P]«l£.0.9 + CP]4.0.9) /{ [R-X]o + [P]Se .0.9 + C P 3 d.0.9 } (is) Table 6 Estimated (P"], t0.„ [P]3ei..o.9/ [PL.o.9, and "UC" for Bulk ATRP of St, MMA and MA Initiated with 1-PECl/CuCl/Bpy (1/1/3) at 130°C a: see Table 4; b: Data from Odlan. G. Principles of Polymerization, Wiley-Interscience, John Wiley & Sons, New York, 1991; In kt MA = 23.43 - (2671/T) , In k..^ = 18.5 - (1432/T) , In k, sc = 17.47 - (962/T) .
As shown in Table 6, at 90% monomer conversion, the concentrations of uncontrolled polymer chains, "UC", are all less than 3% in ATRP's of St, MMA, and MA, when 1-PECl/CuCl/Bpy (1/1/3) is used as the initiator system at 130°C. This may be why ATRP proceeds in a "living" manner. Although the termination rate constant is larger in MA radical polymerization than in the other two processes, ATRP of MA is better controlled than ATRPs of St and MMA. This appears to be due to a lower concentration of growing radicals in the ATRP of MA (Table 6) .
The Significance of the Presence of Fast Exchange Between R-Μ-,-Χ and R-M in Inducing Low Polydispersity in ATRP. At a low concentration of radicals (Tables 4-6), ca. 10~7 to about 10'a mol/l, polymers with very high and uncontrolled molecular weights are usually found. To cope with this problem, a reversible equilibrium between a minute amount of growing, radicals and a large amount of the dormant species needs to be established. Moreover, only if both (1) the initiation reaction between initiating radicals and monomer and (2) the exchange reaction between the growing radicals and the dormant species are faster than (3) the propagation reaction between the growing radicals and the monomer, the molecular weight of the resulting polymers can be predicted by eq. (14) , and low polydispersity polymers can be obtained.
Moreover, in a so-called "living" system with reversible dynamic exchange, there is evidence that the polydispersity of the resulting polymers largely depends on the ratio of the deactivation rate to the propagation rate (Matyjaszewski , K. Polym. Prep. (Am. Chem. Soc. Polym. Chem. Div.), 1995, 36(1), 541) . On the other hand, it has been demonstrated that many transition metal species can be used as efficient retarders or inhibitors in radical polymerization (Bamford, Comprehensive Polymer Science, Allen, G. , Aggarwal, S. L. , Russo, S., eds., Pergamon: Oxford, 1991, p. 1) . For example, the reaction rate constants between (1) PSt" and CuCl2 and (2) PMMA' radicals and CuCl2 are 104 and 103 times greater in comparison with the corresponding propagation rate constants, respectively.
Therefore, the existence of a fast deactivation (scavenging) reaction can explain the low polydispersity obtained in ATRP.
Earlier, Otsu et al reported that an R-Cl/Ni(0) combined initiator system can induce a "living" radical polymerization of St and MMA at 60°C {Chem. Express, 1990, 5(10), 801).
However, the "living" character of the R-Cl/Ni(0) combined initiator of Otsu et al may not be entirely accurate, since (1) the molecular weight of the obtained polymers did not increase linearly with respect to monomer conversion, (2) the initiator efficiency is low (about 1% based on R-Cl) , and (3) the molecular weight distribution is broad and bimodal. The same phenomena were also observed by the present inventors.
Thus, it appears that the R-Cl/Ni(0) combined initiator of Otsu et al does not provide controlled polymers.
Based on the published evidence, the R-Cl/Ni(0) combined initiator of Otsu et al appears to act as a conventional redox initiator, similar to the initiators developed by Bamford (see Reactivity, Mechanism and Structure in Polymer Chemistry, Jenkins, A. D. and Ledwith, A., eds, John Wiley & Sons, London (1974), p. 52; and Comprehensive Polymer Science, Allen, G. , Aggarwal, S. L. , Russo, S., eds., Pergamon: Oxford, 1991, vol. 3, p. 123). The very low initiator efficiency and a broad, bimodal molecular weight distribution observed in the system of Otsu et al suggests that in that system, the small amount of initiating radicals were generated by a redox reaction between R-Cl and Mi(0), and the reversible deactivation of initiating radicals by oxidized Ni species is inefficient in comparison to propagation. This may support the idea that fast exchange between R-X and R" in transition metal-promoted ATRP at the initial step is one of the key factors controlling initiator efficiency and molecular weight distribution.
The Factors Affecting the Concentrations of the Growing Radicals and the Exchange Rate Between R-Μ,,-Χ and R-MQ" in ATRP. Based on the results shown herein, the factors affecting the concentrations of the growing (initiating) radicals and the exchange rate between R-M„-X (R-X) and R-M." (R') in ATRP can be qualitatively discussed.
The stationary concentration of growing radicals can be expressed as in eq. (20) : Mn-X + CuX „Z . Mn* + CuX > "•deacc .
K = kacc./k '(deacc = ([Μη·] x [CuX2])/([Mn-X] x [CUX]) [M„'] = { (kac../kdeac. ) x ([R-X]0 x [CuX]Q)>H (20) An increase in [R-X]Q and [CuX]0 results in an increase in the concentration of growing radicals, and subsequently, in the polymerization rate (Figure 12) .
As also seen from eq. (20) , the concentration of growing (initiating) radicals is proportional and inversely proportional to the activation and deactivation rate constants, respectively, which strongly depend on the structure of the RnR12R"C group in the initiator, the structure of the repeating monomer units M in R-Μ,,-Χ, the leaving group X, and the polymerization temperature (see Tables 3, 4 and 5, Figure 9) .
In terms of polarity, the deactivation reaction between PMA' and CuCl2 is usually 10 times slower than that between Psf and CuCl2 (i.e., kdeact.PSc ./CuC12 > kdeac..PMA./CuC12) (see Bamford, Comprehensive Polymer Science, Allen, G. , Aggarwal, S. L. , Russo, S., eds., Pergamon: Oxford, 1991, p. l) · Thus, the similar concentration of radicals found in the ATRP of St relative to the ATRP of MA indicates that the activation reaction between CuCl and PSt-Cl is faster than the one between PMA-C1 and CuCl (i.e., k.ee.psc.cl > kacc ?MA.C.) . This is in good agreement with the lower bond dissociation energy in PSt-Cl as compared to PMA-Cl (see Danen, W. C. , in Methods in Free Radical Chemistry, Huyser, E. L. S., ed., Dekker, New York, 1974, vol. 5, p.l; and Po :.sma . supra). The higher concentration of growing radicals found in the ATRP of MMA as compared to the ATRP's of St and MA (see Table 4) implies that steric hindrance in both the polymeric halide PMMA-C1 and growing radical PMMA" may significantly affect deactivation and activation rates.
As noted in Figures 10 and 11, the polymerization is much faster in the Br-ATRP of MA than in the Cl-ATRP of MA, due to a higher stationary concentration of radicals in the former system as compared to the latter one. However, the polydispersity is much narrower in Br ATRP than in Cl-ATRP. According to the discussion in the preceding section, this suggests that deactivation of free radicals with CuBr2 is faster in comparison to deactivation of free radicals with CuClj. Since the concentration of growing radicals in Br-ATRP is larger than in Cl-ATRP (see Table 5) , the activation of PMA-Br by Br-containing Cu(I) species must be faster than the activation of PMA-Cl by Cl-containing Cu(I) species. This is also in accordance with the fact that the ease of the abstraction of X from R-X by CuX follows the order Br > Cl (i.e., the lower the bond dissociation energy in R-X, the easier to abstract an X atom; see Curran. Synthesis , in Free Radicals in Synthesis and Biology, and in Comprehensive Organic Synthesis; Danen; and Poutsma, all supra) .
Halogen Atom Transfer (Abstraction) vs. outer-sphere Electron Transfer. The generation of free radicals by reacting an organic halide with a transition metal compound may involve two different mechanisms: either halogen atom transfer (Figure 18A) or outer-sphere electron transfer (Figure 18B) . The former process depends on the carbon-halogen bond dissociation energy, whereas the latter is a function of the electrode potential for the reaction of the organic halide (i.e., RX + e" —> R" + X").
The outer sphere electron transfer process is usually less sensitive than halogen atom transfer to the leaving atom X in R-X and to temperature (Howes et al. Inorg. Chem. 1988, 27, 3147; and references therein). As discussed before, the results presented herein show that transition metal-mediated ATRP has a strong dependence on the leaving group X in R-X, as well as on the reaction temperature. Thus, the results herein suggest that ATRP involves a direct atom transfer process.
Alternatively, the reversible conversion of the radicals R" and R-Mn' to organic halides R-X and R-Μ,,-Χ may involve direct atom transfer (see Kochi, J.K., Organometallic Mechanisms and Catalysis , Academic Press, New York, 1978, and references cited therein; Asscher, M. , Vofsi, D. J. c em.
Soc. , Perkin II. 1968, 947; and Cohen, H. , Meyerstein, D.
Inorg . Chem. 1974, 13, 2434) or oxidative addition/reductive elimination with the formation of organocopper ( III) intermediates (see Kochi, supra; Orochov, A., Asscher, M. , Vofsi D, J. Chem. Soc, Perkin II. 1973, 1000; and Mitani, M. , Kato, L. , Koyama, K. J. Am. Chem. Soc. 1983, 105, 6719). Generally, it is difficult to distinguish between these two mechanisms. Nevertheless, the organocopper ( III) species, if they exist, probably do not react directly with monomer.
Otherwise, some effect on tacticity would be observed.
Thus a successful extension of atom transfer radical addition, ATRA, to atom transfer radical polymerization, ATRP has been demonstrated in a Cu(I)/Cu(II) model redox process. The present process opens a new pathway to conduct a "living" or controlled radical polymerization of alkenes. The controlled process found in ATRP results from two important contributions: (1) a low stationary concentration of growing radicals and (2) a fast and reversible equilibrium between the growing radicals and the dormant species. Many parameters, such as the nature of transition metals, the structure and property of ligands, the polymerization conditions, etc, may affect the course of "living" ATRP. On the other hand, it is anticipated that, like other controlled polymerizations, ATRP will provide a powerful tool for producing various tailor-made polymers .
Other features of the present invention will become apparent in the course of the following descriptions of exemplary embodiments which are given for illustration of the invention, and are not intended to be limiting thereof.
EXAMPLES Example 1; An aralkyl chloride, 1-phenylethyl chloride, 1-PECl, is an efficient initiator, and a transition metal halide, CuCl, complexed by 2 , 2 ' -bipyridine, bpy, is an efficient chlorine atom transfer promoter. This model initiating system affords controlled polymers with predicted molecular weight and narrower molecular weight distribution, M^/M^ < 1.5, than obtained by conventional free radical polymerization.
Phenylethyl chloride, 1-PECl, was prepared according to a literature procedure (Landini, D.; Rolla, F. J. Org. Chem. , 1980, 45, 3527).
A typical polymerization was carried out by heating a reddish brown solution of styrene (St), 1-PECl (0.01 molar equiv. relative to monomer) , CuCl (l molar equiv. relative to 1-PECl) , and bpy (3 molar equiv. relative to CuCl) , in a glass tube sealed under vacuum at 130°C. (The reddish brown color of a slightly heterogeneous solution was formed within 30 seconds at 130°C.) The formed polymer was then dissolved in THF and precipitated in MeOH (three times) , filtered and dried at 60°C under vacuum for 48 hr. Yield, 95%. A linear -79- increase in the number average molecular weight, Mn scc, versus monomer conversions up to 95% was found for PMA. , SEC values were determined by size exclusive chromatography, and were calibrated using polystyrene standards.
The Mn SEC is very close to the theoretical one, Mn_.n, calculated by the following equation (21) : M„.cn. = ([M]0/[1-PEC1]0) x (MW)0 x conversion (21) [M]0 and [1-PEC1]Q represent the initial concentrations of monomer (St) and 1-PECl, respectively, and (MW)3 is the molecular weight of monomer. These results indicate that l-PEC1 acts as an efficient initiator, and that the number of the chains is constant. The molecular weight distribution is fairly narrow (M^/M., = 1.3-1.45). The linear plot of ln([M]0/[M]) versus polymerization time (e.g., Figure 3) implies that the concentration of growing radicals remains constant during propagation, and that termination is not significant. Both of these results suggest a "living" polymerization process with a negligible amount of transfer and termination.
Additionally, a series of experiments has been carried out at 130°C, using various [M]0/ [1-PEC1]0 ratios and a constant [1-PEC1]0/ [CuCl]0/ [bpy]0 ratio of 1:1:3. Similar to Figure 5, a graph was prepared which compares the M„SEC and calculated ch , based on equation (21) above.
A linear plot is observed in the molecular weight range from 3.8 x 103 to 1-05 x 10s g/mol. The slope of the straight line is 0.93, indicating a high initiator efficiency. The polydispersities of all the polymers obtained also remain low and are smaller than in a conventional radical polymerization i.e., Μν/Μ,, < 1.5. These results again support a "living" polymerization process initiated with 1-PECl/CuCl/Bpy system.
Table 7 summarizes the results of styrene polymerization under various experimental conditions. In the absence of l-PEC1, CuCl or bpy, the polymers obtained are ill-controlled with unpredictable molecular weights and with broad molecular weight distributions.
Tablcl RcsulU of Styrcnc Bulk Polymcrlialloii at 130'C (Silo Conv. (1 - PECIJo (CuCI)0 (bypl0 M^1 (mmol) ^ (mrool) (nunoQ (mrool) 4.375 15 0 0 0 o 4.375 52 0 0.182 0.54 0 4.375 40 0.0528 0.0455 0 3. 400 4.40 45 0.0528 0. I3S 4, 100 ■ calculated based on eq . 21 Example 2: The same initiating system, 1-PECl/CuCl/Bpy (1/1/3) , can be also used for the controlled polymerization of acrylic monomers, such as methyl methacrylate, MMA, methyl acrylate, MA, and butyl acrylate, BA. Block copolymers of St and MA have been produced using the same technique as described in Example 1 for homopolymerization of styrene (see the Examples below) . Heating of chlorine atom end-capped polystyrene (0.5 g, M„ = 4000, M^M-, = 1.45) and a two-fold excess of MA (l.o g) in the presence of 1 molar equiv. of CuCl and 3 molar equiv. of bpy (both relative to polystyrene) at 130°C results in MA block polymerization to form the desired PSt-b-PMA block copolymer (yield: 95%, M„ = 13,000, Vl^/ti^ = 1.35).
Discussion By analogy with transition metal catalyzed atom transfer radical addition reactions (ATRA) , used in organic synthesis, the results presented herein can be explained by the mechanism shown in Fig. 2. The present process appears to involve a succession of ATRA processes, and therefore, can be called atom transfer radical polymerization, ATRP.
The model catalyst Cu∑Cl acts as a carrier of the chlorine atom in a redox reaction between Cu(I) and Cu(II) , The coordination of the bidentate nitrogen ligand to Cu^l increases the solubility of the inorganic salt and can also affect the position of the redox equilibrium, so as to facilitate the abstraction of a chlorine from the initiator, 1-PECl, and the dormant species, Pt-Cl, with the formation of initiating and growing radicals, respectively. The reversible conversion of radicals, R' and Pt", to the corresponding halides, R-Cl and Pt-Cl, may involve a direct atom transfer reaction (Kochi, J.K. Organometallic Mechanisms and Catalysis , Academic Press: New York, 1978, and' references therein; Asscher, M. , Vofsi, D. J. Chem. Soc. , Perkin II. 1968, 947; Cohen, H., Meyerstein, D. Inorg. Chem. 1974, 13, 2434) or oxidative addition/reductive elimination with the formation of the organocopper (III) intermediates (Kochi, supra; Orochov, A., Asscher, M. , Vofsi D. J. Chem. Soc, Perkin II. 1973, 1000; Mitani, M. , Kato, L. , Koyama, K. J. Am. Chem. Soc. 1983, 105, 6719). If the concentration of growing radicals is low and the redox reaction is fast compared to bimolecular reactions of the radicals, the extent of the termination reactions is minimized, resulting in a "living" process. Moreover, if the rate of reversiJle exchange between P^-Cl and P," is comparable to that of propagation, the number average molecular weight should be defined by eq. (21) , and the molecular weight distribution should remain narrow.
Two observations support the participation of free radicals in ATRP. First, the tacticity of the polymers is similar to those synthesized by typical radical initiators. For example, the tacticity of poly (methyl methacrylate) M_ = ,400, 1.40) synthesized using a 1-PECl/Cucl/Bpy initiator system (in a 1:1:3 molar ratio) at 130°C is rr/mr (rm) /mm: 53/38/9. These values are very close to those of PMMA prepared using a typical radical initiator, BPO, at the same temperature. Therefore, the organocuprate (III) species, if it exists, probably does not react directly with monomer, otherwise some effect on tacticity would be expected. Secondly, addition of 1.5 molar equiv. of galvinoxyl (relative to l-PECl) effectively inhibits the polymerization. In the presence of galvinoxyl, no styrene polymerization was found within 18 hours.
The low proportion of termination, despite the relatively rapid polymerization, may be explained by stabilizing interactions between radicals P^' and CuCl2. It may be possible that the monomer reacts with a radical P,' within a solvent cage, in which the ratio of rate constants of propagation to termination is higher than for uncomplexed radicals in solution.
At 130°C, styrene may polymerize thermally by self- initiation. (Moad, G. , Rizzardo, E. , Solomon, D. H. Polym. Bull., 1982, 6, 589). The contribution of this reaction in ATRP is rather small, because (1) ATRP is fast and (2) the relative rate of self-initiation is further reduced with the progress of the reaction. However, the small contribution of self-initiation may enhance polydispersities to the range of M.-7Mn ¾ 1.4, and may reduce molecular weights to slightly lower values than theoretically predicted.
It must be stressed that the present transition-metal promoted ATRP, in which the molecular weight linearly increases with monomer conversion, is very different from typical redox radical telomerization promoted by transition metal species in which the molecular weight does not increase with conversion (Boutevin, B. , Pietrasant, Y . , in Comprehensive Polymer Science, Allen, G. , Aggarwal, S. L. , Russo, S., eds., Pergamon: Oxford, 1991, vol. 3. p 185; Bamford, C. H. , in Comprehensive Polymer Science (First Supplement), Allen, G. , Aggarwal, S. L. , Russo, S., eds., Pergamon: Oxford, 1991, p. l) .
In conclusion, the model alkyl chloride initiator, l- PEC1, and model transition metal complex CuCl/bpy polymerize styrene by repetitive atom transfer radical additions to give well-defined high molecular weight polymers with narrow > molecular weight distributions.
For examples 3-22, the polymers were isolated by either of two procedures: (1) The polymer was dissolved in THF and precipitated in MeOH (three times) , filtered and dried under vacuum; or (2) The heterogeneous reaction solution was filtered, and the solvent was removed under vacuum.
Removal of solvent or drying can optionally be conducted using mild heat (e.g., 25-60°C) . The same polymeric product is obtained, regardless of the isolation procedure.
Monomers, and ethyl acetate were vacuum-distilled over CaH2 before use. CuCl and CuBr were purified according to the known procedures (see Nagashima, H. ; Ozaki, N. ; Ishii, M. ; Seki, K. ; Washiyama, M. ; Itoh, K. J. Org. Chem. 1993, 58, 464 ; (c) Udding, J. H. ; Tuijp, K. J. M. ; van Zanden, M. N. A. ; Hiemstra, H. ; Speckamp, . N. J. Org. Chem. 1994, 59, 1993 ; (c) Seiias et al. Tetrahedron, 1992, 48(9), 1637; (d) Nagashima, H.; Wakamatsu, H.; Ozaki, N. ; Ishii, T. ; Watanabe, M. ; Tajima, T. ; Itoh, K. J. Org. Chem. 1992, 57, 1682).
Example 3: Polystyrene was prepared by heating styrene (0.9 g), l-phenylethyl chloride (1 μΐ,, 7.54 x 10"5 mol) , Cu(I)Cl (7.54 x 10"6 mol) and 2 , 2 ' -bipyridine (Bpy; 2.26 x 10"5 mol) at 130° in a sealed tube for 21.5 h. The polymerization reaction mixture was then dissolved in THF, and precipitated in methanol. The precipitated polymer was filtered, and the dissolving, precipitating and filtering steps were repeated two additional times. The obtained polymer was dried at 60 °C under vacuum for 48 h.
The dried polymer had a number average molecular weight as measured by size exclusion chromatography (SEC) , M-SEC, of 95,000, in good agreement with the theoretical number average -87- molecular weight, M., ch , of 102,000. The dried polymer was obtained in 85% yield. The polydispersity , Μ,,/Μ,,, was 1.45.
Example 4 ; Polystyrene was prepared according to the procedure described in Example 3, except polymerization was conducted at 100°C for 88 h. The polymer was obtained in 80% yield. The Mn.sEc of 93,300 was in excellent agreement with the M„ ch of 97,000. The Μ,,/Μ,, of the obtained polymer was 1.50.
Example 5: The procedure of Example 3 was repeated, except that 0.45 g of styrene and 2.5 ML (1.89 x 10~s mol) of l-PECl were employed, Ni(0) (2.73 x 10"5 mol) was used as the transition metal in place of Cu(I)Cl, and PPh3 (1.41 x 10"· mol) was used as the ligand in place of Bpy. The reaction was conducted at 130°C for 12 h.
The polymer was obtained in 85% yield. The M„_SEC of the obtained polymer was 189,000 (!!,.-„. = 17,600), and the Κ,/Μη = 1.70.
Example 6: Polystyrene was prepared according to the procedure of Example 3, except that the concentration of 1-PECl was 2.26 x 10"5 mol (amount = 3 ML) , RuCl2 (2.26 x 10-s mol) was used in place of Cu(I)Cl, and PPh, (6.78 x 10s mol) was used in place of Bpy. The polymerization was conducted at 130°C for 13.5 h. The polymer was obtained in 90% yield. The M. SEC of 18,300 was in excellent agreement with the M„ ch of 17,900. The obtained polymer had an of 2.0.
Example 7; Polystyrene was prepared according to the procedure of Example 3, except that AIBN (1.7 x 10"s mol) was used in place of 1-PECl, Cu(II)Cl2 (3 x 10"5 mol) was used in place of Cu(I)Cl, and Bpy was present in a molar amount of 7 x I0's mol. The polymerization was conducted at 130°C for 5 h. The polymer was obtained in 90% yield. The M„ SEC of 18,500 was in agreement with the M„ c(1 of 25,000. The obtained polymer had an M M,, of 1.7.
Example 8; Polystyrene was prepared according to the procedure, of Example 3, except that 2-chloropropionitrile (3.75 x 10"6 mol) was used in place of 1-PECl; Cu(I)Cl and Cu(II)Cl2 were used in an equimolar mixture (3.76 x 10"* mol of each) in place of Cu(I)Cl alone; and Bpy was present in a molar amount of 1.9 x '5 mol. The polymerization was conducted at 130°C for 33 h. The polymer was obtained in 80% yield. The M„ SEC of 81,500 was in good agreement with the M„ ch of 95,500. The obtained polymer had an M^M., of 1.4.
Example 9: Polystyrene was prepared according to the procedure of Example 3, except that benzyl chloride (3.75 x lCT5 mol) was used in place of 1-PECl, FeCl2 (3.75 x lCT5 mol) was used in place of Cu(I)Cl, and (EtO)3P (1.15 x lCT" mol) was used in place of Bpy. The polymerization was conducted at 130°C for 5.5 h. The polymer was obtained in 85% yield. The M„>SEC of 19, 300 was in good agreement with the M,, ch of 21,100. The obtained polymer had an M^M,, of 3.0.
Example 10: Poly (methyl acrylate), PMA, was prepared according to the procedure of Example 3, except that 1.45 grams of MA were used, a, a' -dibromoxylene (4.4 x 10"5 mol) was used in place of 1-PECl, Cu(I)Br (8 x 10'5 mol) was used in place of Cu(I)Cl, and Bpy was present in a molar amount of 2.5 x 10" mol. The polymerization was conducted at 80 °C for 36 h. The polymer was obtained in 90% yield. The M,, SEC of 31,000 was in very good agreement with the M„ ch of 29,500, The obtained polymer had an Μ,,/Μ,, of 1.2.
Example 11: Poly (methyl acrylate) was prepared according to the procedure of Example 10, except that 0.48 g of MA were used, 2-methylbromopropionate (1.47 x 10"5 mol) was used in place of a , a ' -dibromoxylene, Cu(I)Br was used in an amount of 1.47 x '5 mol, and Bpy was present in a molar amount of 4.5 x 10"5 mol. The polymerization was conducted at 100 °C for 15 h. The polymer was obtained in 95% yield. The R. SEC of 29,500 was in very good agreement with the M„ _h of 31,000. The obtained polymer had an M^t^ of 1.15.
Example 12: Poly (methyl methacrylate) , PMMA, was prepared according to the procedure of Example 3, except that 0.5 g of MMA were used, 0.5 ml of ethyl acetate was employed as a solvent, 2-ethyl bromoisobutyrate (2.5 x 10"5 mol) was used in place of l-PEC1, Cu(I)Br (1.5 x 10"5 mol) was used in place of Cu(I)Cl, and Bpy was present in a molar amount of 4.5 x 10"5 mol. The polymerization was conducted at 100°C for 1.5 h. The polymer was obtained in 95% yield. The Mn>SEC of 20,500 was in excellent agreement with the Μ of 19,000. The obtained polymer had an l^/M,, of 1.40.
Example 13: Polyisoprene was prepared according to the procedure of Example 3, except that 0.45 g of isoprene was used in place of St, 3.77 x 10'5 mol of 1-PECl was used, 3.9 x 10"5 mol of Cu(I)Cl was used, and Bpy was present in a molar amount of 1.2 x 10"4 mol. The polymerization was conducted at 130°C for 45 h. The polymer was obtained in 80% yield. The Mn SEC of 12,700 -91- was in agreement with the Mn.ch of 9,500. The obtained polymer had an Μ,/Μ,, of 2.0.
Example 14: A PSt-b-PMA block copolymer was produced according to the procedure of Example 3, except that 0.5 g of PSt-ci ( H^ = 4,000, M^M-, = 1.45) was used in place of 1-P.ECl as the initiator, 1.0 g of MA was used as the monomer, Cu(I)Cl was present in a molar amount of 1.25 x 10"* mol and Bpy was present in a molar amount of 3.75 x 10"· mol. The polymerization was conducted at 130°C for 5 h. The polymer was obtained in 95% yield. The M„>SBC of 13,000 was in good agreement with the ^ of 11,600. The obtained polymer had Example 15 ; A PSt-b-PMA-b-PSt triblock copolymer was produced as follows. To a flask equipped with a water condenser and a magnetic stirring bar, the initiator α,α'-dibromoxylene (l x 10"4 mol), CuBr (2 x 10"4 mol), Bpy (6 x 10"4 mol), MA (3 g) and EtOAc (10 ml) were added. Argon was then bubbled through the solution, and the solution was heated at 100°C for 18 h. One ml of solution was withdrawn using a syringe and was analyzed by gas chromatography (GC) and SEC to determine the monomer conversion and M„, respectively. PMA was obtained in 100% -92- yield. The M-,iSEC of 30,500 was in excellent agreement with the M_, ch of 30,000, and the M,/Mn of the PMA was 1.3.
Styrene (1 g) was added to the PMA reaction solution, and the mixture was heated at 100°C for 18 h. The triblock polymer was obtained in 100% yield. The Mn SEC of 42,000 was in excellent agreement with the M„ ch of 40,000, and the triblock polymer had an M^ ., of 1.45.
Example 16: A PMA-b-PSt block copolymer was prepared according to the procedure of Example 3 , except that 0.5 g of PMA-Cl (M„ = 2,000, Μν/Μ-, = 1.30) was used in place of 1-PECl as the initiator, 1.0 g of MA was used as the monomer, Cu(I)Cl was present in a molar amount of 2.5 x 10" mol and Bpy was present in a molar amount of 7.5 x 10'4 mol. The polymerization was conducted at 130°C for 10 h. The polymer was obtained in 90% yield. The M of 11,500 was in excellent agreement with the M„jCh. of 11,000. The obtained polymer had an Mw/Mn of 1.29.
Example 17 ; A random P(St-co-MA) copolymer was prepared according to the procedure of Example 3, except that mixture of MA (0.48 g) and St (0.45 g) was used as comonomers, 1-PECl was used in an amount of 3 μΐ, (2.26 x 10"5 mol), Cu(I)Cl was used in an amount of 2.22 x 10's mol and Bpy was present in a molar amount of 6.5 x 10"5 mol. The polymerization was conducted at 130°C for 5 h.
The polymer was obtained in 95% yield. The Mn SEC of 39,000 was in excellent agreement with the , cil of 39,100. The obtained polymer had an Μ^,/Μ^ of 1.45.
The composition as determined by lH NMR contained 48% MA, and 52% St.
Example 18: A random P(St-co-MMA) copolymer was prepared according to the procedure of Example 17, except that mixture of MMA (0.45 g) and St (0.45 g) was used as comonomers, 1-PEBr (3 pL, 2.2 x 10"5 mol) was used in place of 1-PECl, Cu(I)Br (2.0 x 10"5 mol) was used in place of Cu(I)Cl and Bpy was present in a molar amount of 4.5 x 10*5 mol. The polymerization was conducted at 100°C for 14 h. The polymer was obtained in 90% yield. The Mn.sEc of 38,000 was in excellent agreement with the M„ ch of 36,900. The obtained polymer had an of 1.55.
Example 19: A six arm star PMA polymer was prepared according to the procedure of Example 3, except that C6(CH2Br)6 (1 x 10"4 mol) was used in place of 1-PECl, MA (1 ml, 0.96 g) was used as the monomer, CuBr (1.8 x 10"4 mol) was used in place of Cu(I)Cl, and Bpy was present in a molar amount of 5.8 x 10'4 mol. The polyme ization was conducted at 110 °C for 45 h. The polymer was obtained in 100% yield. The Mn SEC of 9,600 was in perfect -94- agreeraent with the Mn ch. of 9,600. The obtained polymer had an K VL^ of 2.0.
Example 20: A six-arm star PSt polymer was prepared according to the procedure of Example 3, except that 1.53 x 10"5 mol of Cs(CH2Br)6 was used in place of l-PECl. The polymer was obtained in 90% yield. The It, SEC of 24,100 was in close agreement with the M-, th. of 26,800. The obtained polymer had Example 21: An end-functional PSt having a COOH end group was prepared according to the procedure of Example 3 , except that 2-chloropropionic acid (1.74 x 10"s mol) was used in place of l-PECl, and the reaction was conducted for 14 h. The polymer was obtained in 50% yield, and had an Mn SEC = 39,600 and an = 1.45.
Example 22: A telechelic PMMA with two Br end groups was prepared at 100 °C in ethyl acetate according to the procedure of Example 3, except that 1.00 x 10"4 mol of CsH4(CH2Br)2 was used in place of l-PECl, 0.5 g of MMA was used, 2.00 x 10-4 mol of CuCl was used, and 5.2 x 10"" mol of Bpy was present. The polymer was obtained in 100% yield after 8 h. The Mn SEC of 4,800 was in -95- close agreement with the Mn>ch. of 5,000. The obtained polymer had an ^/It, of 1.35.
Example 23: HBr abstraction (by known methods) of the Br-functional PMMA produced in Example 22 can lead to a telechelic (co) polymer with olefinic end groups, from which a telechelic (co) polymer with primary alcohol end groups can be formed by sequential hydroboration/oxidation (by known methods) .
Nitration/reduction (by known methods) gives the corresponding amine-ended telechelic (co) polymer.
A Br-ended telechelic (co) polymer ("Br-Pn-Br") can be converted to other groups in one or two step as follows: NaN3 Br-Pn-Br > N3-Pn-N3 KCN > NC-Pn-CN 1) CHjCOOK > ΗΟ-Ρπ-ΟΗ 2) NaOH - 2 HBr BrCH2CH2-Pn-CH2CH2Br > H2C=CH-Pn-CH=CH2 Example 24: An end-functional and in-chain functional PSt with two Br end groups and two central Br groups was prepared at 100 °C according to the procedure of Example 3, except that 0.900 x 10" mol of CBr4 was used in place of 1-PECl, 0.5 g of St was used, 1.5 x 10"4 mol of CuCl was used, and 3.2 x lO'4 mol of Bpy was present. The polymer was obtained in 90% yield after 20 h. The Mn SEC of 4,500 was in agreement with the Mn ch of 5,000. The obtained polymer had an I^/M., of 1.45. The obtained polymer can be converted to any of the other four functional PSt's according to the procedures described in Example 23.
A number of ATRP's of styrene using transition metal complexes other than CuCl/Bpy are summarized in Table 8, and a number of ATRP's of methyl methacrylate using transition metal complexes other than CuCl/Bpy are summarized in Table 9.
TABLE 8 S! ATRP in the Presence of Other Transition Metal Complexes Other Than Initiator Mt L Temp. time conv. Mn.th M M M •c h AIBN CuCI2 Bpy 130 3.5h 0.85 7500 O H M 0.076M 0.38 - PECI FeCI2 (EtO)3P 130 5.5 0.85 21 100 .075M 0.075 0.375 1 PECI CuO/CuCl2 Bpy 130 21 0.80 95500 .0075M 0.0075M/" 0.038M AIBN CuCI2 bpy 130 21 0.90 25000 .034M 0.06 0.14 AIBN 130 21 0.6 0.034 PECI RuCI2(PPh3)3 130 13 0.9 18400 .044 0.037M TABLE 9 MMA ATRP in (he Presence of Other Transition Metal Complexes Other Tha Initiator Ml L Tcmp.CC) time conv. Mn.th (M) ( ) (M) hr -CIEPN FeCI2 PPh3 130 5 0.85 8460 .047M 0.021 M 0.073 FeCI2 PPh3 130 5 0.80 8000 0.042 0.14 FeC12 PPh3 130 5 0.85 8500 0.047 0.28 FeC12 PPh3 130 5 0.90 8700 0.084 0.3
Claims (21)
1. A controlled free radical polymerization process, of atom or group transfer radical polymerization, comprising the steps of: radically polymerizing one or more radically (co)polymerizable monomers in the presence of an initiator having a radically transferable atom or group, and a catalyst system comprising a transition metal compound which participates in a reversible redox cycle with said initiator or a dormant polymer chain end, and a ligand to form a (co)polymer, and the ligand being any N-, 0-, P- or S- containing compound which can coordinate in a σ-bond to the transition metal or any carbon-containing compound which can coordinate in a π-bond to the transition metal, such that direct bonds between the transition metal and growing polymer radicals are not formed, wherein said transition metal compound and said ligand are matched with one another in order to .provide reaction with said initiator to reversibly generate a radical.
2. The process of claim 1 , wherein the amounts of said monomer(s), said initiator, said transition metal compound and said ligand are such that growing radicals are present during said polymerizing in a concentration in the range of from 0'9 mol/L to 10"6 mol/L, and dormant polymer chains are present during said polymerizing in a concentration in the range of from 10'4 mol/L to 1 mol/L.
3. The process of claim 2, wherein the concentration of said growing radicals is from 10. '8 mol/L to 10"6 mol/L 117,626/4 100
4. · I he process of claim 2, wherein the concentration of said dormant polymer chains is from 10"2 mol/L to 10'1 mcf/L.
5. " Tne process of claim 1 , wherein said monomer(s) are of the formula: wherein R1 and R2 are independently selected from the group consisting of H, halogen, CN, CF3, straight or branched alkyl of from 1 to 20 carbon atoms, α,β-unsaturated straight or branched alkenyl or alkynyl of 2 to 10 carbon atoms, α,β-unsaturated straight or branched alkenyl of 2 to 6 carbon atoms substituted with halogen, C3 -C8 cycloalkyl, phenyl which may optionally have from 1 to 5 substituents on the phenyl ring selected from the group consisting of Ci -Cs 0 -alkyl, Ci -s -alkenyl, Ci -Ce -alkoxy, halogen, nitro. carboxy, C -alkoxycarbonyl, hydroxy protected with a C1 -Ce -acyl, cyano and phenyl, heterocyclyl, C(=Y)RS, C(=Y)NR6 R7, YCR6 R7 R8 and YC(=Y)R8 ; where Y may be NR8 r O; R= is alkyl of from 1 to 20 carbon atoms, alkoxy of from 1 to 20 carbon atoms, aryloxy or heterocyclyloxy; R6 and R7 are independently H or alkyl of from 1 to 20 carbon atoms, or optionally R6 and R7 are joined together to form an alkylene group of from 2 to 5 carbon atoms, thus forming a 3- to 6-membered ring; and R8 is H, straight or branched Ci -C20 alkyl or aryl; and 117 ,626/4 101 R3 and R4 are independently selected from the group consisting of H, halogen, Ci -C6 alkyl and COOR9, where R9 is H, an alkali metal, or a d -C3 alkyl group; or optionally, R1 and R3 are joined to form a group of the formula (CH2)n- or a group of the formula C(=O)-Y-C(=0), where π' is from 2 to 6, or, optionally, the group (CH2)n' is substituted with from 1 to 2n' halogen atoms or CV -C4 alkyl groups, and Y is as defined above; and at least two of R1, R2, R3 and R4 are H or halogen.
6. The process of claim 1 , wherein said initiator is of the formula: R11 R12 R13 C— X where: X is selected from the group consisting of CI, Br, I, OR10, SR14, SeR14, OP(=0)R14, OP(=O) (OR14^ OP(=0)OR14, 0-N(R14)2 and S-C(=S)N(R 4)2, where R10 is alkyl of from 1 to 20 carbon atoms in which each of the hydrogen atoms are, optionally, independently replaced by halide, R 4 is aryi or a straight or branched Ci -C20 alkyl group, and where an N(R14)2 group is present the two R14 groups may be joined to form a 5- or 6-membred heterocyclic ring; and R11, R12, and R13 are each independently selected from the group consisting of H, haiogen, d -C20 alkyl, Ca -C8 cycloalkyi, C(=Y)R5, C(=Y)NR6 R7, COCI, OH, CN, Cs -C20 alkenyl, C2 -C20 alkynyl, glycidyl, aryl, heterocyclyl, aralkyi, aralkenyl, C^ -Ce alkyl in which from 1 to all of the hydrogsn atoms are replaced with halogen and Ci -Ce alkyl substituted with from 1 to 3 substituents selected from the group consisting of C1 -C4 117,626/ 5 102 alkoxy, aryl, heterocyclyl, C(=Y)R5, C(=Y)NR5R7, and glycidyl; where R5 is aikyl of from 1 to 20 carbon atoms, a!kcxy of from 1 to 20 carbon atoms, aryloxy or hetarocyclyloxy: and R6:and R7 are independently H or alkyi of from 1 to 20 carbon atoms, or optionally R6 and R7 are joined together to form an alkylene group of from 2 to 5 carbon atoms, thus forming a 3- to 6-membered ring; such that no more than two of R , R12 and R13 are H, ; and Y is as defined above.
7. The process of claim 6, wherein no more than one of R R12s and R13 is H.
8. The process of claim 1 , wherein said transition metal compound is of the formula ,n+ X'n, where: Mtn+ ]s selected from the group consisting of Cu14, Cu2*, Fe2+, Fe3*, Ru2+, Ru3*, Cr2*, Cr3*, Mo2+, Mo3*, W2+, W3*, Mn3*, Mn4+, Rh3*, R 4 Re +, Re3*, Co+, • Co2+, V2+, V3*, Zn+, Zn2+, Au+, Au2+, Ag* and Ag2+; X' is selected from the group consisting of halogen, C-i -C6 -alkoxy, (S04)1 2, (Ρ04)ΐβ, (Ru P04)i/2, (R142 O4), triflate, hexafluorophosphate, methanesulfonate, arylsulfonate, CN and R15 C02l where R15 is H or a straight or branched C-i -C6 alkyl group which, optionally, are substituted from 1 to 5 times with a halogen; and n is the formal charge on the metal where 0 < n < 7.
9. The process of claim 1 , wherein said ligand is selected from the group consisting of: compounds of the formulas: 117,626/2 03 R 6 -Z-(R18 -Z)m — R17 where: R16 and R 7 are independently selected from the group consisting of H, Ci -C2o alkyl, aryl, heterocyclyl and Ci -C6 alkyl substituted with Ci -C6 alkoxy, Ci -C4 dialkylamino, C(=Y)R5, C(=Y)R6 R7 and YC(=Y)R8, where Y may be NR8 or 0; R5 is alkyl of from 1 to 20 carbon atoms, alkoxy of from 1 to 20 carbon atoms, aryloxy or heterocyclyloxy; R6 and R7 are independently H or alkyl of from 1 to 20 carbon atoms, or, optionally, R6 and R7 are joined together to form an alkylene group of from 2 to 5 carbon atoms, thus forming a 3-6-membered ring; and R8 is H, straight or branched Ci -C20 alkyl or aryl; Z is O, S, NR19or PR19, where R19 is selected from the same group as R16 and R17, and where Z is PR19, R19 can also be Ci -C2o -alkoxy; each R18 is independently a divalent group selected from the group consisting of C3 -C8 cycloalkanediyl, C3 -C8 cycloalkenediyl, areriediyl and heterocyclylidene where the covalent bonds to each Z are at vicinal positions, and C2 -C4 alkylene and C2 -C4 alkenylene where the covalent bonds to each Z are at vicinal positions or at β-positions; and m is from 1 to 6; compounds of the above formulas where R16 and R17 can be joined to form a saturated, unsaturated or heterocyclic ring; compounds of the above formulas where each of R16 -Z and R 7-Z, form a ring with the R18 group to which the Z is bound to form a linked or fused heterocyclic ring system; 117,626/3 104 compounds of the above formulas where one or both of R16 and R17 are heterocyclyl, and in which Z is a covalent bond, CH2 or a 4- to 7-membered ring fused to R16 or R17 or both ; or said ligand may be CO; porphyrins and porphycenes, which, optionally, are substituted with from 1 to 6 halogen atoms, Ci -C6 alkyl groups, Ci -C6 -alkoxy groups, Ci -C6 alkoxycarbonyl, aryl groups, heterocyclyl groups, and Ci -C6 alkyl groups further substituted with from 1 to 3 halogens; compounds of the formula R20R21C(C=(Y)R5)2 where Y and R5 are as defined above, and each of R20 and R2 is independently selected from the group consisting of H, halogen, Ci -C2o alkyl, aryl and heterocyclyl, and, optionally, R20 and R21 are joined to form a C3 -C8 cycloalkyl ring or a hydrogenated aromatic or heterocyclic ririg, any of which, except for H and halogen, optionally, are further substituted with 1 to 5 Ci -C6 alkyl groups, Ci -C6 alkoxy groups, halogen atoms, aryl groups, or combinations thereof; and arenes and cyclopentadienyl ligands, where, said cyclopentadienyl ligand may be substituted with from one to five methyl groups, or, may be linked through an ethylene or propylene chain to a second cyclopentadienyl ligand.
10. 0. The process of claim 1 , wherein the initiator is present in a concentration of from lO^ M to l M.
11. The process of claim 1 , wherein the initiator and monomer(s) are present in amounts providing a molar ratio of from 10"4 :1 to 10"1 :1 of initiator to monomer(s). 117,626/2 105
12. The process of claim 1 , wherein the transition metal compound is present in an amount providing a molar ratio of transition metal compound to initiator of from 0.0001 :1 to 10:1.
13. The process of claim 1 , wherein the ligand is present in an amount providing a ratio of (a) coordination sites on the transition metal compound to (b) coordination sites which the ligand will occupy of from 0.1 :1 to 100:1.
14. The process of claim 1 , wherein the monomer, initiator, transition metal compound and ligand are selected such that (a) the rate of initiation in said polymerizing step is not less than 1 ,000 times slower than (b) the rate of propagation in said polymerizing step or of transfer of the radically transferable group to the polymer radical.
15. The process of claim 1 , wherein at least one of said monomers are of the formula: wherein at least one of R1, R2, R3 and R4 are selected from the group consisting of halogen and YC(=Y)R8 ; where Y may be NR8 or O, and R8 is H, straight or branched Ci -C2 alkyl or aryl; and said process further comprises a second polymerizing step using one or more additional radically (co)polymerizable monomers, conducted in the presence of said transition metal compound and said ligand, such that (a) the rate of initiation in said 117,626/6 106 polymerizing step is not less than 1 ,000 times slower than (b) the rate of propagation in said polymerizing step or of transfer of the radically transferable group to the polymer radical..
16. The process of claim 5, wherein at least one of R , R2, R3 and R4 are chlorine or bromine.
17. 7. The process as claimed in. claim 1 , wherein the polymerization is carried out in bulk, in solution, in dispersion, in suspension, in an emulsion, in the gas phase, or at a pressure of from 0.1 to 100 atmospheres .
18. The process as claimed in claim 17, wherein said polymerization is conducted 1n a supercri ti cal sol vent.
19. 9. The process as claimed in claim 1 , wherein one or more (co)polymerizable monomers are added sequentially proportionally or continuously to the reaction.
20. The process as claimed in claim 1 , wherein the transition metal is selected from the group consisting of copper, iron, nickel or ruthenium.
21. The process as claimed in claim 1 , wherein either of the initiator or the radically (co)polymerizable monomer contain a substituent bearing an unconjugated ethylene or acetylene moiety. 107 117,626/7 The process of claim 1 , wherein the transition metal complex is in its oxidized state and the polymerization is initiated by a radical initiator. For the Applicant WOLFF, BREGMAN AND GOLLER
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Families Citing this family (548)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2730241B1 (en) * | 1995-02-07 | 1997-02-28 | Atofina | PROCESS FOR MANUFACTURING A COMPOSITION COMPRISING A VINYLAROMATIC POLYMER AND A RUBBER BY POLYMERIZATION IN THE PRESENCE OF A FREE STABLE RADICAL |
US6541580B1 (en) * | 1995-03-31 | 2003-04-01 | Carnegie Mellon University | Atom or group transfer radical polymerization |
US5763548A (en) | 1995-03-31 | 1998-06-09 | Carnegie-Mellon University | (Co)polymers and a novel polymerization process based on atom (or group) transfer radical polymerization |
US5807937A (en) * | 1995-11-15 | 1998-09-15 | Carnegie Mellon University | Processes based on atom (or group) transfer radical polymerization and novel (co) polymers having useful structures and properties |
JP3806475B2 (en) | 1996-02-08 | 2006-08-09 | 株式会社カネカ | Method for producing (meth) acrylic polymer having functional group at terminal |
EP0906342B2 (en) | 1996-06-12 | 2015-02-11 | Warwick Effect Polymers Limited | Polymerisation catalyst and process |
DE69710130T2 (en) * | 1996-06-26 | 2002-08-29 | Kaneka Corp., Osaka | Process for the production of vinyl polymers |
US5789487A (en) | 1996-07-10 | 1998-08-04 | Carnegie-Mellon University | Preparation of novel homo- and copolymers using atom transfer radical polymerization |
FR2752238B1 (en) * | 1996-08-12 | 1998-09-18 | Atochem Elf Sa | METHOD FOR CONTROLLED RADICAL POLYMERIZATION OR COPOLYMERIZATION OF (METH) ACRYLIC AND VINYLIC MONOMERS AND (CO) POLYMERS OBTAINED |
US5910549A (en) | 1996-08-22 | 1999-06-08 | Carnegie-Mellon University | Method for preparation of alkoxyamines from nitroxyl radicals |
US20030198825A1 (en) * | 1996-08-26 | 2003-10-23 | Massachusetts Institute Of Technology | Polymeric membranes and other polymer articles having desired surface characteristics and method for their preparation |
EP0845479B1 (en) | 1996-11-28 | 2004-07-14 | Kaneka Corporation | Method for producing a hydroxyl-terminated (meth)acrylic polymer, the said polymer |
GB2321247A (en) * | 1997-01-20 | 1998-07-22 | Courtaulds Plc | Polymerisation reactions |
TW593347B (en) * | 1997-03-11 | 2004-06-21 | Univ Carnegie Mellon | Improvements in atom or group transfer radical polymerization |
US7125938B2 (en) * | 1997-03-11 | 2006-10-24 | Carnegie Mellon University | Atom or group transfer radical polymerization |
US5886118C1 (en) * | 1997-04-14 | 2001-02-20 | Univ Case Western Reserve | Process for polymerizing acrylonitrile |
EP1637544A3 (en) * | 1997-04-18 | 2006-05-17 | Kaneka Corporation | Polymers, process for processing the same, and curable compositions produced therefrom |
US6074628A (en) * | 1997-04-25 | 2000-06-13 | Procter & Gamble | Hairspray compositions containing silicon block copolymers |
US6136296A (en) * | 1997-04-25 | 2000-10-24 | The Procter & Gamble Company | Personal care compositions |
US6113883A (en) * | 1997-04-25 | 2000-09-05 | The Procter & Gamble Company | Hair styling compositions comprising silicone-containing copolymers |
ZA984087B (en) * | 1997-05-16 | 1998-11-16 | Procter & Gamble | Personal care compositions containing graft polymers |
US5986015A (en) * | 1997-05-16 | 1999-11-16 | The Procter & Gamble Company | Method of making graft polymers |
US6720395B2 (en) * | 1997-07-28 | 2004-04-13 | Kaneka Corporation | Method for producing a stellar polymer |
CN1137938C (en) | 1997-07-28 | 2004-02-11 | 钟渊化学工业株式会社 | Curable adhesive compsn. |
CN1265116A (en) * | 1997-07-28 | 2000-08-30 | 钟渊化学工业株式会社 | Polymers and process for producing polymers |
US6274688B1 (en) * | 1997-07-28 | 2001-08-14 | Kaneka Corporation | Functional groups-terminated vinyl polymers |
US6388006B1 (en) | 1997-08-06 | 2002-05-14 | Kaneka Corporation | Self-adhesive composition |
US6071980A (en) * | 1997-08-27 | 2000-06-06 | E. I. Du Pont De Nemours And Company | Atom transfer radical polymerization |
US6822782B2 (en) * | 2001-05-15 | 2004-11-23 | E Ink Corporation | Electrophoretic particles and processes for the production thereof |
WO1999015567A1 (en) * | 1997-09-22 | 1999-04-01 | Kaneka Corporation | Polymer, process for producing the polymer, and curable composition containing the polymer |
US6069205A (en) * | 1997-10-03 | 2000-05-30 | Eastman Kodak Company | Block copolymers |
US6143848A (en) | 1997-10-23 | 2000-11-07 | The B.F.Goodrich Company | End-functionalized polymers by controlled free-radical polymerization process and polymers made therefrom |
FR2770219A1 (en) * | 1997-10-24 | 1999-04-30 | Atochem Elf Sa | PROCESS FOR THE MANUFACTURING OF ARCHITECTURALLY CONTROLLED COPOLYMERS USING FUNCTIONAL RADICAL PRIMERS IN LIVE RADICAL POLYMERIZATION, AND CORRESPONDING PRIMER COMPOUNDS AND COPOLYMERS |
US6121380A (en) * | 1997-11-06 | 2000-09-19 | Nitto Denko Corporation | Preparation of adhesive (CO) polymers from isocyanate chain extended narrow molecular weight distribution telechelic (CO) polymers made by pseudo living polymerization |
GB9725455D0 (en) | 1997-12-02 | 1998-01-28 | Univ Warwick | Supported polymerisation catalyst |
CN1152061C (en) | 1998-02-27 | 2004-06-02 | 钟渊化学工业株式会社 | Polymer and curable composition |
JP4176900B2 (en) * | 1998-02-27 | 2008-11-05 | 株式会社カネカ | Curable composition |
DE19813353A1 (en) * | 1998-03-26 | 1999-09-30 | Bayer Ag | Processes for the production of telecheles, telecheles thus produced and their use |
US6649701B1 (en) | 1998-03-27 | 2003-11-18 | Kaneka Corporation | Polymer and process for producing polymer |
US6121371A (en) * | 1998-07-31 | 2000-09-19 | Carnegie Mellon University | Application of atom transfer radical polymerization to water-borne polymerization systems |
EP0947527A1 (en) * | 1998-04-03 | 1999-10-06 | The B.F. Goodrich Company | Waterborne block copolymers and process for making the same |
JP3776626B2 (en) * | 1998-04-27 | 2006-05-17 | 株式会社カネカ | Saturated hydrocarbon polymer having a functional group at its terminal and method for producing the same |
EP0992519B1 (en) | 1998-04-28 | 2004-10-20 | Kaneka Corporation | Block copolymer |
JP4057190B2 (en) * | 1998-04-28 | 2008-03-05 | 株式会社カネカ | Block copolymer |
AUPP337298A0 (en) * | 1998-05-07 | 1998-05-28 | University Of Melbourne, The | Process for microgel preparation |
GB9809926D0 (en) * | 1998-05-08 | 1998-07-08 | Bp Chem Int Ltd | Catalyst and polymerisation process |
WO1999062959A1 (en) | 1998-06-01 | 1999-12-09 | Kaneka Corporation | Polymerization method |
CA2333925A1 (en) | 1998-06-01 | 1999-12-09 | Kaneka Corporation | Process for producing polymer, the polymer and curable composition comprising the polymer |
EP0962473A1 (en) * | 1998-06-04 | 1999-12-08 | Dsm N.V. | Block polymer and powder-paint binder composition |
JP3990110B2 (en) | 1998-06-19 | 2007-10-10 | 株式会社カネカ | Method for producing branched polymer and polymer |
EP0970972A1 (en) * | 1998-07-10 | 2000-01-12 | Ciba SC Holding AG | Polymerizable composition containing Ru(II)-or Os(II)-complex catalysts |
US6252025B1 (en) | 1998-08-11 | 2001-06-26 | Eastman Kodak Company | Vinyl hyperbranched polymer with photographically useful end groups |
CA2342799A1 (en) | 1998-08-20 | 2000-03-02 | Kaneka Corporation | Composition for roller and roller therefrom |
WO2000011045A1 (en) * | 1998-08-20 | 2000-03-02 | Kaneka Corporation | Polymer and epoxy resin compositions |
US6479584B1 (en) | 1998-08-20 | 2002-11-12 | Kaneka Corporation | Resin composition, polymer, and process for producing polymer |
US6268433B1 (en) | 1998-08-31 | 2001-07-31 | Ppg Industries Ohio, Inc. | Thermosetting compositions containing epoxy functional polymers prepared by atom transfer radical polymerization |
US6306965B1 (en) | 1998-08-31 | 2001-10-23 | Ppg Industries Ohio, Inc. | Thermosetting compositions containing carbamate-functional polylmers prepared using atom transfer radical polymerization |
US6355729B1 (en) | 1998-08-31 | 2002-03-12 | Ppg Industries Ohio, Inc. | Electrodepositable coating compositions comprising amine salt group-containing polymers prepared by atom transfer radical polymerization |
US6365666B1 (en) | 1998-08-31 | 2002-04-02 | Ppg Industries Ohio, Inc. | Electrodepositable coating compositions comprising onium salt group-containing polymers prepared by atom transfer radical polymerization |
US6265489B1 (en) | 1998-08-31 | 2001-07-24 | Ppg Industries Ohio, Inc. | Thermosetting compositions containing carboxylic acid functional polymers prepared by atom transfer radical polymerization |
US6319988B1 (en) | 1998-08-31 | 2001-11-20 | Ppg Industries Ohio, Inc. | Thermosetting compositions containing hydroxy functional polymers prepared by atom transfer radical polymerization |
US6339126B1 (en) | 1998-08-31 | 2002-01-15 | Ppg Industries Ohio, Inc. | Thermosetting compositions containing carboxylic acid functional polymers prepared by atom transfer radical polymerization |
US6319987B1 (en) | 1998-08-31 | 2001-11-20 | Ppg Industries Ohio, Inc. | Thermosetting compositions containing hydroxyl-functional polymers prepared using atom transfer radical polymerization |
US6191225B1 (en) | 1998-08-31 | 2001-02-20 | Ppg Industries Ohio, Inc. | Thermosetting compositions containing carboxylic acid functional polymers and epoxy functional polymers prepared by atom transfer radical polymerization |
US6319967B1 (en) | 1998-08-31 | 2001-11-20 | Ppg Industries Ohio, Inc. | Thermosetting compositions containing epoxy-functional polymers prepared using atom transfer radical polymerization |
JP4015327B2 (en) * | 1998-09-02 | 2007-11-28 | 株式会社カネカ | Polymer, polymer production method and composition |
EP2028197A1 (en) * | 1998-09-02 | 2009-02-25 | Kaneka Corporation | Polymer, process for producing polymer and composition |
CN1272380C (en) | 1998-10-08 | 2006-08-30 | 钟渊化学工业株式会社 | Curable compositions |
US6137012A (en) | 1998-10-13 | 2000-10-24 | E. I. Du Pont De Nemours And Company | Phosphole and diphosphole ligands for catalysis |
JP4572006B2 (en) * | 1998-12-08 | 2010-10-27 | 日東電工株式会社 | Adhesive composition, method for producing the same, and adhesive sheet |
JP3984381B2 (en) * | 1998-12-08 | 2007-10-03 | 株式会社カネカ | Method for producing star polymer |
GB9827080D0 (en) * | 1998-12-10 | 1999-02-03 | Ici Ltd | Production of vinylic polymers |
US6162578A (en) * | 1998-12-18 | 2000-12-19 | Eastman Kodak Company | Imaging member containing heat sensitive hyperbranched polymer and methods of use |
US6734256B1 (en) * | 1998-12-29 | 2004-05-11 | 3M Innovative Properties Company | Block copolymer hot-melt processable adhesives, methods of their preparation, and articles therefrom |
DE69833800T3 (en) * | 1998-12-29 | 2013-08-22 | Minnesota Mining And Mfg. Co. | MELT ADHESIVES FROM BLOCK COPOLYMERS, METHOD FOR THEIR PRODUCTION AND OBJECTS THEREFOR |
JP5035938B2 (en) * | 1998-12-31 | 2012-09-26 | チバ ホールディング インコーポレーテッド | ATRP polymer-containing pigment composition |
WO2000044796A1 (en) * | 1999-01-28 | 2000-08-03 | Kaneka Corporation | Polymer, process for producing the polymer, and curable composition containing the polymer |
GB9902564D0 (en) * | 1999-02-08 | 1999-03-24 | Ici Plc | Production of vinylic polymers |
US6472486B2 (en) | 1999-03-09 | 2002-10-29 | Symyx Technologies, Inc. | Controlled stable free radical emulsion polymerization processes |
EP1637550B1 (en) * | 1999-03-23 | 2017-09-20 | Carnegie Mellon University | Catalytic processes for the controlled polymerization of free radically (co) polymerizable monomers and functional polymeric systems prepared thereby |
WO2000056795A1 (en) * | 1999-03-23 | 2000-09-28 | Carnegie Mellon University | Catalytic processes for the controlled polymerization of free radically (co)polymerizable monomers and functional polymeric systems prepared thereby |
DE19914953A1 (en) | 1999-04-01 | 2000-10-05 | Basf Ag | Radical-initiated emulsion polymerisation for production of aqueous polymer dispersions, for use e.g. as adhesives, carried out in presence of special metal-organic compound which is more soluble in water than in styrene |
DE19917675A1 (en) * | 1999-04-19 | 2000-10-26 | Basf Ag | Preparation of rubber-elastic vinyl aromatic polymer-diene block copolymer, for use in shaped articles, films or foams, involves polymerization of monomers by radical polymerization initiation |
US6355756B1 (en) | 1999-05-18 | 2002-03-12 | International Business Machines Corporation | Dual purpose electroactive copolymers, preparation thereof, and use in opto-electronic devices |
US6288173B1 (en) | 1999-06-03 | 2001-09-11 | Ppg Industries Ohio, Inc. | Block copolymers |
US6197883B1 (en) | 1999-06-03 | 2001-03-06 | Ppg Industries Ohio, Inc. | Thermosetting coating compositions containing flow modifiers prepared by controlled radical polymerization |
US7049373B2 (en) * | 1999-08-06 | 2006-05-23 | Carnegie Mellon University | Process for preparation of graft polymers |
WO2001021678A1 (en) * | 1999-09-21 | 2001-03-29 | Northwestern University | Self-assembling compounds and use of the same to induce order in organic media |
US6310175B1 (en) | 1999-10-23 | 2001-10-30 | Nippon Shokubai Co., Ltd. | Star-shaped block copolymer and production process therefor |
JP2001200026A (en) * | 1999-11-12 | 2001-07-24 | Kanegafuchi Chem Ind Co Ltd | Method for manufacturing block copolymer and block copolymer obtained by the same |
US6403745B1 (en) | 1999-11-30 | 2002-06-11 | Rohmax Additives Gmbh | Gradient copolymers, as well as a method for their preparation and their use |
US6403746B1 (en) | 1999-11-30 | 2002-06-11 | Rohmax Additives Gmbh | Method for preparation of a composition that contains polymer ester compounds with long-chain alkyl residues and use of this composition |
US6391996B1 (en) | 1999-11-30 | 2002-05-21 | Rohmax Additives Gmbh | Copolymers obtainable by the ATRP method and a method for their preparation and their use |
US6462125B1 (en) | 1999-12-16 | 2002-10-08 | Ppg Industries Ohio, Inc. | Pigment dispersions containing dispersants prepared by controlled radical polymerization having hydrophilic and hydrophobic segments |
US6441066B1 (en) | 1999-12-16 | 2002-08-27 | Ppg Industries Ohio, Inc. | Pigment dispersions containing dispersants prepared by controlled radical polymerization and having pendent hydrophobic polymeric segments |
US6376597B1 (en) | 1999-12-16 | 2002-04-23 | Ppg Industries Ohio, Inc. | Pigment dispersions containing dispersants having pendent hydrophilic polymeric segments prepared by controlled radical polymerization |
US6326420B1 (en) | 1999-12-16 | 2001-12-04 | Ppg Industries Ohio, Inc. | Pigment dispersions containing dispersants prepared by controlled radical polymerization |
US6336966B1 (en) | 1999-12-16 | 2002-01-08 | Ppg Industries Ohio, Inc. | Pigment dispersions containing dispersants having core and arm star architecture prepared by controlled radical polymerization |
US6306209B1 (en) | 1999-12-16 | 2001-10-23 | Ppg Industries Ohio, Inc. | Pigment dispersions containing dispersants having pendent hydrophobic polymeric segments prepared by controlled radical polymerization |
US6590049B1 (en) | 1999-12-16 | 2003-07-08 | Ppg Industries Ohio, Inc. | Multi-functional initiators for atom transfer radical (Co)polymerization |
US6294014B1 (en) | 1999-12-16 | 2001-09-25 | Ppg Industries Ohio, Inc. | Pigment dispersions containing dispersants prepared by controlled radical polymerization and having pendent hydrophilic polymeric segments |
JP4607274B2 (en) * | 2000-02-24 | 2011-01-05 | 日東電工株式会社 | Adhesive composition, its adhesive sheet and method for producing them |
JP4607275B2 (en) * | 2000-02-24 | 2011-01-05 | 日東電工株式会社 | Adhesive composition, its adhesive sheet and method for producing them |
JP4977286B2 (en) | 2000-03-07 | 2012-07-18 | 日東電工株式会社 | Method for producing polymer |
US6503975B1 (en) | 2000-03-29 | 2003-01-07 | E. I Du Pont De Nemours And Company | Surfactant free aqueous emulsions |
WO2001085804A1 (en) | 2000-05-12 | 2001-11-15 | Kaneka Corporation | Method of purifying vinyl polymer |
US6815010B2 (en) * | 2000-05-31 | 2004-11-09 | Rohm and Naas Company | Method of inhibiting the loss of solar reflectance over time of an exterior elastomeric |
DE10027153A1 (en) * | 2000-05-31 | 2001-12-06 | Bayer Ag | Block polymer, useful for optical elements and data storage contains a block comprising at least 3 repeating units not containing photoisomerizable groups and a block containing STQP groups |
JP4768103B2 (en) * | 2000-06-06 | 2011-09-07 | 日東電工株式会社 | Adhesive composition, its adhesive sheet and method for producing them |
US6500871B1 (en) | 2000-06-08 | 2002-12-31 | Rhodia Chimie | Process for preparing colloids of particles coming from the hydrolysis of a salt of a metal cation |
GB0014225D0 (en) | 2000-06-09 | 2000-08-02 | Univ Warwick | Polymerisation initiator and use |
DE10036802A1 (en) * | 2000-07-28 | 2002-02-07 | Tesa Ag | PSAs based on block copolymers with the structure P (A) -P (B) -P (A) |
DE10036803A1 (en) * | 2000-07-28 | 2002-02-07 | Tesa Ag | PSAs based on block copolymers with the structure P (A / C) -P (B) -P (A / C) |
US6506859B1 (en) | 2000-08-18 | 2003-01-14 | Exxonmobil Research And Engineering Company | Polymerization using late transition metal catalyst complexes formed in situ |
US6479425B1 (en) | 2000-08-18 | 2002-11-12 | Exxonmobile Research And Engineering Company | Late transition metal complexes, their use as catalysts and polymers therefrom |
DE60144361D1 (en) | 2000-08-25 | 2011-05-19 | Kaneka Corp | Process for purifying vinyl polymers |
JP4679703B2 (en) * | 2000-09-05 | 2011-04-27 | ダイセル化学工業株式会社 | Composite polymerization initiator |
US7332550B2 (en) * | 2000-10-06 | 2008-02-19 | Carnegie Mellon University | Stabilization of transition metal complexes for catalysis in diverse environments |
US6790919B2 (en) | 2000-10-06 | 2004-09-14 | Carnegie Mellon University | Catalyst system for controlled polymerization |
AU2002211467A1 (en) | 2000-10-06 | 2002-04-15 | Carnegie-Mellon University | Preparation of nanocomposite structures by controlled polymerization |
DE60129148T2 (en) * | 2000-10-06 | 2008-02-28 | Biocompatibles Uk Ltd., Farnham | TWITTER POLYMERS |
JP5005155B2 (en) * | 2000-10-06 | 2012-08-22 | カーネギー−メロン ユニバーシティ | Polymerization method of ionic monomer |
US6639029B1 (en) * | 2000-11-13 | 2003-10-28 | Rohmax Additives Gmbh | Process for continuous synthesis of polymer compositions as well as use of same |
US6610801B1 (en) | 2000-11-13 | 2003-08-26 | Rohmax Additives Gmbh | Processes for synthesis of polymer compositions |
JP4768115B2 (en) * | 2000-12-01 | 2011-09-07 | 日東電工株式会社 | Ultraviolet crosslinking adhesive composition and method for producing the same, and adhesive sheet and method for producing the same |
US6576722B2 (en) * | 2000-12-13 | 2003-06-10 | Ppg Industries Ohio, Inc. | Acrylic-halogenated polyolefin copolymer adhesion promoters |
US6716918B2 (en) | 2000-12-22 | 2004-04-06 | Mitsubishi Chemical Corporation | Methacrylate-based polymer and process for producing the same |
US6437044B1 (en) * | 2001-01-26 | 2002-08-20 | University Of Pennsylvania | Living radical graft copolymerization of vinyl monomers initiated from the structural defects of polyvinylchloride |
US6579947B2 (en) | 2001-02-20 | 2003-06-17 | Rhodia Chimie | Hydraulic fracturing fluid comprising a block copolymer containing at least one water-soluble block and one hydrophobic block |
DE10109067A1 (en) | 2001-02-24 | 2002-09-12 | Tesa Ag | PSA with low outgassing behavior |
US6838535B2 (en) * | 2001-03-23 | 2005-01-04 | University Of Pennsylvania | Process for the living radical polymerization of chlorine containing monomers |
US6911515B2 (en) * | 2001-03-23 | 2005-06-28 | University Of Pennsylvania | Aqueous room temperature living radical polymerization of vinyl halides |
US7345127B2 (en) * | 2001-03-23 | 2008-03-18 | University Of Pennsylvania | Living radical polymerization of halogen-containing and acrylic monomers and the formation of block copolymers therefrom |
AU2002307151A1 (en) * | 2001-04-06 | 2002-10-21 | Carnegie Mellon University | A process for the preparation of nanostructured materials |
US6875832B2 (en) * | 2001-04-24 | 2005-04-05 | Ppg Industries Ohio, Inc. | Synthesis of vinyl polymers by controlled radical polymerization |
US6689844B2 (en) * | 2001-05-29 | 2004-02-10 | Rohmax Additives Gmbh | Process for synthesis of polymer compositions with reduced halogen content, polymer composition with reduced halogen content as well as use of this composition |
FR2829494B1 (en) | 2001-07-13 | 2005-10-28 | Rhodia Chimie Sa | AQUEOUS COMPOSITIONS COMPRISING A CHEMICAL MICRO-GEL ASSOCIATED WITH A POLYMER FOR PONDING, PREPARATION AND USE |
JP2003342133A (en) * | 2002-05-30 | 2003-12-03 | Mitsubishi Chemicals Corp | Polymer composition for hair cosmetic and hair cosmetic using the same |
JP4039829B2 (en) * | 2001-09-13 | 2008-01-30 | 三菱化学株式会社 | Resin composition for cosmetics and cosmetics using the same |
JP2003342132A (en) * | 2002-05-28 | 2003-12-03 | Mitsubishi Chemicals Corp | Polymer composition for hair cosmetic and hair cosmetic using the same |
JP2003335637A (en) * | 2002-05-21 | 2003-11-25 | Mitsubishi Chemicals Corp | Polymer composition for hair cosmetic and hair cosmetic using the same |
JP2003286142A (en) * | 2002-03-29 | 2003-10-07 | Mitsubishi Chemicals Corp | Polymer composition for hair cosmetic and the resulting hair cosmetic |
JP2004051569A (en) * | 2002-07-22 | 2004-02-19 | Mitsubishi Chemicals Corp | Polymer composition for hair cosmetic and hair cosmetic using the same |
JP2004051549A (en) * | 2002-07-19 | 2004-02-19 | Mitsubishi Chemicals Corp | Polymer composition for hair cosmetic and hair cosmetic using the same |
JP4806501B2 (en) * | 2001-09-25 | 2011-11-02 | 日東電工株式会社 | Non-crosslinked adhesive composition, method for producing the same, and adhesive sheet |
US6586530B1 (en) | 2001-09-27 | 2003-07-01 | Ppg Industries Ohio, Inc. | Low surface tension (meth) acrylate containing block copolymer prepared by controlled radical polymerization |
US6841641B2 (en) * | 2001-09-27 | 2005-01-11 | Ppg Industries Ohio, Inc. | Copolymers comprising low surface tension (meth) acrylates |
US6583223B2 (en) | 2001-09-27 | 2003-06-24 | Ppg Industries Ohio, Inc. | Coating compositions which contain a low surface tension (meth) acrylate containing block copolymer flow control agent |
US6759491B2 (en) * | 2001-10-12 | 2004-07-06 | Carnegie Mellon University | Simultaneous reverse and normal initiation of ATRP |
WO2003031480A2 (en) * | 2001-10-12 | 2003-04-17 | Carnegie Mellon University | Process for monomer sequence control in polymerizations |
US20030144441A1 (en) * | 2001-11-13 | 2003-07-31 | Ayusman Sen | Controlled copolymerization of methyl acrylate with olefins under mild conditions |
FR2832719B1 (en) * | 2001-11-29 | 2004-02-13 | Oreal | ADHESIVE SEQUENCE ETHYLENIC COPOLYMERS, COSMETIC COMPOSITIONS CONTAINING THEM, AND USE OF SUCH COPOLYMERS IN COSMETICS |
TW200407363A (en) * | 2001-11-29 | 2004-05-16 | Ciba Sc Holding Ag | Pigment compositions with modified ATRP copolymer dispersants |
GB0131112D0 (en) * | 2001-12-31 | 2002-02-13 | Univ London Pharmacy | Block copolymers |
US20030225623A1 (en) * | 2002-01-04 | 2003-12-04 | John Wankmueller | Method and system for conducting transactions using a payment card with account information encoded in bar code |
US20030153708A1 (en) * | 2002-01-11 | 2003-08-14 | Caneba Gerald Tablada | Free radical retrograde precipitation copolymers and process for making same |
DE60315949T2 (en) * | 2002-01-16 | 2008-06-12 | Biocompatibles Uk Ltd., Farnham | polymer conjugates |
WO2003062293A1 (en) * | 2002-01-22 | 2003-07-31 | Atofina | Method of producing and using materials which are reinforced against impact and which contain block copolymers that are obtained by means of controlled radical polymerisation in the presence of nitroxides |
ATE429437T1 (en) * | 2002-01-22 | 2009-05-15 | Telene Sas | METAL COMPLEXES FOR METATHESIS, ATOMIC TRANSFER RADICAL REACTIONS. ADDITION POLYMERIZATION AND VINYLATION REACTIONS, PROCESSES AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION. |
EP1329455A1 (en) * | 2002-01-22 | 2003-07-23 | Universiteit Gent | Metal carbene complexes, methods and intermediates for making them and their use in metathesis reactions |
AU2003210236A1 (en) | 2002-02-11 | 2003-09-04 | Rhodia Chimie | Detergent composition comprising a block copolymer |
US20040143079A1 (en) * | 2003-01-21 | 2004-07-22 | Simion Coca | Compositions containing copolymers of isobutylene type monomers |
US7619040B2 (en) * | 2002-02-15 | 2009-11-17 | Ppg Industries Ohio, Inc. | Compositions containing copolymers of olefinic monomers |
US6784248B2 (en) * | 2002-02-15 | 2004-08-31 | Ppg Industries Ohio, Inc. | Thermosetting compositions containing alternating copolymers of isobutylene type monomers |
US20030216528A1 (en) * | 2002-03-13 | 2003-11-20 | Krzysztof Matyjaszewski | Novel (co)polymers and a novel polymerization process based on atom (or group) transfer radical polymerization |
JP4247788B2 (en) | 2002-03-29 | 2009-04-02 | 日東電工株式会社 | Polymer, method for producing the same, and photorefractive composition |
US6930151B2 (en) * | 2002-04-04 | 2005-08-16 | University Of Akron | Star block copolymers comprising polyisobutylene-B-polyacrylonitrile arms radiating from an aromatic core |
DE10227338B4 (en) | 2002-06-19 | 2006-05-24 | Byk-Chemie Gmbh | Use of polyacrylate-modified polysiloxanes as flow control agents in coating compositions |
SE0202016D0 (en) * | 2002-06-27 | 2002-06-27 | Amersham Biosciences Ab | Polymeric Support Having Novel Pore Structures |
JP3606855B2 (en) * | 2002-06-28 | 2005-01-05 | ドン ウン インターナショナル カンパニー リミテッド | Method for producing carbon nanoparticles |
DE10234246A1 (en) * | 2002-07-27 | 2004-02-05 | Tesa Ag | Pressure-sensitive adhesive material for bonding transparent substrates, e.g. in liquid crystal displays and other optical applications, comprises block copolymers with blocks of different refractive index |
JP2004059783A (en) * | 2002-07-30 | 2004-02-26 | Kanegafuchi Chem Ind Co Ltd | Curable composition having mold releasability |
WO2004013192A1 (en) * | 2002-08-02 | 2004-02-12 | Kaneka Corporation | Acrylic block copolymer and thermoplastic resin composition |
DE10235696B4 (en) * | 2002-08-03 | 2005-09-15 | Degussa Construction Chemicals Gmbh | Process for the preparation of homo-, co- and block polymers |
FR2843314B1 (en) | 2002-08-06 | 2004-09-24 | Rhodia Chimie Sa | SYNTHESIS OF STATISTICAL MICROGELS BY CONTROLLED RADICAL POLYMERIZATION |
DE10236133A1 (en) * | 2002-08-07 | 2004-02-26 | Byk-Chemie Gmbh | Use of gradient copolymers produced by living, controlled polymerization of ethylenically unsaturated monomers as dispersants, especially in coating compositions, pastes or molding materials |
FR2843394B1 (en) * | 2002-08-07 | 2005-12-30 | Atofina | ALCOXYAMINES FROM NITROXIDES B-PHOSPHORUS, THEIR USE IN RADICAL POLYMERIZATION |
WO2004014963A2 (en) * | 2002-08-09 | 2004-02-19 | Carnegie Mellon University | Polymers, supersoft elastomers and methods for preparing the same |
DE10237286A1 (en) * | 2002-08-14 | 2004-02-26 | Degussa Construction Chemicals Gmbh | Use of block copolymers produced by polymerizing a polyalkylene oxide compound with an ethylenically unsaturated monomer as dispersants for aqueous suspensions, e.g. cement mixes |
US6841636B2 (en) * | 2002-08-19 | 2005-01-11 | National Starch And Chemical Investment Holding Corporation | Dispersions containing living radicals |
US7375175B2 (en) * | 2002-08-19 | 2008-05-20 | National Starch And Chemical Investment Holding Corporation | Dispersions containing living radicals |
FR2846973B1 (en) | 2002-11-07 | 2004-12-17 | Rhodia Chimie Sa | ANTI-WRINKLE COMPOSITION COMPRISING A COPOLYMER WITH CONTROLLED ARCHITECTURE FOR TEXTILE FIBER ARTICLES |
US6806320B2 (en) * | 2002-11-15 | 2004-10-19 | 3M Innovative Properties Company | Block copolymer melt-processable compositions, methods of their preparation, and articles therefrom |
US6992217B2 (en) * | 2002-12-11 | 2006-01-31 | 3M Innovative Properties Company | Ring-opened azlactone initiators for atom transfer radical polymerization |
US6894133B2 (en) * | 2002-12-11 | 2005-05-17 | 3M Innovative Properties Company | Azlactone initiators for atom transfer radical polymerization |
EP1433799A3 (en) * | 2002-12-23 | 2004-07-14 | Ucb, S.A. | Star shaped acrylic block copolymer |
WO2004061525A1 (en) * | 2002-12-28 | 2004-07-22 | Jsr Corporation | Radiation-sensitive resin composition |
TWI237032B (en) * | 2002-12-31 | 2005-08-01 | Ind Tech Res Inst | Polyacrylonitrile block copolymer and method for producing the same |
GB0301014D0 (en) | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
US6677413B1 (en) | 2003-02-05 | 2004-01-13 | 3M Innovative Properties Company | Azlactone initiators for nitroxide-mediated polymerization |
US6680362B1 (en) | 2003-02-05 | 2004-01-20 | 3M Innovative Properties Company | Ring-opened azlactone initiators for nitroxide-mediated polymerization |
JP2007525543A (en) * | 2003-02-20 | 2007-09-06 | プロメラス, エルエルシー | Dissolution rate modifier for photoresist compositions |
US7754839B2 (en) * | 2003-03-03 | 2010-07-13 | The Regents Of The University Of California | Quasi-living metal catalyst for ethylene homo-polymerization and co-polymerization with 5-norbornen -2-yl acetate |
US6908952B2 (en) * | 2003-03-21 | 2005-06-21 | 3M Innovative Properties Company | Ring-opened azlactone photoiniferters for radical polymerization |
US6747104B1 (en) | 2003-03-21 | 2004-06-08 | 3M Innovative Properties Company | Azlactone photoiniferters for radical polymerization |
US6762257B1 (en) * | 2003-05-05 | 2004-07-13 | 3M Innovative Properties Company | Azlactone chain transfer agents for radical polymerization |
US6753391B1 (en) | 2003-05-05 | 2004-06-22 | 3M Innovative Properties Company | Ring-opened azlactone chain transfer agents for radical polymerization |
GB0314472D0 (en) * | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
WO2005003230A1 (en) | 2003-07-08 | 2005-01-13 | Kaneka Corporation | Curing composition |
FR2859728B1 (en) * | 2003-09-15 | 2008-07-11 | Oreal | ETHYLENIC COPOLYMER SEQUENCES COMPRISING A VINYLLACTAM SEQUENCE, COSMETIC OR PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THE USE OF THESE COPOLYMERS IN COSMETICS |
US20050238594A1 (en) * | 2003-09-15 | 2005-10-27 | Nathalie Mougin | Block ethylenic copolymers comprising a vinyllactam block, cosmetic or pharmaceutical compositions comprising them and cosmetic use of these copolymers |
JP2005139251A (en) * | 2003-11-05 | 2005-06-02 | Canon Inc | Block copolymer, polymer-containing composition containing the same, ink composition, ink-application method and apparatus |
CN102775535B (en) * | 2003-11-26 | 2014-08-27 | 日本曹达株式会社 | Novel hyperbranched polymer |
US7468413B2 (en) | 2004-01-30 | 2008-12-23 | Khodia Inc. | Rare earth aggregate formulation using di-block copolmers |
US20060057180A1 (en) * | 2004-02-20 | 2006-03-16 | Ashutosh Chilkoti | Tunable nonfouling surface of oligoethylene glycol |
US20070185343A1 (en) * | 2004-02-26 | 2007-08-09 | Universiteit Gent | Metal complexes for use in olefin metathesis and atom group transfer reactions |
US7250480B2 (en) * | 2004-03-04 | 2007-07-31 | Basf Corporation | Acrylic composition and a curable coating composition including the same |
US7220811B2 (en) * | 2004-03-04 | 2007-05-22 | Basf Corporation | Acrylic composition and a curable coating composition including the same |
US7342077B2 (en) | 2004-06-04 | 2008-03-11 | Basf Corporation | Acrylic composition and a method of forming the same via free-radical polymerization |
US7375174B2 (en) * | 2004-03-04 | 2008-05-20 | Basf Corporation | Acrylic composition and a curable coating composition including the same |
EP1725590A4 (en) * | 2004-03-05 | 2013-08-07 | Univ Carnegie Mellon | Atom transfer radical polymerization process |
WO2005087818A1 (en) * | 2004-03-05 | 2005-09-22 | Carnegie Mellon University | Preparation of functional polymers |
US7632905B2 (en) * | 2004-04-09 | 2009-12-15 | L'oreal S.A. | Block copolymer, composition comprising it and cosmetic treatment process |
WO2005097909A1 (en) | 2004-04-05 | 2005-10-20 | Kaneka Corporation | Curable compositions |
US20050253120A1 (en) * | 2004-05-13 | 2005-11-17 | Michiharu Yamamoto | Non-linear optical device material composition |
US7250121B2 (en) * | 2004-05-13 | 2007-07-31 | Nitto Denko Corporation | Non-linear optical device material composition |
DE602005014972D1 (en) * | 2004-05-26 | 2009-07-30 | Dentsply Detrey Gmbh | PARTICLE |
FR2871470B1 (en) | 2004-06-11 | 2007-01-12 | Oreal | GRADIENT COPOLYMER, COMPOSITION AND COSMETIC PROCESS FOR MAKE-UP OR CARE |
FR2872039B1 (en) * | 2004-06-23 | 2006-08-04 | Rhodia Chimie Sa | COSMETIC COMPOSITION COMPRISING POLYORGANOSILOXANE AND USES THEREOF |
JP2006016488A (en) * | 2004-07-01 | 2006-01-19 | Toyo Ink Mfg Co Ltd | Organic pigment-grafted with resin and method for producing the same |
EP1776399B1 (en) * | 2004-07-01 | 2012-11-14 | Universiteit Gent | Monodisperse polymers containing (alkyl)acrylic acid moieties, precursors and methods for making them and their applications |
US8563213B2 (en) | 2004-07-16 | 2013-10-22 | Transitions Optical, Inc. | Methods for producing photosensitive microparticles |
JP5090915B2 (en) * | 2004-10-08 | 2012-12-05 | フイルメニツヒ ソシエテ アノニム | Amphiphilic star block polymer |
US20060079624A1 (en) * | 2004-10-08 | 2006-04-13 | Hildeberto Nava | Crosslinkable polymer systems |
US7317058B2 (en) * | 2004-11-01 | 2008-01-08 | Nitto Denko Corporation | (Meth)acrylate polymer and non-linear optical device material composition |
US7279446B2 (en) | 2004-11-15 | 2007-10-09 | Rhodia Inc. | Viscoelastic surfactant fluids having enhanced shear recovery, rheology and stability performance |
US20090221739A1 (en) | 2005-01-11 | 2009-09-03 | Ralf Knischka | Process for the Post-Modification of Homo and Copolymers Prepared by Controlled Free Radical Polymerization Processes |
US20060173142A1 (en) * | 2005-02-01 | 2006-08-03 | Hildeberto Nava | Functionalized thermosetting resin systems |
US7691937B2 (en) * | 2005-02-04 | 2010-04-06 | Agfa Graphics Nv | Polymeric dispersants containing (meth)acryloyloxybenzoic acid |
JP4768997B2 (en) * | 2005-02-24 | 2011-09-07 | 株式会社リコー | Compound |
US7960305B2 (en) | 2005-02-25 | 2011-06-14 | Mitsui Chemicals, Inc. | Polymerization catalyst composition and process for production of polymer |
JP4742647B2 (en) * | 2005-03-31 | 2011-08-10 | 住友化学株式会社 | Method for producing polar monomer-olefin copolymer |
EP1877863A2 (en) * | 2005-04-14 | 2008-01-16 | The President and Fellows of Harvard College | Adjustable solubility in sacrificial layers for microfabrication |
US7279527B2 (en) * | 2005-04-22 | 2007-10-09 | Bridgestone Corporation | Method of converting anionic living end to protected free radical living end and applications thereof |
RU2412211C2 (en) * | 2005-06-13 | 2011-02-20 | Алькон, Инк. | Materials for ophthalmological or otolaryngological articles |
US8263721B2 (en) * | 2005-06-13 | 2012-09-11 | Novartis Ag | Ophthalmic and otorhinolaryngological device materials |
CN101193929B (en) * | 2005-06-13 | 2012-02-01 | 爱尔康公司 | Ophthalmic and otorhinolaryngological device materials |
EP1754731A1 (en) | 2005-08-16 | 2007-02-21 | Nederlandse Organisatie voor Toegepast-Natuuurwetenschappelijk Onderzoek TNO | Method of modifying materials surfaces |
GB0517137D0 (en) | 2005-08-22 | 2005-09-28 | Viacatt N V | Multicoordinated metal complexes for use in metalthesis reactions |
CN101356197B (en) | 2005-08-23 | 2016-02-17 | 卡内基梅隆大学 | Atom transfer radical polymerization in microemulsion and real letex polymerization |
EP1946333A2 (en) * | 2005-08-26 | 2008-07-23 | Carnegie Mellon University | Electrically conductive blockcopolymers and controlled radical polymerization |
WO2007025310A1 (en) * | 2005-08-26 | 2007-03-01 | Carnegie Mellon University | Polymerization process with catalyst reactivation |
DE102005041528A1 (en) | 2005-08-31 | 2007-03-01 | Rohmax Additives Gmbh | Multi-arm star-shaped polymer for use as lubricating oil additive, e.g. viscosity modifier or dispersant, has at least three arms containing units derived from esters of higher alkanols and unsaturated carboxylic acids |
JPWO2007029733A1 (en) | 2005-09-08 | 2009-03-19 | 株式会社カネカ | Curable composition |
US20070123646A1 (en) * | 2005-09-13 | 2007-05-31 | Lele Bhalchandra S | Protein-polymer conjugates and synthesis thereof |
JP2009507980A (en) | 2005-09-14 | 2009-02-26 | ユセベ ファルマ ソシエテ アノニム | Comb polymer |
WO2007035527A2 (en) * | 2005-09-15 | 2007-03-29 | Duke University | Non-fouling polymeric surface modification and signal amplification method for biomolecular detection |
JP5243797B2 (en) | 2005-09-22 | 2013-07-24 | 株式会社カネカ | Photo radical curing / photo cationic curing combined curable composition |
ES2336473T5 (en) * | 2005-09-26 | 2014-01-07 | Nippon Shokubai Co., Ltd. | Polymer, process for its preparation and cement mixture containing it |
US20090292075A1 (en) | 2005-12-13 | 2009-11-26 | Kaneka Corporation | Curable composition for damping material and damping material |
US20090171024A1 (en) * | 2005-12-21 | 2009-07-02 | Carnegie Mellon University | Preparation of block copolymers |
US7671152B2 (en) * | 2005-12-22 | 2010-03-02 | The Goodyear Tire & Rubber Company | Surfactantless synthesis of amphiphilic cationic block copolymers |
WO2007077888A1 (en) | 2005-12-28 | 2007-07-12 | Kaneka Corporation | Curable composition |
JP5388161B2 (en) | 2005-12-28 | 2014-01-15 | 株式会社カネカ | Thermal radical curing / thermal latent curing type epoxy curable composition |
EP1967533B1 (en) | 2005-12-28 | 2013-03-13 | Kaneka Corporation | Photoradically and thermally radically curable composition |
ATE532828T1 (en) | 2006-01-18 | 2011-11-15 | Kaneka Corp | CURDABLE COMPOSITION |
WO2007094270A1 (en) | 2006-02-14 | 2007-08-23 | Kaneka Corporation | Vinyl polymer having polar functional group and method for production thereof |
EP1988910B1 (en) | 2006-02-28 | 2017-12-06 | Kodiak Sciences Inc. | Acryloyloxyethylphosphorylcholine containing polymer conjugates and their preparation |
EP2006326A4 (en) | 2006-03-29 | 2009-07-22 | Mitsui Chemicals Inc | Resin composition containing olefin block polymer and use of the same |
US7728092B1 (en) | 2006-04-13 | 2010-06-01 | Henkel Corporation | Anaerobically curable compositions |
WO2007139463A1 (en) * | 2006-05-29 | 2007-12-06 | Ge Healthcare Bio-Sciences Ab | Preparation of monolithic articles |
US20080153077A1 (en) * | 2006-06-12 | 2008-06-26 | David Henry | Substrates for immobilizing cells and tissues and methods of use thereof |
EP1873205A1 (en) * | 2006-06-12 | 2008-01-02 | Corning Incorporated | Thermo-responsive blends and uses thereof |
EP2054765A2 (en) * | 2006-07-25 | 2009-05-06 | Nitto Denko Corporation | Non-linear optical device sensitive to green laser |
US7736548B2 (en) * | 2006-07-25 | 2010-06-15 | Nitto Denko Corporation | Non-linear optical device with long grating persistency |
EP2069408B1 (en) * | 2006-08-04 | 2012-12-05 | The Trustees of the University of Pennsylvania | Living radical polymerization of activated and nonactivated monomers containing electron-withdrawing side groups |
US8349410B2 (en) | 2006-08-17 | 2013-01-08 | University of Pittsburgh—of the Commonwealth System of Higher Education | Modification of surfaces with polymers |
WO2008020614A1 (en) | 2006-08-18 | 2008-02-21 | Kaneka Corporation | Method for producing branched vinyl polymer having functional group |
KR20090049094A (en) * | 2006-09-06 | 2009-05-15 | 코닝 인코포레이티드 | Nanofibers, nanofilms and methods of making/using thereof |
EP2072577B1 (en) | 2006-10-05 | 2010-08-04 | Kaneka Corporation | Curable composition |
WO2008057163A2 (en) * | 2006-10-09 | 2008-05-15 | Carnegie Mellon University | Preparation of functional gel particles with a dual crosslink network |
FR2909093B1 (en) * | 2006-11-28 | 2012-07-13 | Arkema France | 3D OPTICAL MEMORY COMPRISING A BLOCK COPOLYMER CONTAINING A PHOTOACTIVE MONOMER CARRYING A PHOTOISOMERIZABLE GROUP. |
FR2909094A1 (en) * | 2006-11-28 | 2008-05-30 | Arkema France | 3D OPTICAL MEMORY COMPRISING MULTILAYER PARTICLES COMPRISING A PHOTOACTIVE MONOMER WITH A PHOTOISOMERIZABLE GROUP. |
US7994101B2 (en) * | 2006-12-12 | 2011-08-09 | Halliburton Energy Services, Inc. | Corrosion inhibitor intensifier compositions and associated methods |
US7560509B2 (en) * | 2006-12-29 | 2009-07-14 | Bridgestone Corporation | Method of directing grafting by controlling the location of high vinyl segments in a polymer |
US8030410B2 (en) | 2006-12-29 | 2011-10-04 | Bridgestone Corporation | Method for generating free radical capable polymers using carbonyl-containing compounds |
US7396887B1 (en) * | 2006-12-29 | 2008-07-08 | Bridgestone Corporation | Insitu removal of chelator from anionic polymerization reactions |
US7737218B2 (en) | 2006-12-29 | 2010-06-15 | Bridgestone Corporation | Method for generating free radical capable polymers using tin or silicon halide compounds |
US20080157641A1 (en) * | 2006-12-31 | 2008-07-03 | Rachael Wren Grout | Multi-use Free Standing Seating and Storage Unit |
FR2911609B1 (en) * | 2007-01-19 | 2009-03-06 | Rhodia Recherches & Tech | DIBLOC COPOLYMER COMPRISING STYRENE-DERIVING UNITS AND ACRYLIC ACID-DERIVING UNITS |
FR2923487B1 (en) * | 2007-11-09 | 2009-12-04 | Rhodia Operations | AMPHOLYTE COPOLYMER WITH CONTROLLED ARCHITECTURE |
DE102007006105A1 (en) | 2007-02-02 | 2008-08-07 | Evonik Röhm Gmbh | Process for the preparation of telechelic polymers |
US9056988B2 (en) | 2007-02-05 | 2015-06-16 | Ppg Industries Ohio, Inc. | Solar reflective coatings and coating systems |
US20100136353A1 (en) * | 2007-04-05 | 2010-06-03 | Michael Arnoldus Jacobus Schellekens | Aqueous oligomer / polymer emulsion with cationic functionality |
FI122734B (en) | 2007-05-21 | 2012-06-15 | Kemira Oyj | Process chemical for use in the manufacture of paper or board |
GB2463198B (en) * | 2007-05-23 | 2013-05-22 | Univ Carnegie Mellon | Hybrid particle composite structures with reduced scattering |
WO2008148000A1 (en) * | 2007-05-23 | 2008-12-04 | Carnegie Mellon University | Atom transfer dispersion polymerization |
WO2008154331A1 (en) * | 2007-06-07 | 2008-12-18 | Chevron U.S.A. Inc. | Removal of branched dibenzothiophenes from hydrocarbon mixtures via charge transfer complexes with a tapa-functionalized adsorbent |
DE102007046223A1 (en) | 2007-09-26 | 2009-04-02 | Evonik Rohmax Additives Gmbh | Use of comb polymer comprising repeating units derived from polyolefin-based macro-monomer and repeating units derived from low molecular monomers comprising e.g. styrene monomer, to reduce fuel consumption in motor vehicles |
DE102007032120A1 (en) | 2007-07-09 | 2009-01-15 | Evonik Rohmax Additives Gmbh | Use of comb polymer comprising polyolefin-based macro-monomer derived from repeating units and repeating units derived from low molecular monomers comprising e.g. styrene monomer, to reduce the fuel consumption in motor vehicles |
DE102007036856A1 (en) | 2007-08-06 | 2009-02-26 | Evonik Rohmax Additives Gmbh | Use of ester-group-containing polymers as antifatigue additives |
DE102007043048A1 (en) | 2007-09-11 | 2009-03-12 | Byk-Chemie Gmbh | Polypropylene-containing polyethers and their mixtures with poly (meth) acrylates as powder coating development agent |
US20090074709A1 (en) * | 2007-09-14 | 2009-03-19 | Koepsel Richard R | Methods, devices and systems for biocidal surface activity |
FR2921663A1 (en) | 2007-10-02 | 2009-04-03 | Bluestar Silicones France Soc | POLYORGANOSILOXANES WITH PIPERIDINE FUNCTION WITHOUT CUTANE CONTACT TOXICITY AND USE OF THE SAME IN COSMETIC COMPOSITIONS |
TWI426931B (en) * | 2007-10-03 | 2014-02-21 | Alcon Inc | Ophthalmic and otorhinolaryngological device materials |
TWI461186B (en) * | 2007-10-05 | 2014-11-21 | Alcon Inc | Ophthalmic and otorhinolaryngological device materials |
TWI426932B (en) | 2007-10-05 | 2014-02-21 | Alcon Inc | Ophthalmic and otorhinolaryngological device materials |
US7789160B2 (en) * | 2007-10-31 | 2010-09-07 | Rhodia Inc. | Addition of nonionic surfactants to water soluble block copolymers to increase the stability of the copolymer in aqueous solutions containing salt and/or surfactants |
US20090111957A1 (en) * | 2007-10-31 | 2009-04-30 | National Taipei University Of Technology | Fluoro-ponytailed bipyridine derivatives and their use as ligands in the metal-catalyzed atrp |
EP2205826A4 (en) * | 2007-10-31 | 2011-06-29 | Rhodia | Addition of zwitterionic surfactant to water soluble polymer to increase the stability of the polymers in aqueous solutions containing salt and/or surfactants |
US8058211B2 (en) * | 2007-12-12 | 2011-11-15 | Halliburton Energy Services, Inc. | Corrosion inhibitor intensifier compositions and associated methods |
US20090156771A1 (en) * | 2007-12-17 | 2009-06-18 | Youqing Shen | Amine-Containing Compounds for Enhancing the Activity of ATRP Catalysts and Removal of the Terminal Halogen Groups from the ATRP Polymer Products |
KR101574815B1 (en) * | 2007-12-18 | 2015-12-04 | 바스프 에스이 | Biodiesel Cold Flow Improver |
WO2009085759A1 (en) * | 2007-12-27 | 2009-07-09 | Bausch & Lomb Incorporated | Segmented reactive block copolymers |
WO2009085754A1 (en) * | 2007-12-27 | 2009-07-09 | Bausch & Lomb Incorporated | Segmented interactive block copolymers |
US20090171049A1 (en) * | 2007-12-27 | 2009-07-02 | Linhardt Jeffrey G | Segmented reactive block copolymers |
US8796184B2 (en) | 2008-03-28 | 2014-08-05 | Sentilus, Inc. | Detection assay devices and methods of making and using the same |
US8497320B2 (en) | 2008-05-07 | 2013-07-30 | Advanced Softmaterials Inc. | Polyrotaxane, crosslinked structure comprising polyrotaxane and polymer, and processes for producing these |
FR2931827A1 (en) * | 2008-05-27 | 2009-12-04 | Arkema France | BLOCK COPOLYMER CONTAINING A PHOTOACTIVE MONOMER WITH A PHOTOISOMERIZABLE GROUP, USE THEREOF IN A 3D OPTICAL MEMORY. |
JP5642671B2 (en) * | 2008-06-18 | 2014-12-17 | ヘンケル コーポレイションHenkel Corporation | Apparatus and method for controlled radical polymerization |
US8829136B2 (en) * | 2008-06-18 | 2014-09-09 | Henkel US IP LLC | Apparatus and methods for controlled radical polymerization |
WO2009156277A1 (en) | 2008-06-23 | 2009-12-30 | Basf Se | Pigment dispersants with modified copolymers |
FR2934154B1 (en) * | 2008-07-23 | 2010-08-13 | Rhodia Operations | THERMOSENSITIVE EMULSIONS |
ES2397073T3 (en) * | 2008-08-05 | 2013-03-04 | Polymers Crc Limited | Functionalized thin film polyamide membranes |
EP2160945A1 (en) | 2008-09-09 | 2010-03-10 | Polymers CRC Limited | Antimicrobial Article |
EP2160946A1 (en) | 2008-09-09 | 2010-03-10 | Polymers CRC Limited | Process for the preparation of an antimicrobial article |
US20100099789A1 (en) * | 2008-10-20 | 2010-04-22 | Nitto Denko Corporation | Method for modulating light of photorefractive composition |
US20100096603A1 (en) * | 2008-10-20 | 2010-04-22 | Nitto Denko Corporation | Optical devices responsive to near infrared laser and methods of modulating light |
FR2937336B1 (en) | 2008-10-22 | 2011-06-10 | Rhodia Operations | COMPOSITION FOR HOUSEHOLD CARE COMPRISING A CATIONIC NANOGEL |
US8815971B2 (en) * | 2008-12-22 | 2014-08-26 | ATRP Solutions, Inc. | Control over controlled radical polymerization processes |
US8822610B2 (en) | 2008-12-22 | 2014-09-02 | ATRP Solutions, Inc. | Control over controlled radical polymerization processes |
US20100162693A1 (en) | 2008-12-31 | 2010-07-01 | Michael Paul W | Method of reducing torque ripple in hydraulic motors |
KR20110101199A (en) | 2009-01-13 | 2011-09-15 | 에보니크 로막스 아디티페스 게엠베하 | Fuel compositions having improved cloud point and improved storage properties |
FR2941704B1 (en) | 2009-01-30 | 2011-12-23 | Arkema France | BLOCK COPOLYMERS WITH ASSOCIATIVE GROUPS AND ADHESIVE COMPRISING SAME |
US8110797B2 (en) * | 2009-02-06 | 2012-02-07 | Florida State University Research Foundation, Inc. | Electrospray ionization mass spectrometry methodology |
DE102009001446A1 (en) | 2009-03-10 | 2010-09-23 | Evonik Rohmax Additives Gmbh | Use of comb polymers as antifatigue additives |
DE102009001447A1 (en) | 2009-03-10 | 2010-09-16 | Evonik Rohmax Additives Gmbh | Use of comb polymers to improve the load carrying capacity |
US8962764B2 (en) | 2009-03-27 | 2015-02-24 | Carnegie Mellon University | Preparation of functional star macromolecules |
US8173750B2 (en) | 2009-04-23 | 2012-05-08 | ATRP Solutions, Inc. | Star macromolecules for personal and home care |
WO2010123575A1 (en) | 2009-04-23 | 2010-10-28 | Atrp Solutions Inc | Well defined stars with segmented arms |
WO2010123574A1 (en) | 2009-04-23 | 2010-10-28 | Atrp Solutions Inc | Star macromolecules for personal and home care |
US9783628B2 (en) | 2009-04-23 | 2017-10-10 | ATRP Solutions, Inc. | Dual-mechanism thickening agents for hydraulic fracturing fluids |
DE102009002730A1 (en) | 2009-04-29 | 2010-11-04 | Evonik Rohmax Additives Gmbh | Preparing copolymer, useful as additive for e.g. mineral oil and ester oil, comprises polymerizing a monomer composition (comprising e.g. ethylenically unsaturated ester compounds and comonomer) in the presence of alkyl(ene) compounds |
US8673295B2 (en) | 2009-04-30 | 2014-03-18 | University of Pittsburgh—of the Commonwealth System of Higher Education | Thermoresponsive, biodegradable, elastomeric material and uses therefor |
US8470205B2 (en) | 2009-06-05 | 2013-06-25 | Air Products And Chemicals, Inc. | Electrically conductive films formed from dispersions comprising conductive polymers and hyperbranched polymers |
GB0912160D0 (en) | 2009-07-13 | 2009-08-26 | Warwick Effect Polymers Ltd | Polymer modified macromolecules |
DK2453942T3 (en) | 2009-07-15 | 2014-11-24 | Univ Denmark Tech Dtu | Polymer coating, which comprises 2-methoxyethylacrylatenheder synthesized by surface-initiated Atom transfer radical polymerisation |
ATE547472T1 (en) | 2009-09-25 | 2012-03-15 | Evonik Rohmax Additives Gmbh | COMPOSITION FOR IMPROVING THE COLD FLOW PROPERTIES OF FUEL OILS |
CN101691417B (en) * | 2009-10-13 | 2011-05-25 | 华东理工大学 | Preparation method of star poly-(methyl)acrylate long-chain ester polymer |
CN102282222B (en) | 2009-12-01 | 2014-07-16 | 星铂联制造公司 | Polymer encapsulated aluminum particulates |
WO2011075185A1 (en) | 2009-12-18 | 2011-06-23 | Oligasis | Targeted drug phosphorylcholine polymer conjugates |
DE102010001040A1 (en) | 2010-01-20 | 2011-07-21 | Evonik RohMax Additives GmbH, 64293 | (Meth) acrylate polymers for improving the viscosity index |
US20110192076A1 (en) | 2010-02-05 | 2011-08-11 | Evonik Rohmax Additives Gmbh | Composition having improved filterability |
CN101787093B (en) * | 2010-03-12 | 2012-01-18 | 江苏工业学院 | Self-initiated atom transfer radical polymerization method of Dimethylaminoethyl Methacrylate |
DE102010028195A1 (en) | 2010-04-26 | 2011-10-27 | Evonik Rohmax Additives Gmbh | Lubricant for transmissions |
BR112012027294B1 (en) | 2010-04-26 | 2020-01-28 | Evonik Oil Additives Gmbh | polymer useful as a viscosity index enhancer, lubricant composition and its use |
WO2011146486A1 (en) | 2010-05-17 | 2011-11-24 | Duke University | Detection devices and related methods of use |
CN102295712B (en) * | 2010-06-24 | 2013-02-27 | 中国科学院化学研究所 | Water-phase ligand-free transition metal catalytic activity/controllable free radical polymerization method |
US8912252B2 (en) | 2010-07-20 | 2014-12-16 | Silberline Manufacturing Company, Inc. | Film-forming pigments and coating system including the same |
US8815982B2 (en) | 2010-07-20 | 2014-08-26 | Silberline Manufacturing Company, Inc. | Colored system |
DE102010038615A1 (en) | 2010-07-29 | 2012-02-02 | Evonik Rohmax Additives Gmbh | Polyalkyl (meth) acrylate for improving lubricating oil properties |
EP2604633B1 (en) | 2010-08-10 | 2015-07-08 | Kaneka Corporation | Manufacturing method of (meth) acrylic polymer |
US8816001B2 (en) | 2010-09-10 | 2014-08-26 | Franklin And Marshall College | Genetically encoded initiator for polymer growth from proteins |
FR2965264B1 (en) | 2010-09-27 | 2013-11-29 | Rhodia Operations | CONTROLLED RADICAL POLYMERIZATION OF N-VINYL LACTAMS IN AQUEOUS MEDIUM |
FR2965564B1 (en) | 2010-09-30 | 2012-10-26 | Rhodia Operations | PREPARATION OF HIGH-MASS HYDROPHILIC POLYMERS BY CONTROLLED RADICAL POLYMERIZATION |
JP5809633B2 (en) | 2010-09-30 | 2015-11-11 | 株式会社カネカ | Composition for vibration damping material containing branched polymer |
SG189514A1 (en) | 2010-10-29 | 2013-05-31 | Evonik Oil Additives Gmbh | A diesel motor having improved properties |
US9587064B2 (en) | 2010-12-08 | 2017-03-07 | ATRP Solutions, Inc. | Salt-tolerant star macromolecules |
WO2012076676A1 (en) | 2010-12-10 | 2012-06-14 | Evonik Rohmax Additives Gmbh | A viscosity index improver comprising a polyalkyl(meth)acrylate polymer |
WO2012076285A1 (en) | 2010-12-10 | 2012-06-14 | Evonik Rohmax Additives Gmbh | A lubricant composition |
US9518249B2 (en) | 2010-12-16 | 2016-12-13 | General Electric Company | Cell carrier, associated methods for making cell carrier and culturing cells using the same |
US9926523B2 (en) | 2010-12-16 | 2018-03-27 | General Electric Company | Cell carriers and methods for culturing cells |
US9453196B2 (en) | 2010-12-16 | 2016-09-27 | General Electric Company | Cell carrier, methods of making and use |
US9534206B2 (en) | 2010-12-16 | 2017-01-03 | General Electric Company | Cell carrier, associated methods for making cell carrier and culturing cells using the same |
US9453197B2 (en) | 2010-12-16 | 2016-09-27 | General Electric Company | Methods of making cell carrier |
WO2012091965A1 (en) | 2010-12-17 | 2012-07-05 | Carnegie Mellon University | Electrochemically mediated atom transfer radical polymerization |
DE102011003855A1 (en) | 2011-02-09 | 2012-08-09 | Evonik Rohmax Additives Gmbh | Process for dewaxing mineral oil compositions |
WO2012130535A1 (en) | 2011-03-25 | 2012-10-04 | Evonik Rohmax Additives Gmbh | A composition to improve oxidation stability of fuel oils |
DE102011075969A1 (en) | 2011-05-17 | 2012-11-22 | Evonik Rohmax Additives Gmbh | Friction-improving polymers for DLC-coated surfaces |
DE102011076364A1 (en) | 2011-05-24 | 2012-11-29 | Evonik Rohmax Additives Gmbh | Lubricant composition with phosphate-functionalized polymers |
US9057835B2 (en) | 2011-06-06 | 2015-06-16 | Ppg Industries Ohio, Inc. | Coating compositions that transmit infrared radiation and exhibit color stability and related coating systems |
EP2551338A1 (en) | 2011-07-27 | 2013-01-30 | Henkel AG & Co. KGaA | Laundry detergent compositions with stain removal properties |
US20140275420A1 (en) | 2011-08-22 | 2014-09-18 | Carnegie Mellon University | Atom transfer radical polymerization under biologically compatible conditions |
EP2751143A1 (en) * | 2011-08-30 | 2014-07-09 | Basf Se | Production of polymers by means of controlled radical polymerisation |
US9790305B2 (en) | 2011-09-09 | 2017-10-17 | Franklin And Marshall College | Site specifically incorporated initiator for growth of polymers from proteins |
US9574094B2 (en) | 2013-12-09 | 2017-02-21 | Ppg Industries Ohio, Inc. | Graphenic carbon particle dispersions and methods of making same |
US10294375B2 (en) | 2011-09-30 | 2019-05-21 | Ppg Industries Ohio, Inc. | Electrically conductive coatings containing graphenic carbon particles |
US9761903B2 (en) | 2011-09-30 | 2017-09-12 | Ppg Industries Ohio, Inc. | Lithium ion battery electrodes including graphenic carbon particles |
US10240052B2 (en) | 2011-09-30 | 2019-03-26 | Ppg Industries Ohio, Inc. | Supercapacitor electrodes including graphenic carbon particles |
US9988551B2 (en) | 2011-09-30 | 2018-06-05 | Ppg Industries Ohio, Inc. | Black pigments comprising graphenic carbon particles |
US9832818B2 (en) | 2011-09-30 | 2017-11-28 | Ppg Industries Ohio, Inc. | Resistive heating coatings containing graphenic carbon particles |
US10763490B2 (en) | 2011-09-30 | 2020-09-01 | Ppg Industries Ohio, Inc. | Methods of coating an electrically conductive substrate and related electrodepositable compositions including graphenic carbon particles |
US9938416B2 (en) | 2011-09-30 | 2018-04-10 | Ppg Industries Ohio, Inc. | Absorptive pigments comprising graphenic carbon particles |
US9475946B2 (en) | 2011-09-30 | 2016-10-25 | Ppg Industries Ohio, Inc. | Graphenic carbon particle co-dispersions and methods of making same |
WO2013060741A1 (en) | 2011-10-24 | 2013-05-02 | Rhodia Operations | Preparation of amphiphilic block polymers by controlled radical micellar polymerisation |
CN104011117B (en) * | 2011-12-22 | 2016-11-23 | 朗盛国际股份公司 | The method of the polymer of preparation solidification |
CN108623762B (en) | 2012-01-18 | 2021-11-23 | 爱荷华州立大学研究基金会有限公司 | Thermoplastic elastomer via atom transfer radical polymerization of vegetable oils |
WO2013158183A2 (en) | 2012-01-27 | 2013-10-24 | Carnegie Mellon University | Processable self-organizing nanoparticles |
CN104144956B (en) | 2012-01-31 | 2017-04-12 | 罗地亚运作公司 | Dispersed phase polymerisation of halogenated vinyl monomers in the presence of live reactive stabilisers |
WO2013113750A1 (en) | 2012-01-31 | 2013-08-08 | Rhodia Operations | Live poly(n-vinyl lactam) reactive stabilisers for dispersed phase polymerisation |
US9533297B2 (en) | 2012-02-23 | 2017-01-03 | Carnegie Mellon University | Ligands designed to provide highly active catalyst complexes |
EP3778768A1 (en) | 2012-02-23 | 2021-02-17 | Basf Se | Fluorinated acrylate block copolymers with low dynamic surface tension |
JP5888648B2 (en) * | 2012-02-29 | 2016-03-22 | ニッタ株式会社 | Method for producing temperature-sensitive adhesive |
FR2987837B1 (en) | 2012-03-09 | 2014-03-14 | Rhodia Operations | RADICAL CONTROLLED POLYMERIZATION IN WATER-IN-WATER DISPERSION |
US9382387B2 (en) | 2012-03-13 | 2016-07-05 | California Institute Of Technology | Rapid self-assembly of block copolymers to photonic crystals |
WO2013138494A1 (en) | 2012-03-13 | 2013-09-19 | California Institute Of Technology | Periodic nanostructures from self assembled wedge-type block-copolymers |
US20150059238A1 (en) | 2012-04-27 | 2015-03-05 | Evonik Oil Additives Gmbh | Use of cold flow improver compositions for fuels, blends thereof with biofuels and formulations thereof |
US8975346B2 (en) | 2012-05-18 | 2015-03-10 | Sabic Global Technologies B.V. | Polycarbonate copolymers via controlled radical polymerization |
CN104471041A (en) | 2012-06-06 | 2015-03-25 | 范德比尔特化学品有限责任公司 | Fuel efficient lubricating oils |
US9453943B2 (en) | 2012-06-28 | 2016-09-27 | California Institute Of Technology | Photonic structures from self assembly of brush block copolymers and polymer blends |
EP2890760A4 (en) | 2012-08-30 | 2016-10-12 | Atrp Solutions Inc | Dual mechanism thickening agents for hydraulic fracturing fluids |
KR20150054817A (en) | 2012-09-13 | 2015-05-20 | 에보니크 오일 아디티페스 게엠베하 | A composition to improve low temperature properties and oxidation stability of vegetable oils and animal fats |
EP2812091B1 (en) | 2012-09-17 | 2021-03-10 | W.R. Grace & CO. - CONN. | Chromatography media and devices |
US11529610B2 (en) | 2012-09-17 | 2022-12-20 | W.R. Grace & Co.-Conn. | Functionalized particulate support material and methods of making and using the same |
US9914870B2 (en) | 2013-01-22 | 2018-03-13 | Carnegie Mellon University | Lignin-containing polymers and compositions including lignin-containing polymers |
ES2584839T3 (en) | 2013-02-04 | 2016-09-29 | Evonik Oil Additives Gmbh | Cold flow improver with wide applicability in mineral diesel, biodiesel and combinations thereof |
JP6700789B2 (en) | 2013-02-04 | 2020-05-27 | パイロット ポリマー テクノロジーズ, インク. | Salt-tolerant star polymer, salt-tolerant thickener containing salt-tolerant star polymer, method for producing salt-resistant composition, method for making salt-containing composition salt-tolerant, method for producing star polymer |
US20140256874A1 (en) | 2013-03-05 | 2014-09-11 | Ppg Industries Ohio, Inc. | Curable solid particulate compositions |
WO2014151543A1 (en) | 2013-03-15 | 2014-09-25 | Ppg Industries Ohio, Inc. | Controlled radical polymerization initiators |
CN103205202A (en) * | 2013-04-03 | 2013-07-17 | 中山职业技术学院 | Gradient function coating with surface tension changed in gradient way and preparation method thereof |
FR3004458A1 (en) | 2013-04-11 | 2014-10-17 | Rhodia Operations | FRACTURING FLUIDS BASED ON ASSOCIATIVE POLYMERS AND SURFACTANTS LABILES |
US9765169B2 (en) | 2013-04-18 | 2017-09-19 | Carnegie Mellon University | Functionalized polymer hybrids |
EP3632942A1 (en) | 2013-05-20 | 2020-04-08 | Iowa State University Research Foundation, Inc. | Thermoplastic elastomers via reversible addition-fragmentation chain transfer polymerization of triglycerides |
CA2949948A1 (en) | 2013-05-22 | 2014-11-27 | Triblue Corporation | Methods of forming a polymer layer on a polymer surface |
EP2824155A1 (en) | 2013-07-09 | 2015-01-14 | HILTI Aktiengesellschaft | Reaction resin composition and its use |
EP2824117A1 (en) | 2013-07-09 | 2015-01-14 | HILTI Aktiengesellschaft | Reaction resin composition and its use |
DK3041513T3 (en) | 2013-09-08 | 2020-10-26 | Kodiak Sciences Inc | ZWITTERIONIC FACTOR VIII POLYMER CONJUGATES |
FR3011555A1 (en) | 2013-10-04 | 2015-04-10 | Rhodia Operations | POLYMER SEQUENCES FOR FILTRAT CONTROL |
JP2015117356A (en) | 2013-11-18 | 2015-06-25 | 株式会社リコー | Method for producing polymer, polymer product, particle, film, molded part and fiber |
JP6853670B2 (en) | 2014-01-16 | 2021-04-07 | ダブリュー・アール・グレース・アンド・カンパニー−コーンW R Grace & Co−Conn | Affinity Chromatography Medium and Chromatography Devices |
EP2896637A1 (en) | 2014-01-21 | 2015-07-22 | Rhodia Operations | Copolymer comprising units of type A deriving from carboxylic acid monomers and units of type B deriving from sulfonic acid monomers |
CN103788266B (en) * | 2014-02-12 | 2016-03-30 | 中国科学院长春应用化学研究所 | A kind of method of atom transfer radical polymerization |
JP6096381B2 (en) * | 2014-04-08 | 2017-03-15 | 東洋ゴム工業株式会社 | Rubber composition and pneumatic tire |
US10589002B2 (en) | 2014-04-14 | 2020-03-17 | University of Pittsburgh—of the Commonwealth System of Higher Education | Biodegradable, thermally responsive injectable hydrogel for treatment of ischemic cardiomyopathy |
ES2929099T3 (en) | 2014-05-02 | 2022-11-24 | Grace W R & Co | Functionalized support material and methods of manufacturing and use of functionalized support material |
MX2016014977A (en) | 2014-05-21 | 2017-03-31 | Univ Iowa State Res Found Inc | Poly(acrylated polyol) and method for making and using thereof as asphalt rubber modifiers, adhesives, fracking additives, or fracking fluids. |
WO2015200442A1 (en) | 2014-06-27 | 2015-12-30 | Henkel IP & Holding GmbH | Alkoxysilane-functionalized hydrocarbon compounds, intermediates thereof and methods of preparation thereof |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
US10336848B2 (en) | 2014-07-03 | 2019-07-02 | Pilot Polymer Technologies, Inc. | Surfactant-compatible star macromolecules |
WO2016042770A1 (en) | 2014-09-17 | 2016-03-24 | クラレノリタケデンタル株式会社 | Dental polymerizable composition |
FR3027309B1 (en) | 2014-10-17 | 2018-08-10 | Rhodia Operations | POLYFUNCTIONAL POLYMERS BASED ON PHOSPHONATE UNITS AND AMINE UNITS |
WO2016061562A2 (en) | 2014-10-17 | 2016-04-21 | Kodiak Sciences Inc. | Butyrylcholinesterase zwitterionic polymer conjugates |
CN107001818A (en) | 2014-10-28 | 2017-08-01 | Ppg工业俄亥俄公司 | Include the black pigment of graphene carbon particle |
JP6724786B2 (en) * | 2014-10-29 | 2020-07-15 | 日本ゼオン株式会社 | Method for producing conjugated diene polymer |
WO2016070068A1 (en) | 2014-10-31 | 2016-05-06 | Ppg Industries Ohio, Inc. | Resistive heating coatings containing graphene carbon particles and use of such coatings for low energy curing |
EP3034573A1 (en) | 2014-12-16 | 2016-06-22 | ALLNEX AUSTRIA GmbH | Flow modifier for coating compositions |
EP3034520A1 (en) | 2014-12-19 | 2016-06-22 | HILTI Aktiengesellschaft | Reaction resin composition and its use |
EP3242899A4 (en) * | 2015-01-08 | 2018-07-04 | Henkel IP & Holding GmbH | Process for preparing high molecular weight polyacrylates having narrow polydispersity indices |
US9982070B2 (en) | 2015-01-12 | 2018-05-29 | Carnegie Mellon University | Aqueous ATRP in the presence of an activator regenerator |
CN107427589A (en) | 2015-02-10 | 2017-12-01 | 卡内基梅隆大学 | The non-aqueous solution and correlation technique of enzymatic polymerization thing conjugate |
US10608280B2 (en) | 2015-03-09 | 2020-03-31 | California Institute Of Technology | Brush block copolymer electrolytes and electrocatalyst compositions |
FR3034776A1 (en) | 2015-04-07 | 2016-10-14 | Rhodia Operations | POLYMER SEQUENCES FOR FILTRAT CONTROL |
FR3034768B1 (en) | 2015-04-07 | 2017-05-05 | Rhodia Operations | POLYMER SEQUENCES FOR FILTRAT CONTROL |
FR3034777A1 (en) | 2015-04-07 | 2016-10-14 | Rhodia Operations | POLYMER SEQUENCES FOR FILTRAT CONTROL AND RHEOLOGY |
US9650480B2 (en) | 2015-04-15 | 2017-05-16 | Ppg Industries Ohio, Inc. | Curable film-forming compositions containing encapsulated catalyst components |
EP3292189A2 (en) | 2015-05-04 | 2018-03-14 | Rhodia Operations | Copolymers for lubricating metals |
FR3037074B1 (en) | 2015-06-03 | 2017-07-14 | Rhodia Operations | SUSPENSION AGENTS OBTAINED BY MICELLAR POLYMERIZATION |
PL3302784T3 (en) | 2015-06-05 | 2022-01-17 | W.R. Grace & Co.-Conn. | Adsorbent bioprocessing clarification agents and methods of making and using the same |
EP3325966B1 (en) | 2015-07-20 | 2021-01-20 | Sentilus Holdco, LLC | Chips, detectors, and methods of making and using the same |
WO2017024182A1 (en) | 2015-08-04 | 2017-02-09 | Duke University | Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same |
FR3043083B1 (en) | 2015-10-30 | 2019-04-19 | Rhodia Operations | SOLUBLE AMPHIPHILIC SEQUENCE POLYMERS IN HIGHLY SALT MEDIA |
UA123505C2 (en) | 2015-12-10 | 2021-04-14 | Адама Махтешім Лтд. | Polyelectrolyte-layer forming block copolymers and compositions and used thereof |
WO2017103635A1 (en) | 2015-12-16 | 2017-06-22 | Rhodia Poliamida E Especialidades Ltda | Emulsifier system for explosive emulsions |
EP3184499A1 (en) | 2015-12-21 | 2017-06-28 | HILTI Aktiengesellschaft | Reaction resin composition, multi-component system and its use |
US11752213B2 (en) | 2015-12-21 | 2023-09-12 | Duke University | Surfaces having reduced non-specific binding and antigenicity |
CN108712911A (en) | 2015-12-30 | 2018-10-26 | 科达制药股份有限公司 | Antibody and its conjugate |
WO2017132137A1 (en) | 2016-01-25 | 2017-08-03 | Carnegie Mellon University | Composite composition and modification of inorganic particles for use in composite compositions |
CN109071736B (en) | 2016-05-13 | 2021-08-10 | 赢创运营有限公司 | Graft copolymers based on a polyolefin backbone and methacrylate side chains |
US11467156B2 (en) | 2016-06-01 | 2022-10-11 | Duke University | Nonfouling biosensors |
EP3478751A4 (en) | 2016-07-02 | 2019-07-17 | Rheomod De Mexico, S.A.P.I. De C.V. | Grafted polymers |
US11072674B2 (en) | 2016-07-07 | 2021-07-27 | Iowa State University Research Foundation, Inc. | Multiblock copolymer and method of making thereof |
WO2018031373A1 (en) | 2016-08-12 | 2018-02-15 | Iowa State University Research Foundation, Inc. | Acrylated and acylated or acetalized polyol as a biobased substitute for hard, rigid thermoplastic and thermoplastic and thermoset materials |
JP6720405B2 (en) | 2016-08-31 | 2020-07-08 | エボニック オペレーションズ ゲーエムベーハー | Comb polymers for improving Noack evaporation loss in engine oil formulations |
US11590162B2 (en) | 2016-10-07 | 2023-02-28 | University of Pittsburgh—of the Commonwealth System of Higher Education | Biodegradable, antioxidant, thermally responsive injectable hydrogel and uses therefor |
US10982266B2 (en) | 2016-11-03 | 2021-04-20 | Carnegie Mellon University | Nucleic acid-polymer conjugates for bright fluorescent tags |
MX2019006158A (en) | 2016-11-29 | 2019-09-09 | Rhodia Operations | Polymeric systems for particle dispersion. |
KR102461593B1 (en) | 2016-12-19 | 2022-11-02 | 에보니크 오퍼레이션즈 게엠베하 | Lubricating Oil Composition Comprising Dispersant Comb Polymer |
WO2018132696A2 (en) | 2017-01-12 | 2018-07-19 | Russell Alan J | Stomach acid-stable and mucin-binding protein-polymer conjugates |
WO2018132582A1 (en) | 2017-01-12 | 2018-07-19 | Carnegie Mellon University | Surfactant assisted formation of a catalyst complex for emulsion atom transfer radical polymerization processes |
US11648200B2 (en) | 2017-01-12 | 2023-05-16 | Duke University | Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly |
CN110192149A (en) | 2017-01-20 | 2019-08-30 | 伊英克加利福尼亚有限责任公司 | Coloured organic pigment and electrophoretic display medium containing the pigment |
US11053356B2 (en) | 2017-03-07 | 2021-07-06 | California Institute Of Technology | Control of polymer architectures by living ring-opening metathesis copolymerization |
US9995987B1 (en) | 2017-03-20 | 2018-06-12 | E Ink Corporation | Composite particles and method for making the same |
FR3064641A1 (en) | 2017-04-03 | 2018-10-05 | Rhodia Operations | ASSOCIATION FOR FILTRAT CONTROL AND GAS MIGRATION |
US11554097B2 (en) | 2017-05-15 | 2023-01-17 | Duke University | Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents |
WO2019006374A1 (en) | 2017-06-30 | 2019-01-03 | Duke University | Order and disorder as a design principle for stimuli-responsive biopolymer networks |
EP3652284B1 (en) | 2017-07-14 | 2021-06-02 | Evonik Operations GmbH | Comb polymers comprising imide functionality |
FR3070043B1 (en) | 2017-08-09 | 2019-08-16 | Rhodia Operations | FORMULATION CONTAINING AN ASSOCIATIVE POLYMER |
EP3450527B1 (en) | 2017-09-04 | 2020-12-02 | Evonik Operations GmbH | New viscosity index improvers with defined molecular weight distributions |
US11261531B2 (en) | 2017-09-14 | 2022-03-01 | Chemetall Gmbh | Method for pretreating aluminum materials, particularly aluminum wheels |
US11292906B2 (en) | 2017-10-23 | 2022-04-05 | Basf Se | Aqueous silicone polymer emulsion |
WO2019092036A1 (en) | 2017-11-07 | 2019-05-16 | Clariant Plastics & Coatings Ltd | Dispersion agent for pigments in non-aqueous colourant preparations |
US20190144686A1 (en) * | 2017-11-10 | 2019-05-16 | Aculon, Inc. | Surface treatment compositions and coated articles prepared therefrom |
KR102655922B1 (en) | 2017-11-15 | 2024-04-08 | 주식회사 쿠라레 | (meth)acrylic block copolymer and active energy ray-curable composition containing the same |
EP3498808B1 (en) | 2017-12-13 | 2020-05-13 | Evonik Operations GmbH | Viscosity index improver with improved shear-resistance and solubility after shear |
US11421147B2 (en) | 2017-12-19 | 2022-08-23 | Rhodia Operations | Aqueous formulations of surfactants and associative polymers for the assisted recovery of petroleum |
CN111492035B (en) | 2017-12-20 | 2023-05-02 | 罗地亚经营管理公司 | Polymer system for particle dispersion |
AR114185A1 (en) | 2018-01-23 | 2020-07-29 | Adama Makhteshim Ltd | SYNTHESIS OF 5-CHLORINE-2 - [(3,4,4-TRIFLUORO-3-BUTEN-1-IL) THIO] -THAZOLE |
MX2020009152A (en) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Il-6 antibodies and fusion constructs and conjugates thereof. |
US12049934B2 (en) * | 2018-03-26 | 2024-07-30 | Goodrich Corporation | Carbon fiber crystal orientation improvement by polymer modification, fiber stretching and oxidation for brake application |
FR3079833B1 (en) | 2018-04-10 | 2020-10-09 | Rhodia Operations | GELIFIED AQUEOUS COMPOSITION FOR OIL EXTRACTION |
CN108251898A (en) * | 2018-04-12 | 2018-07-06 | 江苏恒神股份有限公司 | Polyacrylonitrile-based carbon fibre oil feeding system |
US11857634B2 (en) | 2018-04-20 | 2024-01-02 | University of Pittsburgh—of the Commonwealth System of Higher Education | Cationic amphiphilic polymers for codelivery of hydrophobic agents and nucleic acids |
EP3811924A4 (en) | 2018-05-29 | 2022-03-09 | Shiseido Company, Ltd. | Block copolymer-containing inorganic particle dispersion for cosmetics |
JP7366011B2 (en) | 2018-05-29 | 2023-10-20 | 株式会社 資生堂 | Hair cosmetics containing block copolymers |
WO2019246123A1 (en) | 2018-06-18 | 2019-12-26 | Cornell University | Systems and methods for n-halamine-dopamine copolymers for high-performance, low-cost, and easy-to-apply antimicrobial coatings |
FR3083238A1 (en) | 2018-07-02 | 2020-01-03 | Rhodia Operations | PROGRESSIVE RELEASE OF POLYMER CHAINS IN A LIQUID MEDIUM |
WO2020007926A1 (en) | 2018-07-05 | 2020-01-09 | Chemetall Gmbh | Method for treating metallic surfaces with an acidic aqueous composition and a post rinsing composition to improve corrosion resistance |
JP2022501519A (en) | 2018-07-05 | 2022-01-06 | ケメタル ゲゼルシャフト ミット ベシュレンクテル ハフツング | A method of treating a metal surface with an acidic aqueous composition to improve corrosion resistance. |
US11472894B2 (en) | 2018-07-23 | 2022-10-18 | Carnegie Mellon University | Enzyme-assisted ATRP procedures |
US12053529B2 (en) | 2018-08-01 | 2024-08-06 | Carnegie Mellon University | Amino-reactive positively charged ATRP initiators that maintain their positive charge during synthesis of biomacro-initiators |
WO2020028806A1 (en) | 2018-08-02 | 2020-02-06 | Duke University | Dual agonist fusion proteins |
JP7458378B2 (en) | 2018-08-27 | 2024-03-29 | ビーエーエスエフ コーティングス ゲゼルシャフト ミット ベシュレンクテル ハフツング | Pigment dispersant for coatings |
MX2021002384A (en) | 2018-08-29 | 2021-04-29 | Basf Coatings Gmbh | Pigment dispersant. |
US11958989B2 (en) | 2018-09-07 | 2024-04-16 | Rhodia Operations | Method for treating surfaces of aluminum containing substrates |
KR20210046796A (en) | 2018-09-07 | 2021-04-28 | 케메탈 게엠베하 | How to treat the surface of an aluminum-containing substrate |
CN112888809A (en) | 2018-10-08 | 2021-06-01 | 凯密特尔有限责任公司 | Method for nickel-free phosphating of metal surfaces and composition for use in such a method |
CN112930420A (en) | 2018-10-08 | 2021-06-08 | 凯密特尔有限责任公司 | Method for nickel-free phosphating of metal surfaces and composition for use in such a method |
US11649400B2 (en) | 2018-10-11 | 2023-05-16 | Energy Solutions (US) LLC | Polymer dispersion by controlled radical polymerization |
CA3118972A1 (en) | 2018-11-13 | 2020-05-22 | Evonik Operations Gmbh | Random copolymers for use as base oils or lubricant additives |
KR20210093874A (en) * | 2018-12-19 | 2021-07-28 | 헨켈 아게 운트 코. 카게아아 | Direct substrate coating via in situ polymerization |
WO2020172330A1 (en) | 2019-02-20 | 2020-08-27 | Ppg Industries Ohio, Inc. | Dispersions containing graphenic carbon nanoparticles and dispersant resins |
EP3931229A1 (en) | 2019-02-28 | 2022-01-05 | Rhodia Operations | Compositions for high stabilization of emulsions |
FR3093514A1 (en) | 2019-03-05 | 2020-09-11 | Rhodia Operations | Suspension of associative polymers for the treatment of underground formations |
KR20200108793A (en) | 2019-03-11 | 2020-09-21 | 에보닉 오퍼레이션스 게엠베하 | Novel viscosity index improvers |
CN113557284A (en) | 2019-03-12 | 2021-10-26 | 罗地亚经营管理公司 | Stabilized friction reducer emulsions |
MX2021010694A (en) | 2019-03-15 | 2021-10-01 | Rhodia Operations | Polymer compositions and use of the same. |
JP2022526501A (en) | 2019-03-20 | 2022-05-25 | エボニック オペレーションズ ゲーエムベーハー | Polyalkyl (meth) acrylate to improve fuel economy, dispersibility and deposit performance |
US11733647B2 (en) * | 2019-05-08 | 2023-08-22 | Meta Platforms Technologies, Llc | Light-activated controlled radical polymerization |
US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
EP3778839B1 (en) | 2019-08-13 | 2021-08-04 | Evonik Operations GmbH | Viscosity index improver with improved shear-resistance |
CN114786731A (en) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | Methods of treating ocular disorders |
CN115003776A (en) | 2019-12-02 | 2022-09-02 | 索尔维美国有限公司 | Polymer dispersions for oil field friction reduction |
US11365273B2 (en) | 2019-12-16 | 2022-06-21 | Infineum International Limited | High viscosity index comb polymer viscosity modifiers and methods of modifying lubricant viscosity using same |
US11384311B2 (en) | 2019-12-16 | 2022-07-12 | Infineum International Limited | High viscosity index comb polymer viscosity modifiers and methods of modifying lubricant viscosity using same |
US11685874B2 (en) | 2019-12-16 | 2023-06-27 | Infineum International Limited | High viscosity index comb polymer viscosity modifiers and methods of modifying lubricant viscosity using same |
WO2021158381A1 (en) | 2020-02-06 | 2021-08-12 | E Ink Corporation | Electrophoretic core-shell particles having an organic pigment core and a shell with a thin metal oxide layer and a silane layer |
CN115380054A (en) | 2020-04-14 | 2022-11-22 | 巴斯夫欧洲公司 | Amine-modified polymers, controlled radical polymerization for their preparation and their implementation |
EP3907269B1 (en) | 2020-05-05 | 2023-05-03 | Evonik Operations GmbH | Hydrogenated linear polydiene copolymers as base stock or lubricant additives for lubricant compositions |
EP4204467A1 (en) | 2020-08-25 | 2023-07-05 | Merck Patent GmbH | Fluorine containing polymers |
WO2022083963A1 (en) | 2020-10-23 | 2022-04-28 | Rhodia Operations | Polymeric systems having enhanced viscosity and proppant transport properties |
CA3198514A1 (en) | 2020-11-18 | 2022-05-27 | Thomas Schimmel | Compressor oils with high viscosity index |
EP4060009B1 (en) | 2021-03-19 | 2023-05-03 | Evonik Operations GmbH | Viscosity index improver and lubricant compositions thereof |
WO2022238468A1 (en) | 2021-05-12 | 2022-11-17 | Basf Se | Compositions, comprising platelet-shaped transition metal particles |
FR3125296A1 (en) | 2021-07-13 | 2023-01-20 | Rhodia Operations | Preparation of amphiphilic block polymers by reverse micellar radical polymerization |
ES2955513T3 (en) | 2021-07-16 | 2023-12-04 | Evonik Operations Gmbh | Composition of lubricant additive containing poly(alkyl methacrylates) |
CA3221492A1 (en) | 2021-07-29 | 2023-02-02 | Sofia SIRAK | Process for preparing low molecular weight polyacrylates and products thereof |
WO2023072740A1 (en) | 2021-10-26 | 2023-05-04 | Basf Se | A method for producing interference elements |
CN118488996A (en) | 2021-11-22 | 2024-08-13 | Ppg工业俄亥俄公司 | Acrylic materials and uses thereof |
WO2023099637A1 (en) | 2021-12-03 | 2023-06-08 | Totalenergies Onetech | Lubricant compositions |
WO2023099630A1 (en) | 2021-12-03 | 2023-06-08 | Evonik Operations Gmbh | Boronic ester modified polyalkyl(meth)acrylate polymers |
WO2023099631A1 (en) | 2021-12-03 | 2023-06-08 | Evonik Operations Gmbh | Boronic ester modified polyalkyl(meth)acrylate polymers |
WO2023099634A1 (en) | 2021-12-03 | 2023-06-08 | Totalenergies Onetech | Lubricant compositions |
WO2023099632A1 (en) | 2021-12-03 | 2023-06-08 | Evonik Operations Gmbh | Boronic ester modified polyalkyl(meth)acrylate polymers |
WO2023099635A1 (en) | 2021-12-03 | 2023-06-08 | Totalenergies Onetech | Lubricant compositions |
WO2024033156A1 (en) | 2022-08-08 | 2024-02-15 | Evonik Operations Gmbh | Polyalkyl (meth)acrylate-based polymers with improved low temperature properties |
EP4321602A1 (en) | 2022-08-10 | 2024-02-14 | Evonik Operations GmbH | Sulfur free poly alkyl(meth)acrylate copolymers as viscosity index improvers in lubricants |
WO2024120926A1 (en) | 2022-12-07 | 2024-06-13 | Evonik Operations Gmbh | Sulfur-free dispersant polymers for industrial applications |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3862978A (en) | 1967-08-24 | 1975-01-28 | Dow Chemical Co | Catalytic synthesis of organic halogen compounds from an ethylenically unsaturated compound and a halogenated organic compound |
US4145486A (en) | 1974-08-29 | 1979-03-20 | Mobil Oil Corporation | Insoluble weak base exchange resin-metal compound complex |
DE3486145T2 (en) * | 1983-07-11 | 1993-09-23 | Commw Scient Ind Res Org | METHOD FOR POLYMERIZATION AND POLYMERS PRODUCED BY THIS METHOD. |
US5324879A (en) * | 1985-12-03 | 1994-06-28 | Commonwealth Scientific And Industrial Research Organisation | Oligomerization process |
US4728706A (en) * | 1986-08-29 | 1988-03-01 | E. I. Du Pont De Nemours And Company | Titanium, zirconium- and hafnium containing initiators in the polymerization of acrylic monomers to "living" polymers |
AU7895387A (en) | 1986-09-29 | 1988-03-31 | E.I. Du Pont De Nemours And Company | Living polymers from unsaturated si, sn or ge initiators |
US4940760A (en) * | 1988-02-16 | 1990-07-10 | E. I. Du Pont De Nemours And Company | Group Transfer Polymerization process employing supported initiators |
US5169914A (en) | 1988-05-03 | 1992-12-08 | Edison Polymer Innovation Corporation | Uniform molecular weight polymers |
CA1326322C (en) * | 1988-05-03 | 1994-01-18 | Gabor Kaszas | Uniform molecular weight polymers |
WO1993002110A1 (en) * | 1991-07-15 | 1993-02-04 | Exxon Chemical Patents Inc. | Living carbocationic polymerization process |
US5405913A (en) * | 1993-03-22 | 1995-04-11 | The University Of Akron | Free radical copper(II)-enolate polymerization initiators |
US5312871A (en) * | 1993-07-27 | 1994-05-17 | Carnegie Mellon University | Free radical polymerization process |
US5530079A (en) * | 1995-01-03 | 1996-06-25 | Xerox Corporation | Polymerization processes |
FR2730240A1 (en) | 1995-02-07 | 1996-08-09 | Atochem Elf Sa | STABILIZATION OF A POLYMER BY A STABLE FREE RADICAL |
US5708102A (en) | 1995-03-03 | 1998-01-13 | E. I. Du Pont De Nemours And Company | Living radical polymerization of vinyl monomers |
US5763548A (en) | 1995-03-31 | 1998-06-09 | Carnegie-Mellon University | (Co)polymers and a novel polymerization process based on atom (or group) transfer radical polymerization |
US5807937A (en) | 1995-11-15 | 1998-09-15 | Carnegie Mellon University | Processes based on atom (or group) transfer radical polymerization and novel (co) polymers having useful structures and properties |
JP3806475B2 (en) | 1996-02-08 | 2006-08-09 | 株式会社カネカ | Method for producing (meth) acrylic polymer having functional group at terminal |
EP0906342B2 (en) | 1996-06-12 | 2015-02-11 | Warwick Effect Polymers Limited | Polymerisation catalyst and process |
DE69710130T2 (en) | 1996-06-26 | 2002-08-29 | Kaneka Corp., Osaka | Process for the production of vinyl polymers |
US5789487A (en) | 1996-07-10 | 1998-08-04 | Carnegie-Mellon University | Preparation of novel homo- and copolymers using atom transfer radical polymerization |
TW505665B (en) | 1996-08-09 | 2002-10-11 | Du Pont | Process for polymerization of olefinic monomers |
FR2752238B1 (en) | 1996-08-12 | 1998-09-18 | Atochem Elf Sa | METHOD FOR CONTROLLED RADICAL POLYMERIZATION OR COPOLYMERIZATION OF (METH) ACRYLIC AND VINYLIC MONOMERS AND (CO) POLYMERS OBTAINED |
FR2752237B1 (en) | 1996-08-12 | 1998-09-18 | Atochem Elf Sa | METHOD FOR CONTROLLED RADICAL POLYMERIZATION OR COPOLYMERIZATION OF (METH) ACRYLIC AND VINYLIC MONOMERS AND (CO) POLYMERS OBTAINED |
US5910549A (en) | 1996-08-22 | 1999-06-08 | Carnegie-Mellon University | Method for preparation of alkoxyamines from nitroxyl radicals |
FR2752845B1 (en) | 1996-08-30 | 1998-10-30 | Atochem Elf Sa | PROCESS FOR CONTROLLED RADICAL (CO) POLYMERIZATION OF (METH) ACRYLIC AND VINYL MONOMERS IN THE PRESENCE OF A FE, RU OR BONE COMPLEX AND (CO) POLYMERS OBTAINED |
WO1998020050A2 (en) | 1996-11-01 | 1998-05-14 | E.I. Du Pont De Nemours And Company | Polymerization of vinyl monomers |
FR2755441B1 (en) | 1996-11-07 | 1998-12-24 | Atochem Elf Sa | PROCESS FOR CONTROLLED RADICAL (CO) POLYMERIZATION OF (METH) ACRYLIC, VINYLIC, VINYLIDENIC AND DIENE MONOMERS IN THE PRESENCE OF AN RH, CO OR IR COMPLEX |
FR2757865B1 (en) | 1996-12-26 | 1999-04-02 | Atochem Elf Sa | METHOD FOR CONTROLLED RADICAL POLYMERIZATION OR COPOLYMERIZATION OF (METH) ACRYLIC, VINYLIC, VINYLIDENIC AND DIENE MONOMERS AND (CO) POLYMERS OBTAINED |
CN1165828A (en) | 1997-03-13 | 1997-11-26 | 华东理工大学 | Catalyst able to control polymerizing reaction and its application |
US5886118C1 (en) | 1997-04-14 | 2001-02-20 | Univ Case Western Reserve | Process for polymerizing acrylonitrile |
US5773538A (en) | 1997-07-16 | 1998-06-30 | E. I. Du Pont De Nemours And Company | Process for polymerization of olefinic monomers |
-
1995
- 1995-03-31 US US08/414,415 patent/US5763548A/en not_active Expired - Lifetime
-
1996
- 1996-03-19 CN CNB961936215A patent/CN1150234C/en not_active Expired - Lifetime
- 1996-03-19 BR BR9604887-5A patent/BR9604887A/en not_active IP Right Cessation
- 1996-03-19 CN CNA2003101183124A patent/CN1515599A/en active Pending
- 1996-03-19 AT AT96909643T patent/ATE317405T1/en not_active IP Right Cessation
- 1996-03-19 EP EP05025891A patent/EP1637543A3/en not_active Withdrawn
- 1996-03-19 JP JP08529428A patent/JP3040172B2/en not_active Expired - Fee Related
- 1996-03-19 KR KR1019970706823A patent/KR19980703419A/en not_active IP Right Cessation
- 1996-03-19 DE DE69635802T patent/DE69635802T2/en not_active Expired - Lifetime
- 1996-03-19 AU AU53069/96A patent/AU720512B2/en not_active Ceased
- 1996-03-19 KR KR1019970706823A patent/KR100282757B1/en active
- 1996-03-19 CA CA002216853A patent/CA2216853C/en not_active Expired - Lifetime
- 1996-03-19 WO PCT/US1996/003302 patent/WO1996030421A1/en active IP Right Grant
- 1996-03-19 EP EP96909643A patent/EP0817806B1/en not_active Expired - Lifetime
- 1996-03-24 IL IL117626A patent/IL117626A/en not_active IP Right Cessation
- 1996-03-28 TW TW085103747A patent/TW520380B/en not_active IP Right Cessation
- 1996-03-28 TW TW091106374A patent/TWI254720B/en not_active IP Right Cessation
-
1997
- 1997-09-29 MX MX0008668A patent/MX244246B/en unknown
- 1997-09-29 MX MX9707437A patent/MX9707437A/en unknown
-
1998
- 1998-03-03 US US09/034,187 patent/US6407187B1/en not_active Expired - Lifetime
-
1999
- 1999-07-23 US US09/359,591 patent/US6512060B1/en not_active Expired - Lifetime
-
2002
- 2002-03-13 US US10/098,052 patent/US6624263B2/en not_active Expired - Fee Related
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WO1996030421A1 (en) | 1996-10-03 |
EP1637543A3 (en) | 2006-11-22 |
EP1637543A2 (en) | 2006-03-22 |
AU720512B2 (en) | 2000-06-01 |
US6407187B1 (en) | 2002-06-18 |
IL117626A0 (en) | 1996-07-23 |
US5763548A (en) | 1998-06-09 |
TWI254720B (en) | 2006-05-11 |
CN1183107A (en) | 1998-05-27 |
MX244246B (en) | 2007-03-20 |
DE69635802T2 (en) | 2006-10-19 |
CN1150234C (en) | 2004-05-19 |
KR19980703419A (en) | 1998-11-05 |
EP0817806B1 (en) | 2006-02-08 |
MX9707437A (en) | 1998-07-31 |
ATE317405T1 (en) | 2006-02-15 |
US6512060B1 (en) | 2003-01-28 |
EP0817806A1 (en) | 1998-01-14 |
JPH10509475A (en) | 1998-09-14 |
EP0817806A4 (en) | 1998-05-27 |
JP3040172B2 (en) | 2000-05-08 |
AU5306996A (en) | 1996-10-16 |
CN1515599A (en) | 2004-07-28 |
BR9604887A (en) | 1999-11-30 |
US20020193538A1 (en) | 2002-12-19 |
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