IL115471A0 - Inhibitors of farnesyl-protein transferase and their use - Google Patents

Inhibitors of farnesyl-protein transferase and their use

Info

Publication number
IL115471A0
IL115471A0 IL11547195A IL11547195A IL115471A0 IL 115471 A0 IL115471 A0 IL 115471A0 IL 11547195 A IL11547195 A IL 11547195A IL 11547195 A IL11547195 A IL 11547195A IL 115471 A0 IL115471 A0 IL 115471A0
Authority
IL
Israel
Prior art keywords
farnesyl
inhibitors
protein transferase
transferase
protein
Prior art date
Application number
IL11547195A
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/526,244 external-priority patent/US5652257A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL115471A0 publication Critical patent/IL115471A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL11547195A 1994-09-29 1995-09-29 Inhibitors of farnesyl-protein transferase and their use IL115471A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31497494A 1994-09-29 1994-09-29
US08/526,244 US5652257A (en) 1994-09-29 1995-09-21 Heterocycle-containing inhibitors of farnesyl-protein transferase

Publications (1)

Publication Number Publication Date
IL115471A0 true IL115471A0 (en) 1995-12-31

Family

ID=26979651

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11547195A IL115471A0 (en) 1994-09-29 1995-09-29 Inhibitors of farnesyl-protein transferase and their use

Country Status (5)

Country Link
EP (1) EP0783517A2 (en)
JP (1) JPH10508005A (en)
AU (1) AU700175B2 (en)
IL (1) IL115471A0 (en)
WO (1) WO1996010034A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997027752A1 (en) * 1996-01-30 1997-08-07 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997036877A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU717298B2 (en) * 1996-04-03 2000-03-23 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2001519766A (en) * 1996-04-03 2001-10-23 メルク エンド カンパニー インコーポレーテッド Inhibitors of farnesyl protein transferase
AU707139B2 (en) * 1996-04-03 1999-07-01 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2000507581A (en) * 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド Farnesyl-protein transferase inhibitor
US5932590A (en) * 1996-12-05 1999-08-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US8143210B2 (en) 2002-02-14 2012-03-27 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
CA2475972C (en) 2002-02-14 2017-07-11 Felix Hausch Enzyme treatment of foodstuffs for celiac sprue
AU2003234634A1 (en) * 2002-05-14 2003-12-02 Felix Hausch Drug therapy for celiac sprue
DK1563300T3 (en) 2002-11-20 2012-07-23 Univ Leland Stanford Junior Diagnostic procedure for celiac disease
US7579313B2 (en) 2003-11-18 2009-08-25 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof
EP2136833B1 (en) 2007-03-16 2019-05-01 The Board of Trustees of the Leland Stanford Junior University Combination enzyme therapy for digestion of dietary gluten

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141851A (en) * 1990-04-18 1992-08-25 Board Of Regents, The University Of Texas System Isolated farnesyl protein transferase enzyme
US5468733A (en) * 1993-09-30 1995-11-21 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
KR100362338B1 (en) * 1993-11-05 2003-04-08 워너-램버트 캄파니 Protein: Substituted Di- and Tripeptide Inhibitors of Farnesyl Transferase

Also Published As

Publication number Publication date
JPH10508005A (en) 1998-08-04
EP0783517A2 (en) 1997-07-16
WO1996010034A2 (en) 1996-04-04
AU3724895A (en) 1996-04-19
WO1996010034A3 (en) 1996-05-09
AU700175B2 (en) 1998-12-24

Similar Documents

Publication Publication Date Title
EP0755383A4 (en) Inhibitors of farnesyl-protein transferase
EP0784473A4 (en) Inhibitors of farnesyl-protein transferase
EP0777475A4 (en) Inhibitors of farnesyl-protein transferase
EP0891350A4 (en) Inhibitors of farnesyl-protein transferase
EP1011669A4 (en) Inhibitors of farnesyl-protein transferase
EP0783318A4 (en) Inhibitors of farnesyl-protein transferase
GB9604311D0 (en) Inhibitors of farnesyl-protein transferase
EP0891360A4 (en) Inhibitors of farnesyl-protein transferase
EP0904080A4 (en) Inhibitors of farnesyl-protein transferase
EP0783305A4 (en) Inhibitors of farnesyl-protein transferase
EP0880320A4 (en) Inhibitors of farnesyl-protein transferase
EP0891349A4 (en) Inhibitors of farnesyl-protein transferase
IL115471A0 (en) Inhibitors of farnesyl-protein transferase and their use
EP0760813A4 (en) Inhibitors of farnesyl-protein transferase
EP0891352A4 (en) Inhibitors of farnesyl-protein transferase
GB9506174D0 (en) Inhibitors of farnesyl-protein transferase
EP0891335A4 (en) Inhibitors of farnesyl-protein transferase
EP0891353A4 (en) Inhibitors of farnesyl-protein transferase
EP0787123A4 (en) Inhibitors of farnesyl-protein transferase
EP0959883A4 (en) Inhibitors of farnesyl-protein transferase
EP0877610A4 (en) Inhibitors of farnesyl-protein transferase
EP0900081A4 (en) Inhibitors of farnesyl-protein transferase
ZA958225B (en) Inhibitors of farnesyl-protein transferase
ZA958162B (en) Inhibitors of farnesyl-protein transferase
IL115446A0 (en) Inhibitors of farnesyl-protein transferase pharmaceutical compositions containing them and their use