IL109866A - Crystalline 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine(+)L-hydrogentartrate its preparation and pharmaceutical compositions containing it - Google Patents
Crystalline 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine(+)L-hydrogentartrate its preparation and pharmaceutical compositions containing itInfo
- Publication number
- IL109866A IL109866A IL10986694A IL10986694A IL109866A IL 109866 A IL109866 A IL 109866A IL 10986694 A IL10986694 A IL 10986694A IL 10986694 A IL10986694 A IL 10986694A IL 109866 A IL109866 A IL 109866A
- Authority
- IL
- Israel
- Prior art keywords
- hydrogentartrate
- thiadiazol
- methylpyridine
- hexyloxy
- tetrahydro
- Prior art date
Links
- JOLJIIDDOBNFHW-UHFFFAOYSA-N xanomeline Chemical compound CCCCCCOC1=NSN=C1C1=CCCN(C)C1 JOLJIIDDOBNFHW-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7257293A | 1993-06-04 | 1993-06-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL109866A0 IL109866A0 (en) | 1994-10-07 |
IL109866A true IL109866A (en) | 2000-06-01 |
Family
ID=22108479
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10986694A IL109866A (en) | 1993-06-04 | 1994-06-02 | Crystalline 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine(+)L-hydrogentartrate its preparation and pharmaceutical compositions containing it |
Country Status (22)
Country | Link |
---|---|
US (1) | US5834495A (fr) |
EP (1) | EP0703915B1 (fr) |
JP (1) | JP3190679B2 (fr) |
KR (1) | KR100339115B1 (fr) |
CN (1) | CN1064681C (fr) |
AT (1) | ATE196631T1 (fr) |
AU (1) | AU698673B2 (fr) |
CA (1) | CA2164296C (fr) |
CZ (1) | CZ290550B6 (fr) |
DE (1) | DE69426021T2 (fr) |
DK (1) | DK0703915T3 (fr) |
ES (1) | ES2152315T3 (fr) |
FI (1) | FI955829A (fr) |
GR (1) | GR3035033T3 (fr) |
HU (1) | HUT75038A (fr) |
IL (1) | IL109866A (fr) |
NO (1) | NO305560B1 (fr) |
NZ (2) | NZ267062A (fr) |
PT (1) | PT703915E (fr) |
SK (1) | SK281980B6 (fr) |
WO (1) | WO1994029303A1 (fr) |
ZA (1) | ZA943904B (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0821956A1 (fr) * | 1996-08-01 | 1998-02-04 | Eli Lilly And Company | Méthode de traitement de troubles disruptifs de comportement |
US6117890A (en) * | 1996-08-01 | 2000-09-12 | Eli Lilly And Company | Method for treating bipolar disorder |
US6043258A (en) * | 1996-08-01 | 2000-03-28 | Eli Lilly And Company | Method for treating disruptive behavior disorders with xanomeline |
US6090829A (en) * | 1996-08-01 | 2000-07-18 | Eli Lilly And Company | Method for treating excessive aggression |
EP0821954A1 (fr) * | 1996-08-01 | 1998-02-04 | Eli Lilly And Company | Méthode de traitement d'arriération mentale |
US6034108A (en) * | 1997-07-28 | 2000-03-07 | Eli Lilly And Company | Method for treating mental retardation |
EP3265128A4 (fr) * | 2015-03-06 | 2018-09-12 | Chase Pharmaceuticals Corporation | Combinaison d'agoniste des récepteurs muscariniques et d'oxybutynine dans un système thérapeutique transdermique |
WO2023061372A1 (fr) * | 2021-10-14 | 2023-04-20 | 南京迈诺威医药科技有限公司 | Sel de malate de dérivé de xanoméline, forme cristalline a, procédé de préparation correspondant et utilisation associée |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5043345A (en) * | 1989-02-22 | 1991-08-27 | Novo Nordisk A/S | Piperidine compounds and their preparation and use |
US5260311A (en) * | 1989-02-22 | 1993-11-09 | Novo Nordisk A/S | Piperidine compounds and their use |
US5264444A (en) * | 1989-02-22 | 1993-11-23 | Novo Nordisk A/S | Piperidine compounds and use |
-
1994
- 1994-05-26 SK SK1520-95A patent/SK281980B6/sk unknown
- 1994-05-26 PT PT94917567T patent/PT703915E/pt unknown
- 1994-05-26 DE DE69426021T patent/DE69426021T2/de not_active Expired - Fee Related
- 1994-05-26 ES ES94917567T patent/ES2152315T3/es not_active Expired - Lifetime
- 1994-05-26 CZ CZ19953210A patent/CZ290550B6/cs not_active IP Right Cessation
- 1994-05-26 AT AT94917567T patent/ATE196631T1/de not_active IP Right Cessation
- 1994-05-26 NZ NZ267062A patent/NZ267062A/en unknown
- 1994-05-26 AU AU69242/94A patent/AU698673B2/en not_active Ceased
- 1994-05-26 JP JP50120095A patent/JP3190679B2/ja not_active Expired - Fee Related
- 1994-05-26 CN CN94192681A patent/CN1064681C/zh not_active Expired - Fee Related
- 1994-05-26 DK DK94917567T patent/DK0703915T3/da active
- 1994-05-26 EP EP94917567A patent/EP0703915B1/fr not_active Expired - Lifetime
- 1994-05-26 CA CA002164296A patent/CA2164296C/fr not_active Expired - Fee Related
- 1994-05-26 KR KR1019950705467A patent/KR100339115B1/ko not_active IP Right Cessation
- 1994-05-26 HU HU9503453A patent/HUT75038A/hu unknown
- 1994-05-26 WO PCT/DK1994/000205 patent/WO1994029303A1/fr active IP Right Grant
- 1994-06-02 IL IL10986694A patent/IL109866A/xx not_active IP Right Cessation
- 1994-06-03 ZA ZA943904A patent/ZA943904B/xx unknown
-
1995
- 1995-12-01 NO NO954892A patent/NO305560B1/no not_active IP Right Cessation
- 1995-12-04 FI FI955829A patent/FI955829A/fi not_active Application Discontinuation
-
1996
- 1996-11-26 US US08/756,835 patent/US5834495A/en not_active Expired - Fee Related
-
1999
- 1999-07-09 NZ NZ336733A patent/NZ336733A/en unknown
-
2000
- 2000-12-12 GR GR20000402720T patent/GR3035033T3/el not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |