IL109528A - Anthracyclines are related to polymers, their preparation and pharmaceutical preparations containing them - Google Patents

Anthracyclines are related to polymers, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL109528A
IL109528A IL10952894A IL10952894A IL109528A IL 109528 A IL109528 A IL 109528A IL 10952894 A IL10952894 A IL 10952894A IL 10952894 A IL10952894 A IL 10952894A IL 109528 A IL109528 A IL 109528A
Authority
IL
Israel
Prior art keywords
anthracycline
gly
polymer
formula
bound
Prior art date
Application number
IL10952894A
Other languages
English (en)
Hebrew (he)
Other versions
IL109528A0 (en
Inventor
Francesco Angelucci
Maria Grandi
Antonino Suarato
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of IL109528A0 publication Critical patent/IL109528A0/xx
Publication of IL109528A publication Critical patent/IL109528A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL10952894A 1993-05-11 1994-05-03 Anthracyclines are related to polymers, their preparation and pharmaceutical preparations containing them IL109528A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939309663A GB9309663D0 (en) 1993-05-11 1993-05-11 Biologically active compounds

Publications (2)

Publication Number Publication Date
IL109528A0 IL109528A0 (en) 1994-08-26
IL109528A true IL109528A (en) 1998-08-16

Family

ID=10735264

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10952894A IL109528A (en) 1993-05-11 1994-05-03 Anthracyclines are related to polymers, their preparation and pharmaceutical preparations containing them

Country Status (25)

Country Link
US (1) US5571785A (da)
EP (1) EP0649312B1 (da)
JP (1) JPH08502519A (da)
KR (1) KR100330635B1 (da)
CN (1) CN1098106C (da)
AT (1) ATE203414T1 (da)
AU (1) AU671741B2 (da)
CA (1) CA2136438C (da)
DE (1) DE69427799T2 (da)
DK (1) DK0649312T3 (da)
ES (1) ES2161764T3 (da)
FI (1) FI112602B (da)
GB (1) GB9309663D0 (da)
GR (1) GR3036978T3 (da)
HU (2) HUT70509A (da)
IL (1) IL109528A (da)
MY (1) MY110974A (da)
NZ (1) NZ265266A (da)
PL (1) PL175325B1 (da)
PT (1) PT649312E (da)
RU (1) RU2145965C1 (da)
TW (1) TW268015B (da)
UA (1) UA42695C2 (da)
WO (1) WO1994026311A1 (da)
ZA (1) ZA943212B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9320781D0 (en) * 1993-10-08 1993-12-01 Erba Carlo Spa Polymer-bound camptothecin derivatives
GB9721070D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Bioactive derivatives of camptothecin
GB9721069D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Polymeric derivatives of camptothecin
US20040234497A1 (en) * 2001-05-04 2004-11-25 Yi Luo Hyaluronic acid containing bioconjugates:targeted delivery of anti-cancer drugs to cancer cells
US7049285B2 (en) * 2001-10-31 2006-05-23 Myung-Ok Park Biocompatible polymers including peptide spacer
CA2483696A1 (en) * 2002-05-06 2003-11-20 University Of Utah Research Foundation Preblocking with non-ha gags increases effectiveness of ha conjugated anticancer agents
WO2015192124A1 (en) 2014-06-13 2015-12-17 Trustees Of Tufts College Fap-activated therapeutic agents, and uses related thereto
IL291922A (en) 2014-06-13 2022-06-01 Tufts College Fap-enabled medical substances and related uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162512A (en) * 1982-03-09 1992-11-10 Cytogen Corporation Amine derivatives of anthracycline antibodies
JPS60246400A (ja) * 1984-05-22 1985-12-06 Ajinomoto Co Inc アントラサイクリン系化合物及び制ガン剤
US5169937A (en) * 1986-11-18 1992-12-08 The Scripps Research Institute Method for producing stable glycosylated hemoglobin
GB9017024D0 (en) * 1990-08-03 1990-09-19 Erba Carlo Spa New linker for bioactive agents

Also Published As

Publication number Publication date
RU2145965C1 (ru) 2000-02-27
AU6566694A (en) 1994-12-12
FI946128A (fi) 1994-12-28
DE69427799T2 (de) 2002-05-02
PL175325B1 (pl) 1998-12-31
PL306861A1 (en) 1995-04-18
HUT70509A (en) 1995-10-30
RU94046336A (ru) 1996-10-27
FI112602B (fi) 2003-12-31
EP0649312A1 (en) 1995-04-26
DK0649312T3 (da) 2001-11-12
UA42695C2 (uk) 2001-11-15
PT649312E (pt) 2002-01-30
GR3036978T3 (en) 2002-01-31
CA2136438A1 (en) 1994-11-24
CN1108454A (zh) 1995-09-13
ATE203414T1 (de) 2001-08-15
DE69427799D1 (de) 2001-08-30
WO1994026311A1 (en) 1994-11-24
NZ265266A (en) 1996-06-25
KR100330635B1 (ko) 2002-09-17
GB9309663D0 (en) 1993-06-23
FI946128A0 (fi) 1994-12-28
TW268015B (da) 1996-01-11
JPH08502519A (ja) 1996-03-19
HU211538A9 (en) 1995-12-28
EP0649312B1 (en) 2001-07-25
CA2136438C (en) 2004-09-14
KR950702201A (ko) 1995-06-19
AU671741B2 (en) 1996-09-05
HU9403811D0 (en) 1995-03-28
ZA943212B (en) 1995-01-18
CN1098106C (zh) 2003-01-08
ES2161764T3 (es) 2001-12-16
IL109528A0 (en) 1994-08-26
US5571785A (en) 1996-11-05
MY110974A (en) 1999-07-31

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees