IL109258A0 - Production of recombinant factor xa inhibitor of leech hirudo medicinalis - Google Patents

Production of recombinant factor xa inhibitor of leech hirudo medicinalis

Info

Publication number
IL109258A0
IL109258A0 IL10925894A IL10925894A IL109258A0 IL 109258 A0 IL109258 A0 IL 109258A0 IL 10925894 A IL10925894 A IL 10925894A IL 10925894 A IL10925894 A IL 10925894A IL 109258 A0 IL109258 A0 IL 109258A0
Authority
IL
Israel
Prior art keywords
polypeptide
inhibitor
production
recombinant factor
hirudo medicinalis
Prior art date
Application number
IL10925894A
Other languages
English (en)
Original Assignee
Bio Technology General Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Technology General Corp filed Critical Bio Technology General Corp
Publication of IL109258A0 publication Critical patent/IL109258A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL10925894A 1993-04-09 1994-04-08 Production of recombinant factor xa inhibitor of leech hirudo medicinalis IL109258A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4580493A 1993-04-09 1993-04-09

Publications (1)

Publication Number Publication Date
IL109258A0 true IL109258A0 (en) 1994-07-31

Family

ID=21939978

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10925894A IL109258A0 (en) 1993-04-09 1994-04-08 Production of recombinant factor xa inhibitor of leech hirudo medicinalis

Country Status (8)

Country Link
US (1) US5801017A (de)
EP (1) EP0693925B1 (de)
JP (1) JPH08510903A (de)
AT (1) ATE213155T1 (de)
AU (1) AU6630294A (de)
DE (1) DE69429858D1 (de)
IL (1) IL109258A0 (de)
WO (1) WO1994023709A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ270194A (en) * 1994-01-07 1996-05-28 Ciba Geigy Ag Hirustasin, a serine protease inhibitor from hirudo medicinalis
DE4440892A1 (de) * 1994-11-17 1996-05-23 Gruenenthal Gmbh Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
GB9930659D0 (en) * 1999-12-24 2000-02-16 Bio Discovery Ltd Inhibitors of complement activation
AU2008210538B2 (en) * 2007-01-31 2013-06-06 Pelican Technology Holdings, Inc. Bacterial leader sequences for increased expression

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588587A (en) * 1983-03-01 1986-05-13 Pennsylvania Hospital Method of treatment to inhibit metastasis
US4742004A (en) * 1984-08-27 1988-05-03 Bio-Technology General Corp. Method for producing enzymatically active eucaryotic sod in bacteria
EP0209061B1 (de) * 1985-07-17 1994-01-12 Hoechst Aktiengesellschaft Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
NO170430C (no) * 1986-09-18 1992-10-14 Pennsylvania Hospital Fremgangsmaate for fremstilling av et protein som har antikoagulerende og anti-metastatiske egenskaper
US4832849A (en) * 1988-06-16 1989-05-23 Merrell Dow Pharmaceuticals Inc. Extraction and purification of an anticoagulant principle from the south american leech, haementeria ghilianii
IL86856A0 (en) * 1988-06-24 1988-11-30 Yissum Res Dev Co Bovine xa factor and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
DE69429858D1 (de) 2002-03-21
EP0693925B1 (de) 2002-02-13
US5801017A (en) 1998-09-01
JPH08510903A (ja) 1996-11-19
AU6630294A (en) 1994-11-08
ATE213155T1 (de) 2002-02-15
EP0693925A1 (de) 1996-01-31
WO1994023709A1 (en) 1994-10-27
EP0693925A4 (de) 1998-08-26

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