IL108694A0 - Farnesyl: protein transferase inhibitors as anticancer agents - Google Patents
Farnesyl: protein transferase inhibitors as anticancer agentsInfo
- Publication number
- IL108694A0 IL108694A0 IL10869494A IL10869494A IL108694A0 IL 108694 A0 IL108694 A0 IL 108694A0 IL 10869494 A IL10869494 A IL 10869494A IL 10869494 A IL10869494 A IL 10869494A IL 108694 A0 IL108694 A0 IL 108694A0
- Authority
- IL
- Israel
- Prior art keywords
- farnesyl
- anticancer agents
- protein transferase
- transferase inhibitors
- alkyl
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000003558 transferase inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4015—Esters of acyclic unsaturated acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C07F9/3821—Acyclic saturated acids which can have further substituents on alkyl substituted by B, Si, P or a metal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3826—Acyclic unsaturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- C07F9/4012—Esters of acyclic acids which can have further substituents on alkyl substituted by B, Si, P or a metal
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2141193A | 1993-02-23 | 1993-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL108694A0 true IL108694A0 (en) | 1994-05-30 |
Family
ID=21804071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10869494A IL108694A0 (en) | 1993-02-23 | 1994-02-17 | Farnesyl: protein transferase inhibitors as anticancer agents |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5463181A (fi) |
| EP (1) | EP0686159B1 (fi) |
| JP (1) | JPH08509470A (fi) |
| KR (1) | KR100305128B1 (fi) |
| CN (1) | CN1045207C (fi) |
| AT (1) | ATE159023T1 (fi) |
| AU (1) | AU684071B2 (fi) |
| CA (1) | CA2154871C (fi) |
| DE (1) | DE69406110T2 (fi) |
| DK (1) | DK0686159T3 (fi) |
| ES (1) | ES2110738T3 (fi) |
| FI (1) | FI111369B (fi) |
| GR (1) | GR3025499T3 (fi) |
| HU (1) | HUT72647A (fi) |
| IL (1) | IL108694A0 (fi) |
| NO (1) | NO306618B1 (fi) |
| NZ (1) | NZ262585A (fi) |
| TW (1) | TW265345B (fi) |
| ZA (1) | ZA941099B (fi) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE445838T1 (de) | 2001-07-25 | 2009-10-15 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
| FR2833266B1 (fr) * | 2001-12-11 | 2004-10-22 | Mayoly Spindler Lab | Nouveaux derives phosphonates, leur procede de preparation, leur utilisation comme modulateurs de l'activite des lymphocytes tgamma9 delta2 |
| EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
| CA2663377A1 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
| HUE059078T2 (hu) | 2009-02-20 | 2022-10-28 | Enhanx Biopharm Inc | Glutation-alapú hatóanyagszállító rendszer |
| JP2012526144A (ja) | 2009-05-06 | 2012-10-25 | ラボラトリー スキン ケア インコーポレイテッド | 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57142993A (en) * | 1981-02-28 | 1982-09-03 | Sagami Chem Res Center | 2-hydroxyphosphonic diester |
| DE3313070A1 (de) * | 1983-04-12 | 1984-10-18 | Bayer Ag, 5090 Leverkusen | Chlorierte phosphorylmethylcarbonyl-derivate, verfahren zu ihrer herstellung und ihre verwendung in pflanzenschutmitteln |
| DE3425701A1 (de) * | 1984-07-12 | 1986-01-16 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von chlorierten phosphorylmethylcarbonyl-derivaten und neue zwischenprodukte zu ihrer herstellung |
| US4924024A (en) * | 1988-01-11 | 1990-05-08 | E. R. Squibb & Sons, Inc. | Phosphorus-containing squalene synthetase inhibitors, new intermediates and method |
| US5177239A (en) * | 1989-07-18 | 1993-01-05 | E. R. Squibb & Sons, Inc. | Method for preparing a phosphonic acid ester |
| US5298655A (en) * | 1991-09-27 | 1994-03-29 | Merck & Co., Inc. | Farnesyl pyrophosphate analogs |
-
1993
- 1993-11-08 US US08/148,188 patent/US5463181A/en not_active Expired - Fee Related
-
1994
- 1994-01-24 CA CA002154871A patent/CA2154871C/en not_active Expired - Fee Related
- 1994-01-24 NZ NZ262585A patent/NZ262585A/en unknown
- 1994-01-24 EP EP94909497A patent/EP0686159B1/en not_active Expired - Lifetime
- 1994-01-24 CN CN94191274A patent/CN1045207C/zh not_active Expired - Fee Related
- 1994-01-24 KR KR1019950703547A patent/KR100305128B1/ko not_active IP Right Cessation
- 1994-01-24 DK DK94909497.3T patent/DK0686159T3/da active
- 1994-01-24 ES ES94909497T patent/ES2110738T3/es not_active Expired - Lifetime
- 1994-01-24 AU AU62324/94A patent/AU684071B2/en not_active Ceased
- 1994-01-24 AT AT94909497T patent/ATE159023T1/de not_active IP Right Cessation
- 1994-01-24 DE DE69406110T patent/DE69406110T2/de not_active Expired - Fee Related
- 1994-01-24 HU HU9502455A patent/HUT72647A/hu unknown
- 1994-01-24 JP JP6518980A patent/JPH08509470A/ja not_active Ceased
- 1994-02-17 IL IL10869494A patent/IL108694A0/xx unknown
- 1994-02-17 ZA ZA941099A patent/ZA941099B/xx unknown
- 1994-02-18 TW TW083101358A patent/TW265345B/zh active
-
1995
- 1995-08-22 NO NO953292A patent/NO306618B1/no unknown
- 1995-08-22 FI FI953934A patent/FI111369B/fi active
-
1997
- 1997-11-26 GR GR970403148T patent/GR3025499T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0686159T3 (da) | 1998-01-26 |
| TW265345B (fi) | 1995-12-11 |
| CA2154871A1 (en) | 1994-09-01 |
| KR100305128B1 (ko) | 2001-11-22 |
| EP0686159B1 (en) | 1997-10-08 |
| NO953292L (no) | 1995-08-22 |
| CA2154871C (en) | 1998-04-07 |
| NO306618B1 (no) | 1999-11-29 |
| DE69406110D1 (de) | 1997-11-13 |
| AU6232494A (en) | 1994-09-14 |
| JPH08509470A (ja) | 1996-10-08 |
| NZ262585A (en) | 1997-12-19 |
| EP0686159A1 (en) | 1995-12-13 |
| DE69406110T2 (de) | 1998-05-14 |
| FI953934A0 (fi) | 1995-08-22 |
| ES2110738T3 (es) | 1998-02-16 |
| CN1045207C (zh) | 1999-09-22 |
| FI111369B (fi) | 2003-07-15 |
| GR3025499T3 (en) | 1998-02-27 |
| AU684071B2 (en) | 1997-12-04 |
| FI953934A (fi) | 1995-08-22 |
| ATE159023T1 (de) | 1997-10-15 |
| NO953292D0 (no) | 1995-08-22 |
| HUT72647A (en) | 1996-05-28 |
| HU9502455D0 (en) | 1995-10-30 |
| US5463181A (en) | 1995-10-31 |
| ZA941099B (en) | 1994-08-30 |
| CN1118166A (zh) | 1996-03-06 |
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