IL106502A - Piperazine and 1,4 diazepine carboxamides and pharmaceutical compositions containing them - Google Patents
Piperazine and 1,4 diazepine carboxamides and pharmaceutical compositions containing themInfo
- Publication number
- IL106502A IL106502A IL10650293A IL10650293A IL106502A IL 106502 A IL106502 A IL 106502A IL 10650293 A IL10650293 A IL 10650293A IL 10650293 A IL10650293 A IL 10650293A IL 106502 A IL106502 A IL 106502A
- Authority
- IL
- Israel
- Prior art keywords
- pct
- nitrogen
- diazepine
- carboxamides
- piperazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9202266A SE9202266D0 (sv) | 1992-07-31 | 1992-07-31 | Novel piperazine carboxamides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL106502A0 IL106502A0 (en) | 1993-11-15 |
| IL106502A true IL106502A (en) | 1997-08-14 |
Family
ID=20386860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10650293A IL106502A (en) | 1992-07-31 | 1993-07-28 | Piperazine and 1,4 diazepine carboxamides and pharmaceutical compositions containing them |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5574031A (el) |
| EP (1) | EP0620814B1 (el) |
| JP (1) | JP3418195B2 (el) |
| CN (1) | CN1055687C (el) |
| AT (1) | ATE190973T1 (el) |
| AU (1) | AU666212B2 (el) |
| CA (1) | CA2141210A1 (el) |
| DE (1) | DE69328165T2 (el) |
| DK (1) | DK0620814T3 (el) |
| ES (1) | ES2144009T3 (el) |
| GR (1) | GR3033629T3 (el) |
| IL (1) | IL106502A (el) |
| NZ (1) | NZ254312A (el) |
| PT (1) | PT620814E (el) |
| SE (1) | SE9202266D0 (el) |
| WO (1) | WO1994003436A1 (el) |
| ZA (1) | ZA935534B (el) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4533534B2 (ja) | 1998-06-19 | 2010-09-01 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | グリコーゲンシンターゼキナーゼ３のインヒビター |
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| KR100443570B1 (ko) * | 2001-07-31 | 2004-08-09 | 크레아젠 주식회사 | 재조합 인간 인터루킨-4의 제조방법 |
| US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US7732451B2 (en) | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
| JP2005504043A (ja) | 2001-08-10 | 2005-02-10 | パラチン テクノロジーズ インク． | 生物学的に活性な金属ペプチド類のペプチド模倣体類 |
| US7354923B2 (en) * | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| US7456184B2 (en) | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| US7655658B2 (en) | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
| US7968548B2 (en) | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE791501A (fr) * | 1971-11-19 | 1973-05-17 | Albert Ag Chem Werke | Diamines cycliques n,n'-disubstituees et leur procede de preparation |
| US4082755A (en) * | 1977-02-14 | 1978-04-04 | Janssen Pharmaceutica N.V. | 1-[(Diarylmethyl)aminoalkyl]piperidimes |
| NO154582C (no) * | 1978-10-20 | 1986-11-05 | Ferrosan Ab | Analogifremgangsmaate for fremstilling av terapeutisk aktive difenyl-dibutylpiperazinkarboksamider. |
| US4766125A (en) * | 1981-06-23 | 1988-08-23 | Janssen Pharmaceutica N.V. | N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia |
| SE8302886D0 (sv) * | 1983-05-20 | 1983-05-20 | Ferrosan Ab | Intermediates for preparing substituted 1-piperazine-carboxamides and carbothioamides and use thereof |
| HU196194B (en) * | 1986-04-28 | 1988-10-28 | Richter Gedeon Vegyeszet | Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds |
| NZ223847A (en) * | 1987-04-01 | 1989-12-21 | Janssen Pharmaceutica Nv | Substituted piperazine derivatives and pharmaceutical compositions |
| US5026853A (en) * | 1987-04-01 | 1991-06-25 | Janssen Pharmaceutica N.V. | 4-substituted-2(or 3)aminocarbonyl-1-piperazineacetamide |
| US4880808A (en) * | 1987-04-01 | 1989-11-14 | Janssen Pharmaceutica N.V. | N-aryl-piperazinealkanamides useful for improving sleep |
| EP0455789B1 (en) * | 1989-11-22 | 1994-03-16 | Janssen Pharmaceutica N.V. | Method of preventing or limiting reperfusion damage |
-
1992
- 1992-07-31 SE SE9202266A patent/SE9202266D0/xx unknown
-
1993
- 1993-07-22 DK DK93916377T patent/DK0620814T3/da active
- 1993-07-22 NZ NZ254312A patent/NZ254312A/en unknown
- 1993-07-22 CA CA002141210A patent/CA2141210A1/en not_active Abandoned
- 1993-07-22 AT AT93916377T patent/ATE190973T1/de not_active IP Right Cessation
- 1993-07-22 ES ES93916377T patent/ES2144009T3/es not_active Expired - Lifetime
- 1993-07-22 AU AU45953/93A patent/AU666212B2/en not_active Ceased
- 1993-07-22 PT PT93916377T patent/PT620814E/pt unknown
- 1993-07-22 DE DE69328165T patent/DE69328165T2/de not_active Expired - Fee Related
- 1993-07-22 US US08/374,797 patent/US5574031A/en not_active Expired - Fee Related
- 1993-07-22 EP EP93916377A patent/EP0620814B1/en not_active Expired - Lifetime
- 1993-07-22 JP JP50522394A patent/JP3418195B2/ja not_active Expired - Fee Related
- 1993-07-22 WO PCT/SE1993/000639 patent/WO1994003436A1/en active IP Right Grant
- 1993-07-28 IL IL10650293A patent/IL106502A/xx not_active IP Right Cessation
- 1993-07-30 ZA ZA935534A patent/ZA935534B/xx unknown
- 1993-07-30 CN CN93116827A patent/CN1055687C/zh not_active Expired - Fee Related
-
2000
- 2000-06-07 GR GR20000401315T patent/GR3033629T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69328165D1 (de) | 2000-04-27 |
| IL106502A0 (en) | 1993-11-15 |
| DK0620814T3 (da) | 2000-07-17 |
| NZ254312A (en) | 1997-06-24 |
| US5574031A (en) | 1996-11-12 |
| PT620814E (pt) | 2000-09-29 |
| EP0620814B1 (en) | 2000-03-22 |
| ES2144009T3 (es) | 2000-06-01 |
| AU4595393A (en) | 1994-03-03 |
| ATE190973T1 (de) | 2000-04-15 |
| AU666212B2 (en) | 1996-02-01 |
| WO1994003436A1 (en) | 1994-02-17 |
| CN1055687C (zh) | 2000-08-23 |
| GR3033629T3 (en) | 2000-10-31 |
| SE9202266D0 (sv) | 1992-07-31 |
| DE69328165T2 (de) | 2000-10-05 |
| ZA935534B (en) | 1994-02-24 |
| JP3418195B2 (ja) | 2003-06-16 |
| JPH08508008A (ja) | 1996-08-27 |
| EP0620814A1 (en) | 1994-10-26 |
| CN1088579A (zh) | 1994-06-29 |
| CA2141210A1 (en) | 1994-02-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL106502A (en) | Piperazine and 1,4 diazepine carboxamides and pharmaceutical compositions containing them | |
| DE69327541D1 (en) | 4-arylmethyloxymethyl piperidine als tachykinin antagonisten | |
| DE69223989D1 (en) | Azyklische ethylendiaminderivate als 'substance p rezeptor' antagonisten | |
| AU686520B2 (en) | Macrocyclic immunomodulators | |
| ZA924760B (en) | Bicyclic fibrinogen antagonists | |
| DE69227088D1 (de) | Verwendung von 1-(aminoalkyl)-3-Quinoxalin-2-on Derivaten zur Herstellung von neuroprotektiven Mitteln | |
| IL108258A0 (en) | Piperazine derivates, their preparation and pharmaceutical compositions containing them | |
| ES8500888A1 (es) | Un procedimiento para la preparacion de nuevos derivados de propanolamina. | |
| GB2311780B (en) | Pharmaceutical Piperazine Compounds | |
| HU9503807D0 (en) | Pyridazinone derivatives with pharmaceutical activity | |
| IL106469A (en) | Pyridyl- and pyrimidylpiperazine compounds methods for the manufacture of said compounds and pharmaceutical compositions comprising said compounds | |
| YU6996A (sh) | Upotreba benzotiofena za dobijanje leka | |
| SE9401353D0 (sv) | Novel antitumour compounds with antimitotic activity | |
| MX9603868A (es) | Composicion farmaceutica de derivados de indeno para la regulacion de la apoptosis. | |
| FR2695643B1 (fr) | Dérivés d'uréido-acétamide, leur préparation et les médicaments les contenant. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| RH | Patent void | ||
| HP | Change in proprietorship | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |