IL104821A - Octahydro-3-hydroxy-2, 6-methano-2h-quinolizin-8-yl ester of 5-chloro-2, 3-dihydro-2, 2-dimethylbenzofuran-7-carboxylic acid its preparation pharmaceutical compositions and use as 5-ht3-receptor antagonist - Google Patents
Octahydro-3-hydroxy-2, 6-methano-2h-quinolizin-8-yl ester of 5-chloro-2, 3-dihydro-2, 2-dimethylbenzofuran-7-carboxylic acid its preparation pharmaceutical compositions and use as 5-ht3-receptor antagonistInfo
- Publication number
- IL104821A IL104821A IL10482193A IL10482193A IL104821A IL 104821 A IL104821 A IL 104821A IL 10482193 A IL10482193 A IL 10482193A IL 10482193 A IL10482193 A IL 10482193A IL 104821 A IL104821 A IL 104821A
- Authority
- IL
- Israel
- Prior art keywords
- dimethylbenzofuran
- quinolizin
- methano
- octahydro
- dihydro
- Prior art date
Links
- 229940113081 5 Hydroxytryptamine 3 receptor antagonist Drugs 0.000 title 1
- QXHUQQSVSDVEBE-UHFFFAOYSA-N 5-chloro-2,2-dimethyl-3h-1-benzofuran-7-carboxylic acid Chemical compound ClC1=CC(C(O)=O)=C2OC(C)(C)CC2=C1 QXHUQQSVSDVEBE-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP92400474 | 1992-02-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL104821A0 IL104821A0 (en) | 1993-06-10 |
| IL104821A true IL104821A (en) | 1997-01-10 |
Family
ID=8211614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10482193A IL104821A (en) | 1992-02-24 | 1993-02-22 | Octahydro-3-hydroxy-2, 6-methano-2h-quinolizin-8-yl ester of 5-chloro-2, 3-dihydro-2, 2-dimethylbenzofuran-7-carboxylic acid its preparation pharmaceutical compositions and use as 5-ht3-receptor antagonist |
Country Status (14)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2672500A (en) | 1999-02-18 | 2000-09-04 | Novartis Ag | Systemic use of 5-ht3 receptor antagonists against rheumatic inflammatory processes |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| JP5241484B2 (ja) | 2005-03-07 | 2013-07-17 | ザ ユニヴァーシティー オヴ シカゴ | 内皮細胞増殖及び内皮細胞遊走を減弱するためのオピオイドアンタゴニストの使用 |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2080727T3 (es) * | 1988-02-23 | 1996-02-16 | Merrell Pharma Inc | Uso de quinolizina y derivados de quinolizinona en la fabricacion de medicamentos. |
| EP0517984A1 (en) * | 1991-06-11 | 1992-12-16 | Merrell Dow Pharmaceuticals Inc. | Derivatives of amide analogs of certain methano bridged quinolizines |
-
1993
- 1993-02-03 AU AU36034/93A patent/AU675060B2/en not_active Expired
- 1993-02-03 JP JP5514868A patent/JPH07504192A/ja active Pending
- 1993-02-03 WO PCT/US1993/000880 patent/WO1993017019A1/en active IP Right Grant
- 1993-02-03 NZ NZ249346A patent/NZ249346A/en not_active IP Right Cessation
- 1993-02-03 KR KR1019940702945A patent/KR100287933B1/ko not_active Expired - Lifetime
- 1993-02-03 HU HU9402436A patent/HU216831B/hu unknown
- 1993-02-03 CA CA002130563A patent/CA2130563C/en not_active Expired - Lifetime
- 1993-02-03 EP EP93904797A patent/EP0628043A1/en not_active Withdrawn
- 1993-02-18 ZA ZA931146A patent/ZA931146B/xx unknown
- 1993-02-19 TW TW082101189A patent/TW226374B/zh not_active IP Right Cessation
- 1993-02-22 IL IL10482193A patent/IL104821A/xx not_active IP Right Cessation
- 1993-02-22 MX MX9300948A patent/MX9300948A/es unknown
-
1994
- 1994-08-23 FI FI943872A patent/FI105917B/fi not_active IP Right Cessation
- 1994-08-23 NO NO943101A patent/NO943101L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW226374B (enrdf_load_html_response) | 1994-07-11 |
| NO943101D0 (no) | 1994-08-23 |
| KR950700297A (ko) | 1995-01-16 |
| MX9300948A (es) | 1993-08-01 |
| FI943872L (fi) | 1994-08-23 |
| ZA931146B (en) | 1993-09-14 |
| HUT68249A (en) | 1995-06-28 |
| CA2130563A1 (en) | 1993-09-02 |
| JPH07504192A (ja) | 1995-05-11 |
| EP0628043A1 (en) | 1994-12-14 |
| CA2130563C (en) | 1997-11-11 |
| AU3603493A (en) | 1993-09-13 |
| NO943101L (no) | 1994-08-23 |
| AU675060B2 (en) | 1997-01-23 |
| FI943872A0 (fi) | 1994-08-23 |
| NZ249346A (en) | 1995-10-26 |
| HU9402436D0 (en) | 1994-10-28 |
| FI105917B (fi) | 2000-10-31 |
| IL104821A0 (en) | 1993-06-10 |
| HU216831B (hu) | 1999-09-28 |
| WO1993017019A1 (en) | 1993-09-02 |
| KR100287933B1 (ko) | 2001-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |