IL104256A - Lyophilized pharmaceutical compositions containing anthracycline glycosides bound to polymer derivatives and their preparation - Google Patents
Lyophilized pharmaceutical compositions containing anthracycline glycosides bound to polymer derivatives and their preparationInfo
- Publication number
- IL104256A IL104256A IL10425692A IL10425692A IL104256A IL 104256 A IL104256 A IL 104256A IL 10425692 A IL10425692 A IL 10425692A IL 10425692 A IL10425692 A IL 10425692A IL 104256 A IL104256 A IL 104256A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- polymer derivatives
- lyophilized pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929200247A GB9200247D0 (en) | 1992-01-07 | 1992-01-07 | Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
IL104256A0 IL104256A0 (en) | 1993-05-13 |
IL104256A true IL104256A (en) | 1997-02-18 |
Family
ID=10708214
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10425692A IL104256A (en) | 1992-01-07 | 1992-12-29 | Lyophilized pharmaceutical compositions containing anthracycline glycosides bound to polymer derivatives and their preparation |
Country Status (22)
Country | Link |
---|---|
US (1) | US6245358B1 (de) |
EP (1) | EP0574571B1 (de) |
JP (1) | JPH06505755A (de) |
KR (1) | KR100290222B1 (de) |
AT (1) | ATE179618T1 (de) |
AU (1) | AU666513B2 (de) |
CA (1) | CA2105466A1 (de) |
DE (1) | DE69229109T2 (de) |
DK (1) | DK0574571T3 (de) |
ES (1) | ES2133380T3 (de) |
FI (1) | FI933853A (de) |
GB (1) | GB9200247D0 (de) |
GR (1) | GR3030633T3 (de) |
HU (2) | HU217806B (de) |
IL (1) | IL104256A (de) |
MX (1) | MX9207605A (de) |
NZ (1) | NZ246577A (de) |
RU (1) | RU2118171C1 (de) |
TW (1) | TW218847B (de) |
UA (1) | UA32522C2 (de) |
WO (1) | WO1993013804A1 (de) |
ZA (1) | ZA9210049B (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9320781D0 (en) * | 1993-10-08 | 1993-12-01 | Erba Carlo Spa | Polymer-bound camptothecin derivatives |
WO1998047496A2 (en) * | 1997-04-18 | 1998-10-29 | Access Pharmaceuticals, Inc. | Polymer-platinum compounds |
US5965118A (en) * | 1997-04-18 | 1999-10-12 | Access Pharmaceuticals, Inc. | Polymer-platinum compounds |
US7314956B2 (en) | 2001-08-08 | 2008-01-01 | Vaxim, Inc. | Multifunctional carrier for the delivery of a pharmacological agent or genetic material into a cell |
WO2003017938A2 (en) * | 2001-08-22 | 2003-03-06 | Watson Pharmaceuticals, Inc. | Conjugates targeted to target receptors |
US20030125268A1 (en) * | 2002-08-28 | 2003-07-03 | Rybak Mary Ellen Margaret | Farnesyl protein transferase inhibitor combinations with anti-tumor anthracycline derivatives |
EP1562546A1 (de) * | 2002-10-25 | 2005-08-17 | Pfizer Products Inc. | Depotformulierungen arylheterozyklischer wirkstoffen in form von suspensionen |
CN1774259B (zh) * | 2003-01-14 | 2011-12-28 | 特瓦制药工业有限公司 | 治疗系统性红斑狼疮的肽的胃肠道外制剂 |
BRPI0605832A2 (pt) * | 2005-05-11 | 2009-05-26 | Sicor Inc | glicosìdeos de antraciclina liofilizados estáveis |
US20100160442A1 (en) * | 2006-07-18 | 2010-06-24 | Ossovskaya Valeria S | Formulations for cancer treatment |
RS52633B (en) * | 2007-01-16 | 2013-06-28 | Bipar Sciences Inc. | CANCER TREATMENT FORMULATION |
EP2222273A2 (de) * | 2007-11-12 | 2010-09-01 | Novartis AG | Flüssigkeitszusammensetzungen mit valsartan |
WO2009118754A2 (en) * | 2008-03-28 | 2009-10-01 | Astron Research Limited | A process for preparing a stable lyophilized composition |
CA2723315A1 (en) * | 2008-04-30 | 2009-11-05 | Ben-Gurion University Of The Negev Research And Development Authority | Vascular delivery systems |
KR102239752B1 (ko) * | 2019-12-11 | 2021-04-13 | 한국과학기술연구원 | 종양 특이적 약물복합체와 항pd-l1 항체를 유효성분으로 하는 암 예방 또는 치료를 위한 병용 투여용 약학 조성물 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS173846B1 (de) * | 1974-04-23 | 1977-03-31 | ||
US4460560A (en) * | 1982-06-18 | 1984-07-17 | University Of Southern California | Drug delivery by polymeric carriers |
FR2561916B1 (fr) * | 1984-03-30 | 1987-12-11 | Lafon Labor | Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau |
FR2583983B1 (fr) * | 1985-06-07 | 1988-05-27 | Centre Nat Rech Scient | Nouvelles prodrogues macromoleculaires hydrosolubles, leur preparation et leur utilisation comme medicaments notamment antitumoraux et antiparasitaires |
GB8519452D0 (en) * | 1985-08-02 | 1985-09-11 | Erba Farmitalia | Injectable solutions |
US4968742A (en) * | 1987-11-09 | 1990-11-06 | Miles Inc. | Preparation of ligand-polymer conjugate having a controlled number of introduced ligands |
US5135736A (en) * | 1988-08-15 | 1992-08-04 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
US5094848A (en) * | 1989-06-30 | 1992-03-10 | Neorx Corporation | Cleavable diphosphate and amidated diphosphate linkers |
US5079018A (en) * | 1989-08-14 | 1992-01-07 | Neophore Technologies, Inc. | Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs |
-
1992
- 1992-01-07 GB GB929200247A patent/GB9200247D0/en active Pending
- 1992-12-21 AU AU33468/93A patent/AU666513B2/en not_active Ceased
- 1992-12-21 KR KR1019930702671A patent/KR100290222B1/ko not_active IP Right Cessation
- 1992-12-21 CA CA002105466A patent/CA2105466A1/en not_active Abandoned
- 1992-12-21 UA UA93003781A patent/UA32522C2/uk unknown
- 1992-12-21 RU RU93055778A patent/RU2118171C1/ru active
- 1992-12-21 JP JP5512103A patent/JPH06505755A/ja active Pending
- 1992-12-21 EP EP93902124A patent/EP0574571B1/de not_active Expired - Lifetime
- 1992-12-21 WO PCT/EP1992/002968 patent/WO1993013804A1/en active IP Right Grant
- 1992-12-21 HU HU9302517A patent/HU217806B/hu not_active IP Right Cessation
- 1992-12-21 ES ES93902124T patent/ES2133380T3/es not_active Expired - Lifetime
- 1992-12-21 AT AT93902124T patent/ATE179618T1/de not_active IP Right Cessation
- 1992-12-21 NZ NZ246577A patent/NZ246577A/en unknown
- 1992-12-21 DK DK93902124T patent/DK0574571T3/da active
- 1992-12-21 DE DE69229109T patent/DE69229109T2/de not_active Expired - Fee Related
- 1992-12-28 ZA ZA9210049A patent/ZA9210049B/xx unknown
- 1992-12-28 US US07/997,582 patent/US6245358B1/en not_active Expired - Fee Related
- 1992-12-29 IL IL10425692A patent/IL104256A/xx not_active IP Right Cessation
- 1992-12-29 MX MX9207605A patent/MX9207605A/es not_active IP Right Cessation
- 1992-12-31 TW TW081110531A patent/TW218847B/zh active
-
1993
- 1993-09-03 FI FI933853A patent/FI933853A/fi unknown
-
1995
- 1995-06-30 HU HU95P/P00705P patent/HU211636A9/hu unknown
-
1999
- 1999-06-30 GR GR990401719T patent/GR3030633T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69229109D1 (de) | 1999-06-10 |
WO1993013804A1 (en) | 1993-07-22 |
RU2118171C1 (ru) | 1998-08-27 |
GR3030633T3 (en) | 1999-10-29 |
MX9207605A (es) | 1993-08-01 |
ATE179618T1 (de) | 1999-05-15 |
HU211636A9 (en) | 1995-12-28 |
DK0574571T3 (da) | 1999-11-01 |
AU3346893A (en) | 1993-08-03 |
HU9302517D0 (en) | 1993-12-28 |
GB9200247D0 (en) | 1992-02-26 |
NZ246577A (en) | 1996-03-26 |
ZA9210049B (en) | 1993-10-06 |
FI933853A0 (fi) | 1993-09-03 |
IL104256A0 (en) | 1993-05-13 |
TW218847B (de) | 1994-01-11 |
CA2105466A1 (en) | 1993-07-08 |
FI933853A (fi) | 1993-09-03 |
UA32522C2 (uk) | 2001-02-15 |
HU217806B (hu) | 2000-04-28 |
US6245358B1 (en) | 2001-06-12 |
DE69229109T2 (de) | 1999-08-26 |
JPH06505755A (ja) | 1994-06-30 |
KR100290222B1 (ko) | 2001-09-17 |
HUT74578A (en) | 1997-01-28 |
AU666513B2 (en) | 1996-02-15 |
EP0574571B1 (de) | 1999-05-06 |
ES2133380T3 (es) | 1999-09-16 |
EP0574571A1 (de) | 1993-12-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL104256A (en) | Lyophilized pharmaceutical compositions containing anthracycline glycosides bound to polymer derivatives and their preparation | |
IE852593L (en) | Compositions containing anthracycline glycosides | |
MX9203072A (es) | Asialoglucoproteina-agente conjugado medicinal. | |
RU93055778A (ru) | Фармацевтические композиции, содержащие антрациклиновые гликозиды, связанные с полимерным производным, и способ их получения | |
IL47372A (en) | Fab'dimers bound to daunomycin or adriamycin,their preparation and pharmaceutical compositions containing same | |
MY104944A (en) | Anthracycline immunoconjugates having a novel linker and methods for their production | |
TR200002299T2 (tr) | Epotilon kompozisyonları. | |
PL302437A1 (en) | Paklitaxel derivatives bound with a polymer | |
MY103365A (en) | 4-demethoxy-4-amino-anthracyclines | |
IL89199A0 (en) | 3'-deamino-4'-deoxy-4'-amino anthracyclines,their preparation and pharmaceutical compositions containing them | |
EP0398305A3 (de) | Anthracyclin-Konjugate mit einem neuen Linker und Verfahren zu dessen Herstellung | |
DK0666762T3 (da) | Fremgangsmåde til fremstilling af lipid-konjugater | |
WO1994010317A3 (en) | Conjugate vaccine against group b streptococcus | |
UA42695C2 (uk) | Полімерзв'язаний антрациклін, фармацевтична композиція та проміжна сполука | |
CA2504963A1 (en) | Conjugates of tnf and a ligand of cd13 receptor in combination with interferon-gamma for treating cancer | |
IL84146A0 (en) | Anthracycline glycosides,their preparation and pharmaceutical compositions containing them | |
NZ220604A (en) | Anthracycline glycoside derivatives, their preparation and pharmaceutical compositions containing them | |
CA2119675A1 (en) | Antitumor mitoxantrone polymeric compositions | |
EP0305972A3 (de) | 3'-Demethoxyepipodophyllotoxinglucosid-Derivate | |
IL93676A0 (en) | Anthracycline derivatives,their preparation and pharmaceutical compositions containing them | |
IL104975A0 (en) | Anthracycline glycosides,their preparation and pharmaceutical compositions containing them |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
RH | Patent void | ||
RH1 | Patent not in force |