IL102204A0 - Therapeutic preparations - Google Patents

Therapeutic preparations

Info

Publication number
IL102204A0
IL102204A0 IL102204A IL10220492A IL102204A0 IL 102204 A0 IL102204 A0 IL 102204A0 IL 102204 A IL102204 A IL 102204A IL 10220492 A IL10220492 A IL 10220492A IL 102204 A0 IL102204 A0 IL 102204A0
Authority
IL
Israel
Prior art keywords
novel quinazoline
trifluoromethyl
nitro
alkyl
quinazoline derivatives
Prior art date
Application number
IL102204A
Other versions
IL102204A (en
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919113970A external-priority patent/GB9113970D0/en
Priority claimed from GB929201133A external-priority patent/GB9201133D0/en
Application filed by Ici Plc filed Critical Ici Plc
Publication of IL102204A0 publication Critical patent/IL102204A0/en
Publication of IL102204A publication Critical patent/IL102204A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention concerns a pharamceutical composition which comprises known or novel quinazoline derivatives of the formula I <CHEM> wherein, for example, R<1> is hydrogen, trifluoromethyl or nitro, n is 1 and R<2> is halogeno, trifluoromethyl, nitro, cyano, (1-4C)alkyl, (1-4C)alkoxy, N-(1-4C)alkylamino, N,N-di-((1-4C)alkyl]amino, (1-4C)alkylthio, (1-4C)alkylsulphinyl or (1-4C)alkylsulphonyl; and pharmaceutically-acceptable diluents or carriers thereof; the novel quinazoline deribatives and a process for their preparation; and the use of the receptor tyrosine kinase inhibitory properties of both the known and novel quinazoline derivatives in the treatment of cancer.
IL102204A 1991-06-28 1992-06-15 Therapeutic preparations containing quinazoline derivatives, some such quinazolines and a process for their preparation IL102204A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919113970A GB9113970D0 (en) 1991-06-28 1991-06-28 Therapeutic preparations
GB929201133A GB9201133D0 (en) 1992-01-20 1992-01-20 Therapeutic preparations

Publications (2)

Publication Number Publication Date
IL102204A0 true IL102204A0 (en) 1993-01-14
IL102204A IL102204A (en) 1997-03-18

Family

ID=26299148

Family Applications (1)

Application Number Title Priority Date Filing Date
IL102204A IL102204A (en) 1991-06-28 1992-06-15 Therapeutic preparations containing quinazoline derivatives, some such quinazolines and a process for their preparation

Country Status (19)

Country Link
EP (1) EP0520722B1 (en)
JP (1) JPH05208911A (en)
KR (1) KR930000490A (en)
AT (1) ATE146781T1 (en)
AU (1) AU651215B2 (en)
CA (1) CA2071087A1 (en)
CZ (1) CZ182792A3 (en)
DE (1) DE69216158T2 (en)
DK (1) DK0520722T3 (en)
FI (1) FI922785A (en)
GB (1) GB9213181D0 (en)
GR (1) GR3022167T3 (en)
HU (1) HUT61290A (en)
IE (1) IE921799A1 (en)
IL (1) IL102204A (en)
NO (1) NO180105C (en)
NZ (1) NZ243082A (en)
SK (1) SK182792A3 (en)
TW (1) TW202436B (en)

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JPH05208911A (en) 1993-08-20
TW202436B (en) 1993-03-21
FI922785A (en) 1992-12-29
AU1842292A (en) 1993-01-07
IL102204A (en) 1997-03-18
HUT61290A (en) 1992-12-28
KR930000490A (en) 1993-01-15
CA2071087A1 (en) 1992-12-29
GB9213181D0 (en) 1992-08-05
HU9201964D0 (en) 1992-09-28
NO922517D0 (en) 1992-06-25
NO180105C (en) 1997-02-19

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