IL101686A - Process for increasing the in vivo yield of native protein when disulfide-bonded proteins are secreted - Google Patents
Process for increasing the in vivo yield of native protein when disulfide-bonded proteins are secretedInfo
- Publication number
- IL101686A IL101686A IL10168692A IL10168692A IL101686A IL 101686 A IL101686 A IL 101686A IL 10168692 A IL10168692 A IL 10168692A IL 10168692 A IL10168692 A IL 10168692A IL 101686 A IL101686 A IL 101686A
- Authority
- IL
- Israel
- Prior art keywords
- secreted
- disulfide
- increasing
- native protein
- bonded proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Saccharide Compounds (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4113750A DE4113750A1 (de) | 1991-04-26 | 1991-04-26 | Verbesserung der renaturierung bei der sekretion von disulfidverbrueckten proteinen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL101686A0 IL101686A0 (en) | 1992-12-30 |
| IL101686A true IL101686A (en) | 2001-08-26 |
Family
ID=6430469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10168692A IL101686A (en) | 1991-04-26 | 1992-04-23 | Process for increasing the in vivo yield of native protein when disulfide-bonded proteins are secreted |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6333175B1 (ko) |
| EP (1) | EP0510658B1 (ko) |
| JP (1) | JPH0753118B2 (ko) |
| KR (1) | KR960002869B1 (ko) |
| AT (1) | ATE109205T1 (ko) |
| AU (1) | AU636537B2 (ko) |
| CA (1) | CA2066370C (ko) |
| DE (2) | DE4113750A1 (ko) |
| DK (1) | DK0510658T3 (ko) |
| ES (1) | ES2057944T3 (ko) |
| FI (1) | FI104262B (ko) |
| IE (1) | IE65792B1 (ko) |
| IL (1) | IL101686A (ko) |
| NO (1) | NO309153B1 (ko) |
| NZ (1) | NZ242492A (ko) |
| ZA (1) | ZA922971B (ko) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2119779T3 (es) * | 1990-09-05 | 1998-10-16 | Southern Cross Biotech Pty Ltd | Solubilizacion de proteinas en formas activas. |
| US6291205B1 (en) * | 1992-06-12 | 2001-09-18 | Merck & Co., Inc. | Method of increasing production of disulfide bonded recombinant proteins by saccharomyces cerevisiae |
| US5789199A (en) * | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5639635A (en) * | 1994-11-03 | 1997-06-17 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US6027888A (en) * | 1996-04-05 | 2000-02-22 | Board Of Regents, The University Of Texas System | Methods for producing soluble, biologically-active disulfide-bond containing eukaryotic proteins in bacterial cells |
| US6083715A (en) * | 1997-06-09 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells |
| US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
| US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
| EP1012184B1 (en) | 1997-07-14 | 2007-10-10 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
| US7153943B2 (en) | 1997-07-14 | 2006-12-26 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins, and methods of use thereof |
| US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| BR122013003013B8 (pt) * | 1999-01-14 | 2021-07-06 | Bolder Biotechnology Inc | proteína isolada monopeguilada do hormônio do crescimento e método para sua obtenção |
| US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| EP1048732A1 (de) | 1999-04-26 | 2000-11-02 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von natürlich gefalteten und sekretierten Proteinen |
| EP1077263A1 (de) * | 1999-07-29 | 2001-02-21 | F.Hoffmann-La Roche Ag | Verfahren zur Herstellung von natürlich gefalteten und sekretierten Proteinen durch Co-Sekretion von Chaperonen |
| US20040203132A1 (en) | 2003-02-28 | 2004-10-14 | Cognetix, Inc. | Conus protein disulfide isomerase |
| US7244616B2 (en) | 2003-06-27 | 2007-07-17 | Bayer Pharmaceuticals Corporation | Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells |
| KR20050070512A (ko) * | 2003-12-30 | 2005-07-07 | 삼성정밀화학 주식회사 | 재조합 단백질의 생산성을 증가시키는 무혈청 배지 및동물세포 배양방법 |
| AU2005299716B2 (en) | 2004-10-22 | 2012-09-06 | Amgen Inc. | Methods for refolding of recombinant antibodies |
| EP2004804A2 (en) * | 2006-04-07 | 2008-12-24 | Dow Global Technologies Inc. | Processes for improved disulfide bond formation in recombinant systems |
| KR100743973B1 (ko) * | 2006-04-27 | 2007-07-30 | 한국과학기술원 | 목적단백질 및 코펙터를 재생시키는 효소를 동시에 세포표면에 표면발현시키는 방법 |
| GB201101794D0 (en) | 2011-02-02 | 2011-03-16 | Fermentas Uab | Protein production |
| US9944960B2 (en) * | 2015-11-17 | 2018-04-17 | Premier Research Labs, Lp | Process for microbial production of dihydrolipoic acid and extraction of dihydrolipoic acid with edible oils |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3537708A1 (de) * | 1985-10-23 | 1987-04-23 | Boehringer Mannheim Gmbh | Verfahren zur aktivierung von t-pa nach expression in prokaryonten |
| US4904602A (en) * | 1985-11-27 | 1990-02-27 | Repligen Corporation | Thioredoxin shufflease and use thereof |
| IL86455A0 (en) * | 1987-06-01 | 1988-11-15 | Takeda Chemical Industries Ltd | Polypeptide and production thereof |
| EP0315782B1 (de) * | 1987-10-13 | 1994-09-28 | Dr. Karl Thomae GmbH | Verfahren zur Herstellung von Proteinen |
| DE3813107A1 (de) | 1988-04-19 | 1989-11-02 | Consortium Elektrochem Ind | Sekretormutante von escherichia coli |
| EP0568647B1 (en) * | 1991-01-21 | 1996-09-11 | Genzyme Corporation | Production of enzymatically active glucocerebrosidase from recombinant cells |
-
1991
- 1991-04-26 DE DE4113750A patent/DE4113750A1/de not_active Withdrawn
-
1992
- 1992-04-16 CA CA002066370A patent/CA2066370C/en not_active Expired - Lifetime
- 1992-04-22 IE IE921291A patent/IE65792B1/en not_active IP Right Cessation
- 1992-04-23 EP EP92106978A patent/EP0510658B1/de not_active Expired - Lifetime
- 1992-04-23 ES ES92106978T patent/ES2057944T3/es not_active Expired - Lifetime
- 1992-04-23 DE DE59200312T patent/DE59200312D1/de not_active Expired - Lifetime
- 1992-04-23 DK DK92106978.7T patent/DK0510658T3/da active
- 1992-04-23 NO NO921574A patent/NO309153B1/no unknown
- 1992-04-23 IL IL10168692A patent/IL101686A/xx unknown
- 1992-04-23 AT AT92106978T patent/ATE109205T1/de not_active IP Right Cessation
- 1992-04-24 NZ NZ242492A patent/NZ242492A/xx not_active IP Right Cessation
- 1992-04-24 ZA ZA922971A patent/ZA922971B/xx unknown
- 1992-04-24 FI FI921838A patent/FI104262B/fi not_active IP Right Cessation
- 1992-04-24 AU AU15159/92A patent/AU636537B2/en not_active Ceased
- 1992-04-25 KR KR1019920007039A patent/KR960002869B1/ko not_active IP Right Cessation
- 1992-04-27 JP JP4107284A patent/JPH0753118B2/ja not_active Expired - Lifetime
-
1993
- 1993-07-27 US US08/097,621 patent/US6333175B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU636537B2 (en) | 1993-04-29 |
| JPH05268983A (ja) | 1993-10-19 |
| NO921574D0 (no) | 1992-04-23 |
| FI921838A (fi) | 1992-10-27 |
| EP0510658B1 (de) | 1994-07-27 |
| FI104262B1 (fi) | 1999-12-15 |
| DE59200312D1 (de) | 1994-09-01 |
| AU1515992A (en) | 1992-11-19 |
| CA2066370A1 (en) | 1992-10-27 |
| FI104262B (fi) | 1999-12-15 |
| ES2057944T3 (es) | 1994-10-16 |
| DE4113750A1 (de) | 1992-10-29 |
| NZ242492A (en) | 1993-09-27 |
| IL101686A0 (en) | 1992-12-30 |
| KR920019818A (ko) | 1992-11-20 |
| FI921838A0 (fi) | 1992-04-24 |
| IE921291A1 (en) | 1992-11-04 |
| CA2066370C (en) | 1996-04-02 |
| IE65792B1 (en) | 1995-11-29 |
| NO309153B1 (no) | 2000-12-18 |
| EP0510658A2 (de) | 1992-10-28 |
| KR960002869B1 (ko) | 1996-02-27 |
| DK0510658T3 (da) | 1994-11-28 |
| NO921574L (no) | 1992-10-27 |
| ZA922971B (en) | 1992-12-30 |
| JPH0753118B2 (ja) | 1995-06-07 |
| US6333175B1 (en) | 2001-12-25 |
| ATE109205T1 (de) | 1994-08-15 |
| EP0510658A3 (en) | 1993-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed |