IL101637A - Blood substitute solutions and dry mixtures thereof - Google Patents
Blood substitute solutions and dry mixtures thereofInfo
- Publication number
- IL101637A IL101637A IL101637A IL10163792A IL101637A IL 101637 A IL101637 A IL 101637A IL 101637 A IL101637 A IL 101637A IL 10163792 A IL10163792 A IL 10163792A IL 101637 A IL101637 A IL 101637A
- Authority
- IL
- Israel
- Prior art keywords
- solutions
- subject
- solution
- sodium
- matter
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000003633 blood substitute Substances 0.000 title 1
- 239000000243 solution Substances 0.000 abstract 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical class C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 210000000056 organ Anatomy 0.000 abstract 2
- 229910052708 sodium Inorganic materials 0.000 abstract 2
- 239000011734 sodium Chemical class 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical class [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical class [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000003841 chloride salts Chemical class 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 150000002402 hexoses Chemical class 0.000 abstract 1
- 239000011777 magnesium Chemical class 0.000 abstract 1
- 229910052749 magnesium Chemical class 0.000 abstract 1
- 230000010412 perfusion Effects 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68784191A | 1991-04-19 | 1991-04-19 | |
US86070392A | 1992-04-01 | 1992-04-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL101637A0 IL101637A0 (en) | 1992-12-30 |
IL101637A true IL101637A (en) | 1997-09-30 |
Family
ID=27104094
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL101637A IL101637A (en) | 1991-04-19 | 1992-04-17 | Blood substitute solutions and dry mixtures thereof |
Country Status (9)
Country | Link |
---|---|
US (1) | US5574019A (ja) |
EP (1) | EP0581883B1 (ja) |
JP (1) | JP3133330B2 (ja) |
AT (1) | ATE202937T1 (ja) |
CA (1) | CA2066374C (ja) |
DE (1) | DE69231929T2 (ja) |
ES (1) | ES2162797T3 (ja) |
IL (1) | IL101637A (ja) |
WO (1) | WO1992018136A1 (ja) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2164668T3 (es) * | 1992-10-30 | 2002-03-01 | Gennady Alexandrovich Markov | Compuesto para la estimulacion biologica y correccion del fenotipo de un organismo y un procedimiento para su produccion. |
US6680305B1 (en) | 1993-06-04 | 2004-01-20 | Biotime, Inc. | Physiologically acceptable aqueous solutions and methods for their use |
CA2164321C (en) * | 1993-06-04 | 2002-08-20 | Paul E. Segall | Plasma-like solution |
US6300322B1 (en) | 1993-06-04 | 2001-10-09 | Biotime, Inc. | Plasma-like solution |
CA2174806A1 (en) * | 1995-04-24 | 1996-10-25 | Frank Sever Jr. | Method and apparatus for enabling extracorporeal therapeutic treatment of a living patient's entire blood supply during a single uninterrupted time interval |
SE505499C2 (sv) * | 1995-12-15 | 1997-09-08 | Stiftelsen Facthor | Förvaringslösning för organ och vävnad eller delar därav från människor och djur innehållande kalcium och nitroglycerin, användning därav samt förfarande för förvaring därmed |
US6794124B2 (en) | 1995-12-15 | 2004-09-21 | Stiftelsen Facthor | Preservation solution |
US5843024A (en) * | 1996-05-17 | 1998-12-01 | Breonics, Inc. | Solution and process for resuscitation and preparation of ischemically damaged tissue |
US6743575B2 (en) | 1996-06-14 | 2004-06-01 | Biostore New Zealand Ltd. | Compositions and methods for the preservation of living tissues |
US6114107A (en) * | 1996-06-14 | 2000-09-05 | Biostore New Zealand Limited | Composition comprising raffinose, TMAO, sodium citrate and methods for the preservation of living tissues |
WO1997047192A1 (en) * | 1996-06-14 | 1997-12-18 | Biostore New Zealand Limited | Compositions and methods for the preservation of living tissues |
US20040229203A1 (en) * | 1996-06-14 | 2004-11-18 | Biostore New Zealand Ltd. | Compositions and methods for the preservation of living tissues |
US6361933B1 (en) | 1996-06-14 | 2002-03-26 | Biostore New Zealand Limited | Solutions for the preservation of tissues |
US5827640A (en) * | 1996-06-14 | 1998-10-27 | Biostore New Zealand Limited | Methods for the preservation of cells and tissues using trimethylamine oxide or betaine with raffinose or trehalose |
US5879875A (en) * | 1996-06-14 | 1999-03-09 | Biostore New Zealand | Compositions and methods for the preservation of living tissues |
US6040132A (en) * | 1996-06-14 | 2000-03-21 | Biostore New Zealand, Ltd. | Methods for the lyophilization of living biological materials |
US5962213A (en) * | 1996-06-14 | 1999-10-05 | Biostore New Zealand Limited | Compositions and methods for the preservation of living tissues |
US6037116A (en) * | 1996-06-14 | 2000-03-14 | Biostore New Zealand, Ltd. | Compositions comprising betaine, sodium citrate and sodium chloride and methods for the preservation of biological materials |
US6060233A (en) * | 1996-06-14 | 2000-05-09 | Biostore New Zealand, Ltd | Methods for the lyophilization of platelets, platelet membranes or erythrocytes |
US5814601A (en) * | 1997-02-28 | 1998-09-29 | The Regents Of The University Of California | Methods and compositions for optimization of oxygen transport by cell-free systems |
AU735799C (en) * | 1997-02-28 | 2005-04-28 | Regents Of The University Of California, The | Methods and compositions for optimisation of oxygen transport by cell-free systems |
CZ294795B6 (cs) * | 1997-10-31 | 2005-03-16 | Biotime, Inc. | Fyziologicky přijatelný vodný roztok a jeho použití |
US6589223B1 (en) * | 1999-02-03 | 2003-07-08 | Biotime, Inc. | Method and compositions for use in perfusion applications |
US6824389B1 (en) * | 1999-03-04 | 2004-11-30 | Medical Education & Research Institute | Post mortem reconstitution of circulation |
US6492103B1 (en) | 2000-01-31 | 2002-12-10 | Organ Recovery Systems, Inc. | System for organ and tissue preservation and hypothermic blood substitution |
JP2002302401A (ja) * | 2001-04-02 | 2002-10-18 | Okinawa Prefecture Deep Ocean Water Development Coop Society | 鮮度液及びその製造方法 |
EP1390518B1 (de) * | 2001-04-23 | 2004-10-06 | Amaxa GmbH | Pufferlössung für die elektroporation und verfahren umfassend die verwendung derselben |
US20070213793A1 (en) * | 2001-08-06 | 2007-09-13 | Radiant Medical, Inc. | Use of endovascular hypothermia in organ and/or tissue transplantations |
US20030153491A1 (en) * | 2002-01-11 | 2003-08-14 | Winslow Robert M. | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
US20050164915A1 (en) * | 2002-04-01 | 2005-07-28 | Sangart, Inc. | Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
JP3912206B2 (ja) * | 2002-07-05 | 2007-05-09 | 株式会社日立製作所 | 筒内直接燃料噴射装置用燃料ポンプ |
JP5470597B2 (ja) * | 2004-05-26 | 2014-04-16 | 国立大学法人 香川大学 | 希少糖d−アロースを利用した細胞・組織・臓器保存液及び該液を用いる保存方法 |
WO2006015353A2 (en) * | 2004-07-30 | 2006-02-09 | Washington University In St. Louis | Surgical cooling system and method |
GB0712833D0 (en) * | 2007-07-03 | 2007-08-08 | Aqix Ltd | Body Fluid Expander |
US8835104B2 (en) | 2007-12-20 | 2014-09-16 | Fenwal, Inc. | Medium and methods for the storage of platelets |
US8288084B2 (en) * | 2009-07-12 | 2012-10-16 | Revive Organtech, Inc. | Composition and method for flushing and cold/cryo preserving organs, tissues, and cells |
US9402866B2 (en) | 2011-04-07 | 2016-08-02 | Fenwal, Inc. | Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates |
BR112017000052B1 (pt) * | 2014-07-11 | 2022-09-13 | Limited Liability Company "Cardiosystempharma" (Llc "Csp") | Soluções cardioplégicas para alcançar e para manter a assistolia alcançada em cardioplegia sanguínea |
EP3221859B1 (en) | 2014-11-18 | 2020-10-21 | Maximum Fidelity Surgical Simulations, LLC | Post mortem reconstitution of circulation |
JP2018087154A (ja) * | 2016-11-28 | 2018-06-07 | 3C株式会社 | 保存装置および臓器移植方法 |
KR102700330B1 (ko) | 2017-01-17 | 2024-08-30 | 시비보 펄퓨전 에이비 | 장기 보존 및/또는 관류 용액 |
AU2018365257B2 (en) | 2017-11-13 | 2021-05-13 | Maximum Fidelity Surgical Simulations, LLC | Reconstitution of post mortem circulation, specialized methods and procedures |
CN113795247B (zh) | 2018-12-14 | 2024-04-05 | 陈益祥 | 用于心脏手术的稳定心脏麻痹液 |
US11716989B2 (en) | 2019-04-16 | 2023-08-08 | Maximum Fidelity Surgical Simulations, LLC | Cadaver preservation systems and methods |
US11915610B2 (en) | 2019-05-15 | 2024-02-27 | Maximum Fidelity Surgical Simulations, LLC | Cadaverous heart model |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4001401A (en) * | 1975-02-02 | 1977-01-04 | Alza Corporation | Blood substitute and blood plasma expander comprising polyhemoglobin |
US4061736A (en) * | 1975-02-02 | 1977-12-06 | Alza Corporation | Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin |
DE2801123C2 (de) * | 1977-01-26 | 1986-01-02 | Armour Pharma GmbH & Co KG, 3440 Eschwege | Verfahren zur Herstellung eines intravenös applizierbaren Serumeiweiß-Präparates |
US4170597A (en) * | 1977-12-08 | 1979-10-09 | American Cyanamid Company | 1-Hydroxymethyl-1-oxo-prostane derivatives of the E2 series |
US4245121A (en) * | 1980-02-04 | 1981-01-13 | American Cyanamid Company | Prostenoic acids and esters |
US5084377A (en) * | 1984-09-19 | 1992-01-28 | Larry Rowan | Cryogenic suspension method |
US4908350A (en) * | 1985-10-31 | 1990-03-13 | The Regents Of The University Of California | Hyperosmotic/hyperoncotic solutions for resuscitation of hypodynamic shock |
US5084558A (en) * | 1987-10-13 | 1992-01-28 | Biopure Corporation | Extra pure semi-synthetic blood substitute |
US4927806A (en) * | 1987-04-23 | 1990-05-22 | The Regents Of The University Of California | Saturated salt/concentrated dextran formulation to treat hemorrhage |
US5130230A (en) * | 1988-05-02 | 1992-07-14 | Cryomedical Sciences, Inc. | Blood substitute |
US4923442A (en) * | 1988-05-02 | 1990-05-08 | Cryomedical Sciences Inc. | Blood substitute |
US5082831A (en) * | 1989-12-05 | 1992-01-21 | Cryovita Laboratories, Inc. | Total body washout solution and method of use |
-
1992
- 1992-04-16 CA CA002066374A patent/CA2066374C/en not_active Expired - Fee Related
- 1992-04-17 IL IL101637A patent/IL101637A/xx active IP Right Grant
- 1992-04-17 AT AT92912306T patent/ATE202937T1/de not_active IP Right Cessation
- 1992-04-17 DE DE69231929T patent/DE69231929T2/de not_active Expired - Fee Related
- 1992-04-17 EP EP92912306A patent/EP0581883B1/en not_active Expired - Lifetime
- 1992-04-17 JP JP04511145A patent/JP3133330B2/ja not_active Expired - Lifetime
- 1992-04-17 WO PCT/US1992/003240 patent/WO1992018136A1/en active IP Right Grant
- 1992-04-17 ES ES92912306T patent/ES2162797T3/es not_active Expired - Lifetime
-
1993
- 1993-09-10 US US08/119,962 patent/US5574019A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
IL101637A0 (en) | 1992-12-30 |
ES2162797T3 (es) | 2002-01-16 |
ATE202937T1 (de) | 2001-07-15 |
US5574019A (en) | 1996-11-12 |
DE69231929T2 (de) | 2002-04-11 |
JPH06506950A (ja) | 1994-08-04 |
JP3133330B2 (ja) | 2001-02-05 |
EP0581883B1 (en) | 2001-07-11 |
EP0581883A1 (en) | 1994-02-09 |
DE69231929D1 (de) | 2001-08-16 |
EP0581883A4 (en) | 1995-04-19 |
CA2066374A1 (en) | 1992-10-20 |
WO1992018136A1 (en) | 1992-10-29 |
CA2066374C (en) | 2002-01-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL101637A (en) | Blood substitute solutions and dry mixtures thereof | |
CA2164321A1 (en) | Plasma-like solution | |
Arlian et al. | Survival and infestivity of Sarcoptes scabiei var. canis and var. hominis | |
DE60121027T2 (de) | Lösung zur evaluierung und konservierung | |
KR890009409A (ko) | 기관 보존 및 저장에 적당한 조성물 및 기관 보조 방법 | |
US20060088606A1 (en) | Methods and compositions for use in perfusion applications | |
WO1995002326A1 (en) | Solutions for tissue preservation and bloodless surgery and methods using same | |
Proctor et al. | Acute orthotopic transplantation of hearts stored for 72 hours | |
JP2004513955A (ja) | フラッシュ保存溶液(FlushPreservationSolution) | |
HUP9900112A2 (hu) | Tartósító oldat | |
US20080286745A1 (en) | Methods and Solutions for Tissue Preservation | |
Mankad et al. | Superior qualities of University of Wisconsin solution for ex vivo preservation of the pig heart | |
JP3989574B2 (ja) | 歯牙保存液 | |
McGowan Jr et al. | Prolonged neonatal myocardial preservation with a highly buffered low-calcium solution | |
JPH03188001A (ja) | 臓器保存用溶液 | |
KR900701286A (ko) | 혈액 대용품 | |
Takeuchi et al. | Prolonged preservation of the blood-perfused canine heart with glycolysis-promoting solution | |
JP2000191401A (ja) | 臓器保存剤 | |
Manax et al. | Observations on the homotransplanted canine heart following in vitro storage by hypothermia and hyperbaric oxygen | |
Day et al. | Development of Interarterial Intercoronary Anastomoses by Arteriovenous Fistula Between Pulmonary Artery and Left Atrium. | |
Kirklin | Historic overview of cardioplegia and reperfusion | |
Kosaka et al. | Ultrastructural damage to the preserved lung and its function after reperfusion | |
Bolli | Myocardial “reperfusion injury”: Fact or fiction? | |
Strete | Histological, ultrastructural, and ionic changes in rabbit ischemic myocardium: The effect of verapamil on tissue recovery. | |
Wiggins | A technique of adrenalectomizing lambs and a study of the associated pathological changes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed |