DE69231929D1 - Blutsubstitutions- und organerhaltende lösungen - Google Patents

Blutsubstitutions- und organerhaltende lösungen

Info

Publication number
DE69231929D1
DE69231929D1 DE69231929T DE69231929T DE69231929D1 DE 69231929 D1 DE69231929 D1 DE 69231929D1 DE 69231929 T DE69231929 T DE 69231929T DE 69231929 T DE69231929 T DE 69231929T DE 69231929 D1 DE69231929 D1 DE 69231929D1
Authority
DE
Germany
Prior art keywords
solutions
subject
solution
sodium
matter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69231929T
Other languages
English (en)
Other versions
DE69231929T2 (de
Inventor
Paul E Segall
Hal Sternberg
Harold D Waitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotime Inc
Original Assignee
Biotime Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotime Inc filed Critical Biotime Inc
Application granted granted Critical
Publication of DE69231929D1 publication Critical patent/DE69231929D1/de
Publication of DE69231929T2 publication Critical patent/DE69231929T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69231929T 1991-04-19 1992-04-17 Blutsubstitutions- und organerhaltende lösungen Expired - Fee Related DE69231929T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68784191A 1991-04-19 1991-04-19
US86070392A 1992-04-01 1992-04-01
PCT/US1992/003240 WO1992018136A1 (en) 1991-04-19 1992-04-17 Blood substitutes and organ preservative solutions

Publications (2)

Publication Number Publication Date
DE69231929D1 true DE69231929D1 (de) 2001-08-16
DE69231929T2 DE69231929T2 (de) 2002-04-11

Family

ID=27104094

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69231929T Expired - Fee Related DE69231929T2 (de) 1991-04-19 1992-04-17 Blutsubstitutions- und organerhaltende lösungen

Country Status (9)

Country Link
US (1) US5574019A (de)
EP (1) EP0581883B1 (de)
JP (1) JP3133330B2 (de)
AT (1) ATE202937T1 (de)
CA (1) CA2066374C (de)
DE (1) DE69231929T2 (de)
ES (1) ES2162797T3 (de)
IL (1) IL101637A (de)
WO (1) WO1992018136A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2164668T3 (es) * 1992-10-30 2002-03-01 Gennady Alexandrovich Markov Compuesto para la estimulacion biologica y correccion del fenotipo de un organismo y un procedimiento para su produccion.
US6680305B1 (en) 1993-06-04 2004-01-20 Biotime, Inc. Physiologically acceptable aqueous solutions and methods for their use
CA2164321C (en) * 1993-06-04 2002-08-20 Paul E. Segall Plasma-like solution
US6300322B1 (en) 1993-06-04 2001-10-09 Biotime, Inc. Plasma-like solution
CA2174806A1 (en) * 1995-04-24 1996-10-25 Frank Sever Jr. Method and apparatus for enabling extracorporeal therapeutic treatment of a living patient's entire blood supply during a single uninterrupted time interval
SE505499C2 (sv) * 1995-12-15 1997-09-08 Stiftelsen Facthor Förvaringslösning för organ och vävnad eller delar därav från människor och djur innehållande kalcium och nitroglycerin, användning därav samt förfarande för förvaring därmed
US6794124B2 (en) 1995-12-15 2004-09-21 Stiftelsen Facthor Preservation solution
US5843024A (en) * 1996-05-17 1998-12-01 Breonics, Inc. Solution and process for resuscitation and preparation of ischemically damaged tissue
US6743575B2 (en) 1996-06-14 2004-06-01 Biostore New Zealand Ltd. Compositions and methods for the preservation of living tissues
US6114107A (en) * 1996-06-14 2000-09-05 Biostore New Zealand Limited Composition comprising raffinose, TMAO, sodium citrate and methods for the preservation of living tissues
WO1997047192A1 (en) * 1996-06-14 1997-12-18 Biostore New Zealand Limited Compositions and methods for the preservation of living tissues
US20040229203A1 (en) * 1996-06-14 2004-11-18 Biostore New Zealand Ltd. Compositions and methods for the preservation of living tissues
US6361933B1 (en) 1996-06-14 2002-03-26 Biostore New Zealand Limited Solutions for the preservation of tissues
US5827640A (en) * 1996-06-14 1998-10-27 Biostore New Zealand Limited Methods for the preservation of cells and tissues using trimethylamine oxide or betaine with raffinose or trehalose
US5879875A (en) * 1996-06-14 1999-03-09 Biostore New Zealand Compositions and methods for the preservation of living tissues
US6040132A (en) * 1996-06-14 2000-03-21 Biostore New Zealand, Ltd. Methods for the lyophilization of living biological materials
US5962213A (en) * 1996-06-14 1999-10-05 Biostore New Zealand Limited Compositions and methods for the preservation of living tissues
US6037116A (en) * 1996-06-14 2000-03-14 Biostore New Zealand, Ltd. Compositions comprising betaine, sodium citrate and sodium chloride and methods for the preservation of biological materials
US6060233A (en) * 1996-06-14 2000-05-09 Biostore New Zealand, Ltd Methods for the lyophilization of platelets, platelet membranes or erythrocytes
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
AU735799C (en) * 1997-02-28 2005-04-28 Regents Of The University Of California, The Methods and compositions for optimisation of oxygen transport by cell-free systems
CZ294795B6 (cs) * 1997-10-31 2005-03-16 Biotime, Inc. Fyziologicky přijatelný vodný roztok a jeho použití
US6589223B1 (en) * 1999-02-03 2003-07-08 Biotime, Inc. Method and compositions for use in perfusion applications
US6824389B1 (en) * 1999-03-04 2004-11-30 Medical Education & Research Institute Post mortem reconstitution of circulation
US6492103B1 (en) 2000-01-31 2002-12-10 Organ Recovery Systems, Inc. System for organ and tissue preservation and hypothermic blood substitution
JP2002302401A (ja) * 2001-04-02 2002-10-18 Okinawa Prefecture Deep Ocean Water Development Coop Society 鮮度液及びその製造方法
EP1390518B1 (de) * 2001-04-23 2004-10-06 Amaxa GmbH Pufferlössung für die elektroporation und verfahren umfassend die verwendung derselben
US20070213793A1 (en) * 2001-08-06 2007-09-13 Radiant Medical, Inc. Use of endovascular hypothermia in organ and/or tissue transplantations
US20030153491A1 (en) * 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20050164915A1 (en) * 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
JP5470597B2 (ja) * 2004-05-26 2014-04-16 国立大学法人 香川大学 希少糖ｄ−アロースを利用した細胞・組織・臓器保存液及び該液を用いる保存方法
WO2006015353A2 (en) * 2004-07-30 2006-02-09 Washington University In St. Louis Surgical cooling system and method
GB0712833D0 (en) * 2007-07-03 2007-08-08 Aqix Ltd Body Fluid Expander
US8835104B2 (en) 2007-12-20 2014-09-16 Fenwal, Inc. Medium and methods for the storage of platelets
US8288084B2 (en) * 2009-07-12 2012-10-16 Revive Organtech, Inc. Composition and method for flushing and cold/cryo preserving organs, tissues, and cells
US9402866B2 (en) 2011-04-07 2016-08-02 Fenwal, Inc. Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates
BR112017000052B1 (pt) * 2014-07-11 2022-09-13 Limited Liability Company "Cardiosystempharma" (Llc "Csp") Soluções cardioplégicas para alcançar e para manter a assistolia alcançada em cardioplegia sanguínea
EP3221859B1 (de) 2014-11-18 2020-10-21 Maximum Fidelity Surgical Simulations, LLC Postmortale zirkulationsrekonstitution
JP2018087154A (ja) * 2016-11-28 2018-06-07 ３Ｃ株式会社 保存装置および臓器移植方法
KR102700330B1 (ko) 2017-01-17 2024-08-30 시비보 펄퓨전 에이비 장기 보존 및/또는 관류 용액
AU2018365257B2 (en) 2017-11-13 2021-05-13 Maximum Fidelity Surgical Simulations, LLC Reconstitution of post mortem circulation, specialized methods and procedures
CN113795247B (zh) 2018-12-14 2024-04-05 陈益祥 用于心脏手术的稳定心脏麻痹液
US11716989B2 (en) 2019-04-16 2023-08-08 Maximum Fidelity Surgical Simulations, LLC Cadaver preservation systems and methods
US11915610B2 (en) 2019-05-15 2024-02-27 Maximum Fidelity Surgical Simulations, LLC Cadaverous heart model

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4061736A (en) * 1975-02-02 1977-12-06 Alza Corporation Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
DE2801123C2 (de) * 1977-01-26 1986-01-02 Armour Pharma GmbH & Co KG, 3440 Eschwege Verfahren zur Herstellung eines intravenös applizierbaren Serumeiweiß-Präparates
US4170597A (en) * 1977-12-08 1979-10-09 American Cyanamid Company 1-Hydroxymethyl-1-oxo-prostane derivatives of the E2 series
US4245121A (en) * 1980-02-04 1981-01-13 American Cyanamid Company Prostenoic acids and esters
US5084377A (en) * 1984-09-19 1992-01-28 Larry Rowan Cryogenic suspension method
US4908350A (en) * 1985-10-31 1990-03-13 The Regents Of The University Of California Hyperosmotic/hyperoncotic solutions for resuscitation of hypodynamic shock
US5084558A (en) * 1987-10-13 1992-01-28 Biopure Corporation Extra pure semi-synthetic blood substitute
US4927806A (en) * 1987-04-23 1990-05-22 The Regents Of The University Of California Saturated salt/concentrated dextran formulation to treat hemorrhage
US5130230A (en) * 1988-05-02 1992-07-14 Cryomedical Sciences, Inc. Blood substitute
US4923442A (en) * 1988-05-02 1990-05-08 Cryomedical Sciences Inc. Blood substitute
US5082831A (en) * 1989-12-05 1992-01-21 Cryovita Laboratories, Inc. Total body washout solution and method of use

Also Published As

Publication number Publication date
IL101637A0 (en) 1992-12-30
IL101637A (en) 1997-09-30
ES2162797T3 (es) 2002-01-16
ATE202937T1 (de) 2001-07-15
US5574019A (en) 1996-11-12
DE69231929T2 (de) 2002-04-11
JPH06506950A (ja) 1994-08-04
JP3133330B2 (ja) 2001-02-05
EP0581883B1 (de) 2001-07-11
EP0581883A1 (de) 1994-02-09
EP0581883A4 (de) 1995-04-19
CA2066374A1 (en) 1992-10-20
WO1992018136A1 (en) 1992-10-29
CA2066374C (en) 2002-01-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee