IL101373A - Azadeclin Amides and thioamides and cholesterol biosynthetic inhibitors containing them - Google Patents

Azadeclin Amides and thioamides and cholesterol biosynthetic inhibitors containing them

Info

Publication number
IL101373A
IL101373A IL10137392A IL10137392A IL101373A IL 101373 A IL101373 A IL 101373A IL 10137392 A IL10137392 A IL 10137392A IL 10137392 A IL10137392 A IL 10137392A IL 101373 A IL101373 A IL 101373A
Authority
IL
Israel
Prior art keywords
aza
decal
dimethyl
compound
formula
Prior art date
Application number
IL10137392A
Other languages
English (en)
Hebrew (he)
Other versions
IL101373A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL101373A0 publication Critical patent/IL101373A0/xx
Publication of IL101373A publication Critical patent/IL101373A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL10137392A 1991-03-27 1992-03-25 Azadeclin Amides and thioamides and cholesterol biosynthetic inhibitors containing them IL101373A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/676,149 US5084461A (en) 1991-03-27 1991-03-27 Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis

Publications (2)

Publication Number Publication Date
IL101373A0 IL101373A0 (en) 1992-11-15
IL101373A true IL101373A (en) 1996-10-16

Family

ID=24713429

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10137392A IL101373A (en) 1991-03-27 1992-03-25 Azadeclin Amides and thioamides and cholesterol biosynthetic inhibitors containing them

Country Status (18)

Country Link
US (2) US5084461A (fr)
EP (1) EP0506072B1 (fr)
JP (1) JP3172975B2 (fr)
KR (1) KR100224046B1 (fr)
AT (1) ATE153021T1 (fr)
AU (1) AU641089B2 (fr)
CA (1) CA2063938C (fr)
DE (1) DE69219660T2 (fr)
DK (1) DK0506072T3 (fr)
ES (1) ES2103847T3 (fr)
FI (1) FI102373B1 (fr)
GR (1) GR3024367T3 (fr)
HU (1) HUT66656A (fr)
IE (1) IE920969A1 (fr)
IL (1) IL101373A (fr)
NO (1) NO178301C (fr)
NZ (1) NZ242108A (fr)
ZA (1) ZA922107B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5348964A (en) * 1990-07-25 1994-09-20 Merrell Dow Pharmaceuticals Inc. Piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis
US5084461A (en) * 1991-03-27 1992-01-28 Merrell Dow Pharmaceuticals Inc. Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis
US5350758A (en) * 1992-07-08 1994-09-27 Merrell Dow Pharmaceuticals Inc. Piperidyl sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis
DE4303840A1 (de) * 1992-10-22 1994-08-11 Thomae Gmbh Dr K Aryliden-1-azacycloalkane und Arylalkyl-1-azacycloalkane, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
US5466687A (en) * 1992-10-22 1995-11-14 Dr. Karl Thomae Gmbh Arylidene-1-azacycloalkanes and arylalkyl-1-azacyclo-alkanes, their salts, medicaments containing these compounds and their use, and processes for their preparation
FR2697252B1 (fr) * 1992-10-28 1994-12-09 Fournier Ind & Sante Dérivés de 1,2,3,5,6,7,8,8a-octahydro-5,5,8a-triméthyl-(8abeta)-6-isoquinolineamine, leur procédé de préparation et leur utilisation en thérapeutique.
DE19754795A1 (de) * 1997-12-10 1999-06-17 Boehringer Ingelheim Pharma Neue Urethane, ihre Thio- und Dithioanaloga, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
US6103733A (en) * 1998-09-09 2000-08-15 Bachmann; Kenneth A. Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200831497A (en) * 2006-10-12 2008-08-01 Epix Delaware Inc Carboxamide compounds and their use
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
KR20100102646A (ko) 2007-12-11 2010-09-24 가부시키가이샤 사이토파스파인더 카르복스아미드 화합물 및 케모카인 수용체 길항제로서의 이의 용도
EP2571860A1 (fr) 2010-05-21 2013-03-27 Pfizer Inc 2-phénylbenzoylamides
US20130345392A1 (en) 2011-03-04 2013-12-26 Pfizer Inc Edn3-like peptides and uses thereof
EP2986599A1 (fr) 2013-04-17 2016-02-24 Pfizer Inc. Dérivés de n-pipéridin-3-ylbenzamide dans le traitement des maladies cardiovasculaires
WO2016055901A1 (fr) 2014-10-08 2016-04-14 Pfizer Inc. Composés d'amide substitué
CA3125765A1 (fr) 2019-01-18 2020-07-23 Astrazeneca Ab Inhibiteurs de pcsk9 et leurs procedes d'utilisation
CN111334460A (zh) * 2020-03-30 2020-06-26 江苏师范大学 一种抑制黄曲霉温度耐受性的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565819A (en) * 1979-12-07 1986-01-21 Adir Substituted imino diacids, their preparation and pharmaceutical compositions which contain them
US5039801A (en) * 1985-12-20 1991-08-13 The United States Of America As Represented By The Department Of Health & Human Services Thermal fragmentation of methylbenzylurea disastereomers or secondary amines and preparation of optically active secondary amines
US4792555A (en) * 1987-03-20 1988-12-20 American Home Products Corporation Phospholipase A2 inhibitors
DK168069B1 (da) * 1987-11-11 1994-01-31 Hoffmann La Roche Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne
NZ230121A (en) * 1988-08-29 1993-08-26 Squibb & Sons Inc Pyridine and quinoline terminal groups for hmg-coenzyme a reductase inhibitors and pharmaceutical compositions for lowering blood serum cholesterol levels
US5084461A (en) * 1991-03-27 1992-01-28 Merrell Dow Pharmaceuticals Inc. Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis
US5124337A (en) * 1991-05-20 1992-06-23 Schering Corporation N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase

Also Published As

Publication number Publication date
NO921187D0 (no) 1992-03-26
NZ242108A (en) 1993-09-27
KR920018028A (ko) 1992-10-21
EP0506072A1 (fr) 1992-09-30
JPH05140112A (ja) 1993-06-08
DE69219660T2 (de) 1997-09-11
US5084461A (en) 1992-01-28
CA2063938A1 (fr) 1992-09-28
CA2063938C (fr) 2002-08-13
IE920969A1 (en) 1992-10-07
IL101373A0 (en) 1992-11-15
FI921327A0 (fi) 1992-03-26
HUT66656A (en) 1994-12-28
KR100224046B1 (ko) 1999-10-15
FI102373B (fi) 1998-11-30
NO921187L (no) 1992-09-28
DK0506072T3 (fr) 1997-06-09
FI102373B1 (fi) 1998-11-30
HU9200944D0 (en) 1992-05-28
ZA922107B (en) 1992-11-25
FI921327A (fi) 1992-09-28
EP0506072B1 (fr) 1997-05-14
NO178301B (no) 1995-11-20
JP3172975B2 (ja) 2001-06-04
GR3024367T3 (en) 1997-11-28
AU641089B2 (en) 1993-09-09
ATE153021T1 (de) 1997-05-15
DE69219660D1 (de) 1997-06-19
AU1309092A (en) 1992-10-01
ES2103847T3 (es) 1997-10-01
US5278171A (en) 1994-01-11
NO178301C (no) 1996-02-28

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Legal Events

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KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees