IE792501L - Citric acid derivatives. - Google Patents

Citric acid derivatives.

Info

Publication number
IE792501L
IE792501L IE792501A IE250179A IE792501L IE 792501 L IE792501 L IE 792501L IE 792501 A IE792501 A IE 792501A IE 250179 A IE250179 A IE 250179A IE 792501 L IE792501 L IE 792501L
Authority
IE
Ireland
Prior art keywords
formula
acid
see diagramm
threo
formula see
Prior art date
Application number
IE792501A
Other versions
IE49341B1 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/973,504 external-priority patent/US4312885A/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IE792501L publication Critical patent/IE792501L/en
Publication of IE49341B1 publication Critical patent/IE49341B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/295—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1. Claims for the Contracting States : BE CH DE FR GB IT LU NL SE Monochlorocitric acid derivatives of the formula see diagramm : EP0016867,P13,F3 and the corresponding threo-beta-lactones of the formula see diagramm : EP0016867,P13,F4 and pharmaceutically usable salts of these compounds. 1. Claims for the Contracting State : AT Process for the manufacture of monochlorocitric acid derivatives of the formula see diagramm : EP0016867,P15,F1 and the corresponding threo-beta-lactones of the formula see diagramm : EP0016867,P15,F2 as well as the pharmaceutically usable salts thereof, characterized by a) for the manufacture of a (+-)-threo-lactone of formula Ib, reacting an aqueous solution of a trialkali metal or trialkaline earth metal cis- or trans-aconitate with chlorine or hypochlorous acid and reacting the resulting salt of (+-)-threo-chlorocitric acid beta-lactone of the formula see diagramm : EP0016867,P15,F3 wherein M is an alkali metal or alkaline earth metal, with an acid, b) for the manufacture of (+-)-threo-chlorocitric acid of the formula see diagramm : EP0016867,P16,F1 hydrolyzing a compound of formula Ib or Ib 1, c) for the manufacture of a compound of formula Ia, cleaving epoxyaconitic acid with an alkali metal or alkaline earth metal chloride in an aqueous solvent in the presence of an acid, d) for the manufacture of (+-)-erythro-chlorocitric acid of the formula see diagramm : EP0016867,P16,F2 cleaving a compound of the formula see diagramm : EP0016867,P16,F3 wherein M' represents an alkali metal and R represents hydrogen or M', with an alkali metal chloride in an aqueous solvent in the presence of an acid, e) if desired, resolving a resulting (+-)-threo-citric acid derivative of formula Ia or Ib or (+-)-erythro-citric acid derivative of formula Ia into the optically active antipodes and isolating the desired antipode, f) if desired, isolating a resulting compound of formula Ia or Ib in the form of a pharmaceutically usable salt. [EP0016867A1]
IE2501/79A 1978-12-26 1979-12-21 Citric acid derivatives IE49341B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/973,504 US4312885A (en) 1978-12-26 1978-12-26 Chlorocitric acids
CH1058079 1979-11-28

Publications (2)

Publication Number Publication Date
IE792501L true IE792501L (en) 1980-06-26
IE49341B1 IE49341B1 (en) 1985-09-18

Family

ID=25706941

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2501/79A IE49341B1 (en) 1978-12-26 1979-12-21 Citric acid derivatives

Country Status (16)

Country Link
EP (1) EP0016867B1 (en)
AR (1) AR222201A1 (en)
AU (1) AU527139B2 (en)
CA (1) CA1138470A (en)
DE (1) DE2965783D1 (en)
DK (1) DK154641C (en)
ES (2) ES487247A0 (en)
FI (1) FI67073C (en)
HU (1) HU179987B (en)
IE (1) IE49341B1 (en)
IL (1) IL59015A (en)
MC (1) MC1299A1 (en)
NO (1) NO153491C (en)
NZ (1) NZ192423A (en)
PH (1) PH14915A (en)
PT (1) PT70628A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT500800B1 (en) 2004-09-08 2008-07-15 Biomedica Medizinprodukte Gmbh PROCESS FOR DETERMINING PROBNP

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3356721A (en) * 1962-03-21 1967-12-05 Richard H Wiley Citric acid manufacture
US3764692A (en) * 1970-09-30 1973-10-09 Hoffmann La Roche Method of treating obesity
US3901915A (en) * 1973-10-10 1975-08-26 Hoffmann La Roche Optical resolution of organic carboxylic acids
US4123458A (en) * 1975-12-22 1978-10-31 Lever Brothers Company Preparation of cis and trans aconitic acids and their salts

Also Published As

Publication number Publication date
IL59015A (en) 1983-10-31
NZ192423A (en) 1981-12-15
FI793976A (en) 1980-06-27
AR222201A1 (en) 1981-04-30
DK554079A (en) 1980-06-27
ES492727A0 (en) 1981-06-01
ES8105252A1 (en) 1981-06-01
CA1138470A (en) 1982-12-28
ES8100243A1 (en) 1980-11-01
EP0016867B1 (en) 1983-06-22
MC1299A1 (en) 1980-10-03
PH14915A (en) 1982-01-29
ES487247A0 (en) 1980-11-01
DK154641C (en) 1989-05-08
HU179987B (en) 1983-01-28
PT70628A (en) 1980-01-01
NO153491C (en) 1986-04-02
IE49341B1 (en) 1985-09-18
AU527139B2 (en) 1983-02-17
FI67073C (en) 1985-01-10
NO794232L (en) 1980-06-27
DK154641B (en) 1988-12-05
EP0016867A1 (en) 1980-10-15
NO153491B (en) 1985-12-23
IL59015A0 (en) 1980-03-31
DE2965783D1 (en) 1983-07-28
FI67073B (en) 1984-09-28
AU5400979A (en) 1980-07-03

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