IE780115L - Tetrahydro 1,2,4-triazines - Google Patents
Tetrahydro 1,2,4-triazinesInfo
- Publication number
- IE780115L IE780115L IE780115A IE11578A IE780115L IE 780115 L IE780115 L IE 780115L IE 780115 A IE780115 A IE 780115A IE 11578 A IE11578 A IE 11578A IE 780115 L IE780115 L IE 780115L
- Authority
- IE
- Ireland
- Prior art keywords
- group
- naphthyl
- phenyl
- phenyl group
- triazines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A nitrile is reacted with a 2-aminoethylhydrazine in the presence of transition metal salts or of elemental sulphur as catalyst. The new 3-diarylethyl-tetrahydro-1,2,4-triazines thus obtained, of formula <IMAGE> in which m = 0, n = 1, R is a hydrogen atom or a methyl or acetyl group, R1 is a hydrogen atom or a methyl group, A and B independently represent a naphthyl, 1,3-benzodioxol-5-yl or phenyl group or a phenyl group substituted by one or two fragments chosen from the following: lower alkyl, lower alkoxy, halo and naphthyl, provided that A is not a phenyl group when B is a phenyl or naphthyl group, and their pharmaceutically acceptable salts can be used as anxiolytic medicaments.
[GB1576579A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/761,177 US4071684A (en) | 1977-01-21 | 1977-01-21 | Process for producing 3-substituted 1,2,4-triazines |
| US05/803,927 US4263295A (en) | 1977-06-06 | 1977-06-06 | Psychoactive 3-(1-2-diarylethyl)-1,4,5,6-tetrahydro-1,2,4-triazines and their method of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE780115L true IE780115L (en) | 1978-07-21 |
| IE46246B1 IE46246B1 (en) | 1983-04-06 |
Family
ID=27116938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE115/78A IE46246B1 (en) | 1977-01-21 | 1978-01-18 | 3-substituted 1,2,4-triazines and their preparation |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5395987A (en) |
| AT (1) | AT360032B (en) |
| CH (1) | CH639080A5 (en) |
| DE (1) | DE2800385A1 (en) |
| DK (1) | DK152755C (en) |
| ES (1) | ES466205A1 (en) |
| FR (1) | FR2378019A1 (en) |
| GB (1) | GB1576579A (en) |
| IE (1) | IE46246B1 (en) |
| IT (1) | IT1111157B (en) |
| NL (1) | NL7800535A (en) |
| NO (1) | NO159529C (en) |
| SE (1) | SE447380B (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3497509A (en) * | 1966-12-05 | 1970-02-24 | Dow Chemical Co | Imino ester method for producing 1,4,5,6-tetrahydro-as-triazine |
| US3428635A (en) * | 1966-12-05 | 1969-02-18 | Dow Chemical Co | Substituted 1,4,5,6 - tetrahydro - as - triazines and a method for their production |
| US3471486A (en) * | 1967-10-23 | 1969-10-07 | Dow Chemical Co | 3-aralkyl-as-triazines |
-
1978
- 1978-01-05 DE DE19782800385 patent/DE2800385A1/en active Granted
- 1978-01-17 NL NL7800535A patent/NL7800535A/en not_active Application Discontinuation
- 1978-01-17 DK DK023078A patent/DK152755C/en not_active IP Right Cessation
- 1978-01-18 IE IE115/78A patent/IE46246B1/en not_active IP Right Cessation
- 1978-01-19 IT IT19422/78A patent/IT1111157B/en active
- 1978-01-19 NO NO78780201A patent/NO159529C/en unknown
- 1978-01-19 JP JP378478A patent/JPS5395987A/en active Granted
- 1978-01-20 SE SE7800737A patent/SE447380B/en not_active IP Right Cessation
- 1978-01-20 AT AT44378A patent/AT360032B/en not_active IP Right Cessation
- 1978-01-20 CH CH65378A patent/CH639080A5/en not_active IP Right Cessation
- 1978-01-20 FR FR7801672A patent/FR2378019A1/en active Granted
- 1978-01-20 ES ES466205A patent/ES466205A1/en not_active Expired
- 1978-01-20 GB GB2389/78A patent/GB1576579A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1576579A (en) | 1980-10-08 |
| SE447380B (en) | 1986-11-10 |
| NL7800535A (en) | 1978-07-25 |
| AT360032B (en) | 1980-12-10 |
| DK152755B (en) | 1988-05-09 |
| CH639080A5 (en) | 1983-10-31 |
| DK23078A (en) | 1978-07-22 |
| NO159529C (en) | 1989-01-11 |
| SE7800737L (en) | 1978-07-22 |
| ES466205A1 (en) | 1979-06-01 |
| DK152755C (en) | 1988-10-03 |
| IT7819422A0 (en) | 1978-01-19 |
| NO780201L (en) | 1978-07-24 |
| FR2378019A1 (en) | 1978-08-18 |
| JPS6241227B2 (en) | 1987-09-02 |
| FR2378019B1 (en) | 1980-08-22 |
| DE2800385C2 (en) | 1989-01-26 |
| IE46246B1 (en) | 1983-04-06 |
| IT1111157B (en) | 1986-01-13 |
| NO159529B (en) | 1988-10-03 |
| JPS5395987A (en) | 1978-08-22 |
| DE2800385A1 (en) | 1978-07-27 |
| ATA44378A (en) | 1980-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |