FR2378019A1 - MANUFACTURING PROCESS OF TETRAHYDRO-1,2,4, -TRIAZINES 3-SUBSTITUTES AND NEWS 3-DIARYLETHYLTETRAHYDRO-1,2,4-TRIAZINES, USEFUL IN PARTICULAR AS ANTIANXIETY AGENTS - Google Patents

MANUFACTURING PROCESS OF TETRAHYDRO-1,2,4, -TRIAZINES 3-SUBSTITUTES AND NEWS 3-DIARYLETHYLTETRAHYDRO-1,2,4-TRIAZINES, USEFUL IN PARTICULAR AS ANTIANXIETY AGENTS

Info

Publication number
FR2378019A1
FR2378019A1 FR7801672A FR7801672A FR2378019A1 FR 2378019 A1 FR2378019 A1 FR 2378019A1 FR 7801672 A FR7801672 A FR 7801672A FR 7801672 A FR7801672 A FR 7801672A FR 2378019 A1 FR2378019 A1 FR 2378019A1
Authority
FR
France
Prior art keywords
triazines
tetrahydro
diarylethyltetrahydro
news
substitutes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7801672A
Other languages
French (fr)
Other versions
FR2378019B1 (en
Inventor
Albert Joseph Schuster Jr
John Martin
David Mark Spatz
Paul James Widner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/761,177 external-priority patent/US4071684A/en
Priority claimed from US05/803,927 external-priority patent/US4263295A/en
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of FR2378019A1 publication Critical patent/FR2378019A1/en
Application granted granted Critical
Publication of FR2378019B1 publication Critical patent/FR2378019B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

L'invention concerne un procédé de préparation de tétrahydro-1,2,4-triazines 3-substituées et de nouveaux médicaments psychoactifs obtenus par ce procédé. Selon l'invention, on fait réagir un nitrile avec une 2-aminoéthylhydrazine ou une 2-aminoethylhydrazine subsituée en présence d'une quantité catalytique de soufre élémentaire ou d'un sel de métal de transition. Application : notamment comme agents antianxiété en compositions contenant 0,01 à 95 % en poids de l'ingrédient actif, à des doses de 0,2 à 40 mg/kg.The invention relates to a process for the preparation of 3-substituted tetrahydro-1,2,4-triazines and to novel psychoactive drugs obtained by this process. According to the invention, a nitrile is reacted with a 2-aminoethylhydrazine or a substituted 2-aminoethylhydrazine in the presence of a catalytic amount of elemental sulfur or of a transition metal salt. Application: in particular as anti-anxiety agents in compositions containing 0.01 to 95% by weight of the active ingredient, at doses of 0.2 to 40 mg / kg.

FR7801672A 1977-01-21 1978-01-20 MANUFACTURING PROCESS OF TETRAHYDRO-1,2,4, -TRIAZINES 3-SUBSTITUTES AND NEWS 3-DIARYLETHYLTETRAHYDRO-1,2,4-TRIAZINES, USEFUL IN PARTICULAR AS ANTIANXIETY AGENTS Granted FR2378019A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/761,177 US4071684A (en) 1977-01-21 1977-01-21 Process for producing 3-substituted 1,2,4-triazines
US05/803,927 US4263295A (en) 1977-06-06 1977-06-06 Psychoactive 3-(1-2-diarylethyl)-1,4,5,6-tetrahydro-1,2,4-triazines and their method of use

Publications (2)

Publication Number Publication Date
FR2378019A1 true FR2378019A1 (en) 1978-08-18
FR2378019B1 FR2378019B1 (en) 1980-08-22

Family

ID=27116938

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7801672A Granted FR2378019A1 (en) 1977-01-21 1978-01-20 MANUFACTURING PROCESS OF TETRAHYDRO-1,2,4, -TRIAZINES 3-SUBSTITUTES AND NEWS 3-DIARYLETHYLTETRAHYDRO-1,2,4-TRIAZINES, USEFUL IN PARTICULAR AS ANTIANXIETY AGENTS

Country Status (13)

Country Link
JP (1) JPS5395987A (en)
AT (1) AT360032B (en)
CH (1) CH639080A5 (en)
DE (1) DE2800385A1 (en)
DK (1) DK152755C (en)
ES (1) ES466205A1 (en)
FR (1) FR2378019A1 (en)
GB (1) GB1576579A (en)
IE (1) IE46246B1 (en)
IT (1) IT1111157B (en)
NL (1) NL7800535A (en)
NO (1) NO159529C (en)
SE (1) SE447380B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3471486A (en) * 1967-10-23 1969-10-07 Dow Chemical Co 3-aralkyl-as-triazines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3428635A (en) * 1966-12-05 1969-02-18 Dow Chemical Co Substituted 1,4,5,6 - tetrahydro - as - triazines and a method for their production
US3497509A (en) * 1966-12-05 1970-02-24 Dow Chemical Co Imino ester method for producing 1,4,5,6-tetrahydro-as-triazine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3471486A (en) * 1967-10-23 1969-10-07 Dow Chemical Co 3-aralkyl-as-triazines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NV2054/69 *

Also Published As

Publication number Publication date
SE447380B (en) 1986-11-10
SE7800737L (en) 1978-07-22
AT360032B (en) 1980-12-10
IE780115L (en) 1978-07-21
DK152755B (en) 1988-05-09
DK152755C (en) 1988-10-03
JPS5395987A (en) 1978-08-22
DE2800385A1 (en) 1978-07-27
ES466205A1 (en) 1979-06-01
ATA44378A (en) 1980-05-15
NL7800535A (en) 1978-07-25
NO159529C (en) 1989-01-11
IE46246B1 (en) 1983-04-06
DK23078A (en) 1978-07-22
FR2378019B1 (en) 1980-08-22
CH639080A5 (en) 1983-10-31
NO780201L (en) 1978-07-24
IT7819422A0 (en) 1978-01-19
IT1111157B (en) 1986-01-13
JPS6241227B2 (en) 1987-09-02
DE2800385C2 (en) 1989-01-26
NO159529B (en) 1988-10-03
GB1576579A (en) 1980-10-08

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