IE55645B1 - Artificial milk for feeding the newborn and young infants - Google Patents

Artificial milk for feeding the newborn and young infants

Info

Publication number
IE55645B1
IE55645B1 IE262984A IE262984A IE55645B1 IE 55645 B1 IE55645 B1 IE 55645B1 IE 262984 A IE262984 A IE 262984A IE 262984 A IE262984 A IE 262984A IE 55645 B1 IE55645 B1 IE 55645B1
Authority
IE
Ireland
Prior art keywords
artificial milk
placenta
milk according
fatty acids
lipid extract
Prior art date
Application number
IE262984A
Other versions
IE842629L (en
Original Assignee
Bio Extraction S A R L
Oleagineux Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Extraction S A R L, Oleagineux Ind filed Critical Bio Extraction S A R L
Publication of IE842629L publication Critical patent/IE842629L/en
Publication of IE55645B1 publication Critical patent/IE55645B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C11/00—Milk substitutes, e.g. coffee whitener compositions
    • A23C11/02—Milk substitutes, e.g. coffee whitener compositions containing at least one non-milk component as source of fats or proteins
    • A23C11/04—Milk substitutes, e.g. coffee whitener compositions containing at least one non-milk component as source of fats or proteins containing non-milk fats but no non-milk proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/1528—Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Dairy Products (AREA)
  • Cosmetics (AREA)

Description

2 The present invention has as its subject an artificial milk for feeding the newborn and infants.
Artificial milks are used to carry out feeding in infants in the weeks and months following birth, insofar as the feeding cannot be carried out with breast milk.
An artificial milk is obtained by mixing proteins, carbohydrates, fats, vitamins and mineral supplies, which have to be emulsified in water to give a milk. This emulsification is only possible in the presence of emulsifiers.
It is also known that artificial milks do not contain certain constituents present in breast milk. This is the case with arachidonic acid. Now the latter is not synthesised by an infant in the ueeks following birth.
The organism therefore suffers from a deficiency of arachidonic acid which can result in an insufficiency of the latter during the period of organogenesis, especially in relation to the central nervous system.
French Patent Application 2 197 605 concerns improvements relating to food materials, indicating that one may improve nutrition, and notably the nutrition of infants, by supplying the human body regularly with arachidonic acid. Nevertheless the origin of the arachidonic acid is not mentioned in this document.
The problem posed is hence that of obtaining arachidonic acid and incorporating it in an artificial milk. Putting this into practice has never been accomplished, on account, of the difficulties of obtaining arachidonic acid from the known sources, such as pig's liver or other offal with all the disadvantages which stem from this (collection systems poorly suited to the needs of the 'dietetics industry, treatments which run the risk of altering the product or reducing its stability, need to continue purification until a pure fatty acid is 3 obtained, etc.).
On the other hand, it is known that the placenta contains 2.5 to 3X of a complex lipid mixture, substantially comprising 15X of free and esterified cholesterol, 5 45% of phospholipids and 40X of free fatty acids, partial glycerides and triglycerides. In the latter two fractions, the proportion of arachidonic acid is of the order of 16 to 20X. Placenta of human or animal origin hence constitutes a source which is extremely rich in arachidonic 10 acid. The human origin of the product is an advantage which permits a reduction in the monitoring designed for checking the absence of harmful compounds, and which ensures that the composition of the product will be highly suitable to the needs of the infant.
The present invention provides an artificial milk for feeding the newborn and for infants, comprising a mixture of proteins, carbohydrates and fats, and containing long-chain polyunsaturated fatty acids higher than C18, chosen from the acids C20: 4w6, C20: 3w6 and C22: 6w3 present 20 in a lipid extract of human placenta.
This lipid extract contains arachidonic acid in position H, and this constitutes an advantageous characteristic since fatty acids situated in this position are rapidly assimilated.
Furthermore, it has been ascertained that the emulsifying capacity of the lipids of the placenta is especially high, and that it is thus possible to obtain a very fine, stable emulsion for artificial milks. 4 In addition, experiments on stability have shown that the stability to oxidation of arachidonic acid of placental origin can partially explain this phenomenon, in particular certain fractions of unsaponifiable lipid.
Chemical parameters (peroxide and carbonyl) and physicochemical parameters (E^ at 232 nm; E^j at 270 nm; e1| at 303 nm and at 318 nm; acid values and content of C20: 4w6) have verified the stability with respect to time.
The milk according to the invention hence re-10 sembles breast milk much more closely than do the traditional milks, while being more readily digestible on account of the fineness and stability of the emulsion in which form it occurs.
The lipid extract of placenta is incorporated in 13 the mixture forming the milk in proportions such that the content of long-chain (higher than C18) polyunsaturated fatty acids represents approximately 1% of the total lipid phase.
According to a first possibility, the milk con-20 tains the total lipid phase extracted from the placenta.
This solution is advantageous since it provides an excellent emulsion and avoids or reduces the addition of antioxidants.
According to another possibility, the milk con-25 tains only the phospholipids recovered from the total lipid phase extracted from a placenta. These phospholipids are obtained by recovery of the fraction insoluble in acetone, by extraction at low temperature. While this procedure enables cholesterol, free fatty acids and 5 triglycerides to be removed, it causes a number of natural antioxidants to disappear.
For this reason, to improve the resistance to oxidation, it is preferable to add antioxidants to the fatty 5 phase, especially those, such as tocopherols, chosen from the unsaponifiable fraction of the lipids of the placenta.
It should be noted that the total lipid phase can be extracted by any suitable method, such as the FOLCH method.
According to further possibilities, the milk according to the invention contains the free fatty acids or the glycerides of a lipid extract of placenta, or a mixture of these two components or a mixture of one of these components with the phospholipids of an extract of 15 placenta.
Tables I and II show, respectively, the phospholipid composition of an extract of placenta, and the fatty acid composition of, on the one hand the total lipids, and on the other hand the total phospholipids. It should 20 be noted that in Table II, each fatty acid is identified by a complex number the first component of which designates the number of C, the second component designates the number of double bonds, and the third component, following the symbol w, designates the position of the first 25 double bond. Arachidonic acid is the C20 fatty acid C20: 4w6 6 TABLE X PHOSPHOLIPID COMPOSITION (moles %) Phosphatidyl choline 43.20 Sph i ngomyeli n 22.90 Phosphatidyl ethanolaitiine 22.16 Lysophosphatidyl choline 5.46 Lysophosphatidyl ethanolaraine 2.52 Phosphatidyl inositol 1.30 Ca rdiolipids 1.23 Phosphatidyl serine 1 .23 100.00 7 TABLE II FATTY ACID COMPOSITION .OF THE TOTAL LIPIDS .OF THE TOTAL PHOSPHOLIPIDS (in % of the total fatty acids) PERCENTAGE NAME OF THE FATTY ACID TOTAL LIPIDS TOTAL PHOSPHOLIPIDS 14:0 0.57 + 0.02 0.62 + 0.07 15:0 0.24 ± 0.03 0.37 ± 0.15 16:0 2.27 + 0.17 3.59 ± 0.37 16:0 24.53 + 0.19 28.89 + 0.98 16:1 1.56 + 0.10 1 .33 + 0.08 17:0 0.34 ± 0.06 0.50 + 0.20 18:0 1.18 t 0.15 1.87 + 0.31 18:0 12.67 ± 0.55 13.19 + 0.27 18:1 12.58 ± 0.18 11.17 ± 0.25 18:2 10.65 ± 0.03 8.82 + 0.11 19:1 0.07 ± 0.02 Trace 18:3w3 Trace 20:0 0.16 + 0.01 0.42 ± 0.10 20:1 0.22 + 0.02 0.44 + 0.24 20:2w6 0.53 + 0.00 0.80 + Q.40 20:3w6 4.69 + 0.01 4.00 + 1.20 20:4w6 19.08 ± 0.45 16.03 ± 1.15 22:0 ; 0.72 + 0.12 1.36 ± 0.28 22:1 | /or 20 : 5w3 J 0.22 + 0.04 0.10 23:0 0.12 + 0.02 0.15 + 0.02 22:4w6 0.69 ± 0.48 1.17+ 0.08 22:5w6 j 0.63 + 0.04 0.38 + 0.05 24:0 I 0.80 + 0.10 1.14 24:1 ] I /or 22: 5w3 J i 1.30 + 0.16 1 .61 + 0.03 t 22:6w3 1 3.59 + 0.02 2.19 + 0.26

Claims (10)

8
1. Artificial milk for feeding the newborn and infants, comprising a mixture of proteins, carbohydrates and fats, and containing long-chain polyunsaturated fatty acids higher than C18, chosen from the acids C20: 4w6, C20s 3w6 and C22: 6w3 present in a lipid extract of human placenta.
2. Artificial milk according to Claim 1, which contains the phospholipids of a lipid extract of placenta.
3. Artificial milk according to Claim 1, which contains the free fatty acids of a lipid extract of placenta.
4. Artificial milk according to Claim 1, which contains the glycerides of a lipid extract of placenta.
5. Artificial milk according to the combined Claims 1 to 4, which contains a combination of two of the components consisting of the phospholipids, the free fatty acids and the glycerides of a lipid extract of placenta. 9
6. Artificial milk according to the combined Claims 1 to 4, which contains the total lipid phase extracted from the placenta.
7. Artificial milk according to any one of Claims 1 5 to 6, wherein the quantity of lipid extract introduced into the mixture is such that the content of long-chain (higher than C18) polyunsaturated fatty acids is of the order of 1% of the total lipid phase.
8. Artificial milk according to any one of Claims 1 10 to 7, which contains antioxidants.
9. Artificial milk according to Claim 8, wherein the antioxidants correspond to those present in the unsaponifiable fraction of the lipids of the placenta.
10. Artificial milk according to Claim 1, 15 substantially as hereinbefore described. F. R. KELLY & CO., AGENTS FOR THE APPLICANTS.
IE262984A 1983-10-14 1984-10-12 Artificial milk for feeding the newborn and young infants IE55645B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8316664A FR2553261B1 (en) 1983-10-14 1983-10-14 ARTIFICIAL MILK FOR THE FEEDING OF NEWBORNS AND YOUNG CHILDREN

Publications (2)

Publication Number Publication Date
IE842629L IE842629L (en) 1985-04-14
IE55645B1 true IE55645B1 (en) 1990-12-05

Family

ID=9293316

Family Applications (1)

Application Number Title Priority Date Filing Date
IE262984A IE55645B1 (en) 1983-10-14 1984-10-12 Artificial milk for feeding the newborn and young infants

Country Status (6)

Country Link
EP (1) EP0140805B1 (en)
DE (1) DE3468618D1 (en)
DK (1) DK163859C (en)
FR (1) FR2553261B1 (en)
GR (1) GR80632B (en)
IE (1) IE55645B1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3603000A1 (en) * 1986-01-31 1987-08-06 Milupa Ag NEW FATTY MIXTURE OF POLYENIC ACID AND THEIR USE IN THE PRODUCTION OF INFANT FOODS
DE3920679A1 (en) * 1989-06-23 1991-01-10 Milupa Ag FAT MIXTURE FOR THE MANUFACTURE OF FOOD, ESPECIALLY SUGAR FOODS
AU661297B2 (en) * 1991-01-24 1995-07-20 Martek Corporation Microbial oil mixtures and uses thereof
PH11992043811B1 (en) * 1991-01-24 2002-08-22 Martek Corp Arachidonic acid and methods for the production and use thereof
NL9401644A (en) 1994-10-06 1996-05-01 Friesland Brands Bv Food for pregnant and lactating women
EP0711503A3 (en) 1994-11-14 1997-11-26 Scotia Holdings Plc Milk fortified with GLA and/or DGLA
GB9423625D0 (en) 1994-11-23 1995-01-11 Scotia Holdings Plc Fortified fruit juice
US20220369660A1 (en) 2019-09-24 2022-11-24 Societe Des Produits Nestle S.A. Glycyrrhiza and the prevention of lc-pufa oxidation
WO2021255061A1 (en) 2020-06-17 2021-12-23 Société des Produits Nestlé S.A. Stabilization of lc-pufas by side stream product from green coffee decaffeination

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2611706A (en) * 1949-12-21 1952-09-23 Wyeth Corp Fat composition for infants' food
GB955347A (en) * 1962-07-11 1964-04-15 Vaasan Hoeyrymylly Oy A method of producing a drink for calves
US3488198A (en) * 1967-03-01 1970-01-06 Beatrice Foods Co Filled milk product
BE787961A (en) * 1971-08-24 1973-02-26 Behringwerke Ag PROCESS FOR ISOLATING A THROMBOPLASTIC MATERIAL AND A MEDICINAL PRODUCT CONTAINING THE SAID MATERIAL
FR2197605A1 (en) * 1972-09-06 1974-03-29 Williams John Foodstuff or skin nutrient to combat cholesterolaemia - contains arachidonic acid or gamma linolenic acid or esters and salts thereof
CH658458A5 (en) * 1981-12-17 1986-11-14 Lucchini Lab Sa PROCESS FOR OBTAINING LACTO-N-NORHEXAOSYL CERAMIDE.
FR2522935A1 (en) * 1982-03-10 1983-09-16 Chevalier Jacques NOVEL PRODUCTS BASED ON MILK AND ITS DERIVATIVES RICH IN POLYUNSATURATED FATTY ACIDS AND THEIR PREPARATION PROCESS

Also Published As

Publication number Publication date
DK491084D0 (en) 1984-10-12
DK491084A (en) 1985-04-15
EP0140805A3 (en) 1985-06-19
FR2553261A1 (en) 1985-04-19
IE842629L (en) 1985-04-14
EP0140805B1 (en) 1988-01-13
DK163859B (en) 1992-04-13
EP0140805A2 (en) 1985-05-08
FR2553261B1 (en) 1986-02-21
DK163859C (en) 1992-09-14
DE3468618D1 (en) 1988-02-18
GR80632B (en) 1985-02-13

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