JP2525624B2 - Baby milk powder containing polyunsaturated fatty acids - Google Patents
Baby milk powder containing polyunsaturated fatty acidsInfo
- Publication number
- JP2525624B2 JP2525624B2 JP62234886A JP23488687A JP2525624B2 JP 2525624 B2 JP2525624 B2 JP 2525624B2 JP 62234886 A JP62234886 A JP 62234886A JP 23488687 A JP23488687 A JP 23488687A JP 2525624 B2 JP2525624 B2 JP 2525624B2
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- Japan
- Prior art keywords
- acid
- milk powder
- gamma
- polyunsaturated fatty
- infants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Description
【発明の詳細な説明】 産業上の利用分野 本発明は、特定な多価不飽和脂肪酸を特定量配合する
ことにより、栄養及び生理活性を一層高めた育児用粉乳
に関する。TECHNICAL FIELD The present invention relates to a milk powder for child-rearing in which nutrition and physiological activity are further enhanced by incorporating a specific amount of a specific polyunsaturated fatty acid.
技術的背景 従来、多価不飽和脂肪酸であるガンマ・リノレン酸が
アトピー性皮膚炎に対して治療効果を有することは知ら
れており、また、同じくエイコサペンタエン酸並びにド
コサヘキサエン酸が血小板凝集抑制作用、血中中性脂肪
低下作用、血中VLDL及びLDLコレステロール低下作用等
を有していて動脈硬化性疾患の予防、治療効果を有する
ことも知られている。Technical Background Conventionally, it is known that gamma linolenic acid, which is a polyunsaturated fatty acid, has a therapeutic effect on atopic dermatitis, and also eicosapentaenoic acid and docosahexaenoic acid have an inhibitory effect on platelet aggregation, It is also known to have a blood triglyceride lowering action, a blood VLDL and LDL cholesterol lowering action and the like, and to have an effect of preventing and treating arteriosclerotic diseases.
更に、ガンマ・リノレン酸から生合成されるジホモ・
ガンマ・リノレン酸、アラキドン酸及びエイコサペンタ
エン酸は、最近生理活性物質として注目されているプロ
スタグランジンの前駆体として重要であることが報告さ
れている。In addition, dihomo-synthesized from gamma-linolenic acid
It has been reported that gamma linolenic acid, arachidonic acid and eicosapentaenoic acid are important as precursors of prostaglandins, which have recently received attention as physiologically active substances.
一方、ガンマ・リノレン酸、エイコサペンタエン酸及
びドコサヘキサエン酸は、自然界において母乳、月見草
種子、糸状菌（モルテイエレラ属、Mortierella）、魚
油、網膜、脳等に存在しており、また生体内において
も、リノール酸及びアルフア・リノレン酸から不飽和化
酵素（desaturase）及び鎖長延長酵素（elongation enz
yme）により合成されることが知られている。On the other hand, gamma-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid are naturally present in breast milk, evening primrose seed, filamentous fungi (Mortierella, Mortierella), fish oil, retina, brain, etc. Acid and alpha linolenic acid to desaturase and chain elongation enzyme (elongation enz)
yme) is known to be synthesized.
しかしながら、ヒトの生体内におけるリノール酸から
のガンマ・リノレン酸の生成及びアルフア・リノレン酸
からのエイコサペンタエン酸とドコサヘキサエン酸の生
成は少く、又摂取するリノール酸及びアルフア・リノレ
ン酸の量により抑制されること等、種々の合成阻止因子
が存在することが報告されていることに鑑み、これらの
多価不飽和脂肪酸を直接食餌成分として摂取することが
望ましいと考えられている。However, the production of gamma-linolenic acid from linoleic acid and the production of eicosapentaenoic acid and docosahexaenoic acid from alpha-linolenic acid in humans were low, and the amount of linoleic acid and alfa-linolenic acid ingested suppressed the production. In view of the fact that various synthetic inhibitory factors exist, it is considered desirable to directly ingest these polyunsaturated fatty acids as diet components.
特に、乳児期においては、上記不飽和化酵素活性が低
いと考えられること、一方母乳中にはガンマ・リノレン
酸、エイコサペンタエン酸及びドコサヘキサエン酸が共
に多く含まれていることを考慮すると、育児用粉乳によ
る人工栄養で哺育する幼児では、これらの多価不飽和脂
肪酸を摂取することが必要であると言える。In particular, considering that the above desaturase activity is considered to be low in the infancy, on the other hand, considering that milk contains a large amount of both gamma-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid, It can be said that these polyunsaturated fatty acids need to be ingested in infants fed by artificial nutrition with powdered milk.
しかし、育児用粉乳による人工栄養児と母乳栄養児と
の間における上記多価不飽和脂肪酸の摂取量の差異に基
づく栄養代謝及び生理上の影響については未だ明らかに
されていないことから、育児用粉乳へのこれら多価不飽
和脂肪酸の配合の必要性も明らかでない。However, nutritional metabolism and physiological effects based on the difference in the intake of polyunsaturated fatty acids between artificial infants and breast-fed infants with infant formula have not been clarified yet. The necessity of compounding these polyunsaturated fatty acids with milk powder is also not clear.
なお、ガンマ・リノレン酸をミルクへ添加することに
ついては、特開昭61−224932号公報及び特開昭62−7973
2号公報に開示されているが、これらの開示は、前述し
た不飽和酵素の機能低下による生体内でのガンマ・リノ
レン酸の合成能の欠除に伴う健康上の障害を治療するこ
とを目的としており、特に人工栄養児における栄養代謝
及び生理機能を、母乳栄養児に近似させることを意図し
たものでない。Regarding the addition of gamma linolenic acid to milk, JP-A-61-224932 and JP-A-62-7973 are known.
Although disclosed in Japanese Patent Publication No. 2), these disclosures are intended to treat health disorders associated with the lack of the ability to synthesize gamma-linolenic acid in vivo due to the above-mentioned functional deterioration of unsaturated enzymes. In particular, it is not intended to approximate the nutritional metabolism and physiological function of artificially fed infants to those of breast-fed infants.
従来から、乳児にとつての最良の栄養源は母乳である
との観点から、育児用粉乳を母乳の組成及び機能に近似
させるための種々の改良がなされてきたが、上述したよ
うに、ガンマ・リノレン酸、エイコサペンタエン酸及び
ドコサヘキサエン酸から成る多価不飽和脂肪酸の乳児期
における必要性については未だ明らかにされていないこ
とから、これらの多価不飽和脂肪酸の人工栄養児に対す
る摂取の重要性も現在のところ明らかにされていない。From the viewpoint that breast milk is the best nutritional source for infants, various improvements have been made so far to approximate the composition and function of breast milk powder, but as described above, gamma・ Since the need for polyunsaturated fatty acids consisting of linolenic acid, eicosapentaenoic acid and docosahexaenoic acid in infancy has not been clarified yet, the importance of intake of these polyunsaturated fatty acids to artificially fed children is important. Has not been disclosed so far.
発明が解決しようとする課題 本発明は、ガンマ・リノレン酸、エイコサペンタエン
酸及びドコサヘキサエン酸を育児用粉乳に特定量配合し
て人工栄養児に摂取させることにより、人工栄養児の血
清リン脂質画分中脂肪酸組成を、母乳栄養児の血清リン
脂質画分中脂肪酸組成に近似させ得ることの知見に基づ
いてなされたものであつて、乳児の細胞膜機能及び血液
凝固能等を正常に維持するうえで重要な因子である上記
の多価不飽和脂肪酸合成能の未熟な乳児に対して該多価
不飽和脂肪酸を母乳に近似して有効に補給し得る育児用
粉乳を提供することを課題とする。DISCLOSURE OF THE INVENTION Problems to be Solved by the Invention The present invention provides gamma-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid in a specific amount in infant formula by feeding them to artificially fed infants to obtain a serum phospholipid fraction of artificially fed infants. It was made based on the knowledge that the fatty acid composition in the medium can be approximated to the fatty acid composition in the serum phospholipid fraction of breast-fed infants, and in order to maintain normal cell membrane function and blood coagulation ability of the infant. It is an object of the present invention to provide a milk powder for childcare, which can effectively supplement the immature infant having the above-mentioned polyunsaturated fatty acid synthesizing ability, which is an important factor, with the polyunsaturated fatty acid in a manner similar to that of breast milk.
以下本発明を詳しく説明する。 The present invention will be described in detail below.
発明の構成 本発明の特徴は、脂肪含量が17.0〜30.0重量％の育児
用粉乳に対し、その脂肪酸組成中エイコサペンタエン酸
0.03〜0.20％及びドコサヘキサエン酸0.20〜2.0％を配
合するか、もしくは、これに加えて更にガンマ・リノレ
ン酸0.03〜0.40％を配合したことにある。Constitution of the invention The feature of the present invention is that eicosapentaenoic acid is contained in the fatty acid composition of baby milk powder having a fat content of 17.0 to 30.0% by weight.
0.03 to 0.20% and docosahexaenoic acid 0.20 to 2.0% were added, or gamma linolenic acid 0.03 to 0.40% was added in addition to this.
ここでいう“育児用粉乳”には、乳児用調製粉乳、未
熟児用粉乳のほかに治療用粉乳等乳幼児の人工哺育に用
いる粉乳類を包含する。The term "milk powder for child-rearing" as used herein includes milk powder for infants, artificial milk powder for premature infants, and milk powder for artificial nursing of infants such as therapeutic milk powder.
課題を解決するための手段 本発明における育児用粉乳は、育児用粉乳の通常知ら
れている成分の蛋白質、糖質、脂肪、ビタミン類、及び
ミネラル類等から構成される。これらの成分について
は、例えば、昭和61年５月５日同文書院発行「総合食品
事典（第６版）」「調製粉乳」の項に示される成分やあ
るいは昭和58年社団法人日本国際酪農連盟発行FAO/WHO
合同食品規格計画CODEX食品規格委員会著「乳幼児食品
を含む特殊用途食品のCODEX規格及び関連衛生作業規
則」の「乳児用食品に使用する無機塩類及びビタミン化
合物の勧告リスト」に記載されているビタミン類、ミネ
ラル類等を用いることができる。Means for Solving the Problems The infant milk powder of the present invention is composed of proteins, sugars, fats, vitamins, minerals and the like which are commonly known components of infant milk powder. For these ingredients, for example, the ingredients shown in the section "Comprehensive food encyclopedia (6th edition)" and "Powdered milk" issued by Doshoin on May 5, 1986, or the Japan International Dairy Federation, 1983. Published FAO / WHO
Vitamin described in "Recommended List of Inorganic Salts and Vitamin Compounds Used in Infant Foods" in "Codex Standards for Special Purpose Foods including Infant Foods and Related Sanitation Work Regulations" by Joint Food Standards Plan Codex Food Standards Committee And minerals can be used.
特に、本発明では、脂肪を17.0〜30.0重量％（以下、
％は重量％を示す）含有する育児用粉乳に、その脂肪酸
組成中、エイコサペンタエン酸0.03〜0.20％及びドコサ
ヘキサエン酸0.20〜2.0％を配合するか、もしくは、更
にガンマ・リノレン酸を0.03〜0.40％配合する。Particularly, in the present invention, 17.0 to 30.0% by weight of fat (hereinafter,
In the fatty acid composition, 0.03 to 0.20% of eicosapentaenoic acid and 0.20 to 2.0% of docosahexaenoic acid are added to the milk powder for childcare containing 0.03 to 0.40% of gamma-linolenic acid. Compound.
このように多価不飽和脂肪酸を特定量配合した育児用
粉乳の乳児に対する生理上の影響を調べた結果を下記に
示す。The results of examining the physiological effects of infant formula with a specific amount of polyunsaturated fatty acids on infants are shown below.
試験方法： 脂肪を27.8重量％含有する育児用粉乳に、その脂肪酸
組成中エイコサペンタエン酸を０（無添加）、0.03％並
びに0.20％、ドコサヘキサエン酸を０（無添加）、0.20
％並びに2.0％、及びガンマ・リノレン酸を０（無添
加）、0.03％並びに0.40％をそれぞれ配合して調製した
粉乳を、生後３〜４週間乳児に自律哺乳させ、哺乳児の
血清リン脂質画分中の脂肪酸組成を測定した。なお、参
考として母乳栄養児の血清リン脂質画分中の脂肪酸組成
も同様に測定した。Test method: Baby milk powder containing 27.8% by weight of fat, in its fatty acid composition, eicosapentaenoic acid was 0 (no addition), 0.03% and 0.20%, and docosahexaenoic acid was 0 (no addition), 0.20.
% And 2.0%, and gamma linolenic acid 0 (no addition), 0.03% and 0.40%, respectively, were prepared to allow infants to self-feed for 3 to 4 weeks after birth, and serum phospholipid fraction of the infants. The fatty acid composition in the minutes was measured. As a reference, the fatty acid composition in the serum phospholipid fraction of breast-fed infants was also measured in the same manner.
結果は表１に示すとおりである。 The results are shown in Table 1.
表１にみられるとおり、ガンマ・リノレン酸、エイコ
サペンタエン酸及びドコサヘキサエン酸を配合しない育
児用粉乳哺育児の血清リン脂肪では、リノール酸、アル
フア・リノレン酸の量は母乳栄養児に比べて差異が認め
られないものの、ジホモ・ガンマ・リノレン酸、エイコ
サペンタエン酸及びドコサペンタエン酸の量が少ないこ
とがわかる。 As can be seen in Table 1, in the serum phospholipids of breast-fed infants that did not contain gamma-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid, the amounts of linoleic acid and alpha-linolenic acid were different from those of breast-fed infants. Although not observed, it can be seen that the amounts of dihomo gamma linolenic acid, eicosapentaenoic acid and docosapentaenoic acid are small.
これに対し、本発明により得られた脂肪酸組成中エイ
コサペンタエン酸を0.03％及びドコサヘキサエン酸を0.
20％配合した育児用粉乳、並びに更にガンマ・リノレン
酸を0.03％配合した育児用粉乳をそれぞれ哺乳させた乳
児の血清リン脂質の脂肪酸組成は母乳栄養児のそれに近
似しており、更にエイコサペンタエン酸を0.20％とドコ
サヘキサエン酸を2.0％及びガンマ・リノレン酸を0.4％
を配合した育児用粉乳哺乳児の血清リン脂質の脂肪酸組
成は母乳栄養児のそれに近似しているも、ジホモ・ガン
マ・リノレン酸、エイコサペンタエン酸、ドコサペンタ
エン酸及びドコサヘキサエン酸の量がいずれも母乳栄養
児の血清リン脂質脂肪酸組成を越えていることが認めら
れる。On the other hand, in the fatty acid composition obtained by the present invention, 0.03% of eicosapentaenoic acid and docosahexaenoic acid of 0.
The fatty acid composition of serum phospholipids in infants fed 20% infant formula and 0.03% gamma-linolenic acid was similar to that of breast-fed infants. 0.20%, docosahexaenoic acid 2.0% and gamma linolenic acid 0.4%
Although the fatty acid composition of serum phospholipids of infant milk-fed infants containing is similar to that of breast-fed infants, the amounts of dihomo-gamma-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid are all It is observed that the serum phospholipid fatty acid composition of breast-fed infants is exceeded.
したがつて、上記試験結果から、本発明により特定範
囲量のエイコサペンタエン酸及びドコサヘキサエン酸、
更にはガンマ・リノレン酸をそれぞれ配合した育児用粉
乳の乳児に対する優れた生理上の効果を認めることがで
きる。Therefore, from the above test results, according to the present invention, a specific range amount of eicosapentaenoic acid and docosahexaenoic acid,
Furthermore, it is possible to recognize the excellent physiological effects of infant milk powder containing gamma and linolenic acid on infants.
また、本発明において育児用粉乳へ配合するためのガ
ンマ・リノレン酸は、月見草油（種子油）、モルテイエ
レラ属に属する糸状菌体油等を給源として用いることが
でき、エイコサペンタエン酸とドコサヘキサエン酸は、
カツオ、サンマ、カマス及びフグ等の魚油を給源として
用いることができる。Further, in the present invention, gamma linolenic acid for blending with baby milk powder can be used as a source of evening primrose oil (seed oil), filamentous fungal body oil belonging to the genus Morteiella, and eicosapentaenoic acid and docosahexaenoic acid. ,
Fish oils such as skipjack, saury, barracuda and puffer fish can be used as a source.
以下実施例により本発明を具体的に説明する。 The present invention will be specifically described below with reference to examples.
実施例 育児用粉乳の調製： 脱脂乳239kgにホエー粉52.7kg、ビタミンとミネラル
成分1kgを混合して溶解し、これに植物油23.3kg、月見
草油0.13kg及びカツオ油0.4kgを加えて混合し、均質化
し、次いで殺菌処理した後、濃縮、乾燥して粉乳100kg
を得た。Example Preparation of powdered milk for child-rearing: Whey powder 52.7 kg, vitamin and mineral components 1 kg are mixed and dissolved in skim milk 239 kg, and vegetable oil 23.3 kg, evening primrose oil 0.13 kg and skipjack oil 0.4 kg are added and mixed, Homogenized, then sterilized, concentrated and dried to dry powder 100 kg
I got
得られた粉乳中のガンマ・リノレン酸、エイコサペン
タエン酸及びドコサペンタエン酸の含有量は脂肪酸組成
で下記のとおりであつた。The contents of gamma-linolenic acid, eicosapentaenoic acid and docosapentaenoic acid in the obtained milk powder were as follows in terms of fatty acid composition.
ガンマ・リノレン酸 0.30（％） エイコサペンタエン酸 0.10 ドコサペンタエン酸 0.40 次に、上記育児粉乳を乳児に自律哺乳し、生後３〜４
週令時の血清リン脂質中の脂肪酸組成を測定した。結果
は表２に示すとおりである。Gamma-linolenic acid 0.30 (%) eicosapentaenoic acid 0.10 docosapentaenoic acid 0.40 Next, the above-mentioned infant formula is self-feeding to an infant, and 3 to 4 days after birth.
The fatty acid composition in serum phospholipids at the age of week was measured. The results are shown in Table 2.
Claims (2)
に、その脂肪酸組成中エイコサペンタエン酸0.03〜0.20
％及びドコサヘキサエン酸0.20〜2.0％を配合したこと
を特徴とする育児用粉乳。1. Baby milk powder having a fat content of 17.0 to 30.0% by weight and eicosapentaenoic acid of 0.03 to 0.20 in its fatty acid composition.
% And docosahexaenoic acid 0.20 to 2.0% are blended, and a milk powder for childcare characterized by the above-mentioned.
に、その脂肪酸組成中エイコサペンタエン酸0.03〜0.20
％及びドコサヘキサエン酸0.20〜2.0％とガンマ・リノ
レン酸0.03〜0.40％を配合したことを特徴とする育児用
粉乳。2. Baby milk powder having a fat content of 17.0 to 30.0% by weight and eicosapentaenoic acid of 0.03 to 0.20 in its fatty acid composition.
% And docosahexaenoic acid 0.20 to 2.0% and gamma linolenic acid 0.03 to 0.40% are blended.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62234886A JP2525624B2 (en) | 1987-09-21 | 1987-09-21 | Baby milk powder containing polyunsaturated fatty acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62234886A JP2525624B2 (en) | 1987-09-21 | 1987-09-21 | Baby milk powder containing polyunsaturated fatty acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6480250A JPS6480250A (en) | 1989-03-27 |
| JP2525624B2 true JP2525624B2 (en) | 1996-08-21 |
Family
ID=16977861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62234886A Expired - Fee Related JP2525624B2 (en) | 1987-09-21 | 1987-09-21 | Baby milk powder containing polyunsaturated fatty acids |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2525624B2 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2697834B2 (en) * | 1988-02-02 | 1998-01-14 | サントリー株式会社 | Artificial milk with polyunsaturated fatty acid component |
| US5407957A (en) * | 1990-02-13 | 1995-04-18 | Martek Corporation | Production of docosahexaenoic acid by dinoflagellates |
| US5013569A (en) * | 1990-05-21 | 1991-05-07 | Century Laboratories, Inc. | Infant formula |
| EP1787532A3 (en) * | 1991-01-24 | 2010-03-31 | Martek Biosciences Corporation | Microbial oil mixtures and uses thereof |
| JP3419897B2 (en) * | 1994-07-22 | 2003-06-23 | 明治乳業株式会社 | Hypoallergenic formula |
| NL9401644A (en) * | 1994-10-06 | 1996-05-01 | Friesland Brands Bv | Food for pregnant and lactating women |
| WO2009002146A1 (en) | 2007-06-26 | 2008-12-31 | N.V. Nutricia | Supporting activities of daily living |
| WO2009002145A1 (en) * | 2007-06-26 | 2008-12-31 | N.V. Nutricia | Lipid composition for improving function of brain functioning |
| WO2009002148A1 (en) | 2007-06-27 | 2008-12-31 | N.V. Nutricia | Food composition for prodromal dementia patients |
| EP2222311B1 (en) | 2007-12-20 | 2013-03-27 | N.V. Nutricia | Liquid nucleotides/nucleosides-containing product |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6158560A (en) * | 1984-08-29 | 1986-03-25 | Nippon Oil & Fats Co Ltd | Nutrition composition to be fed through intestinal tracks or blood vessels |
| JPS61224932A (en) * | 1985-03-30 | 1986-10-06 | Agency Of Ind Science & Technol | Gammalinoleic acid-containing milk |
| JPS6279732A (en) * | 1985-10-02 | 1987-04-13 | Agency Of Ind Science & Technol | Milk containing added triglyceride containing gamma-linolenic acid |
| US4670285A (en) * | 1982-08-06 | 1987-06-02 | The University Of Toronto Innovations Foundation | Infant formula |
-
1987
- 1987-09-21 JP JP62234886A patent/JP2525624B2/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4670285A (en) * | 1982-08-06 | 1987-06-02 | The University Of Toronto Innovations Foundation | Infant formula |
| JPS6158560A (en) * | 1984-08-29 | 1986-03-25 | Nippon Oil & Fats Co Ltd | Nutrition composition to be fed through intestinal tracks or blood vessels |
| JPS61224932A (en) * | 1985-03-30 | 1986-10-06 | Agency Of Ind Science & Technol | Gammalinoleic acid-containing milk |
| JPS6279732A (en) * | 1985-10-02 | 1987-04-13 | Agency Of Ind Science & Technol | Milk containing added triglyceride containing gamma-linolenic acid |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6480250A (en) | 1989-03-27 |
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