IE52242B1 - Preparation of amino protected-l-aspartyl-l-phenylalanine alkyl ester - Google Patents

Preparation of amino protected-l-aspartyl-l-phenylalanine alkyl ester

Info

Publication number
IE52242B1
IE52242B1 IE220/82A IE22082A IE52242B1 IE 52242 B1 IE52242 B1 IE 52242B1 IE 220/82 A IE220/82 A IE 220/82A IE 22082 A IE22082 A IE 22082A IE 52242 B1 IE52242 B1 IE 52242B1
Authority
IE
Ireland
Prior art keywords
amino
phenylalanine
alkyl ester
protected
aspartyl
Prior art date
Application number
IE220/82A
Other languages
English (en)
Other versions
IE820220L (en
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of IE820220L publication Critical patent/IE820220L/xx
Publication of IE52242B1 publication Critical patent/IE52242B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
IE220/82A 1981-02-02 1982-02-01 Preparation of amino protected-l-aspartyl-l-phenylalanine alkyl ester IE52242B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23056981A 1981-02-02 1981-02-02

Publications (2)

Publication Number Publication Date
IE820220L IE820220L (en) 1982-08-02
IE52242B1 true IE52242B1 (en) 1987-08-19

Family

ID=22865706

Family Applications (1)

Application Number Title Priority Date Filing Date
IE220/82A IE52242B1 (en) 1981-02-02 1982-02-01 Preparation of amino protected-l-aspartyl-l-phenylalanine alkyl ester

Country Status (5)

Country Link
JP (1) JPS57146595A (fr)
DE (1) DE3203292A1 (fr)
FR (1) FR2499098A1 (fr)
GB (1) GB2092161B (fr)
IE (1) IE52242B1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5917997A (ja) * 1982-07-23 1984-01-30 Toyo Soda Mfg Co Ltd ジペプチドエステルとアミノ酸エステルとの付加化合物の製造方法
EP0124313B1 (fr) * 1983-04-28 1989-08-02 Ajinomoto Co., Inc. Procédé pour la préparation de l'ester méthylique de la L-aspartyl-L-phénylalanine ou de la L-aspartyl-L-phénylalanine
JPS60164495A (ja) * 1984-01-16 1985-08-27 モンサント　コンパニー Ｎ‐ホルミルアミノ酸とペプチド残基の酵素的結合法
GB8403611D0 (en) * 1984-02-10 1984-03-14 Tate & Lyle Plc Sweetener
NL8620072A (nl) * 1985-02-15 1986-12-01 Vnii Genetiki Selektsii Promy Werkwijze voor de bereiding van n-formyl-l-peptiden.
EP0230649A1 (fr) * 1986-01-02 1987-08-05 Miles Inc. Immobilisation de phénylalanine-ammonium-lyase
EP0303602A4 (fr) * 1986-04-10 1990-06-26 Commw Scient Ind Res Org Synthese enzymatique.
FR2649121B1 (fr) * 1989-07-03 1991-09-20 Rhone Poulenc Chimie Procede de preparation enzymatique de dipeptides comportant un reste derive d'un acide amino-cycloalkyl carboxylique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3972773A (en) * 1975-04-29 1976-08-03 Sagami Chemical Research Center Process for producing peptide
DE2801238C2 (de) * 1977-01-27 1986-06-05 (Zaidanhojin) Sagami Chemical Research Center, Tokio/Tokyo Verfahren zur Herstellung von Salzen aus L,L-Dipeptiden und Phenylalaninestern
JPS6022918B2 (ja) * 1978-07-27 1985-06-04 財団法人相模中央研究所 Ｎ−ベンジルオキシカルボニル−ｌ−アスパルチル−ｌ−フェニルアラニンメチル−エステルとフェニルアラニンメチルエステルとの付加化合物の製造方法
JPS6022919B2 (ja) * 1978-07-27 1985-06-04 財団法人相模中央研究所 Ｎ―ベンジルオキシカルボニル‐ｌ‐アスパチル‐ｌ‐フエニルアラニンメチルエステルとフエニルアラニンメチルエステルとの付加化合物の製造方法
JPS55135595A (en) * 1979-04-03 1980-10-22 Toyo Soda Mfg Co Ltd Preparation of dipeptide
US4506011A (en) * 1981-09-05 1985-03-19 Toyo Soda Manufacturing Co., Ltd. Process for preparation of aspartylphenylalanine alkyl esters

Also Published As

Publication number Publication date
GB2092161A (en) 1982-08-11
IE820220L (en) 1982-08-02
FR2499098A1 (fr) 1982-08-06
DE3203292C2 (fr) 1990-01-11
DE3203292A1 (de) 1982-09-16
JPS57146595A (en) 1982-09-10
GB2092161B (en) 1984-08-01

Similar Documents

Publication Publication Date Title
US4256836A (en) Addition compound of dipeptide derivative and amino acid derivative
US4119493A (en) Process for producing a peptide
Ager et al. Commercial, synthetic nonnutritive sweeteners
US4116768A (en) Process for producing a peptide
CA1133841A (fr) Methode de production de dipeptides
CA1059051A (fr) Procede de production d'un peptide
JPH11508452A (ja) ペプチドおよびｎ−カルバモイル保護されたペプチドの新規製造法
IE52242B1 (en) Preparation of amino protected-l-aspartyl-l-phenylalanine alkyl ester
EP0149594A2 (fr) Accouplement enzymatique de N-formyl amino-acides et/ou de restes peptidiques
US5002872A (en) Enzyme mediated coupling reactions
Wiggans et al. Action of cathepsin C on dipeptide esters
US4212945A (en) Process for recovering protease
CA1320923C (fr) Reactions de couplage a mediation enzymatique
CA1337936C (fr) Methode de combinaison de la vibriolysine
DE68923625T2 (de) Enzymatischer Prozess zur Herstellung immunomodulatorischer Pentapeptide und Intermediate zu deren Herstellung.
EP0154472B1 (fr) Procédé de préparation de l'ester de L-aspartyl-L-phénylalanine
US5693485A (en) Enzymatic coupling reaction of N-protected-L-aspartic acid and phenylalanine methyl ester
US20040137559A1 (en) Process for producing N-formylamino acid and use thereof
US5279946A (en) Process for the preparation of N-benzyloxycarbonyl-alpha-L-aspartyl-L-phenylalanine methyl ester
EP0768384B1 (fr) Réaction améliorée de couplage enzymatique d'acide L-aspartique N-protégé et d'ester méthylique de phenylalanine
EP0269390B1 (fr) Production enzymatique de l'ester alcoylique de L-aspartyl-L-phénylalanine
JPS6022918B2 (ja) Ｎ−ベンジルオキシカルボニル−ｌ−アスパルチル−ｌ−フェニルアラニンメチル−エステルとフェニルアラニンメチルエステルとの付加化合物の製造方法
CA2075748A1 (fr) Hydrolyse enzymatique de peptides
JPH0525480B2 (fr)
JPH04187095A (ja) 生理活性ジペプチドの製造法