IE45873L - Polymorph of cimetidine - Google Patents

Polymorph of cimetidine

Info

Publication number
IE45873L
IE45873L IE771932A IE193277A IE45873L IE 45873 L IE45873 L IE 45873L IE 771932 A IE771932 A IE 771932A IE 193277 A IE193277 A IE 193277A IE 45873 L IE45873 L IE 45873L
Authority
IE
Ireland
Prior art keywords
peak
cimetidin
pref
practically
methyl
Prior art date
Application number
IE771932A
Other versions
IE45873B1 (en
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB3906576A external-priority patent/GB1543238A/en
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Publication of IE45873L publication Critical patent/IE45873L/en
Publication of IE45873B1 publication Critical patent/IE45873B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A practically crystallographically pure polymorphic form of cimetidin N-methyl-N'-cyano-N"-(2-((5-methyl-4-imidazolyl)-methylthio)ethy- l)guanidine , (as cimetidin A). (I), has an infrared spectrum (1% on KBr disc) having broad, pronounced (high) peaks at 1400 and 1395cm-1, a narrow pronounced peak at 1205 cm-1 and a narrow peak of av. height at 1155cm-1 and no peak at 1180 cm-1. Practically crystallographically pure indicates that (I) contains 5(3)%, of any other polymorphic form. (I) is administered in unit doses of 50-750mg (pref. 200-600mg), 1-6 times daily to give a pref. daily dosage of 500-1500mg. (I) is usually administered orally but may also be given parenterally or topically. [FR2364906A1]
IE1932/77A 1976-09-21 1977-09-21 Polymorph of cimetidine IE45873B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3906576A GB1543238A (en) 1976-09-21 1976-09-21 Polymorph of cimetidine
GB271677 1977-01-24

Publications (2)

Publication Number Publication Date
IE45873L true IE45873L (en) 1978-07-24
IE45873B1 IE45873B1 (en) 1982-12-15

Family

ID=26237687

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1932/77A IE45873B1 (en) 1976-09-21 1977-09-21 Polymorph of cimetidine

Country Status (10)

Country Link
JP (1) JPS5340771A (en)
AU (1) AU510629B2 (en)
BE (1) BE858432A (en)
CA (1) CA1096387A (en)
DE (1) DE2742531A1 (en)
FR (1) FR2364906A1 (en)
IE (1) IE45873B1 (en)
IL (1) IL52784A (en)
LU (1) LU78142A1 (en)
NZ (1) NZ184893A (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56104868A (en) * 1980-01-24 1981-08-20 Fujimoto Seiyaku Kk Conversion between polymorphous crystals of cimetidine
JPS56164122A (en) * 1980-05-21 1981-12-17 Fujimoto Seiyaku Kk Drug composition comprising cimetidine as main agent
HU185636B (en) * 1981-06-26 1985-03-28 Richter Gedeon Vegyeszet Process for preparing new cimetidine-hydrate /cimetidine-h/
HU185457B (en) * 1981-09-25 1985-02-28 Richter Gedeon Vegyeszet Process for preparating cimetidine-z
JPS5888366A (en) * 1981-11-19 1983-05-26 Fujimoto Seiyaku Kk Preparation of guanidine derivative
JPS59128375A (en) * 1983-01-10 1984-07-24 Tokawa Tetsuo Preparation of imidazole compound
JPS59130273A (en) * 1983-01-14 1984-07-26 Tokawa Tetsuo Preparation of imidazole compound
JPS59130274A (en) * 1983-01-14 1984-07-26 Tokawa Tetsuo Preparation of imidazole compound
HU196184B (en) * 1986-09-11 1988-10-28 Richter Gedeon Vegyeszet Process for producing cimetidine-a modification

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
GB1531231A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for the production of cyanoguanidine derivatives
GB1533380A (en) * 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines
PT65369B (en) * 1975-08-20 1978-01-10 Smithkline Corp Reduction process

Also Published As

Publication number Publication date
DE2742531A1 (en) 1978-03-23
JPS6222967B2 (en) 1987-05-20
AU510629B2 (en) 1980-07-03
AU2879277A (en) 1979-03-22
BE858432A (en) 1978-03-06
IL52784A (en) 1980-09-16
FR2364906A1 (en) 1978-04-14
IE45873B1 (en) 1982-12-15
IL52784A0 (en) 1977-10-31
JPS5340771A (en) 1978-04-13
NZ184893A (en) 1980-11-28
LU78142A1 (en) 1978-01-17
CA1096387A (en) 1981-02-24

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Legal Events

Date Code Title Description
MK9A Patent expired