GB1511517A - Alpha-(diethylamino)-propiophenone orotate a process for its preparation and its use in pharmaceutical compositions - Google Patents

Alpha-(diethylamino)-propiophenone orotate a process for its preparation and its use in pharmaceutical compositions

Info

Publication number
GB1511517A
GB1511517A GB3774275A GB3774275A GB1511517A GB 1511517 A GB1511517 A GB 1511517A GB 3774275 A GB3774275 A GB 3774275A GB 3774275 A GB3774275 A GB 3774275A GB 1511517 A GB1511517 A GB 1511517A
Authority
GB
United Kingdom
Prior art keywords
propiophenone
diethylamino
orotate
pharmaceutical compositions
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3774275A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SIRIUS
Original Assignee
SIRIUS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SIRIUS filed Critical SIRIUS
Publication of GB1511517A publication Critical patent/GB1511517A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1511517 α - Diethylamino - propiophenone SIRIUS 15 Sept 1975 [18 Sept 1974] 37742/75 Heading C2C The invention comprises α-diethylamino-propiophenone orotate having the formula It may be obtained by reacting orotic acid with α-diethylamino-propiophenone. Pharmaceutical compositions useful as appetite depressants comprise the compound of the above formula and a non-toxic pharmaceutically acceptable carrier or diluent therefor. They are preferably applied orally or parenterally.
GB3774275A 1974-09-18 1975-09-15 Alpha-(diethylamino)-propiophenone orotate a process for its preparation and its use in pharmaceutical compositions Expired GB1511517A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7431553A FR2285120A1 (en) 1974-09-18 1974-09-18 2- (DIETHYLAMINO) -1-PHENYL-PROPANONE OROTATE AND PROCESS FOR PREPARATION

Publications (1)

Publication Number Publication Date
GB1511517A true GB1511517A (en) 1978-05-17

Family

ID=9143207

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3774275A Expired GB1511517A (en) 1974-09-18 1975-09-15 Alpha-(diethylamino)-propiophenone orotate a process for its preparation and its use in pharmaceutical compositions

Country Status (8)

Country Link
JP (1) JPS5161616A (en)
BE (1) BE833524A (en)
CH (1) CH572912A5 (en)
DE (1) DE2541429A1 (en)
FR (1) FR2285120A1 (en)
GB (1) GB1511517A (en)
LU (1) LU73413A1 (en)
NL (1) NL7510895A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999018083A1 (en) * 1997-10-07 1999-04-15 Alexandr Leonidovich Reshetov N,n'-(sulphonyldi-1, 4-phenylen) bis (n'',n''- dimethylformamidin)-1, 2,3,4-tetrahydro- 6-methyl-2, 4-dioxo-5-pyrimidinsulphonate for stimulating cellular metabolism and having an immunotropic and anti-bacterial activity and method for producing the same
EP1031570A1 (en) * 1997-08-12 2000-08-30 Reshetov, Alexandr Leonidovich Immuno-modulator exhibiting anti-microbial and anti-mycobacterial activities, method for producing the same and pharmaceutical preparation for treating mycobacterioses as well as lung chronic and non specific conditions, sexually transmitted diseases and the resulting immuno-deficiency

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1031570A1 (en) * 1997-08-12 2000-08-30 Reshetov, Alexandr Leonidovich Immuno-modulator exhibiting anti-microbial and anti-mycobacterial activities, method for producing the same and pharmaceutical preparation for treating mycobacterioses as well as lung chronic and non specific conditions, sexually transmitted diseases and the resulting immuno-deficiency
EP1031570A4 (en) * 1997-08-12 2001-09-26 Reshetov Alexandr Leonidovich Immuno-modulator exhibiting anti-microbial and anti-mycobacterial activities, method for producing the same and pharmaceutical preparation for treating mycobacterioses as well as lung chronic and non specific conditions, sexually transmitted diseases and the resulting immuno-deficiency
WO1999018083A1 (en) * 1997-10-07 1999-04-15 Alexandr Leonidovich Reshetov N,n'-(sulphonyldi-1, 4-phenylen) bis (n'',n''- dimethylformamidin)-1, 2,3,4-tetrahydro- 6-methyl-2, 4-dioxo-5-pyrimidinsulphonate for stimulating cellular metabolism and having an immunotropic and anti-bacterial activity and method for producing the same

Also Published As

Publication number Publication date
BE833524A (en) 1976-01-16
JPS5161616A (en) 1976-05-28
LU73413A1 (en) 1976-04-13
FR2285120B1 (en) 1978-07-21
NL7510895A (en) 1976-03-22
FR2285120A1 (en) 1976-04-16
DE2541429A1 (en) 1976-04-01
CH572912A5 (en) 1976-02-27

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Legal Events

Date Code Title Description
PS Patent sealed
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee