IE41835L - Prostadienoic acid derivatives - Google Patents
Prostadienoic acid derivativesInfo
- Publication number
- IE41835L IE41835L IE751383A IE138375A IE41835L IE 41835 L IE41835 L IE 41835L IE 751383 A IE751383 A IE 751383A IE 138375 A IE138375 A IE 138375A IE 41835 L IE41835 L IE 41835L
- Authority
- IE
- Ireland
- Prior art keywords
- compounds
- formula
- prostadienoate
- prostaglandins
- oxo
- Prior art date
Links
- POKRQUNDSGAZIA-OALUTQOASA-N 7-[(1r,2s)-2-octylcyclopentyl]hepta-2,4-dienoic acid Chemical class CCCCCCCC[C@H]1CCC[C@@H]1CCC=CC=CC(O)=O POKRQUNDSGAZIA-OALUTQOASA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- LERHYEVNRIMGPK-IERKJGKXSA-N 7-[(1R,2R)-2-(3-ethenyl-3-hydroxyoct-1-enyl)-5-oxocyclopentyl]hept-5-enoic acid Chemical compound CCCCCC(O)(C=C)C=C[C@H]1CCC(=O)[C@@H]1CC=CCCCC(O)=O LERHYEVNRIMGPK-IERKJGKXSA-N 0.000 abstract 2
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 2
- 150000003180 prostaglandins Chemical class 0.000 abstract 2
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000008602 contraction Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 210000002460 smooth muscle Anatomy 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Cosmetics (AREA)
Abstract
1478262 Prostaglandins ROUSSEL UCLAF 23 June 1975 [21 June 1974] 26591/75 Heading C2C The invention comprises a process for the preparation of prostaglandins of the Formula I wherein R is H or C 1-4 alkyl, R 1 is C 2-4 alkenyl which contains a group of the formula m is 3, 4 or 5 and n is 2, 3 or 4, by catalytically hydrogenating compounds of the above Formula I in which R 1 is C 2-4 alkynyl and the compounds methyl (5Z, 8RS, 12RS, 13E, 15SR) 15- hydroxy - 9 - oxo - 15 - vinyl - 5,13 - prostadienoate and methyl (5Z 8RS, 12RS, 13E, 15RS) 15 - hydroxy - 9 - oxo - 15 - vinyl - 5,13- prostadienoate. Pharmaceutical compositions, suitable for oral, parenteral, rectal or topical administration, contain the above named compounds together with pharmaceutical carriers or excipients. The compounds have hypotensive and anti-broncho-constrictive activities and stimulate contraction of the smooth muscles.
[GB1478262A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7421602A FR2275443A1 (en) | 1974-06-21 | 1974-06-21 | NEW PROCESS FOR PREPARATION OF DERIVATIVES SUBSTITUTES OF PROSTANOIC ACID |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE41835L true IE41835L (en) | 1975-12-21 |
| IE41835B1 IE41835B1 (en) | 1980-04-09 |
Family
ID=9140359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1383/75A IE41835B1 (en) | 1974-06-21 | 1975-06-20 | Prostadienoic acid derivatives |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS5113751A (en) |
| BE (1) | BE830475A (en) |
| CA (1) | CA1061338A (en) |
| CH (1) | CH596163A5 (en) |
| DD (1) | DD118412A5 (en) |
| DE (1) | DE2526355A1 (en) |
| DK (1) | DK142171B (en) |
| ES (1) | ES438725A1 (en) |
| FR (1) | FR2275443A1 (en) |
| GB (1) | GB1478262A (en) |
| IE (1) | IE41835B1 (en) |
| IL (1) | IL47437A (en) |
| LU (1) | LU72786A1 (en) |
| NL (1) | NL7507431A (en) |
| SE (1) | SE7505967L (en) |
| SU (1) | SU577977A3 (en) |
| ZA (1) | ZA753959B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4022912A (en) * | 1976-02-09 | 1977-05-10 | Miles Laboratories, Inc. | Use of 1-decarboxy-1-hydroxymethyl-PGE1 in therapeutic bronchodilation |
| JPH06104644B2 (en) * | 1986-03-04 | 1994-12-21 | 住友化学工業株式会社 | Process for producing optically active cyclopentenone derivative |
-
1974
- 1974-06-21 FR FR7421602A patent/FR2275443A1/en active Granted
-
1975
- 1975-05-26 SE SE7505967A patent/SE7505967L/en not_active Application Discontinuation
- 1975-06-06 IL IL47437A patent/IL47437A/en unknown
- 1975-06-12 DE DE19752526355 patent/DE2526355A1/en not_active Withdrawn
- 1975-06-19 DD DD186765A patent/DD118412A5/xx unknown
- 1975-06-20 SU SU7502145918A patent/SU577977A3/en active
- 1975-06-20 JP JP50074560A patent/JPS5113751A/ja active Pending
- 1975-06-20 CA CA229,850A patent/CA1061338A/en not_active Expired
- 1975-06-20 CH CH808275A patent/CH596163A5/xx not_active IP Right Cessation
- 1975-06-20 ES ES438725A patent/ES438725A1/en not_active Expired
- 1975-06-20 LU LU72786A patent/LU72786A1/xx unknown
- 1975-06-20 IE IE1383/75A patent/IE41835B1/en unknown
- 1975-06-20 DK DK279475AA patent/DK142171B/en not_active IP Right Cessation
- 1975-06-20 BE BE157537A patent/BE830475A/en unknown
- 1975-06-20 ZA ZA3959A patent/ZA753959B/en unknown
- 1975-06-20 NL NL7507431A patent/NL7507431A/en not_active Application Discontinuation
- 1975-06-23 GB GB2659175A patent/GB1478262A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL47437A0 (en) | 1975-08-31 |
| FR2275443B1 (en) | 1976-10-22 |
| ZA753959B (en) | 1977-01-26 |
| BE830475A (en) | 1975-12-22 |
| SE7505967L (en) | 1975-12-22 |
| IE41835B1 (en) | 1980-04-09 |
| CA1061338A (en) | 1979-08-28 |
| DK142171C (en) | 1981-02-09 |
| SU577977A3 (en) | 1977-10-25 |
| DK142171B (en) | 1980-09-15 |
| ES438725A1 (en) | 1977-03-16 |
| AU8211175A (en) | 1976-12-16 |
| FR2275443A1 (en) | 1976-01-16 |
| LU72786A1 (en) | 1976-04-13 |
| IL47437A (en) | 1979-10-31 |
| DE2526355A1 (en) | 1976-01-08 |
| JPS5113751A (en) | 1976-02-03 |
| CH596163A5 (en) | 1978-02-28 |
| DD118412A5 (en) | 1976-03-05 |
| GB1478262A (en) | 1977-06-29 |
| NL7507431A (en) | 1975-12-23 |
| DK279475A (en) | 1975-12-22 |
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