IE39256B1 - Method of deacylating cephalosporins - Google Patents
Method of deacylating cephalosporinsInfo
- Publication number
- IE39256B1 IE39256B1 IE984/74A IE98474A IE39256B1 IE 39256 B1 IE39256 B1 IE 39256B1 IE 984/74 A IE984/74 A IE 984/74A IE 98474 A IE98474 A IE 98474A IE 39256 B1 IE39256 B1 IE 39256B1
- Authority
- IE
- Ireland
- Prior art keywords
- ferrous
- cephalosporins
- deacylation
- enzyme
- bacterial source
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 3
- 229940124587 cephalosporin Drugs 0.000 title abstract 3
- 150000001780 cephalosporins Chemical class 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 238000005947 deacylation reaction Methods 0.000 abstract 3
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 abstract 2
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 229910001448 ferrous ion Inorganic materials 0.000 abstract 2
- 102000004092 Amidohydrolases Human genes 0.000 abstract 1
- 108090000531 Amidohydrolases Proteins 0.000 abstract 1
- 101100234822 Caenorhabditis elegans ltd-1 gene Proteins 0.000 abstract 1
- 241000588698 Erwinia Species 0.000 abstract 1
- 230000020176 deacylation Effects 0.000 abstract 1
- 230000002939 deleterious effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- IMBKASBLAKCLEM-UHFFFAOYSA-L ferrous ammonium sulfate (anhydrous) Chemical compound [NH4+].[NH4+].[Fe+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O IMBKASBLAKCLEM-UHFFFAOYSA-L 0.000 abstract 1
- 235000003891 ferrous sulphate Nutrition 0.000 abstract 1
- 239000011790 ferrous sulphate Substances 0.000 abstract 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 abstract 1
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/847—Erwinia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2238073A GB1473100A (enrdf_load_stackoverflow) | 1973-05-10 | 1973-05-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE39256L IE39256L (en) | 1974-11-10 |
| IE39256B1 true IE39256B1 (en) | 1978-08-30 |
Family
ID=10178454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE984/74A IE39256B1 (en) | 1973-05-10 | 1974-05-09 | Method of deacylating cephalosporins |
Country Status (13)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2355078A1 (de) * | 1973-11-03 | 1975-05-07 | Bayer Ag | Verfahren zur herstellung von 7-amino-delta hoch 3-cephem-derivaten |
| CH590292A5 (enrdf_load_stackoverflow) * | 1973-12-20 | 1977-07-29 | Ciba Geigy Ag | |
| JPS5419914U (enrdf_load_stackoverflow) * | 1977-07-11 | 1979-02-08 | ||
| JPH07102000B2 (ja) * | 1985-11-14 | 1995-11-01 | 松下電器産業株式会社 | 電気掃除機のリモ−トコントロ−ル回路 |
| US4981789A (en) * | 1987-03-18 | 1991-01-01 | Merck & Co., Inc. | One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives |
| IT1224252B (it) * | 1988-04-08 | 1990-09-26 | Sclavo Spa | Metodo di protezione del gruppo carbossilico nella chimica dei composti beta lattamici |
| US5229274A (en) * | 1989-06-27 | 1993-07-20 | Merck & Co., Inc. | Gene encoding one step cephalosporin C amidase and expression thereof in recombinant bacillus |
| US5104800A (en) * | 1989-06-27 | 1992-04-14 | Merck & Co., Inc. | One-step cephalosporin c amidase enzyme |
| DE4030040A1 (de) * | 1990-09-22 | 1992-03-26 | Bayer Ag | Enzymatische de-acylierung von acyl-aminosorbosen und dessen verwendung bei der herstellung von 1-desoxynojirimicin |
| US6319684B1 (en) * | 1997-04-22 | 2001-11-20 | Dms N.V. | Process for the fermentative production of cephalosporin |
| AU8021398A (en) * | 1997-06-10 | 1998-12-30 | Gist-Brocades B.V. | Application of reducing sulphur compounds during enzymatic preparation of beta-lactam compounds |
| EG22838A (en) * | 2000-08-28 | 2003-09-30 | Dsm Nv | Process for the preparation of a b-lactam nucleus and application thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3801464A (en) * | 1972-02-09 | 1974-04-02 | Lilly Co Eli | Antibiotic a16886 and process for production thereof |
-
1973
- 1973-05-10 GB GB2238073A patent/GB1473100A/en not_active Expired
-
1974
- 1974-05-07 US US467733A patent/US3880713A/en not_active Expired - Lifetime
- 1974-05-09 AT AT384374A patent/AT341080B/de not_active IP Right Cessation
- 1974-05-09 YU YU01277/74A patent/YU127774A/xx unknown
- 1974-05-09 DE DE2422374A patent/DE2422374A1/de not_active Withdrawn
- 1974-05-09 CH CH631374A patent/CH602752A5/xx not_active IP Right Cessation
- 1974-05-09 NL NL7406239A patent/NL7406239A/xx not_active Application Discontinuation
- 1974-05-09 IE IE984/74A patent/IE39256B1/xx unknown
- 1974-05-09 DK DK254574AA patent/DK142373B/da unknown
- 1974-05-09 HU HUGA1160A patent/HU170269B/hu unknown
- 1974-05-10 BE BE144187A patent/BE814866A/xx not_active IP Right Cessation
- 1974-05-10 FR FR7416334A patent/FR2228783B1/fr not_active Expired
- 1974-05-10 JP JP5213774A patent/JPS5721993B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL7406239A (enrdf_load_stackoverflow) | 1974-11-12 |
| IE39256L (en) | 1974-11-10 |
| AT341080B (de) | 1978-01-25 |
| FR2228783A1 (enrdf_load_stackoverflow) | 1974-12-06 |
| GB1473100A (enrdf_load_stackoverflow) | 1977-05-11 |
| JPS5035394A (enrdf_load_stackoverflow) | 1975-04-04 |
| US3880713A (en) | 1975-04-29 |
| CH602752A5 (enrdf_load_stackoverflow) | 1978-07-31 |
| BE814866A (fr) | 1974-11-12 |
| YU127774A (en) | 1982-05-31 |
| DK142373C (enrdf_load_stackoverflow) | 1981-03-02 |
| HU170269B (enrdf_load_stackoverflow) | 1977-05-28 |
| JPS5721993B2 (enrdf_load_stackoverflow) | 1982-05-11 |
| DK142373B (da) | 1980-10-20 |
| DE2422374A1 (de) | 1974-11-21 |
| ATA384374A (de) | 1977-05-15 |
| FR2228783B1 (enrdf_load_stackoverflow) | 1977-10-21 |
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