IE37367B1 - New substituted 4,5-dihydropyridines their production and their medicinal use - Google Patents
New substituted 4,5-dihydropyridines their production and their medicinal useInfo
- Publication number
- IE37367B1 IE37367B1 IE343/73A IE34373A IE37367B1 IE 37367 B1 IE37367 B1 IE 37367B1 IE 343/73 A IE343/73 A IE 343/73A IE 34373 A IE34373 A IE 34373A IE 37367 B1 IE37367 B1 IE 37367B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- radicals
- dihydropyridines
- march
- alkoxy
- Prior art date
Links
- RDOAUPPSCNSYPM-UHFFFAOYSA-N 3,4-dihydropyridine Chemical class C1CC=NC=C1 RDOAUPPSCNSYPM-UHFFFAOYSA-N 0.000 title abstract 2
- -1 cyclic hydrocarbyl radical Chemical class 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000005956 isoquinolyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2210650A DE2210650C3 (de) | 1972-03-06 | 1972-03-06 | 2-Amino-6-alkoxy-4,5-dihydropyridin-3,5-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel |
| DE19722260860 DE2260860A1 (de) | 1972-12-13 | 1972-12-13 | Verfahren zur herstellung von neuen 2-amino-6-alkylmercapto-4,5-dihydropyridinen sowie ihre verwendung als antihypertensiva |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37367L IE37367L (en) | 1973-09-06 |
| IE37367B1 true IE37367B1 (en) | 1977-07-06 |
Family
ID=25762843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE343/73A IE37367B1 (en) | 1972-03-06 | 1973-03-05 | New substituted 4,5-dihydropyridines their production and their medicinal use |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US3876646A (en:Method) |
| JP (1) | JPS5626658B2 (en:Method) |
| AT (1) | AT325614B (en:Method) |
| CA (1) | CA985685A (en:Method) |
| CH (1) | CH580591A5 (en:Method) |
| CS (1) | CS179980B2 (en:Method) |
| DD (1) | DD106832A5 (en:Method) |
| DK (1) | DK135714C (en:Method) |
| ES (1) | ES412320A1 (en:Method) |
| FR (1) | FR2183673B1 (en:Method) |
| GB (1) | GB1374551A (en:Method) |
| HU (1) | HU167088B (en:Method) |
| IE (1) | IE37367B1 (en:Method) |
| IL (1) | IL41666A (en:Method) |
| NL (1) | NL7303134A (en:Method) |
| SE (1) | SE384206B (en:Method) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3951993A (en) * | 1972-03-06 | 1976-04-20 | Bayer Aktiengesellschaft | 2-Amino-4,5-dihydropyridine derivatives and process for their preparation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1923990C3 (de) * | 1969-05-10 | 1978-11-23 | Bayer Ag | Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern |
| DE2013431C3 (de) * | 1970-03-20 | 1979-12-20 | Bayer Ag, 5090 Leverkusen | 4-Azidophenyl-l,4-dihydropyridin-3,5-dicarbonsäureester |
| DE1963186C3 (de) * | 1969-12-17 | 1979-02-15 | Bayer Ag, 5090 Leverkusen | Schwefelhaltige 1,4-Dihydropyridin-33-dicarbonsäureester |
| ZA7152B (en) * | 1970-01-24 | 1971-10-27 | Bayer Ag | New pharmaceutically active 1,4-dihydropyridines |
| DE2117572C3 (de) * | 1971-04-10 | 1980-03-20 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| DE2117571C3 (de) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
-
1973
- 1973-02-23 DD DD169020A patent/DD106832A5/xx unknown
- 1973-02-28 US US336481A patent/US3876646A/en not_active Expired - Lifetime
- 1973-03-02 CH CH313673A patent/CH580591A5/xx not_active IP Right Cessation
- 1973-03-02 IL IL41666A patent/IL41666A/en unknown
- 1973-03-02 JP JP2444873A patent/JPS5626658B2/ja not_active Expired
- 1973-03-05 CA CA165,183A patent/CA985685A/en not_active Expired
- 1973-03-05 SE SE7303018A patent/SE384206B/xx unknown
- 1973-03-05 IE IE343/73A patent/IE37367B1/xx unknown
- 1973-03-05 DK DK118273A patent/DK135714C/da active
- 1973-03-05 ES ES412320A patent/ES412320A1/es not_active Expired
- 1973-03-06 CS CS7300001590A patent/CS179980B2/cs unknown
- 1973-03-06 AT AT196973A patent/AT325614B/de not_active IP Right Cessation
- 1973-03-06 HU HUBA2940A patent/HU167088B/hu unknown
- 1973-03-06 FR FR7307920A patent/FR2183673B1/fr not_active Expired
- 1973-03-06 NL NL7303134A patent/NL7303134A/xx not_active Application Discontinuation
- 1973-03-06 GB GB1075573A patent/GB1374551A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH580591A5 (en:Method) | 1976-10-15 |
| CA985685A (en) | 1976-03-16 |
| IE37367L (en) | 1973-09-06 |
| HU167088B (en:Method) | 1975-08-28 |
| SE384206B (sv) | 1976-04-26 |
| US3876646A (en) | 1975-04-08 |
| GB1374551A (en) | 1974-11-20 |
| DK135714B (da) | 1977-06-13 |
| JPS5626658B2 (en:Method) | 1981-06-19 |
| IL41666A0 (en) | 1973-05-31 |
| ATA196973A (de) | 1975-01-15 |
| JPS4899180A (en:Method) | 1973-12-15 |
| DK135714C (da) | 1977-11-14 |
| CS179980B2 (en) | 1977-12-30 |
| AT325614B (de) | 1975-10-27 |
| NL7303134A (en:Method) | 1973-09-10 |
| IL41666A (en) | 1976-02-29 |
| FR2183673A1 (en:Method) | 1973-12-21 |
| ES412320A1 (es) | 1976-04-16 |
| FR2183673B1 (en:Method) | 1976-12-03 |
| DD106832A5 (en:Method) | 1974-07-05 |
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