IE36628L - Stabilisation of penicillins - Google Patents
Stabilisation of penicillinsInfo
- Publication number
- IE36628L IE36628L IE721104A IE110472A IE36628L IE 36628 L IE36628 L IE 36628L IE 721104 A IE721104 A IE 721104A IE 110472 A IE110472 A IE 110472A IE 36628 L IE36628 L IE 36628L
- Authority
- IE
- Ireland
- Prior art keywords
- ampicillin
- stabilisation
- aug
- weight
- trisodium phosphate
- Prior art date
Links
- 230000006641 stabilisation Effects 0.000 title abstract 2
- 229930182555 Penicillin Natural products 0.000 title 1
- 150000002960 penicillins Chemical class 0.000 title 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 4
- 229960000723 ampicillin Drugs 0.000 abstract 2
- 229960003311 ampicillin trihydrate Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000001488 sodium phosphate Substances 0.000 abstract 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 2
- 229910000406 trisodium phosphate Inorganic materials 0.000 abstract 2
- 235000019801 trisodium phosphate Nutrition 0.000 abstract 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 abstract 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 abstract 1
- YHGREDQDBYVEOS-UHFFFAOYSA-N [acetyloxy-[2-(diacetyloxyamino)ethyl]amino] acetate Chemical compound CC(=O)ON(OC(C)=O)CCN(OC(C)=O)OC(C)=O YHGREDQDBYVEOS-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000003352 sequestering agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1391449 Stabilisation of ampicillin BEECHAM GROUP Ltd 2 Aug 1972 [26 Aug 1971] 40001/71 Heading A5B Water-soluble compositions consisting solely of ampicillin trihydrate, trisodium phosphate and optionally a sequestering agent such as ethylenediamine tetracetate or a salt thereof, e.g. the disodium salt, are used to increase the stability of ampicillin when in aqueous solution in the presence of zinc ions. Preferably the weight of trisodium phosphate in the composition is about equal to the weight of ampicillin trihydrate therein.
[GB1391449A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4000171A GB1391449A (en) | 1971-08-26 | 1971-08-26 | Stabilisation of penicillins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36628L true IE36628L (en) | 1973-02-26 |
| IE36628B1 IE36628B1 (en) | 1977-01-19 |
Family
ID=10412657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1104/72A IE36628B1 (en) | 1971-08-26 | 1972-08-08 | Stabilisation of penicillins |
Country Status (4)
| Country | Link |
|---|---|
| AU (1) | AU467685B2 (en) |
| GB (1) | GB1391449A (en) |
| IE (1) | IE36628B1 (en) |
| ZA (1) | ZA725571B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4273763A (en) * | 1978-01-23 | 1981-06-16 | Efamol Limited | Pharmaceutical and dietary compositions |
-
1971
- 1971-08-26 GB GB4000171A patent/GB1391449A/en not_active Expired
-
1972
- 1972-08-08 IE IE1104/72A patent/IE36628B1/en unknown
- 1972-08-14 ZA ZA725571A patent/ZA725571B/en unknown
- 1972-08-24 AU AU45955/72A patent/AU467685B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ZA725571B (en) | 1973-05-30 |
| AU467685B2 (en) | 1975-12-11 |
| GB1391449A (en) | 1975-04-23 |
| AU4595572A (en) | 1974-02-28 |
| IE36628B1 (en) | 1977-01-19 |
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