IE36443B1 - New 3-formylrifamycin sv derivatives - Google Patents
New 3-formylrifamycin sv derivativesInfo
- Publication number
- IE36443B1 IE36443B1 IE634/72A IE63472A IE36443B1 IE 36443 B1 IE36443 B1 IE 36443B1 IE 634/72 A IE634/72 A IE 634/72A IE 63472 A IE63472 A IE 63472A IE 36443 B1 IE36443 B1 IE 36443B1
- Authority
- IE
- Ireland
- Prior art keywords
- formylrifamycin
- alkyl
- hydrogen
- general formula
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
1336399 3-Formylrifamycin SV derivatives GRUPPO LEPETIT SpA 26 April 1972 [24 June 1971] 19458/72 Heading C2A The invention comprises 3-formylrifamycin SV compounds of general Formula I wherein R 1 and R 2 are independently selected from (a) hydrogen, (b) alkyl, (c) alkenyl, (d) alkynyl, (e) aryl, (f) aralkyl, (g) heterocyclic and (h) cycloalkyl, and are further characterized in that only one of R 1 and R 2 can be hydrogen or C 1-4 alkyl, and if hydrogen or lower alkyl is present, the other of R 1 and R 2 must be unsubstituted alkyl or hydroxyalkyl of at least 5 carbon atoms or a substituted alkyl other than dimethylaminoethyl or a member of groups (c), through (h), wherein aryl is other than phenyl and p-carboxyphenyl, and aralkyl is other than benzyl and where R 3 is -H or CH 3 CO- and the 16, 17, 18, 19, 28, 29 hexahydro and 27-demethoxy-27-hydroxy derivatives thereof. A process for the preparation of compounds of Formula I comprises reacting a 3-formylrifamycin of general Formula II or the corresponding hexahydro derivative with a hydrazine of the general formula H 2 N-NR 1 R 2 wherein R 1 and R 2 are as defined above. A therapeutic composition comprises as active ingredient a compound of Formula I in conjunction with a pharmaceutically acceptable carrier.
[GB1336399A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8960871 | 1971-06-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36443L IE36443L (en) | 1972-12-24 |
| IE36443B1 true IE36443B1 (en) | 1976-11-10 |
Family
ID=11331613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE634/72A IE36443B1 (en) | 1971-06-24 | 1972-05-11 | New 3-formylrifamycin sv derivatives |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS5123520B1 (en) |
| AR (1) | AR192939A1 (en) |
| AT (1) | AT315373B (en) |
| BE (1) | BE784532A (en) |
| CA (1) | CA983487A (en) |
| CH (1) | CH564012A5 (en) |
| DD (1) | DD99783A5 (en) |
| DE (1) | DE2227173C2 (en) |
| DK (1) | DK138457B (en) |
| ES (1) | ES403549A1 (en) |
| FI (1) | FI54313C (en) |
| FR (1) | FR2143410B1 (en) |
| GB (1) | GB1336399A (en) |
| HU (1) | HU163901B (en) |
| IE (1) | IE36443B1 (en) |
| IL (1) | IL39306A (en) |
| LU (1) | LU65460A1 (en) |
| NL (1) | NL159985C (en) |
| NO (1) | NO135317C (en) |
| PL (1) | PL81998B1 (en) |
| RO (1) | RO62778A (en) |
| SE (2) | SE383740B (en) |
| SU (1) | SU440841A3 (en) |
| ZA (1) | ZA722667B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2728869A1 (en) * | 1976-06-25 | 1977-12-29 | Antibiotice Iasi Intreprindere | Antibacterial derivs. of (3)-formyl-rifamycin SV - prepd. by reaction with hydrazines, acylhydrazines or hydroxylamines |
| PH13381A (en) * | 1977-03-31 | 1980-03-25 | Takeda Chemical Industries Ltd | Antibiotic c-15003 |
| US4137230A (en) * | 1977-11-14 | 1979-01-30 | Takeda Chemical Industries, Ltd. | Method for the production of maytansinoids |
| US4447432A (en) * | 1981-11-17 | 1984-05-08 | Farmitalia Carlo Erba S.P.A. | Azino rifamycins |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR208F (en) * | 1964-07-31 |
-
1971
- 1971-06-08 GB GB1945872A patent/GB1336399A/en not_active Expired
-
1972
- 1972-04-19 ZA ZA722667A patent/ZA722667B/en unknown
- 1972-04-25 IL IL39306A patent/IL39306A/en unknown
- 1972-05-04 AR AR241804A patent/AR192939A1/en active
- 1972-05-11 IE IE634/72A patent/IE36443B1/en unknown
- 1972-05-16 NO NO1748/72A patent/NO135317C/no unknown
- 1972-05-24 FI FI1450/72A patent/FI54313C/en active
- 1972-06-02 JP JP47054998A patent/JPS5123520B1/ja active Pending
- 1972-06-03 DE DE2227173A patent/DE2227173C2/de not_active Expired
- 1972-06-05 LU LU65460D patent/LU65460A1/xx unknown
- 1972-06-05 CH CH827872A patent/CH564012A5/xx not_active IP Right Cessation
- 1972-06-05 DD DD163438A patent/DD99783A5/xx unknown
- 1972-06-05 SU SU1789259A patent/SU440841A3/en active
- 1972-06-05 PL PL1972155843A patent/PL81998B1/pl unknown
- 1972-06-06 DK DK279672AA patent/DK138457B/en not_active IP Right Cessation
- 1972-06-06 ES ES403549A patent/ES403549A1/en not_active Expired
- 1972-06-06 RO RO7200071157A patent/RO62778A/en unknown
- 1972-06-06 SE SE7207427A patent/SE383740B/en unknown
- 1972-06-06 AT AT486072A patent/AT315373B/en not_active IP Right Cessation
- 1972-06-06 HU HULE659A patent/HU163901B/hu unknown
- 1972-06-07 BE BE784532A patent/BE784532A/en not_active IP Right Cessation
- 1972-06-22 NL NL7208592.A patent/NL159985C/en not_active IP Right Cessation
- 1972-06-23 FR FR7222863A patent/FR2143410B1/fr not_active Expired
- 1972-06-26 CA CA145,745A patent/CA983487A/en not_active Expired
-
1975
- 1975-09-03 SE SE7509793A patent/SE400558B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB1336399A (en) | 1973-11-07 |
| NL159985C (en) | 1979-09-17 |
| DD99783A5 (en) | 1973-08-20 |
| RO62778A (en) | 1978-01-15 |
| AR192939A1 (en) | 1973-03-21 |
| NO135317C (en) | 1977-03-23 |
| NL7208592A (en) | 1972-12-28 |
| NO135317B (en) | 1976-12-13 |
| AT315373B (en) | 1974-05-27 |
| PL81998B1 (en) | 1975-10-31 |
| IE36443L (en) | 1972-12-24 |
| IL39306A (en) | 1977-07-31 |
| IL39306A0 (en) | 1972-06-28 |
| LU65460A1 (en) | 1972-10-05 |
| DE2227173C2 (en) | 1988-12-08 |
| SE383740B (en) | 1976-03-29 |
| AU4143672A (en) | 1973-10-25 |
| JPS5123520B1 (en) | 1976-07-17 |
| SE7509793L (en) | 1975-09-03 |
| SE400558B (en) | 1978-04-03 |
| CH564012A5 (en) | 1975-07-15 |
| DK138457C (en) | 1979-02-19 |
| ES403549A1 (en) | 1975-05-01 |
| FI54313B (en) | 1978-07-31 |
| SU440841A3 (en) | 1974-08-25 |
| FR2143410A1 (en) | 1973-02-02 |
| FI54313C (en) | 1978-11-10 |
| DE2227173A1 (en) | 1972-12-28 |
| FR2143410B1 (en) | 1975-08-08 |
| CA983487A (en) | 1976-02-10 |
| BE784532A (en) | 1972-10-02 |
| NL159985B (en) | 1979-04-17 |
| HU163901B (en) | 1973-11-28 |
| DK138457B (en) | 1978-09-11 |
| ZA722667B (en) | 1973-01-31 |
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