IE36335B1 - Layered bolus for animal husbandry providing for immediate and sustained release of medicament - Google Patents
Layered bolus for animal husbandry providing for immediate and sustained release of medicamentInfo
- Publication number
- IE36335B1 IE36335B1 IE562/72A IE56272A IE36335B1 IE 36335 B1 IE36335 B1 IE 36335B1 IE 562/72 A IE562/72 A IE 562/72A IE 56272 A IE56272 A IE 56272A IE 36335 B1 IE36335 B1 IE 36335B1
- Authority
- IE
- Ireland
- Prior art keywords
- sustained release
- bolus
- medicament
- immediate
- release layer
- Prior art date
Links
- 238000013268 sustained release Methods 0.000 title abstract 9
- 239000012730 sustained-release form Substances 0.000 title abstract 9
- 239000003814 drug Substances 0.000 title abstract 7
- 239000012729 immediate-release (IR) formulation Substances 0.000 title abstract 5
- 241000282849 Ruminantia Species 0.000 abstract 4
- 230000003179 granulation Effects 0.000 abstract 4
- 238000005469 granulation Methods 0.000 abstract 4
- 239000000945 filler Substances 0.000 abstract 3
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 1
- 241000195947 Lycopodium Species 0.000 abstract 1
- RHCOJUBIAOBGKL-UHFFFAOYSA-N O(I)I.[Mg] Chemical compound O(I)I.[Mg] RHCOJUBIAOBGKL-UHFFFAOYSA-N 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- 239000011398 Portland cement Substances 0.000 abstract 1
- 235000021355 Stearic acid Nutrition 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 230000000507 anthelmentic effect Effects 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 abstract 1
- 239000008116 calcium stearate Substances 0.000 abstract 1
- 235000013539 calcium stearate Nutrition 0.000 abstract 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Inorganic materials [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 abstract 1
- PASHVRUKOFIRIK-UHFFFAOYSA-L calcium sulfate dihydrate Chemical compound O.O.[Ca+2].[O-]S([O-])(=O)=O PASHVRUKOFIRIK-UHFFFAOYSA-L 0.000 abstract 1
- ZOMBKNNSYQHRCA-UHFFFAOYSA-J calcium sulfate hemihydrate Chemical compound O.[Ca+2].[Ca+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O ZOMBKNNSYQHRCA-UHFFFAOYSA-J 0.000 abstract 1
- 239000004568 cement Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960005091 chloramphenicol Drugs 0.000 abstract 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 abstract 1
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 abstract 1
- 229960001076 chlorpromazine Drugs 0.000 abstract 1
- 229940110456 cocoa butter Drugs 0.000 abstract 1
- 235000019868 cocoa butter Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- PLHJDBGFXBMTGZ-WEVVVXLNSA-N furazolidone Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)OCC1 PLHJDBGFXBMTGZ-WEVVVXLNSA-N 0.000 abstract 1
- 229960001625 furazolidone Drugs 0.000 abstract 1
- 239000010439 graphite Substances 0.000 abstract 1
- 229910002804 graphite Inorganic materials 0.000 abstract 1
- 239000011507 gypsum plaster Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 abstract 1
- 239000012188 paraffin wax Substances 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- NQQWFVUVBGSGQN-UHFFFAOYSA-N phosphoric acid;piperazine Chemical compound OP(O)(O)=O.C1CNCCN1 NQQWFVUVBGSGQN-UHFFFAOYSA-N 0.000 abstract 1
- 229960001954 piperazine phosphate Drugs 0.000 abstract 1
- 210000004767 rumen Anatomy 0.000 abstract 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 abstract 1
- 239000008117 stearic acid Substances 0.000 abstract 1
- ASWVTGNCAZCNNR-UHFFFAOYSA-N sulfamethazine Chemical compound CC1=CC(C)=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ASWVTGNCAZCNNR-UHFFFAOYSA-N 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- 239000013589 supplement Substances 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- 229940125725 tranquilizer Drugs 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0068—Rumen, e.g. rumen bolus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14449971A | 1971-05-18 | 1971-05-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36335L IE36335L (en) | 1972-11-18 |
| IE36335B1 true IE36335B1 (en) | 1976-10-13 |
Family
ID=22508878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE562/72A IE36335B1 (en) | 1971-05-18 | 1972-04-27 | Layered bolus for animal husbandry providing for immediate and sustained release of medicament |
Country Status (10)
| Country | Link |
|---|---|
| AU (1) | AU470023B2 (ref) |
| BE (1) | BE783321A (ref) |
| CA (1) | CA997677A (ref) |
| DE (1) | DE2224390A1 (ref) |
| ES (1) | ES402545A1 (ref) |
| FR (1) | FR2138011B1 (ref) |
| GB (1) | GB1330829A (ref) |
| IE (1) | IE36335B1 (ref) |
| NL (1) | NL7206328A (ref) |
| ZA (1) | ZA722664B (ref) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4137300A (en) * | 1976-08-20 | 1979-01-30 | Ciba-Geigy Corporation | Sustained action dosage forms |
| GB2093348B (en) * | 1981-02-23 | 1984-09-12 | Leo Pharm Prod Ltd | Pharmaceutical composition for implantation |
| NZ204861A (en) * | 1982-07-20 | 1986-10-08 | Nat Res Dev | Sustained release device:trace element incorporated in cement |
| FR2560768A1 (fr) * | 1984-03-07 | 1985-09-13 | Crb Virbac Sa | Dispositif a liberation programmee |
| NZ234227A (en) * | 1989-06-30 | 1991-08-27 | Smithkline Beecham Corp | Delayed release dosage form |
| US5190760A (en) * | 1989-07-08 | 1993-03-02 | Coopers Animal Health Limited | Solid pharmaceutical composition |
| GB8915716D0 (en) * | 1989-07-08 | 1989-08-31 | Coopers Animal Health | Pharmaceutical compositions |
| USD398395S (en) | 1991-12-23 | 1998-09-15 | Glaxo Wellcome Inc. | Pharmaceutical tablet |
| USD376847S (en) | 1992-06-30 | 1996-12-24 | Burroughs Wellcome Co. | Pharmaceutical tablet |
| AU781718B2 (en) * | 1999-11-02 | 2005-06-09 | Depomed, Inc. | Pharmacological inducement of the fed mode for enhanced drug administration to the stomach |
| EP1251832B1 (en) | 2000-02-04 | 2006-09-27 | Depomed, Inc. | Shell-and-core dosage form approaching zero-order drug release |
| US6723340B2 (en) | 2001-10-25 | 2004-04-20 | Depomed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
| CA2409552A1 (en) | 2001-10-25 | 2003-04-25 | Depomed, Inc. | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
| US6682759B2 (en) | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
| US20050013863A1 (en) | 2003-07-18 | 2005-01-20 | Depomed, Inc., A Corporation Of The State Of California | Dual drug dosage forms with improved separation of drugs |
| CN104523636B (zh) * | 2014-12-25 | 2017-07-18 | 昆明振华制药厂有限公司 | 一种呋喃唑酮缓释片及其制备方法 |
| US12251208B2 (en) * | 2020-11-30 | 2025-03-18 | International Business Machines Corporation | Time controlled medication |
| US11529310B2 (en) | 2020-12-08 | 2022-12-20 | Ruminant Biotech Corp Limited | Devices and methods for delivery of substances to animals |
| WO2025029158A1 (en) * | 2023-08-01 | 2025-02-06 | Ruminant Biotech Corp Limited | Improved bolus designs for administration to a ruminant animal and uses thereof |
-
1972
- 1972-04-19 ZA ZA722664A patent/ZA722664B/xx unknown
- 1972-04-27 IE IE562/72A patent/IE36335B1/xx unknown
- 1972-05-09 ES ES402545A patent/ES402545A1/es not_active Expired
- 1972-05-10 NL NL7206328A patent/NL7206328A/xx not_active Application Discontinuation
- 1972-05-10 BE BE783321A patent/BE783321A/xx not_active IP Right Cessation
- 1972-05-15 AU AU42309/72A patent/AU470023B2/en not_active Expired
- 1972-05-17 CA CA142,402A patent/CA997677A/en not_active Expired
- 1972-05-17 FR FR727217600A patent/FR2138011B1/fr not_active Expired
- 1972-05-18 DE DE2224390A patent/DE2224390A1/de active Pending
- 1972-05-18 GB GB2342672A patent/GB1330829A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2138011A1 (ref) | 1972-12-29 |
| BE783321A (fr) | 1972-11-10 |
| FR2138011B1 (ref) | 1973-07-13 |
| IE36335L (en) | 1972-11-18 |
| AU4230972A (en) | 1973-11-22 |
| ES402545A1 (es) | 1975-04-01 |
| GB1330829A (en) | 1973-09-19 |
| AU470023B2 (en) | 1976-03-04 |
| CA997677A (en) | 1976-09-28 |
| ZA722664B (en) | 1973-01-31 |
| NL7206328A (ref) | 1972-11-21 |
| DE2224390A1 (de) | 1973-12-13 |
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