IE36186B1 - Benzofuran and benzothiphene derivatives - Google Patents
Benzofuran and benzothiphene derivativesInfo
- Publication number
- IE36186B1 IE36186B1 IE354/72A IE35472A IE36186B1 IE 36186 B1 IE36186 B1 IE 36186B1 IE 354/72 A IE354/72 A IE 354/72A IE 35472 A IE35472 A IE 35472A IE 36186 B1 IE36186 B1 IE 36186B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- amino
- compound
- hydrogen
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/76—Dibenzothiophenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1364806 Substituted tricyclic furans and thiophenes F HOFFMANN-LA ROCHE & CO AG 24 March 1972 [26 March 1971] 13877/72 Heading C2C Novel compounds of the Formula I wherein R 1 and R 2 are independently hydrogen, halogen, C 1-7 alkyl, C 1-7 alkoxy, C 1-7 alkylthio, trifluoromethyl, cyano, carbamoyl, carboxy, C 1-7 alkoxycarbonyl, nitro, amino, mono-(C 1-7 alkyl) amino, di-(C 1-7 alkyl) amino, acyl, acylamido, sulphamoyl, di-(C 1-7 alkyl) sulphamoyl, or difluoromethylsulphonyl; R 3 is hydrogen, C 1-7 alkyl, amino-C 1-7 alkyl, mono-(C 1-7 alkyl) amino-C 1-7 alkyl, di-(C 1-7 alkyl) amino C 1-7 alkyl; n is 1 or 2 and X is oxygen or sulphur, may be prepared by (a) cyclizing a compound of the formula II wherein at least one position on the phenyl ring ortho to X is unsubstituted, and R<SP>1</SP> 3 is C 1-7 alkyl, (b) treating a compound IIa wherein R<SP>1</SP> 1 and R<SP>1</SP> 2 are independently hydrogen, nitro, trifluoromethyl, C 1-7 alkoxycarbonyl, cyano or acyl (at least one of R<SP>1</SP> 1 and R<SP>1</SP> 2 being other than hydrogen) with an acidic catalyst to yield an appropriate substituted compound I in which X is oxygen, and (c) interconversion of substituents on I by known methods and separation of isomers, i.e. resolution, conversion to a salt with acid or base, saponification of a carboxylic ester group, conversion of a salt of compound I wherein R 3 represents hydrogen into a compound I wherein R 3 represents other than H or alkyl, reduction of a nitro to an amino group, conversion of an amino group into a diazonium salt and thence into hydrogen, halogen, cyano, hydroxy or alkoxy. Compounds of Formula IIa above are prepared by reacting compounds and Cycloalkanes of Formula IV are obtained by halogenating the corresponding halogen free compound. Pharmaceutical compositions having antiinflammatory and anti-rheumatic activity and which are useful for oral, enteral or parenteral administration, contain the above novel compounds I.
[GB1364806A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12857071A | 1971-03-26 | 1971-03-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36186L IE36186L (en) | 1972-09-26 |
| IE36186B1 true IE36186B1 (en) | 1976-09-01 |
Family
ID=22435954
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2067/74A IE36187B1 (en) | 1971-03-26 | 1972-03-20 | Phenoxy and phenylthio compounds |
| IE354/72A IE36186B1 (en) | 1971-03-26 | 1972-03-20 | Benzofuran and benzothiphene derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2067/74A IE36187B1 (en) | 1971-03-26 | 1972-03-20 | Phenoxy and phenylthio compounds |
Country Status (17)
| Country | Link |
|---|---|
| AR (3) | AR192514A1 (en) |
| AT (2) | AT319227B (en) |
| AU (1) | AU463471B2 (en) |
| BE (1) | BE781176A (en) |
| CA (1) | CA988529A (en) |
| CH (1) | CH574433A5 (en) |
| DE (1) | DE2214501A1 (en) |
| DK (1) | DK130345B (en) |
| ES (1) | ES401162A1 (en) |
| FR (1) | FR2130655B1 (en) |
| GB (2) | GB1364807A (en) |
| HU (1) | HU164250B (en) |
| IE (2) | IE36187B1 (en) |
| IL (2) | IL39036A (en) |
| NL (1) | NL7203979A (en) |
| SE (2) | SE385704B (en) |
| ZA (1) | ZA721612B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ168896A3 (en) * | 1995-06-27 | 1997-01-15 | Egyt Gyogyszervegyeszeti Gyar | Oxaindene derivatives and process for preparing thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7008628A (en) * | 1969-06-25 | 1970-12-29 |
-
1972
- 1972-03-09 CH CH350472A patent/CH574433A5/xx not_active IP Right Cessation
- 1972-03-09 ZA ZA721612A patent/ZA721612B/en unknown
- 1972-03-20 IL IL39036A patent/IL39036A/en unknown
- 1972-03-20 IE IE2067/74A patent/IE36187B1/en unknown
- 1972-03-20 IE IE354/72A patent/IE36186B1/en unknown
- 1972-03-21 AU AU40245/72A patent/AU463471B2/en not_active Expired
- 1972-03-22 CA CA137,759A patent/CA988529A/en not_active Expired
- 1972-03-23 HU HUHO1463A patent/HU164250B/hu unknown
- 1972-03-24 DK DK145472AA patent/DK130345B/en unknown
- 1972-03-24 AT AT229773A patent/AT319227B/en not_active IP Right Cessation
- 1972-03-24 BE BE781176A patent/BE781176A/en unknown
- 1972-03-24 FR FR7210383A patent/FR2130655B1/fr not_active Expired
- 1972-03-24 GB GB5123373A patent/GB1364807A/en not_active Expired
- 1972-03-24 DE DE19722214501 patent/DE2214501A1/en active Pending
- 1972-03-24 AT AT257972A patent/AT313272B/en not_active IP Right Cessation
- 1972-03-24 GB GB1387772A patent/GB1364806A/en not_active Expired
- 1972-03-24 NL NL7203979A patent/NL7203979A/xx not_active Application Discontinuation
- 1972-03-24 SE SE7203902A patent/SE385704B/en unknown
- 1972-03-25 ES ES401162A patent/ES401162A1/en not_active Expired
- 1972-11-23 AR AR245290A patent/AR192514A1/en active
- 1972-11-24 AR AR245289A patent/AR194407A1/en active
- 1972-11-24 AR AR245291A patent/AR192515A1/en active
-
1974
- 1974-12-27 SE SE7416328A patent/SE7416328L/xx unknown
-
1975
- 1975-03-11 IL IL46790A patent/IL46790A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB1364806A (en) | 1974-08-29 |
| FR2130655B1 (en) | 1975-06-20 |
| GB1364807A (en) | 1974-08-29 |
| DK130345C (en) | 1975-07-07 |
| ES401162A1 (en) | 1975-02-01 |
| HU164250B (en) | 1974-01-28 |
| AU463471B2 (en) | 1975-07-08 |
| IL46790A (en) | 1976-05-31 |
| ZA721612B (en) | 1972-11-29 |
| IE36186L (en) | 1972-09-26 |
| AT319227B (en) | 1974-12-10 |
| SE7416328L (en) | 1974-12-27 |
| CH574433A5 (en) | 1976-04-15 |
| DE2214501A1 (en) | 1972-10-05 |
| IL39036A0 (en) | 1972-06-28 |
| IL39036A (en) | 1976-05-31 |
| FR2130655A1 (en) | 1972-11-03 |
| AU4024572A (en) | 1972-03-21 |
| AT313272B (en) | 1974-02-11 |
| SE385704B (en) | 1976-07-19 |
| CA988529A (en) | 1976-05-04 |
| AR194407A1 (en) | 1973-07-13 |
| AR192514A1 (en) | 1973-02-21 |
| NL7203979A (en) | 1972-09-28 |
| BE781176A (en) | 1972-09-25 |
| IE36187B1 (en) | 1976-09-01 |
| AR192515A1 (en) | 1973-02-21 |
| DK130345B (en) | 1975-02-10 |
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