IE36011B1 - Fused ring indole derivatives and a process for the manufacture thereof - Google Patents
Fused ring indole derivatives and a process for the manufacture thereofInfo
- Publication number
- IE36011B1 IE36011B1 IE645/71A IE64571A IE36011B1 IE 36011 B1 IE36011 B1 IE 36011B1 IE 645/71 A IE645/71 A IE 645/71A IE 64571 A IE64571 A IE 64571A IE 36011 B1 IE36011 B1 IE 36011B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- alkoxy
- compounds
- manufacture
- haloacyl
- Prior art date
Links
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 abstract 2
- 125000005252 haloacyl group Chemical group 0.000 abstract 2
- -1 3-substituted cyclopentanone Chemical class 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000003356 anti-rheumatic effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000000609 carbazolyl group Chemical class C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- HKOOXMFOFWEVGF-UHFFFAOYSA-N phenylhydrazine Chemical compound NNC1=CC=CC=C1 HKOOXMFOFWEVGF-UHFFFAOYSA-N 0.000 abstract 1
- 229940067157 phenylhydrazine Drugs 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4044370A | 1970-05-25 | 1970-05-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36011L IE36011L (en) | 1971-11-25 |
| IE36011B1 true IE36011B1 (en) | 1976-07-21 |
Family
ID=21911008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE645/71A IE36011B1 (en) | 1970-05-25 | 1971-05-21 | Fused ring indole derivatives and a process for the manufacture thereof |
Country Status (14)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2226703A1 (de) * | 1972-05-25 | 1973-12-13 | Schering Ag | Neue tetrahydrocarbazolderivate und verfahren zu ihrer herstellung |
| EP0115607A1 (de) * | 1983-01-04 | 1984-08-15 | MERCK PATENT GmbH | Tetrahydrocarbazolderivate |
| DE3631824A1 (de) * | 1986-02-21 | 1988-03-31 | Bayer Ag | Cycloalkano(1.2-b)indol-sulfonamide |
| AU675141B2 (en) * | 1993-07-20 | 1997-01-23 | Adir Et Compagnie | (Thia)cycloalkyl(b)indoles, process for preparing them and pharmaceutical compositions containing them |
| US7662831B2 (en) | 2006-07-27 | 2010-02-16 | Wyeth Llc | Tetracyclic indoles as potassium channel modulators |
| US7601856B2 (en) | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
| EP3078374B1 (en) * | 2011-10-17 | 2019-06-19 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
| CN116854622A (zh) * | 2023-07-10 | 2023-10-10 | 青岛科技大学 | 一种多取代的2,4-二氢环戊二烯并[b]吲哚类化合物的合成方法 |
-
1971
- 1971-05-14 CH CH720271A patent/CH586678A5/xx not_active IP Right Cessation
- 1971-05-17 ZA ZA713173A patent/ZA713173B/xx unknown
- 1971-05-19 FR FR7118182A patent/FR2100677B1/fr not_active Expired
- 1971-05-20 IL IL36926A patent/IL36926A/xx unknown
- 1971-05-21 IE IE645/71A patent/IE36011B1/xx unknown
- 1971-05-24 ES ES391496A patent/ES391496A1/es not_active Expired
- 1971-05-24 AT AT445271A patent/AT310153B/de not_active IP Right Cessation
- 1971-05-24 GB GB06567/71A patent/GB1299041A/en not_active Expired
- 1971-05-24 JP JP46034844A patent/JPS5220476B1/ja active Pending
- 1971-05-24 BE BE767527A patent/BE767527A/xx unknown
- 1971-05-25 CA CA113,754A patent/CA952910A/en not_active Expired
- 1971-05-25 NL NL7107138A patent/NL7107138A/xx not_active Application Discontinuation
- 1971-05-25 DE DE19712125926 patent/DE2125926A1/de not_active Ceased
- 1971-05-25 HU HUHO1379A patent/HU163710B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2100677A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1972-03-24 |
| CA952910A (en) | 1974-08-13 |
| IL36926A0 (en) | 1971-07-28 |
| AT310153B (de) | 1973-09-25 |
| GB1299041A (en) | 1972-12-06 |
| IE36011L (en) | 1971-11-25 |
| BE767527A (fr) | 1971-11-24 |
| ES391496A1 (es) | 1973-06-16 |
| DE2125926A1 (de) | 1972-01-27 |
| HU163710B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-10-27 |
| FR2100677B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-10-18 |
| NL7107138A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-11-29 |
| CH586678A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-04-15 |
| IL36926A (en) | 1974-10-22 |
| JPS5220476B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-06-03 |
| ZA713173B (en) | 1972-01-26 |
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