IE35643B1 - Bis-basic ketones of xanthene and xanthen-9-one and antiviral compositions thereof - Google Patents
Bis-basic ketones of xanthene and xanthen-9-one and antiviral compositions thereofInfo
- Publication number
- IE35643B1 IE35643B1 IE1168/71A IE116871A IE35643B1 IE 35643 B1 IE35643 B1 IE 35643B1 IE 1168/71 A IE1168/71 A IE 1168/71A IE 116871 A IE116871 A IE 116871A IE 35643 B1 IE35643 B1 IE 35643B1
- Authority
- IE
- Ireland
- Prior art keywords
- xanthene
- bis
- compounds
- alkyl
- xanthen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
- C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
- C07D311/86—Oxygen atoms, e.g. xanthones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Insertion, Bundling And Securing Of Wires For Electric Apparatuses (AREA)
Abstract
1313454 Xanthene-derived aminoketones RICHARDSON-MERRELL Inc 15 Sept 1971 [11 Dec 1970] 43026/71 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable acid addition salts, wherein Z is O or H 2 , A is C 1-6 alkylene, and each Y is NR<SP>1</SP>R<SP>2</SP> (R<SP>1</SP>, R<SP>2</SP>=H, C 1-6 alkyl, C 3-6 cycloalkyl or C 3-6 alkenyl), pyrrolidino, piperidino or hexamethyleneimino (any of which may be C 1-4 alkyl substituted), morpholino, piperazino or 4-C 1-4 -alkyl-piperazino. In examples, these compounds are prepared by reacting (1) a bis-(chlaroalkanoyl)xanthene with the appropriate amine; (2) a xanthenebispiperidide with a dialkylaminoalkyl Grignard compound; (3) a diacylxanthene with CH 2 O and a dialkylamine; (4) a bis-(phthalimidylalkanoyl)xanthene, or the bis-ketals of the diketones (I), with HCl; (5) the xanthene with Na 2 Cr 2 O 7 /HOAc, giving the xanthene-9- one. Intermediates otherwise prepared are 2,7- bis-(acetyl- and bromoacetyl-)xanthen-9-ones; 2,7 - bis(1,1 - diethoxy - 4 - chlorobutyl - and 3- chloropropyl- )xanthenes); and 2,7-bis(1,1-diethoxy-4-morpholinobutyl)xanthene. Therapeutic compositions having antiviral activity, and which may be administered orally, topically, bucally, parenterally or by intranasal instillation or aerosol, comprise compounds of the above formula. These compounds may also be used to treat a viral infection in viable biological material such as can be used in the production of vaccines.
[GB1313454A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US097379A US3859286A (en) | 1970-12-11 | 1970-12-11 | Bis-basic ketones of xanthene and xanthen-9-one |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE35643L IE35643L (en) | 1972-06-11 |
| IE35643B1 true IE35643B1 (en) | 1976-04-14 |
Family
ID=22263057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1168/71A IE35643B1 (en) | 1970-12-11 | 1971-09-15 | Bis-basic ketones of xanthene and xanthen-9-one and antiviral compositions thereof |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US3859286A (en) |
| JP (1) | JPS5545549B1 (en) |
| AR (1) | AR196404A1 (en) |
| AT (2) | AT317890B (en) |
| AU (1) | AU453068B2 (en) |
| BE (1) | BE776535A (en) |
| CA (1) | CA948192A (en) |
| CH (1) | CH562818A5 (en) |
| CS (1) | CS166791B2 (en) |
| DE (1) | DE2151707A1 (en) |
| DK (1) | DK132275C (en) |
| ES (1) | ES397821A1 (en) |
| FR (1) | FR2118031B1 (en) |
| GB (1) | GB1313454A (en) |
| HU (1) | HU163026B (en) |
| IE (1) | IE35643B1 (en) |
| IL (1) | IL37755A (en) |
| NL (1) | NL7115559A (en) |
| NO (1) | NO135249C (en) |
| SE (1) | SE382458B (en) |
| ZA (1) | ZA716267B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4061768A (en) * | 1971-09-08 | 1977-12-06 | Burroughs Wellcome Co. | Certain cyclic carbonyl compounds used in the prophylaxis of allergic conditions |
| US4108896A (en) * | 1972-12-21 | 1978-08-22 | Richardson-Merrell Inc. | Anthracene derivatives |
| US3817992A (en) * | 1972-12-21 | 1974-06-18 | Richardson Merrell Inc | Xanthene and thioxanthene derivatives |
| US4008240A (en) | 1972-12-21 | 1977-02-15 | Richardson-Merrell Inc. | Xanthene and thioxanthene derivatives |
| US4250097A (en) * | 1978-03-08 | 1981-02-10 | Syntex (U.S.A.) Inc. | Compositions for and a method of preventing diabetic complications |
| DE3008411A1 (en) * | 1980-03-05 | 1981-09-10 | Merck Patent Gmbh, 6100 Darmstadt | NEW AROMATIC-ALIPHATIC KETONES, THEIR USE AS PHOTOINITIATORS AND PHOTOPOLYMERIZABLE SYSTEMS CONTAINING SUCH KETONES |
| CA2434636A1 (en) * | 2001-01-16 | 2002-07-25 | Guilford Pharmaceuticals, Inc. | Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (adp-ribose) glycohydrolase, and methods for their use |
| US10113075B2 (en) | 2014-09-04 | 2018-10-30 | Igm Malta Limited | Polycyclic photoinitiators |
| WO2018083635A2 (en) * | 2016-11-04 | 2018-05-11 | Auckland Uniservices Limited | Tricyclic heterocyclic derivatives and uses thereof |
| MX2022011765A (en) | 2020-03-26 | 2022-11-09 | Provectus Pharmatech Inc | Novel uses of halogenated xanthenes in oncology and virology. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA711333B (en) * | 1970-03-27 | 1971-11-24 | Richardson Merrell Inc | Bis-basic ketones of fluorene and fluorenone |
| US3767674A (en) * | 1971-10-01 | 1973-10-23 | Ostra Lakemedel Ab | Cyclohexeno thioxanthones |
-
1970
- 1970-12-11 US US097379A patent/US3859286A/en not_active Expired - Lifetime
-
1971
- 1971-07-14 CA CA118,192A patent/CA948192A/en not_active Expired
- 1971-09-07 NO NO3324/71A patent/NO135249C/no unknown
- 1971-09-15 GB GB4302671A patent/GB1313454A/en not_active Expired
- 1971-09-15 IE IE1168/71A patent/IE35643B1/en unknown
- 1971-09-17 IL IL37755A patent/IL37755A/en unknown
- 1971-09-20 ZA ZA716267A patent/ZA716267B/en unknown
- 1971-09-27 AU AU33908/71A patent/AU453068B2/en not_active Expired
- 1971-10-14 CH CH1501371A patent/CH562818A5/xx not_active IP Right Cessation
- 1971-10-18 DE DE19712151707 patent/DE2151707A1/en not_active Withdrawn
- 1971-10-20 JP JP8252971A patent/JPS5545549B1/ja active Pending
- 1971-11-05 AT AT1010272A patent/AT317890B/en not_active IP Right Cessation
- 1971-11-05 AT AT956871A patent/AT319944B/en not_active IP Right Cessation
- 1971-11-12 NL NL7115559A patent/NL7115559A/xx not_active Application Discontinuation
- 1971-11-19 CS CS8104A patent/CS166791B2/cs unknown
- 1971-12-03 SE SE7115518A patent/SE382458B/en unknown
- 1971-12-06 AR AR239429A patent/AR196404A1/en active
- 1971-12-08 HU HURI458A patent/HU163026B/hu unknown
- 1971-12-10 DK DK605771A patent/DK132275C/en active
- 1971-12-10 ES ES397821A patent/ES397821A1/en not_active Expired
- 1971-12-10 FR FR7144506A patent/FR2118031B1/fr not_active Expired
- 1971-12-10 BE BE776535A patent/BE776535A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2151707A1 (en) | 1972-06-29 |
| AR196404A1 (en) | 1973-12-27 |
| IL37755A0 (en) | 1971-11-29 |
| AU3390871A (en) | 1973-04-05 |
| JPS5545549B1 (en) | 1980-11-18 |
| HU163026B (en) | 1973-05-28 |
| DK132275C (en) | 1976-04-12 |
| BE776535A (en) | 1972-04-04 |
| IE35643L (en) | 1972-06-11 |
| NL7115559A (en) | 1972-06-13 |
| CS166791B2 (en) | 1976-03-29 |
| AT317890B (en) | 1974-09-25 |
| US3859286A (en) | 1975-01-07 |
| IL37755A (en) | 1974-07-31 |
| FR2118031A1 (en) | 1972-07-28 |
| DK132275B (en) | 1975-11-17 |
| GB1313454A (en) | 1973-04-11 |
| NO135249C (en) | 1977-03-09 |
| SE382458B (en) | 1976-02-02 |
| AU453068B2 (en) | 1974-09-19 |
| CH562818A5 (en) | 1975-06-13 |
| FR2118031B1 (en) | 1975-06-13 |
| ES397821A1 (en) | 1975-06-16 |
| AT319944B (en) | 1975-01-10 |
| ZA716267B (en) | 1972-05-31 |
| NO135249B (en) | 1976-11-29 |
| CA948192A (en) | 1974-05-28 |
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