IE34676B1 - Benzimidazo (2,1-b) quinazolin derivatives as immuno suppressants - Google Patents
Benzimidazo (2,1-b) quinazolin derivatives as immuno suppressantsInfo
- Publication number
- IE34676B1 IE34676B1 IE1392/70A IE139270A IE34676B1 IE 34676 B1 IE34676 B1 IE 34676B1 IE 1392/70 A IE1392/70 A IE 1392/70A IE 139270 A IE139270 A IE 139270A IE 34676 B1 IE34676 B1 IE 34676B1
- Authority
- IE
- Ireland
- Prior art keywords
- benzimidazo
- reacting
- quinazolin
- quinazolin derivatives
- immuno suppressants
- Prior art date
Links
- KHGJYQRGMPPZCG-UHFFFAOYSA-N benzimidazolo[2,1-b]quinazoline Chemical class C1=CC=CC2=CN3C4=CC=CC=C4N=C3N=C21 KHGJYQRGMPPZCG-UHFFFAOYSA-N 0.000 title 1
- 229960003444 immunosuppressant agent Drugs 0.000 title 1
- 230000001861 immunosuppressant effect Effects 0.000 title 1
- 239000003018 immunosuppressive agent Substances 0.000 title 1
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 abstract 4
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- JWYUFVNJZUSCSM-UHFFFAOYSA-N 2-aminobenzimidazole Chemical compound C1=CC=C2NC(N)=NC2=C1 JWYUFVNJZUSCSM-UHFFFAOYSA-N 0.000 abstract 1
- AYPSHJCKSDNETA-UHFFFAOYSA-N 2-chloro-1h-benzimidazole Chemical compound C1=CC=C2NC(Cl)=NC2=C1 AYPSHJCKSDNETA-UHFFFAOYSA-N 0.000 abstract 1
- OCKJFOHZLXIAAT-UHFFFAOYSA-N 2-methylsulfanyl-1h-benzimidazole Chemical compound C1=CC=C2NC(SC)=NC2=C1 OCKJFOHZLXIAAT-UHFFFAOYSA-N 0.000 abstract 1
- ZNJPVCCDFJKUBS-UHFFFAOYSA-N 6h-benzimidazolo[2,1-b]quinazolin-12-one Chemical class C1=CC=C2N3C(=O)C4=CC=CC=C4N=C3NC2=C1 ZNJPVCCDFJKUBS-UHFFFAOYSA-N 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- -1 anthraniloyl halide Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87957969A | 1969-11-24 | 1969-11-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE34676L IE34676L (en) | 1971-05-24 |
| IE34676B1 true IE34676B1 (en) | 1975-07-09 |
Family
ID=25374430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1392/70A IE34676B1 (en) | 1969-11-24 | 1970-11-02 | Benzimidazo (2,1-b) quinazolin derivatives as immuno suppressants |
Country Status (15)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3963720A (en) * | 1972-10-27 | 1976-06-15 | Sandoz, Inc. | Tetracyclic imidazo [2,1-b] quinazolinone derivatives |
| DE2960689D1 (en) * | 1978-07-28 | 1981-11-19 | Synthelabo | Fluorene and fluoranthene derivatives, process for their preparation and their therapeutic application |
| DE3220438A1 (de) * | 1982-05-29 | 1983-12-01 | Troponwerke GmbH & Co KG, 5000 Köln | Chinazolinonderivate, verfahren zu ihrer herstellung und ihre verwendung inn arzneimitteln |
| AU623910B2 (en) * | 1988-05-16 | 1992-05-28 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Chemotherapeutic composition for aids |
| US6262093B1 (en) | 1995-04-12 | 2001-07-17 | The Proctor & Gamble Company | Methods of treating cancer with benzimidazoles |
| US6479526B1 (en) | 1995-04-12 | 2002-11-12 | The Procter & Gamble Company | Pharmaceutical composition for inhibiting the growth of viruses and cancers |
| ZA962879B (en) * | 1995-04-12 | 1997-03-17 | Procter & Gamble | A pharmaceutical composition for inhibiting the growth of viruses and cancers |
| US6265427B1 (en) | 1995-06-07 | 2001-07-24 | The Proctor & Gamble Company | Pharmaceutical composition for the method of treating leukemia |
| US5900429A (en) | 1997-01-28 | 1999-05-04 | The Procter & Gamble Company | Method for inhibiting the growth of cancers |
| US6506783B1 (en) | 1997-05-16 | 2003-01-14 | The Procter & Gamble Company | Cancer treatments and pharmaceutical compositions therefor |
| US6245789B1 (en) | 1998-05-19 | 2001-06-12 | The Procter & Gamble Company | HIV and viral treatment |
| US6423734B1 (en) | 1999-08-13 | 2002-07-23 | The Procter & Gamble Company | Method of preventing cancer |
| US6462062B1 (en) | 2000-09-26 | 2002-10-08 | The Procter & Gamble Company | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6380232B1 (en) | 2000-09-26 | 2002-04-30 | The Procter & Gamble Company | Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof |
| US6407105B1 (en) * | 2000-09-26 | 2002-06-18 | The Procter & Gamble Company | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6608096B1 (en) | 2000-09-26 | 2003-08-19 | University Of Arizona Foundation | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6515074B2 (en) * | 2001-01-22 | 2003-02-04 | Delphi Technologies, Inc. | Thermoplastic polymer alloy compositions and process for manufacture thereof |
| WO2009038731A2 (en) * | 2007-09-17 | 2009-03-26 | The Trustees Of Columbia University In The City Of New York | Synthesis of resveratrol-based natural products |
| WO2011103442A2 (en) * | 2010-02-18 | 2011-08-25 | The Trustees Of Columbia University In The City Of New York | Synthesis of the potent immunosuppressant agents dalesconol a and b |
| DE102010024542A1 (de) | 2010-06-22 | 2011-12-22 | Merck Patent Gmbh | Materialien für elektronische Vorrichtungen |
| JP6333262B2 (ja) * | 2012-09-20 | 2018-05-30 | ユー・ディー・シー アイルランド リミテッド | 電子用途のためのアザジベンゾフラン |
| CN112010925B (zh) * | 2019-05-28 | 2021-10-26 | 首都医科大学 | Gde及羟甲基修饰的苯并咪唑喹唑啉，其合成，活性和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3244717A (en) * | 1964-06-18 | 1966-04-05 | Searle & Co | 5-hydroxy-2-methyl-7-phenylimidazo [1, 2-a] pyrimidines |
| US3501473A (en) * | 1967-11-09 | 1970-03-17 | American Home Prod | Disubstituted - 11h - quinazolino - (2,3-b) quinazoline - 11,13 (5h) - diones and the process for their preparation |
-
0
- BE BE759337D patent/BE759337A/xx unknown
-
1969
- 1969-11-24 US US879579A patent/US3669969A/en not_active Expired - Lifetime
-
1970
- 1970-11-02 IE IE1392/70A patent/IE34676B1/xx unknown
- 1970-11-04 IL IL35583A patent/IL35583A/xx unknown
- 1970-11-05 ZA ZA707509A patent/ZA707509B/xx unknown
- 1970-11-17 CA CA098,317A patent/CA974992A/en not_active Expired
- 1970-11-18 ES ES385683A patent/ES385683A1/es not_active Expired
- 1970-11-23 GB GB5562170A patent/GB1322930A/en not_active Expired
- 1970-11-23 SE SE7015860A patent/SE388617B/xx unknown
- 1970-11-23 DE DE19702058185 patent/DE2058185A1/de active Pending
- 1970-11-24 JP JP45103606A patent/JPS5026560B1/ja active Pending
- 1970-11-24 CH CH1737470A patent/CH560216A5/xx not_active IP Right Cessation
- 1970-11-24 NL NL7017185A patent/NL7017185A/xx not_active Application Discontinuation
- 1970-11-24 AT AT1058970A patent/AT310758B/de not_active IP Right Cessation
- 1970-11-24 FR FR7042071A patent/FR2073408B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AT310758B (de) | 1973-10-10 |
| US3669969A (en) | 1972-06-13 |
| ES385683A1 (es) | 1973-10-01 |
| CH560216A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-03-27 |
| BE759337A (fr) | 1971-05-24 |
| IL35583A (en) | 1975-02-10 |
| FR2073408A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-10-01 |
| DE2058185A1 (de) | 1971-06-03 |
| GB1322930A (en) | 1973-07-11 |
| IE34676L (en) | 1971-05-24 |
| CA974992A (en) | 1975-09-23 |
| NL7017185A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-05-26 |
| ZA707509B (en) | 1971-08-25 |
| IL35583A0 (en) | 1971-01-28 |
| FR2073408B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-05-24 |
| JPS5026560B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-09-01 |
| SE388617B (sv) | 1976-10-11 |
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