ID26991A - Senyawa-senyawa heterosiklik sebagai penghambat enzim rotamase - Google Patents

Senyawa-senyawa heterosiklik sebagai penghambat enzim rotamase

Info

Publication number
ID26991A
ID26991A IDW20010155A ID20010155A ID26991A ID 26991 A ID26991 A ID 26991A ID W20010155 A IDW20010155 A ID W20010155A ID 20010155 A ID20010155 A ID 20010155A ID 26991 A ID26991 A ID 26991A
Authority
ID
Indonesia
Prior art keywords
heterosiclic
enzymer
rotamase
inhibition
compounds
Prior art date
Application number
IDW20010155A
Other languages
English (en)
Indonesian (id)
Inventor
Mark Ian Kemp
Michael John Palmer
Mark Allen Sanner
Martin James Wythes
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ID26991A publication Critical patent/ID26991A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
IDW20010155A 1998-07-21 1999-06-28 Senyawa-senyawa heterosiklik sebagai penghambat enzim rotamase ID26991A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9815880.1A GB9815880D0 (en) 1998-07-21 1998-07-21 Heterocycles

Publications (1)

Publication Number Publication Date
ID26991A true ID26991A (id) 2001-02-22

Family

ID=10835920

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20010155A ID26991A (id) 1998-07-21 1999-06-28 Senyawa-senyawa heterosiklik sebagai penghambat enzim rotamase

Country Status (45)

Country Link
US (2) US6372736B1 (xx)
EP (1) EP1100797B1 (xx)
JP (2) JP3795329B2 (xx)
KR (2) KR100468185B1 (xx)
CN (3) CN1511837A (xx)
AP (1) AP2001002046A0 (xx)
AR (1) AR019427A1 (xx)
AT (1) ATE233261T1 (xx)
AU (1) AU765925B2 (xx)
BG (1) BG105254A (xx)
BR (1) BR9912330A (xx)
CA (1) CA2338214C (xx)
CO (1) CO5080782A1 (xx)
CR (1) CR6073A (xx)
DE (1) DE69905582T2 (xx)
DK (1) DK1100797T3 (xx)
DZ (1) DZ2851A1 (xx)
EA (1) EA003513B1 (xx)
EE (1) EE200100044A (xx)
ES (1) ES2191484T3 (xx)
GB (1) GB9815880D0 (xx)
GE (1) GEP20033028B (xx)
GT (1) GT199900115A (xx)
HK (1) HK1039779A1 (xx)
HN (1) HN1999000106A (xx)
HR (1) HRP20010052A2 (xx)
HU (1) HUP0103413A3 (xx)
ID (1) ID26991A (xx)
IL (1) IL140244A0 (xx)
IS (1) IS5790A (xx)
MA (1) MA24936A1 (xx)
MY (1) MY118222A (xx)
NO (1) NO20010322L (xx)
NZ (2) NZ522270A (xx)
OA (1) OA11585A (xx)
PA (1) PA8478501A1 (xx)
PE (1) PE20001037A1 (xx)
PL (1) PL345734A1 (xx)
SI (1) SI1100797T1 (xx)
SK (1) SK772001A3 (xx)
SV (1) SV1999000102A (xx)
TN (1) TNSN99147A1 (xx)
TR (1) TR200100135T2 (xx)
TW (1) TWI229672B (xx)
WO (1) WO2000005232A1 (xx)

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GB9815880D0 (en) * 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
DE59911249D1 (de) 1998-11-03 2005-01-13 Abbott Gmbh & Co Kg Substituierte 2-phenylbenzimidazole, deren herstellung und anwendung
GT200000203A (es) 1999-12-01 2002-05-24 Compuestos, composiciones y metodos para estimular el crecimiento y elongacion de neuronas.
FR2805818B1 (fr) * 2000-03-03 2002-04-26 Aventis Pharma Sa Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant
DE10124953A1 (de) * 2001-05-21 2002-12-12 Marlies Knipper Substanz für die therapeutische Behandlung von Tinnitus
DK1778637T3 (da) * 2004-06-29 2012-06-18 Aventis Pharma Inc FKBP-bindingssammensætninger og farmaceutisk anvendelse deraf
US7728026B2 (en) * 2005-04-11 2010-06-01 Abbott Laboratories, Inc. 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors
TWI375673B (en) * 2005-04-11 2012-11-01 Abbott Lab 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
ES2378692T3 (es) * 2005-09-29 2012-04-17 Abbott Laboratories Las 1H-benzimidazol-4-carboxamidas sustituidas con fenilo en la posición 2 son potentes inhibidores de PARP
ATE461923T1 (de) * 2005-11-15 2010-04-15 Abbott Lab Substituierte 1h-benzimidazol-4-carbonsäureamide sind wirksame parp-inhibitoren
ES2614090T3 (es) 2005-12-29 2017-05-29 Celtaxsys, Inc. Derivados de diamina como inhibidores de leucotrieno A4 hidrolasa
GB0602768D0 (en) * 2006-02-10 2006-03-22 Vastox Plc Treatment of muscular dystrophy
MX2008010187A (es) 2006-02-10 2008-10-31 Summit Corp Plc Tratamiento de distrofia muscular de duchenne.
RU2462458C2 (ru) * 2006-02-10 2012-09-27 Байомарин Ига Лимитед Лечение миодистрофии дюшена
ES2385849T3 (es) * 2006-05-02 2012-08-01 Abbott Laboratories Las 1H-bencimidazol-4-carboxamidas substituidas son potentes inhibidores de la PARP
ES2387471T3 (es) * 2006-12-20 2012-09-24 Amgen Inc. Compuestos heterocíclicos y su uso en el tratamiento de la inflamación, la angiogénesis y el cáncer
CL2008000666A1 (es) * 2007-03-07 2008-06-13 Xenon Pharmaceuticals Inc Compuestos derivados de triciclos sustituidos, inhibidores del transportador de metales divalentes-1; y uso para tratar una enfermedad asociada con un trastorno del hierro.
US8067613B2 (en) * 2007-07-16 2011-11-29 Abbott Laboratories Benzimidazole poly(ADP ribose)polymerase inhibitors
CA2685540C (en) * 2007-08-03 2018-10-16 Graham Michael Wynne Drug combinations for the treatment of duchenne muscular dystrophy
GB0715937D0 (en) * 2007-08-15 2007-09-26 Vastox Plc Method of treatment og duchenne muscular dystrophy
GB0715939D0 (en) * 2007-08-15 2007-09-26 Vastox Plc Method of treatment of duchenne muscular dystrophy
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
WO2010083199A1 (en) * 2009-01-19 2010-07-22 Abbott Laboratories Benzthiazole inhibitors of poly(adp-ribose)polymerase
GB0905664D0 (en) * 2009-04-02 2009-05-13 Summit Corp Plc Compounds for treatment of duchenne muscular dystrophy
ES2864862T3 (es) 2013-03-12 2021-10-14 Celltaxis Llc Métodos de inhibición de la leucotrieno A4 hidrolasa
CA2906086A1 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
RU2696559C2 (ru) 2013-03-14 2019-08-05 Селтакссис, Инк. Ингибиторы лейкотриен а4-гидролазы
WO2014152518A2 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
CA2949511A1 (en) * 2014-05-19 2015-11-26 Merial, Inc. Anthelmintic compounds
EP3801559A4 (en) 2018-05-31 2022-03-02 Celltaxis, LLC METHOD FOR REDUCING LUNG EXACERBATIONS IN PATIENTS SUFFERING FROM RESPIRATORY DISEASE
CN109111376B (zh) * 2018-09-18 2021-09-14 四川医立特生物医药有限公司 一种2,5-双脱氧链霉胺衍生物及其应用

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GB9815880D0 (en) * 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles

Also Published As

Publication number Publication date
DE69905582D1 (de) 2003-04-03
KR100468185B1 (ko) 2005-01-26
MA24936A1 (fr) 2000-04-01
BR9912330A (pt) 2001-04-17
KR100450008B1 (ko) 2004-09-24
CN1310718A (zh) 2001-08-29
EP1100797A1 (en) 2001-05-23
AU765925B2 (en) 2003-10-02
CA2338214C (en) 2006-08-01
WO2000005232A1 (en) 2000-02-03
NZ508838A (en) 2002-12-20
NZ522270A (en) 2004-03-26
US6372736B1 (en) 2002-04-16
DZ2851A1 (fr) 2004-02-04
PE20001037A1 (es) 2000-10-11
BG105254A (en) 2001-10-31
CR6073A (es) 2004-04-29
SV1999000102A (es) 2000-07-06
SK772001A3 (en) 2001-12-03
JP3795329B2 (ja) 2006-07-12
CO5080782A1 (es) 2001-09-25
GT199900115A (es) 2001-01-10
IL140244A0 (en) 2002-02-10
CN1511837A (zh) 2004-07-14
PA8478501A1 (es) 2000-05-24
GB9815880D0 (en) 1998-09-16
MY118222A (en) 2004-09-30
HUP0103413A3 (en) 2002-10-28
PL345734A1 (en) 2002-01-02
KR20040062640A (ko) 2004-07-07
NO20010322L (no) 2001-03-15
TWI229672B (en) 2005-03-21
CN1174978C (zh) 2004-11-10
KR20010071013A (ko) 2001-07-28
JP2004002374A (ja) 2004-01-08
US6562964B1 (en) 2003-05-13
EA200100052A1 (ru) 2001-06-25
TR200100135T2 (tr) 2001-06-21
EP1100797B1 (en) 2003-02-26
AP2001002046A0 (en) 2001-03-31
SI1100797T1 (en) 2003-06-30
GEP20033028B (en) 2003-07-25
ATE233261T1 (de) 2003-03-15
IS5790A (is) 2000-12-22
CN1611499A (zh) 2005-05-04
EE200100044A (et) 2002-06-17
DK1100797T3 (da) 2003-04-22
DE69905582T2 (de) 2003-09-04
ES2191484T3 (es) 2003-09-01
HK1039779A1 (zh) 2002-05-10
EA003513B1 (ru) 2003-06-26
AU4285899A (en) 2000-02-14
HRP20010052A2 (en) 2001-12-31
AR019427A1 (es) 2002-02-20
HN1999000106A (es) 1999-11-11
TNSN99147A1 (fr) 2005-11-10
HUP0103413A2 (hu) 2002-05-29
CA2338214A1 (en) 2000-02-03
NO20010322D0 (no) 2001-01-19
JP2002521382A (ja) 2002-07-16
OA11585A (en) 2004-07-26

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