ID18708A - LIGAN METABOTROPIC GLUTAMATE RECEPTORS - Google Patents
LIGAN METABOTROPIC GLUTAMATE RECEPTORSInfo
- Publication number
- ID18708A ID18708A IDP972770A ID972770A ID18708A ID 18708 A ID18708 A ID 18708A ID P972770 A IDP972770 A ID P972770A ID 972770 A ID972770 A ID 972770A ID 18708 A ID18708 A ID 18708A
- Authority
- ID
- Indonesia
- Prior art keywords
- ligan
- metabotropic glutamate
- glutamate receptors
- receptors
- metabotropic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21127896 | 1996-08-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ID18708A true ID18708A (en) | 1998-04-30 |
Family
ID=16603285
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IDP972770A ID18708A (en) | 1996-08-09 | 1997-08-08 | LIGAN METABOTROPIC GLUTAMATE RECEPTORS |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU3783497A (en) |
ID (1) | ID18708A (en) |
WO (1) | WO1998006724A1 (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0891978T3 (en) * | 1997-07-18 | 2002-07-01 | Hoffmann La Roche | 5H-thiazole (3,2-a) pyrimidinderivativer |
EP1059090A4 (en) * | 1998-03-03 | 2002-02-27 | Yamanouchi Pharma Co Ltd | Remedies for brain infarction |
DK1064382T3 (en) | 1998-03-17 | 2008-12-08 | Genentech Inc | Homologous polypeptides for VEGF and BMP1 |
AU2241400A (en) | 1999-04-06 | 2000-10-12 | Yamanouchi Pharmaceutical Co., Ltd. | Novel thiazolobenzoimidazole derivative |
DE19948434A1 (en) * | 1999-10-08 | 2001-06-07 | Gruenenthal Gmbh | Substance library containing bicyclic imidazo-5-amines and / or bicyclic imidazo-3-amines |
WO2002062803A1 (en) * | 2001-02-08 | 2002-08-15 | Yamanouchi Pharmaceutical Co., Ltd. | Thienopyrimidine derivative |
TWI417095B (en) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of mglur2-receptors |
DK2001892T3 (en) | 2006-03-17 | 2013-07-01 | Ambit Biosciences Corp | IMIDAZOLTHIAZOL COMPOUNDS FOR TREATING PROLIFERATIVE DISEASES |
SI2083811T1 (en) | 2006-11-22 | 2017-02-28 | Clinical Research Associates, Llc | Methods of treating down's syndrome, fragile x syndrome and autism |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
PT2203439E (en) | 2007-09-14 | 2011-02-11 | Ortho Mcneil Janssen Pharm | 1`,3`-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1`h-ý1, 4`¨bipyridinyl-2`-ones |
TWI437988B (en) | 2007-09-19 | 2014-05-21 | Ambit Biosciences Corp | Solid forms comprising n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith |
CA2735764C (en) | 2008-09-02 | 2016-06-14 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
MX2011005242A (en) | 2008-11-28 | 2011-09-06 | Ortho Mcneil Janssen Pharm | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors. |
EP2218464A1 (en) * | 2009-02-11 | 2010-08-18 | Technische Universität München | Compounds for non-invasive measurement of aggregates of amyloid peptides |
MX2011011964A (en) | 2009-05-12 | 2012-02-23 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders. |
AR076859A1 (en) | 2009-05-12 | 2011-07-13 | Ortho Mcneil Janssen Pharm | DERIVATIVES OF 1,2,4-TRIAZOLO [4,3-A] PIRIDINE POSITIVE MODULATORS OF MGLUR2 RECEPTORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEMSELVES AND USE OF THE SAME IN THE TREATMENT OF NEUROLOGICAL AND SYNCHIATRIC DISORDERS. |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
EP2496584B1 (en) * | 2009-11-05 | 2016-09-21 | Ambit Biosciences Corporation | Process for the preparation of imidazo[2,1-b][1,3]benzothiazole derivatives |
WO2011109398A2 (en) | 2010-03-02 | 2011-09-09 | President And Fellows Of Harvard College | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
US20110294879A1 (en) | 2010-05-28 | 2011-12-01 | Xenoport, Inc. | Method of treatment of fragile x syndrome, down's syndrome, autism and related disorders |
WO2012009646A1 (en) | 2010-07-15 | 2012-01-19 | Xenoport, Inc. | Methods of treating fragile x syndrome, down's syndrome, autism and related disorders |
PL2649069T3 (en) | 2010-11-08 | 2016-01-29 | Janssen Pharmaceuticals Inc | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
CN103298809B (en) | 2010-11-08 | 2016-08-31 | 杨森制药公司 | 1,2,4-triazol [4,3-a] pyridine derivate and the purposes of the positive allosteric modulators as MGLUR2 acceptor thereof |
CA2814998C (en) | 2010-11-08 | 2019-10-29 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
JO3368B1 (en) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
JO3367B1 (en) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
AU2015208233B2 (en) | 2014-01-21 | 2019-08-29 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
PT3096790T (en) | 2014-01-21 | 2019-10-15 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
US11559518B2 (en) * | 2017-12-28 | 2023-01-24 | Er Stress Research Institute, Inc. | Endoplasmic reticulum stress regulator comprising benzothiazoimidazolyl compound |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2463774A1 (en) * | 1979-08-21 | 1981-02-27 | Yamanouchi Pharma Co Ltd | DERIVATIVES OF 2-PHENYLIMIDAZO (2,1-B) BENZOTHIAZOLE |
JPS56138196A (en) * | 1980-03-29 | 1981-10-28 | Yamanouchi Pharmaceut Co Ltd | Imidazo (2,1-b)benzothiazole derivative |
JPS5740492A (en) * | 1980-08-22 | 1982-03-06 | Yamanouchi Pharmaceut Co Ltd | Novel 2-phenylimidazo 2,1-b benzothiazole derivative |
JPS57149288A (en) * | 1981-03-12 | 1982-09-14 | Yamanouchi Pharmaceut Co Ltd | Imidazo(2,1-b)benzothiazole derivative |
US4464384A (en) * | 1981-12-23 | 1984-08-07 | Yamanouchi Pharmaceutical Co., Ltd. | 2-Phenylimidazo[2,1-b]benzothiazole compounds, salts thereof, process of producing them, and pharmaceutical compositions containing them |
EP0524055A1 (en) * | 1991-07-19 | 1993-01-20 | Synthelabo | Imidazo(2,1-b)benzothiazole-3-acetamide derivatives, process for their preparation and their therapeutical use |
FR2699920B1 (en) * | 1992-12-24 | 1995-02-10 | Synthelabo | Imidazo [2,1-b] benzothiazole-3-acetamide derivatives, their preparation and their therapeutic use. |
FR2699921B1 (en) * | 1992-12-30 | 1995-02-10 | Synthelabo | 2- (Thien-2-yl) imidazo [2,1-b] benzothiazole-3-acetic acid derivatives, their preparation and their therapeutic use. |
CA2185670A1 (en) * | 1994-03-14 | 1995-09-21 | Palle Jakobsen | Heterocyclic compounds, their preparation and use |
-
1997
- 1997-08-07 AU AU37834/97A patent/AU3783497A/en not_active Abandoned
- 1997-08-07 WO PCT/JP1997/002748 patent/WO1998006724A1/en active Application Filing
- 1997-08-08 ID IDP972770A patent/ID18708A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO1998006724A1 (en) | 1998-02-19 |
AU3783497A (en) | 1998-03-06 |
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